Updated on 2025/10/04

写真a

 
ITAGAKI Shiro
 
Organization
Collaboration Center for Community and Industry Special-Appoingment Associate Professor
Title
Special-Appoingment Associate Professor
External link

Degree

  • 博士(薬学) ( 北海道大学 )

Research Interests

  • バイオデザイン

  • ポリフェノール

  • 食品機能成分

  • transporter

  • 薬物相互作用

  • 医工連携

  • 産官学連携

  • 地域連携

  • 科学政策

  • クリニカルクエスチョン

  • 臨床研究

  • URA

Research Areas

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living

  • Life Science / Nutrition science and health science

  • Humanities & Social Sciences / Science education

  • Humanities & Social Sciences / Tertiary education

  • Life Science / Medical management and medical sociology

Education

  • Hokkaido University   Faculty of Pharmaceutical Sciences

    1999.3

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    Country: Japan

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  • Hokkaido University

    2001.3

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    Country: Japan

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  • Hokkaido University

    2003.1

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    Country: Japan

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Research History

  • Sapporo Medical University

    2025.10

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  • Sapporo Medical University

    2025.10

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  • Sapporo Medical University

    2018.4

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  • Hirosaki University   Associate Professor

    2015.10 - 2017.3

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  • Hirosaki University   University Hospital

    2013.7 - 2017.3

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  • Hirosaki University   University Hospital

    2010.4 - 2017.3

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  • Hirosaki University   University Hospital   Associate Professor

    2010.4 - 2015.9

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  • Hirosaki University   University Hospital

    2010.4 - 2013.6

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  • Hokkaido University   Faculty of Pharmaceutical Sciences   Assistant Professor

    2007.4 - 2010.3

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  • 海外長期出張 米国ジョージア医科大学生化学部門   博士研究員

    2005.3 - 2006.3

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  • 博士(薬学)取得

    2004.9

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  • 北海道大学大学院薬学研究科   助手

    2003.2 - 2007.3

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Professional Memberships

Committee Memberships

  • 北海道医療福祉産業研究会   世話人  

    2019.2   

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    Committee type:Other

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  • 日本学術振興会   科学研究費委員会専門委員 (第1段審査委員)  

    2016.12 - 2019.11   

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    Committee type:Academic society

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  • 弘前大学大学院医学研究科   倫理委員会 委員長  

    2016.6 - 2017.3   

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    Committee type:Other

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  • 東北臨床研究審査機構   実務担当委員  

    2015.7 - 2017.3   

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    Committee type:Academic society

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  • 東北臨床研究審査機構   IRB委員  

    2015.7 - 2017.3   

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    Committee type:Other

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  • 医薬品相互作用研究会   理事  

    2014.7 - 2017.3   

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    Committee type:Academic society

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  • 東北地区病院薬剤師会 学術連絡委員会   委員長  

    2014.5 - 2017.3   

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    Committee type:Academic society

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  • 青森県病院薬剤師会   理事  

    2014.5 - 2017.3   

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    Committee type:Academic society

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  • 東北トランスレーショナルリサーチ拠点形成ネットワーク   弘前大学実務担当者  

    2014.5 - 2017.3   

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  • 青森県病院薬剤師会   薬学教育実務実習検討委員会 委員長  

    2014.5 - 2016.3   

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    Committee type:Academic society

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  • 医薬品相互作用研究会   編集委員  

    2013.6 - 2017.3   

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    Committee type:Academic society

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  • 国立大学附属病院臨床研究推進会議   弘前大学代表者  

    2012.11 - 2017.3   

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    Committee type:Academic society

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  • 東北トランスレーショナルリサーチ拠点形成ネットワーク   弘前大学副代表  

    2012.10 - 2014.5   

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  • 日本病院薬剤師会   地域編集委員  

    2012.7 - 2016.6   

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    Committee type:Academic society

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  • 日本病院薬剤師会   東北ブロック第一回学術大会 事務局長  

    2011.7 - 2011.11   

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  • 日本薬学会   年会問題検討委員会 委員  

    2009.4 - 2012.3   

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  • 日本薬学会   北海道支部幹事  

    2009.4 - 2010.3   

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  • 北海道薬物作用談話会   第22回大会 事務局長  

    2008.4 - 2008.7   

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  • 日本医療薬学会   第18回日本医療薬学会年会 事務局  

    2007.10 - 2008.9   

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  • 北海道TDM研究会   幹事 (研究発表会 事務局長)  

    2006.4 - 2010.3   

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Papers

  • Exploration of candidate odorants derived from patient skin lesions using gas chromatography-mass spectrometry Reviewed

    Ryosuke IIZAWA, Masami HORIGUCHI, Hisashi UHARA, Yuji KAN, Kunihiro TOGASHI, Makoto SUZUKI, Takafumi NOMURA, Shiro ITAGAKI, Tomoko UNO, Madoka NAKAMURA

    Journal of Japan Association on Odor Environment   55 ( 5 )   315 - 318   2024.9

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    Publisher:Japan Association on Odor Environment  

    DOI: 10.2171/jao.55.315

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  • A simple, dual direct expression plasmid system in prokaryotic and mammalian cells. International journal

    Manabu Murakami, Agnieszka M Murakami, Manabu Yonekura, Ichiro Miyoshi, Shirou Itagaki, Yasutaka Niwa

    PNAS nexus   2 ( 5 )   pgad139   2023.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    We introduce a simple, dual direct cloning plasmid system (pgMAX-II) for gene expression analysis in both prokaryotic (Escherichia coli) and mammalian cells. This system, which uses a prokaryotic expression unit adapted from the pgMAX system and a mammalian promoter, is effective for subcloning using the DNA topoisomerase II toxin CcdB. Given that molecular biological cloning systems broadly rely on E. coli for rapid growth, the proposed concept may have wide applicability beyond mammalian cells.

    DOI: 10.1093/pnasnexus/pgad139

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  • Rapid method for plasmid DNA recombination (Murakami-system). International journal

    Agnieszka M Murakami, Manabu Yonekura, Katsuhiro Nagatomo, Yasutaka Niwa, Shirou Itagaki, Manabu Murakami

    MethodsX   10   102167 - 102167   2023

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    DNA recombination is a useful technology for cloning and subsequent functional analysis, while standard techniques for plasmid DNA recombination have remained unchanged. In the present study, we introduced rapid method for plasmid DNA recombination, which we named "Murakami-system", to complete the experiments in under 33 h. For this purpose, we selected the following: PCR amplification with 25 cycles and E. coli strain with rapid growth (incubation time of 6-8 h). In addition, we selected rapid plasmid DNA purification (mini-prep; ∼10 min) and rapid restriction enzyme incubation (20 min). This recombination system enabled rapid plasmid DNA recombination within 24-33 h, which could be useful in various fields. We also established a 1-day method for competent cell preparation. Our rapid recombination system allowed several sessions of plasmid DNA recombination to be performed every week, which improves the functional analysis of various genes.•"Rapid method for plasmid DNA recombination (Murakami-system).•E. coli strain with rapid growth (incubation time of 6-8 h).•Combination of rapid protocols (PCR, electrophoresis, DNA purification, ligation, and mini-prep) enabled plasmid DNA recombination within 24-33 h.

    DOI: 10.1016/j.mex.2023.102167

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  • Enhanced β-adrenergic response in mice with dominant-negative expression of the PKD2L1 channel

    Manabu Murakami, Agnieszka M. Murakami, Takayuki Nemoto, Takayoshi Ohba, Manabu Yonekura, Yuichi Toyama, Hirofumi Tomita, Yasushi Matsuzaki, Daisuke Sawamura, Kazuyoshi Hirota, Shirou Itagaki, Yujiro Asada, Ichiro Miyoshi

    PLOS ONE   17 ( 1 )   e0261668 - e0261668   2022

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    Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    Polycystic kidney disease (PKD) is the most common genetic cause of kidney failure in humans. Among the various PKD-related molecules, PKD2L1 forms cation channels, but its physiological importance is obscure. In the present study, we established a transgenic mouse line by overexpressing the dominant-negative form of the mouse PKD2L1 gene (i.e., lacking the pore-forming domain). The resulting PKD2L1del-Tg mice exhibited supraventricular premature contraction, as well as enhanced sensitivity to β-adrenergic stimulation and unstable R-R intervals in electrocardiography. During spontaneous atrial contraction, PKD2L1del-Tg atria showed enhanced sensitivity to isoproterenol, norepinephrine, and epinephrine. Action potential recording revealed a shortened action potential duration in PKD2L1del-Tg atria in response to isoproterenol. These findings indicated increased adrenergic sensitivity in PKD2L1del-Tg mice, suggesting that PKD2L1 is involved in sympathetic regulation.

    DOI: 10.1371/journal.pone.0261668

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  • Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice. Reviewed International journal

    Manabu Murakami, Agnieszka M Murakami, Yasushi Matsuzaki, Daisuke Sawamura, Takayoshi Ohba, Ichirou Miyoshi, Shirou Itagaki, Hiroyuki Sakagami

    PloS one   16 ( 4 )   e0249932   2021

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    In the present study, we examined the importance of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of cardiac function using genetically modified CaMKIV-null mice. RT-PCR analysis revealed decreased expression of voltage-dependent calcium channels in the cardiac myocytes of CaMKIV-null mice compared with wild-type mice. CaMKIV-null mice showed shortened QT time on electrocardiograms. Pharmacological analysis revealed decreased responsiveness to the β-adrenergic blocker propranolol in CaMKIV-null mice, whereas the plasma norepinephrine level was not affected. CaMKIV-null mice showed decreased baroreflex on electrocardiograms. Heart rate variability analysis showed unstable R-R intervals, a decreased low frequency power/high frequency power (LF/HF) ratio, and increased standard deviation of the normal to normal R-R intervals (SDNN) in CaMKIV-null mice, suggesting decreased responsiveness to β-adrenergic stimulation in CaMKIV-null mice. Atrial contraction analysis and cardiac action potential recording showed a decreased response to the β-adrenoceptor agonist isoproterenol in CaMKIV-null mice. Furthermore, fluorescence imaging in a CRE-hrGFP assay revealed a decreased response to isoproterenol in CaMKIV-null cardiac myocytes. Taken together, our data strongly suggest a significant effect of CaMKIV gene ablation on cardiac β-adrenergic signal transduction.

    DOI: 10.1371/journal.pone.0249932

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  • Molecular cloning of medaka orexin and orexin receptor and decreased spontaneous movement in response to an orexin inhibitor. Reviewed

    Niisawa T, Naruta N, Murakami AM, Yonekura M, Hirota K, Itagaki S, Murakami M

    71   55 - 64   2020

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  • Decreased cardiac pacemaking and attenuated β-adrenergic response in TRIC-A knockout mice. Reviewed International journal

    Manabu Murakami, Yuichi Toyama, Manabu Yonekura, Takayoshi Ohba, Yasushi Matsuzaki, Daisuke Sawamura, Agnieszka M Murakami, Miyuki Nishi, Shirou Itagaki, Hirofumi Tomita, Hiroshi Takeshima

    PloS one   15 ( 12 )   e0244254   2020

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    Changes in intracellular calcium levels in the sinus node modulate cardiac pacemaking (the calcium clock). Trimeric intracellular cation (TRIC) channels are counterion channels on the surface of the sarcoplasmic reticulum and compensate for calcium release from ryanodine receptors, which play a major role in calcium-induced calcium release (CICR) and the calcium clock. TRIC channels are expected to affect the calcium clock in the sinus node. However, their physiological importance in cardiac rhythm formation remains unclear. We evaluated the importance of TRIC channels on cardiac pacemaking using TRIC-A-null (TRIC-A-/-) as well as TRIC-B+/-mice. Although systolic blood pressure (SBP) was not significantly different between wild-type (WT), TRIC-B+/-, and TRIC-A-/-mice, heart rate (HR) was significantly lower in TRIC-A-/-mice than other lines. Interestingly, HR and SBP showed a positive correlation in WT and TRIC-B+/-mice, while no such correlation was observed in TRIC-A-/-mice, suggesting modification of the blood pressure regulatory system in these mice. Isoproterenol (0.3 mg/kg) increased the HR in WT mice (98.8 ± 15.1 bpm), whereas a decreased response in HR was observed in TRIC-A-/-mice (23.8 ± 5.8 bpm), suggesting decreased sympathetic responses in TRIC-A-/-mice. Electrocardiography revealed unstable R-R intervals in TRIC-A-/-mice. Furthermore, TRIC-A-/-mice sometimes showed sinus pauses, suggesting a significant role of TRIC-A channels in cardiac pacemaking. In isolated atrium contraction or action potential recording, TRIC-A-/-mice showed decreased response to a β-adrenergic sympathetic nerve agonist (isoproterenol, 100 nM), indicating decreased sympathetic responses. In summary, TRIC-A-/-mice showed decreased cardiac pacemaking in the sinus node and attenuated responses to β-adrenergic stimulation, indicating the involvement of TRIC-A channels in cardiac rhythm formation and decreased sympathetic responses.

    DOI: 10.1371/journal.pone.0244254

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  • Establishment of cardiac action potential recording using a membrane potential indicator in the mouse sinoatrial node. Reviewed

    Toyama Y, Yonekura M, Arakawa Y, Higuchi S, Tomita H, Murakami AM, Itagaki S, Murakami M

    Hirosaki Med J   70   163 - 171   2020

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  • A simple and dual expression plasmid system in prokaryotic (E. coli) and mammalian cells. Reviewed

    Murakami M, Ohba T, Murakami A.M, Han C, Yonekura M, Kuwasako K, Itagaki S

    Plos One,   14   e0216169   2019.5

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  • 入院患者の健康食品・サプリメントと医薬品の相互作用リスクに関する実態調査 Reviewed

    金森 未侑, 冨澤 登志子, 板垣 史郎

    日本老年薬学会雑誌   2   9 - 18   2019.4

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  • Medaka as a model for ECG analysis and the effect of verapamil Reviewed

    Manabu Yonekura, Nami Kondoh, Chong Han, Yuichi Toyama, Takayoshi Ohba, Kyoichi Ono, Shirou Itagaki, Hirofumi Tomita, Manabu Murakami

    Journal of Pharmacological Sciences   137 ( 1 )   55 - 60   2018.5

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    DOI: 10.1016/j.jphs.2018.04.003

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  • Modified parasympathetic nervous system in Goto-Kakizaki diabetic rats. Reviewed

    Han C, Inaba W, Yonekura M, Ogata Y, Ohba T, Kushikata T, Niwa H, Yanagisawa T, Tomita H, Itagaki S, Hirota K, Akai H, Mizukami H, Murakami M

    Hirosaki Med. J.,   68 ( 1 )   33 - 43   2017.10

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    Other Link: http://hdl.handle.net/10129/6146

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  • Storage stability of serum formulations containing ofloxacin for autologous serum eardrop therapy Reviewed

    N. Hashimoto, K. Togami, K. Encou, H. Onodera, H. Tanimoto, S. Itagaki, S. Chono

    PHARMAZIE   72 ( 3 )   139 - 142   2017.3

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    DOI: 10.1691/ph.2017.6832

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  • Effects of halothane anesthesia on electrocardiogram parameters in mice. Reviewed

    Nozaki Shuhei, Ogata Yoshiki, Yonekura Manabu, Han Chong, Niwa Hidetoshi, Kushikata Tetsuya, Hirota Kazuyoshi, Matsuzaki Yasushi, Tomita Hirofumi, Imaizumi Tadaatsu, Itagaki Shirou, Sawamura Daisuke, Murakami Manabu

    Hirosaki Med. J.   67 ( 2 )   129 - 135   2017.2

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    Language:English   Publisher:弘前大学大学院医学研究科・弘前医学会  

    Other Link: http://hdl.handle.net/10129/6012

    Ichushi

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  • Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin Reviewed

    Sumio Chono, Kohei Togami, Shirou Itagaki

    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY   43 ( 11 )   1892 - 1898   2017

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    DOI: 10.1080/03639045.2017.1353521

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  • 「感染性心内膜炎薬物治療の手引き」を用いた抗菌薬適正使用への貢献 Reviewed

    小笠原 真帆, 太田, 岡村 祐嗣, 津山 博匡, 板垣 史郎, 萱場 広之, 早狩 誠

    日本病院薬剤師会雑誌   52 ( 10 )   1287 - 1292   2016.10

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    Ichushi

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  • Sustained distribution of aerosolized PEGylated liposomes in epithelial lining fluids on alveolar surfaces Reviewed

    Keita Kaneko, Kohei Togami, Eri Yamamoto, Shujun Wang, Kazuhiro Morimoto, Shirou Itagaki, Sumio Chono

    DRUG DELIVERY AND TRANSLATIONAL RESEARCH   6 ( 5 )   565 - 571   2016.10

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    DOI: 10.1007/s13346-016-0310-2

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  • 感染防止対策加算連携施設間における抗菌薬使用量サーベイランスの評価 Reviewed

    岡村 祐嗣, 倉内 寿孝, 津山 博匡, 板垣 史郎, 萱場 広之, 早狩 誠

    日本環境感染学会誌   31 ( 5 )   326 - 334   2016.9

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    Language:Japanese   Publisher:(一社)日本環境感染学会  

    Other Link: http://search.jamas.or.jp/link/ui/2017043435

    DOI: 10.4058/jsei.31.326

    Ichushi

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  • ヒト官能試験による口腔内崩壊錠の服用性の実証

    丁野純男, 谷本裕幸, 松井萌, 中村勝貴, 佐藤卓馬, 中川麻奈, 山田恵乃, 金子圭太, 山佳織, 佐藤恵亮, 山下美妃, 丹保好子, 郡修徳, 森本一洋, 板垣史郎, 葛西亮也

    臨床と研究   93 ( 5 )   171 - 174   2016.5

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  • 膵臓がん組織の抗がん剤反応性を予測するバイオマーカーの探索 Invited

    板垣 史郎

    医療の広場,   55   13 - 16   2015.4

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  • THE USEFULNESS OF ANTICANCER DRUG SENSITIVITY TEST (HDRA) FOR THE ADJUVANT CHEMOTHERAPY AND PROFILING IN PANCREATIC CANCER TISSUE AFTER HDRA Reviewed

    The Hirosaki medical journal   65 ( 2 )   173 - 181   2014.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Hirosaki University  

    Other Link: http://hdl.handle.net/10129/5425

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  • ラット肝化学発癌過程におけるCyclophilin Bの発現変化 Reviewed

    細井 一広, 照井 一史, 中川 潤一, 下山 律子, 津山 博匡, 板垣 史郎, 土田 成紀, 早狩 誠

    弘前医学   164 - 172   2014.9

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  • PROFILING OF RAT BRAIN PEPTIDES TREATED WITH CENTRALLY ACTIVE ACE INHIBITOR Reviewed

    The Hirosaki medical journal   65 ( 1 )   95 - 103   2014.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Hirosaki University  

    Other Link: http://hdl.handle.net/10129/5319

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  • Rapid Stimulating Effect of the Antiarrhythmic Agent Amiodarone on Absorption of Organic Anion Compounds Reviewed

    Masahiro Segawa, Jiro Ogura, Satoru Seki, Shirou Itagaki, Natsuko Takahashi, Masaki Kobayashi, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki

    DRUG METABOLISM AND PHARMACOKINETICS   28 ( 3 )   178 - 186   2013.6

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    DOI: 10.2133/dmpk.DMPK-12-RG-010

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  • アンジオテンシン変換酵素に焦点を当てた認知症患者への食事支援に関する基礎研究 Reviewed

    内山 道子, 板垣 史郎, 金澤 佐知子, 細井 一広, 照井 一史, 下山 律子, 早狩 誠

    弘前医学   64   41 - 49   2013.5

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  • STUDY ON IMPROVEMENT OF THE ACCURACY AND PRECISION OF PREDICTED PLASMA CONCENTRATION OF VANCOMYCIN IN THE ADMINISTRATION PLANNING SUPPORT FOR CHILDREN Reviewed

    The Hirosaki medical journal   64 ( 1 )   58 - 64   2013.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Hirosaki University  

    Other Link: http://hdl.handle.net/10129/4903

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  • 処方せんチェックシートを用いたlevofloxacinの用法・用量チェックシステムの効果 Reviewed

    岡村 祐嗣, 高橋 志織, 小原 信一, 板垣 史郎, 早狩 誠

    医薬品相互作用研究   36   1 - 6   2013.5

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  • IDENTIFICATION OF THE ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN THE LOCAL PRODUCT OF AOMORI PREFECTURE Reviewed

    The Hirosaki medical journal   64 ( 1 )   50 - 57   2013.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Hirosaki University  

    Other Link: http://hdl.handle.net/10129/4902

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  • Electrophysiological Characterization of the Polyspecific Organic Cation Transporter Plasma Membrane Monoamine Transporter Reviewed

    Shiro Itagaki, Vadivel Ganapathy, Horace T. B. Ho, Mingyan Zhou, Ellappan Babu, Joanne Wang

    DRUG METABOLISM AND DISPOSITION   40 ( 6 )   1138 - 1143   2012.6

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    DOI: 10.1124/dmd.111.042432

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  • 効果発現パターンにより抗がん薬を分類するための基礎的検討 Reviewed

    高橋 夏子, 小林 正紀, 板垣 史郎, 平野 剛, 武隈 洋, 菅原 満, 井関 健

    薬学雑誌   132 ( 6 )   777 - 783   2012.6

  • Effects of Acidification and Alkalinization Agent on Statins-induced Muscle Toxicity Reviewed

    Masaki Kobayashi, Kazuhiro Hidaka, Ikumi Chisaki, Natsuko Takahashi, Jiro Ogura, Shirou Itagaki, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   132 ( 5 )   609 - 615   2012.5

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  • Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: The role of protein kinase C (PKC) Reviewed

    Katsuya Narumi, Masaki Kobayashi, Sho Otake, Ayako Furugen, Natsuko Takahashi, Jiro Ogura, Shirou Itagaki, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   428 ( 1-2 )   25 - 32   2012.5

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  • Involvement of Cholesterol Membrane Transporter Niemann-Pick C1-Like 1 in the Intestinal Absorption of Lutein Reviewed

    Yuki Sato, Risa Suzuki, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Toshihiro Noda, Satoshi Mizuno, Mitsuru Sugawara, Ken Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   15 ( 2 )   256 - 264   2012

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  • The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion Reviewed

    Jiro Ogura, Yusuke Terada, Takashi Tsujimoto, Takahiro Koizumi, Kaori Kuwayama, Hajime Maruyama, Asuka Fujikawa, Atsushi Takaya, Masaki Kobayashi, Shirou Itagaki, Natsuko Takahashi, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   15 ( 5 )   616 - 631   2012

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  • Intestinal Ischemia-Reperfusion Increases Efflux for Uric Acid Via Paracellular Route in the Intestine, but Decreases that Via Transcellular Route Mediated by BCRP Reviewed

    Jiro Ogura, Kaori Kuwayama, Atsushi Takaya, Yusuke Terada, Takashi Tsujimoto, Takahiro Koizumi, Hajime Maruyama, Asuka Fujikawa, Natsuko Takahashi, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   15 ( 2 )   295 - 304   2012

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  • Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine Reviewed

    Yuki Sato, Shirou Itagaki, Setsu Oikawa, Jiro Ogura, Masaki Kobayashi, Takeshi Hirano, Mitsuru Sugawara, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   34 ( 9 )   1448 - 1454   2011.9

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  • Protective effect of lutein after ischemia-reperfusion in the small intestine Reviewed

    Yuki Sato, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Toshihiro Noda, Satoshi Mizuno, Mitsuru Sugawara, Ken Iseki

    FOOD CHEMISTRY   127 ( 3 )   893 - 898   2011.8

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  • Regulation mechanism of ABCA1 expression by statins in hepatocytes Reviewed

    Masaki Kobayashi, Keisuke Gouda, Ikumi Chisaki, Manami Ochiai, Shirou Itagaki, Ken Iseki

    EUROPEAN JOURNAL OF PHARMACOLOGY   662 ( 1-3 )   9 - 14   2011.7

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  • Pharmacokinetic properties of lutein emulsion after oral administration to rats and effect of food intake on plasma concentration of lutein Reviewed

    Yuki Sato, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Toshihiro Noda, Satoshi Mizuno, Mitsuru Sugawara, Ken Iseki

    BIOPHARMACEUTICS & DRUG DISPOSITION   32 ( 3 )   151 - 158   2011.4

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  • Alteration of P-gp Expression after Intestinal Ischemia-reperfusion Following 16-h Fasting in Rats Reviewed

    Jiro Ogura, Asuka Fujikawa, Hajime Maruyama, Masaki Kobayashi, Shirou Itagaki, Ken Iseki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   131 ( 3 )   453 - 462   2011.3

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  • In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid Reviewed

    Yuki Sato, Shirou Itagaki, Toshimitsu Kurokawa, Jiro Ogura, Masaki Kobayashi, Takeshi Hirano, Mitsuru Sugawara, Ken Iseki

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   403 ( 1-2 )   136 - 138   2011.1

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  • AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle Reviewed

    Ayako Furugen, Masaki Kobayashi, Katsuya Narumi, Meguho Watanabe, Sho Otake, Shirou Itagaki, Ken Iseki

    LIFE SCIENCES   88 ( 3-4 )   163 - 168   2011.1

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  • 有機アニオントランスポータOATP2B1の臨床的有用性 Invited Reviewed

    板垣史郎

    医薬品相互作用研究   35 ( 1 )   1 - 10   2011

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  • 放射線治療に伴う口腔粘膜障害に対する予防・軽減効果が期待される物質の探索 Reviewed

    板垣 史郎, 中田 千絵, 平野 剛, 鷹野 瑠美, 笠師 久美子, 菅原 満, 高橋 夏子, 小林 正紀, 井関 健

    医療薬学   36 ( 9 )   696 - 702   2010.9

  • Regulation of Monocarboxylate Transporter 1 in Skeletal Muscle Cells by Intracellular Signaling Pathways Reviewed

    Katsuya Narumi, Ayako Furugen, Masaki Kobayashi, Sho Otake, Shirou Itagaki, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   33 ( 9 )   1568 - 1573   2010.9

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  • Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2 Reviewed

    Shirou Itagaki, Akiko Ochiai, Masaki Kobayashi, Mitsuru Sugawara, Takeshi Hirano, Ken Iseki

    FOOD CHEMISTRY   120 ( 2 )   552 - 555   2010.5

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  • Pharmacokinetics of Oral and Intravenous Administration of Digoxin after Intestinal Ischemia-Reperfusion Reviewed

    Jiro Ogura, Hajime Maruyama, Masaki Kobayashi, Shirou Itagaki, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   33 ( 5 )   922 - 925   2010.5

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  • In vitro実験系による肺がん化学療法レジメンの抗腫瘍効果の評価 Reviewed

    斎藤 由起子, 平野 剛, 沖 洋充, 笠師 久美子, 菅原 満, 小林 正紀, 高橋 夏子, 板垣 史郎, 井関 健

    医療薬学   36 ( 4 )   220 - 226   2010.4

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  • Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: A RPE specific phenomenon Reviewed

    Sudha Ananth, Lina Zhuang, Elangovan Gopal, Shiro Itagaki, Babu Ellappan, Sylvia B. Smith, Vadivel Ganapathy, Pamela Martin

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   394 ( 1 )   75 - 80   2010.3

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  • Protective effects of quercetin-3-rhamnoglucoside (rutin) on ischemia-reperfusion injury in rat small intestine Reviewed

    Shirou Itagaki, Setsu Oikawa, Jiro Ogura, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    FOOD CHEMISTRY   118 ( 2 )   426 - 429   2010.1

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  • In vitro Evaluation of Anticancer Effects of FOLFIRI and mFOLFOX 6 Chemotherapy Regimens and Their Effects on EGFR Expression Reviewed

    sei mei, sei mei, sei mei, sei mei, sei mei, sei mei, sei mei

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)   36 ( 12 )   855 - 862   2010

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    Recently,the number of patients with colorectal cancer has been increasing.Many patients are not aware of any symptoms until the disease is advanced.It is important to select effective regimens for colorectal cancer therapy and combination therapy with a molecular-targeted agent has recently been used for this purpose.However,the effects of anticancer drugs on epidermal growth factor receptor (EGFR),a molecular-targeted protein,have not been clarified.We therefore evaluated the effects of folinic acid/5-fluorouracil/irinotecan (FOLFIRI) and folinic acid/5-fluorouracil/oxaliplatin (mFOLFOX citation=6)treatments,using the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide (MTT) assay,as well as the effects of these treatments on EGFR expression in LoVo cells.<br>The results suggested that 5-fluorouracil and irinotecan have a stronger antiproliferative effect than oxaliplatin.The reduction in viability for LoVo cells treated with FOLFIRI was greater than that for Lovo cells treated with mFOLFOX 6 on day 22.Moreover,EGFR mRNA and protein levels were increased more by mFOLFOX 6 than by FOLFIRI.These results suggest that FOLFIRI therapy may be more effective than mFOLFOX 6 therapy against LoVo cells in consideration of EGFR expression.

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  • Expression and Role of SNAT3 in the Placenta Reviewed

    C. Yoshioka, S. Yasuda, F. Kimura, M. Kobayashi, S. Itagaki, T. Hirano, K. Iseki

    PLACENTA   30 ( 12 )   1071 - 1077   2009.12

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  • Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver Reviewed

    Ikumi Chisaki, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1788 ( 11 )   2396 - 2403   2009.11

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  • Intestinal Absorption and Secretion Mechanism of Carboxylate Drugs Invited Reviewed

    Shirou Itagaki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   129 ( 11 )   1341 - 1349   2009.11

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  • Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Reviewed

    Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K

    Biochimica et biophysica acta   1788 ( 11 )   2396 - 2403   2009.11

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  • Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Reviewed

    Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K

    Biochimica et biophysica acta   1788 ( 11 )   2396 - 2403   2009.11

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  • Transport by SLC5A8 With Subsequent Inhibition of Histone Deacetylase 1 (HDAC1) and HDAC3 Underlies the Antitumor Activity of 3-bromopyruvate Reviewed

    Muthusamy Thangaraju, Senthil K. Karunakaran, Shiro Itagaki, Elangovan Gopal, Selvakumar Elangovan, Puttur D. Prasad, Vadivel Ganapathy

    CANCER   115 ( 20 )   4655 - 4666   2009.10

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  • Response of the ABCG2 promoter in T47D cells and BeWo cells to sex hormone treatment Reviewed

    Satoru Yasuda, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    MOLECULAR BIOLOGY REPORTS   36 ( 7 )   1889 - 1896   2009.9

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  • Food-Drug Interaction Involving the Ferulic Acid/H plus Transporter Reviewed

    Shirou Itagaki, Yoko Kobayashi, Yoshitaka Saito, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    DRUG METABOLISM REVIEWS   41   60 - 60   2009.8

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  • Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells Reviewed

    Satoru Seki, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1788 ( 5 )   911 - 917   2009.5

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  • In vitro and in vivo antioxidant properties of ferulic acid: A comparative study with other natural oxidation inhibitors Reviewed

    Shirou Itagaki, Toshirnitsu Kurokawa, Chie Nakata, Yoshitaka Saito, Setsu Oikawa, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    FOOD CHEMISTRY   114 ( 2 )   466 - 471   2009.5

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  • Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells. Reviewed International journal

    Seki S, Kobayashi M, Itagaki S, Hirano T, Iseki K

    Biochimica et biophysica acta   1788 ( 5 )   911 - 917   2009.5

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    The accumulation mechanisms of amiodarone (AMD) involving transporters in lung alveolar epithelial type II cells were studied. The uptake of AMD was examined using human alveolar epithelial-derived cell line A549 as a model. AMD was transported by the carrier-mediated system, and the apparent K(m) and V(max) values were 66.8+/-30.3 muM and 49.7+/-9.7 nmol/mg protein/5 min, respectively. The uptake of AMD by A549 cells was Na(+)-independent and was inhibited by substrates of human organic anion transporting polypeptide (OATP). The inhibition profiles were similar to the inhibitory effects of several compounds on OATP2B1-mediated E-3-S transport, and RT-PCR analysis showed mRNA expression of OATP2B1 and 1B3 in A549 cells. SiRNAs targeted to the OATP2B1 gene decreased the OATP2B1 mRNA expression level in A549 cells up to about 50% and reduced the uptake of AMD up to about 40%. These results indicate that AMD uptake mediated by carriers, including OATP2B1, might lead to accumulation of AMD in the lung and AMD-induced pulmonary toxicity (AIPT).

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  • 薬物動態因子の発現変動を反映した肝切除患者に対する薬物治療の最適化に関する研究. Invited

    板垣 史郎, 井関 健

    医療の広場   49   18 - 20   2009.4

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  • Search for Antioxidative Compounds Capable of Preventing Stomatitis Induced by Chemotherapy Reviewed

    TAKANO Rumi, HIRANO Takeshi, NAKATA Chie, KASASHI Kumiko, SUGAWARA Mituru, KOBAYASHI Masaki, ITAGAKI Shirou, ISEKI Ken

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)   35 ( 4 )   247 - 253   2009.4

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    In the clinical setting,the frequency of adverse effects is directly linked to treatment results but during chemotherapy,they are unavoidable.One of them is stomatitis,a distressing toxic effect.In patients receiving myelosuppressive chemotherapy for solid tumors,the prevalence of stomatitis is 5-40% while its prevalence in patients receiving stem cell transplantation is 75-100%.Stomatitis-associated pain is the main source of cancer treatment-related pain and in some patients it is so severe that narcotic analgesia is required.<br>Oxidative stress may also be associated with chemotherapy-induced stomatitis and a mouthwash containing allopurinol,rebamipide and camostat for the removal of free radicals is widely used for the prevention and treatment of such stomatitis.However,such agents are not covered by the Japanese National Health Insurance scheme and there is little scientific evidence for their antioxidative properties and effectiveness in the prevention and treatment of chemotherapy-induced stomatitis.We therefore attempted to establish a more useful mouthwash.In the first part of this study,we investigated the antioxidant properties of various compounds.We then used H<sub>2</sub>O<sub>2</sub>-induced HO-1-N-1 cell injury as a model of stomatitis and found that epigallocatechin gallate had a strong preventive effect against it.Epigallocatechin gallate would therefore be a good component of a mouthwash for the prevention of stomatitis in patients undergoing cancer chemotherapy.

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  • Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer - Discussion Reviewed

    Stephen A. McClave, Gail Cresci

    JOURNAL OF GASTROINTESTINAL SURGERY   12 ( 10 )   1781 - 1782   2008.10

  • Placental folate transport during pregnancy Reviewed

    Satoru Yasuda, Satoko Hasui, Chiaki Yamamoto, Chihiro Yoshioka, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   72 ( 9 )   2277 - 2284   2008.9

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  • Interaction of tryptophan derivatives with SLC6A14 (ATB(0,+)) reveals the potential of the transporter as a drug target for cancer chemotherapy Reviewed

    Senthil Karunakaran, Nagavedi S. Umapathy, Muthusarny Thangaraju, Takahiro Hatanaka, Shiro Itagaki, David H. Munn, Puttur D. Prasad, Vadivel Ganapathy

    BIOCHEMICAL JOURNAL   414 ( 3 )   343 - 355   2008.9

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  • Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein Reviewed

    Shirou Itagaki, Akiko Ochiai, Masaki Kobayashi, Mitsuru Sugawara, Takeshi Hiran, Ken Iseki

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   56 ( 16 )   6923 - 6927   2008.8

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  • Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line Reviewed

    Satoru Seki, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   31 ( 7 )   1449 - 1452   2008.7

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  • Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion Reviewed

    Jiro Ogura, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    LIFE SCIENCES   82 ( 25-26 )   1242 - 1248   2008.6

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  • Post-transcriptional regulation of breast cancer resistance protein after intestinal ischemia-reperfusion Reviewed

    Jiro Ogura, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   31 ( 5 )   1032 - 1035   2008.5

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  • Association between risk of myopathy and cholesterol-lowering effect: A comparison of all statins Reviewed

    Masaki Kobayashi, Ikumi Chisaki, Katsuya Narumi, Kazuhiro Hidaka, Toshiki Kagawa, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    LIFE SCIENCES   82 ( 17-18 )   969 - 975   2008.4

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  • The inhibitory effects of fluoroquinolones on L-carnitine transport in placental cell line BeWo Reviewed

    Takeshi Hirano, Satoru Yasuda, Yuki Osaka, Masaru Asari, Masaki Kobayashi, Shirou Itagaki, Ken Iseki

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   351 ( 1-2 )   113 - 118   2008.3

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  • Sodium-coupled monocarboxylate transporters in normal tissues and in cancer Invited Reviewed

    Vadivel Ganapathy, Muthusamy Thangaraju, Elangovan Gopal, Pamela M. Martin, Shiro Itagaki, Seiji Miyauchi, Puttur D. Prasad

    AAPS JOURNAL   10 ( 1 )   193 - 199   2008.3

  • A new method for determination of both thalidomide enantiomers using HPLC systems Reviewed

    Kaname Sgmbongi, Masanori Tanaka, Kelsuke Sakurada, Masakl Kobayasfi, Shlrou Itagaki, Takeshi Hirano, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   31 ( 3 )   497 - 500   2008.3

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  • The mechanism of carrier-mediated transport of folates in BeWo cells: The involvement of heme carrier protein 1 in placental folate transport Reviewed

    Satoru Yasuda, Satoko Hasui, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   72 ( 2 )   329 - 334   2008.2

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  • Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats Reviewed

    Shirou Itagaki, Makoto Chiba, Masaki Kobayashi, Mitsuru Sugawara, Michlya Kobayashi, Takeshi Hirano, Ken Iseki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1778 ( 1 )   270 - 275   2008.1

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  • Contribution of multidrug resistance-associated protein 2 to secretory intestinal transport of organic anions Reviewed

    Shirou Itagaki, Makoto Chiba, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   31 ( 1 )   146 - 148   2008.1

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  • Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats. Reviewed International journal

    Itagaki S, Chiba M, Kobayashi M, Sugawara M, Kobayashi M, Hirano T, Iseki K

    Biochimica et biophysica acta   1778 ( 1 )   270 - 275   2008.1

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    It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level.

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  • Bicarbonate supplementation as a preventive way in statins-induced muscle damage Reviewed

    Masaki Kobayashi, Toshiki Kagawa, Katsuya Narumi, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   11 ( 1 )   1 - 8   2008

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  • Functional characterization of human monocarboxylate transporter 9 (SLC16A9) Reviewed

    Masaki Kobayashi, Toshiki Kagawa, Katsuya Narumi, Kazuhiro Hidaka, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   128   47 - 48   2008

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  • Preventive effects of bicarbonate on cerivastatin-induced apoptosis Reviewed

    Masaki Kobayashi, Fumie Kaido, Toshiki Kagawa, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   341 ( 1-2 )   181 - 188   2007.8

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  • Effect of medium pH on the cytotoxicity of hydrophilic statins Reviewed

    Masaki Kobayashi, Toshiki Kagawa, Rumi Takano, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   10 ( 3 )   332 - 339   2007.5

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  • Functional and molecular analysis of D-serine transport in retinal Muller cells

    Y. Dun, B. Mysona, S. Itagaki, A. Martin-Studdard, V. Ganapathy, S. B. Smith

    EXPERIMENTAL EYE RESEARCH   84 ( 1 )   191 - 199   2007.1

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    DOI: 10.1016/j.exer.2006.09.015

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  • Improvement in intestinal coenzyme q10 absorption by food intake Reviewed

    Akiko Ochiai, Shirou Itagaki, Toshimitsu Kurokawa, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   127 ( 8 )   1251 - 1254   2007

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  • Characterization of hepatobiliary organic anion transporters in Long-Evans Cinnamon rats Reviewed

    Makoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    DRUG METABOLISM AND PHARMACOKINETICS   22 ( 5 )   387 - 390   2007

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    DOI: 10.2133/dmpk.22.387

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  • Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans Cinnamon rats Reviewed

    Makoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

    DRUG METABOLISM AND PHARMACOKINETICS   22 ( 6 )   450 - 455   2007

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  • Efflux transport of n-monodesethylamiodarone by the human intestinal cell-line caco-2 cells Reviewed

    Emi Kimoto, Satoru Seki, Shirou Itagaki, Maya Matsuura, Masaki Kobayashi, Takeshi Hirano, Yoshikazu Goto, Koji Tadano, Ken Iseki

    DRUG METABOLISM AND PHARMACOKINETICS   22 ( 4 )   307 - 312   2007

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  • Antioxidant activity of a novel extract from bamboo grass (AHSS) against ischemia-reperfusion injury in rat small intestine Reviewed

    Toshimitsu Kurokawa, Shirou Itagaki, Toshihiko Yamaji, Chie Nakata, Toshihiro Noda, Takeshi Hirano, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   29 ( 11 )   2301 - 2303   2006.11

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  • Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells. Reviewed

    Hirano T, Yasuda S, Osaka Y, Kobayashi M, Itagaki S, Iseki K

    Biochimica et biophysica acta   1758 ( 11 )   1743 - 1750   2006.11

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  • Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells. Reviewed International journal

    Hirano T, Yasuda S, Osaka Y, Kobayashi M, Itagaki S, Iseki K

    Biochimica et biophysica acta   1758 ( 11 )   1743 - 1750   2006.11

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    L-Carnitine plays an important role in lipid metabolism by facilitating the transport of long-chain fatty acids across the mitochondrial inner membrane followed by fatty acid beta-oxidation. It is known that L-carnitine exists as a zwitterion and that member of the OCTN family play an important role in its transport. The aims of this study were to characterize L-carnitine transport in the intestine by using Caco-2 cells and to elucidate the effects of levofloxacin (LVFX) and grepafloxacin (GPFX), which are zwitterionic drugs, on L-carnitine uptake. Kinetic analysis showed that the half-saturation Na+ concentration, Hill coefficient and Km value of L-carnitine uptake in Caco-2 cells were 10.3 +/- 4.5 mM, 1.09 and 8.0 +/- 1.0 microM, respectively, suggesting that OCTN2 mainly transports L-carnitine. LVFX and GPFX have two pKa values and the existence ratio of their zwitterionic forms is higher under a neutral condition than under an acidic condition. Experiments on the inhibitory effect of LVFX and GPFX on L-carnitine uptake showed that LVFX and GPFX inhibited L-carnitine uptake more strongly at pH 7.4 than at pH 5.5. It was concluded that the zwitterionic form of drugs plays an important role in inhibition of OCTN2 function.

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  • Mechanism of the inhibitory effect of zwitterionic drugs (levofloxacin and grepafloxacin) on carnitine transporter (OCTN2) in Caco-2 cells Reviewed

    Takeshi Hirano, Satoru Yasuda, Yuki Osaka, Masaki Kobayashi, Shirou Itagaki, Ken Iseki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1758 ( 11 )   1743 - 1750   2006.11

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  • Characterization of the disposition of lutein after i.v. administration to rats Reviewed

    Shirou Itagaki, Wakako Ogura, Yuki Sato, Toshihiro Noda, Takeshi Hirano, Satoshi Mizuno, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   29 ( 10 )   2123 - 2125   2006.10

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  • Protective effect of lutein on ischemia-reperfusion injury in rat small intestine Reviewed

    Wakako Ogura, Shirou Itagaki, Toshirnitsu Kurokawa, Toshihiro Noda, Takeshi Hirano, Satoshi Mizuno, Ken Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   29 ( 8 )   1764 - 1766   2006.8

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  • Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain Reviewed

    PM Martin, E Gopal, S Ananth, L Zhuang, S Itagaki, BM Prasad, SB Smith, PD Prasad, Ganapathy, V

    JOURNAL OF NEUROCHEMISTRY   98 ( 1 )   279 - 288   2006.7

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    DOI: 10.1111/j.1471-4159.2006.03878.x

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  • Inhibitory effects of statins on human monocarboxylate transporter 4 Reviewed

    Masaki Kobayashi, Yukio Otsuka, Shirou Itagaki, Takeshi Hirano, Ken Iseki

    INTERNATIONAL JOURNAL OF PHARMACEUTICS   317 ( 1 )   19 - 25   2006.7

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  • Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) Reviewed

    S Itagaki, E Gopal, LN Zhuang, YJ Fei, S Miyauchi, PD Prasad, Ganapathy, V

    PHARMACEUTICAL RESEARCH   23 ( 6 )   1209 - 1216   2006.6

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    DOI: 10.1007/s11095-006-0023-1

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  • Electrophysiological characterization and Modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3) Reviewed

    HK Hu, CJ Endres, C Chang, NS Umapathy, EW Lee, YJ Fei, S Itagaki, PW Swaan, Ganapathy, V, JD Unadkat

    MOLECULAR PHARMACOLOGY   69 ( 5 )   1542 - 1553   2006.5

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  • Purification by p-aminobenzoic acid (PABA)-affinity chromatography and the functional reconstitution of the nateglinide/H+ cotransport system in the rat intestinal brush-border membrane Reviewed

    Y Saito, S Itagaki, S Kubo, M Kobayashi, T Hirano, K Iseki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   340 ( 3 )   879 - 886   2006.2

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    DOI: 10.1016/j.bbrc.2005.12.092

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  • Characterization of secretory intestinal transport of the lactone form of CPT-11 Reviewed

    Takemoto, I, S Itagaki, M Chiba, T Itoh, T Hirano, K Iseki

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   57 ( 1 )   129 - 133   2006.1

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    DOI: 10.1007/s00280-005-0042-3

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  • Effects of sex hormones on regulation of ABCG2 expression in the placental cell line BeWo. Reviewed

    S Yasuda, S Itagaki, T Hirano, K Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   9 ( 1 )   133 - 139   2006.1

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  • Transepithelial transport of telmisartan in Caco-2 monolayers Reviewed

    Y Goto, S Itagaki, S Umeda, M Kobayashi, T Hirano, K Iseki, K Tadano

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   28 ( 12 )   2235 - 2239   2005.12

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  • Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2) Reviewed

    Srinivas, SR, E Gopal, L Zhuang, S Itagaki, PM Martin, YJ Fei, Ganapathy, V, PD Prasad

    BIOCHEMICAL JOURNAL   392   655 - 664   2005.12

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    DOI: 10.1042/BJ20050927

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  • Expression level of ABCG2 in the placenta decreases from the mid stage to the end of gestation Reviewed

    S Yasuda, S Itagaki, T Hirano, K Iseki

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   69 ( 10 )   1871 - 1876   2005.10

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  • Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane Reviewed

    M Kobayashi, Y Saito, S Itagaki, T Hirano, K Iseki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1715 ( 1 )   19 - 24   2005.8

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    DOI: 10.1016/j.bbamem.2005.05.013

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  • Phenolsulfonphthalein transport by potential-sensitive urate transport system Reviewed

    S Itagaki, S Shimamoto, M Sugawara, M Kobayashi, K Miyazaki, T Hirano, K Iseki

    EUROPEAN JOURNAL OF PHARMACOLOGY   518 ( 2-3 )   83 - 89   2005.8

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    DOI: 10.1016/j.ejphar.2005.06.009

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  • Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane. Reviewed International journal

    Kobayashi M, Saito Y, Itagaki S, Hirano T, Iseki K

    Biochimica et biophysica acta   1715 ( 1 )   19 - 24   2005.8

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    Nateglinide, a novel oral hypoglycemic agent, possesses a carbonyl group and a peptide-type bond in its structure. We previously reported that nateglinide transport occurs via a single system that may be identical to the ceftibuten/H(+) cotransport system by the rat small intestine. We speculated that the absorption system present on the intestinal epithelium may be similar to that found on the renal tubular epithelium. The aim of this study was to characterize the transporters on the apical side of the kidney that may contribute to the reabsorption of ceftibuten and nateglinide. The uptake of nateglinide by rat renal brush-border membranes is associated with an H(+)-coupled transport system. Ceftibuten competitively inhibited H(+)-dependent nateglinide uptake. In contrast, Gly-Sar, cephradine and cephalexin had no effect on nateglinide uptake. Nateglinide competitively inhibited H(+)-driven transporter-mediated ceftibuten uptake. We conclude that nateglinide transport occurs via a single system that is H(+)-dependent and may be identical to the ceftibuten/H(+) cotransport system.

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  • Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells) Reviewed

    M Kobayashi, Fujita, I, S Itagaki, T Hirano, K Iseki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   28 ( 7 )   1197 - 1201   2005.7

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  • Substrate specificity of the nateglinide/H+ cotransport system for phenolic acids Reviewed

    Y Saito, S Itagaki, Y Otsuka, Y Kobayashi, H Okumura, M Kobayashi, T Hirano, K Iseki

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   53 ( 15 )   6100 - 6104   2005.7

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  • Uptake of irinotecan metabolite SN-38 by the human intestinal cell line Caco-2 Reviewed

    T Itoh, S Itagaki, Y Sumi, T Hirano, Takemoto, I, K Iseki

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   55 ( 5 )   420 - 424   2005.5

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    DOI: 10.1007/s00280-004-0937-4

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  • Secretory transport of irinotecan metabolite SN-38 across isolated intestinal tissue Reviewed

    S Itagaki, Y Sumi, S Shimamoto, T Itoh, T Hirano, Takemoto, I, K Iseki

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   55 ( 5 )   502 - 506   2005.5

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    DOI: 10.1007/s00280-004-0948-1

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  • Food-drug interaction between ferulic acid and nateglinide involving the fluorescein/H+ cotransport system Reviewed

    S Itagaki, Y Kobayashi, Y Otsuka, S Kubo, M Kobayashi, T Hirano, K Iseki

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   53 ( 7 )   2499 - 2502   2005.4

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  • Intestinal uptake of nateglinide by an intestinal fluorescein transporter. Reviewed International journal

    Itagaki S, Otsuka Y, Kubo S, Okumura H, Saito Y, Kobayashi M, Hirano T, Iseki K

    Biochimica et biophysica acta   1668 ( 2 )   190 - 194   2005.3

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    Nateglinide, a novel oral hypoglycemic agent, rapidly reaches its maximum serum concentration after oral administration, suggesting that it is rapidly absorbed in the intestine. However, nateglinide itself is not transported by MCT1 or PEPT1. The aim of this study was to characterize the transporters on the apical side of the small intestine that are responsible for the rapid absorption of nateglinide. It has been reported that the uptake of fluorescein by Caco-2 cells occurs via an H+-driven transporter and that the intestinal fluorescein transporter is probably not MCT1. We examined the contribution of the fluorescein transporter to the uptake of nateglinide by Caco-2 cells. Fluorescein competitively inhibited H+-dependent nateglinide uptake. All of fluorescein transporter inhibitors examined reduced the uptake of nateglinide. Furthermore, nateglinide inhibited fluorescein uptake. We conclude that the intestinal nateglinide/H+ cotransport system is identical to the intestinal fluorescein/H+ cotransport system.

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  • Intestinal uptake of nateglinide by an intestinal fluorescein transporter Reviewed

    S Itagaki, Y Otsuka, S Kubo, H Okumura, Y Saito, M Kobayashi, T Hirano, K Seki

    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES   1668 ( 2 )   190 - 194   2005.3

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  • Intestinal uptake of nateglinide by an intestinal fluorescein transporter. Reviewed

    Itagaki S, Otsuka Y, Kubo S, Okumura H, Saito Y, Kobayashi M, Hirano T, Iseki K

    Biochimica et biophysica acta   1668 ( 2 )   190 - 194   2005.3

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  • H+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine Reviewed

    S Itagaki, Y Saito, S Kubo, Y Otsuka, Y Yamamoto, M Kobayashi, T Hirano, K Iseki

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   312 ( 1 )   77 - 82   2005.1

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  • Characterization of Secretory Intestinal Transport of Phenolsulfonphthalein Reviewed

    Shirou Itagaki, Makoto Chiba, Soji Shimamoto, Mitsuru Sugawara, Michiya Kobayashi, Katsumi Miyazaki, Takeshi Hirano, Ken Iseki

    Drug Metabolism and Pharmacokinetics   20 ( 1 )   72 - 78   2005

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  • Mechanism of L-lactic acid transport in L6 skeletal muscle cells. Reviewed

    Kobayashi M, Itagaki S, Hirano T, Iseki K

    Drug metabolism and pharmacokinetics   19 ( 5 )   363 - 368   2004.10

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    DOI: 10.2133/dmpk.19.363

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  • Pharmacokinetic modulation of irinotecan metabolites by sulphobromophthalein in rats Reviewed

    T Itoh, S Itagaki, K Sasaki, T Hirano, Takemoto, I, K Iseki

    JOURNAL OF PHARMACY AND PHARMACOLOGY   56 ( 6 )   809 - 812   2004.6

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  • Comparison of urinary excretion of phenosulfonphthalein in an animal model for Wilson's disease (Long-Evans Cinnamon rats) with that in normal Wistar rats: Involvement of primary active organic anion transporter Reviewed

    Shirou Itagaki, Soji Shimamoto, Takeshi Hirano, Ken Iseki, Mitsuru Sugawara, Sachiho Nishimura, Michio Fujimoto, Michiya Kobayashi, Katsumi Miyazaki

    Journal of Pharmacy and Pharmaceutical Sciences   7 ( 2 )   227 - 234   2004.5

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  • Biliary excretion of irinotecan and its metabolites. Reviewed

    T Itoh, Takemoto, I, S Itagaki, K Sasaki, T Hirano, K Iseki

    JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   7 ( 1 )   13 - 18   2004.1

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  • Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats Reviewed

    Shirou Itagaki, Mitsuru Sugawara, Michiya Kobayashi, Katsumi Miyazaki, Takeshi Hirano, Ken Iseki

    Drug Metabolism and Pharmacokinetics   19 ( 2 )   150 - 154   2004

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    DOI: 10.2133/dmpk.19.150

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  • Major role of organic anion transporters in the uptake of phenolsulfonphthalein in the kidney Reviewed

    S Itagaki, M Sugawara, M Kobayashi, S Nishimura, M Fujimoto, K Miyazaki, K Iseki

    EUROPEAN JOURNAL OF PHARMACOLOGY   475 ( 1-3 )   85 - 92   2003.8

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    DOI: 10.1016/S0014-2999(03)02111-3

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  • Mechanism of Active Secretion of Phenolsulfonphthalein in the Liver via Mrp2 (abcc2), an Organic Anion Transporter Reviewed

    Shirou Itagaki, Ken Iseki, Mitsuru Sugawara, Michiya Kobayashi, Katsumi Miyazaki

    Drug Metabolism and Pharmacokinetics   18 ( 4 )   238 - 244   2003

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    DOI: 10.2133/dmpk.18.238

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Research Projects

  • 札幌医科大学医療機器等関連産業参入研修会を通じた道内地場企業との製品開発

    2024 - 2025

    札幌医科大学  学術振興事業 

    板垣 史郎

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  • 交通事故医療の質の向上に資する、間欠動作機能を備える革新的低圧吸引器の開発

    2024

    三井住友海上福祉財団  研究助成 

    板垣 史郎

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  • DDSがアニサキス感染から身を守る: 萌芽から開拓への新展開

    Grant number:23K17446  2023 - 2025

    日本学術振興会  科学研究費助成事業  挑戦的研究(開拓)

    丁野 純男

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    Grant amount:\24570000 ( Direct Cost: \18900000 、 Indirect Cost:\5670000 )

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  • 血流感染症特異的治療薬の開発に向けた大規模スクリーニングとvivoEF阻害剤ライブラリーの構築

    2021 - 2023

    JST  大学発新産業創出プログラム(START)  プロジェクト支援型(START)

    佐藤 豊孝

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  • 従来の抗菌薬開発法にとらわれない、新たな細菌感染症治療薬のスクリーニングに関する研究開発

    2019 - 2021

    AMED  創薬基盤推進研究事業 

    佐藤 豊孝

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    Grant type:Competitive

    研究開発分担者

    2019年12月6日 札幌医科大学プレスリリース
    停滞していた抗菌薬開発に光明!
    これまでにない新たなスクリーニング法の構築がAMED令和元年度「創薬基盤推進研究事業」に採択されました

    https://web.sapmed.ac.jp/jp/news/photo/jmjbbn000000ky3l.html

    https://web.sapmed.ac.jp/jp/news/press/jmjbbn000000kxhc.html

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  • アニサキス駆虫薬の探索とDDS創製:魚生食文化継承のため先人の研究挫折を超克する

    2019 - 2020

    日本学術振興会  科学研究費補助金 挑戦的研究(萌芽) 

    丁野 純男

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    Grant type:Competitive

    研究分担者

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  • 脳内酸化ストレス抑制効果の個体レベル画像化解析に基づくコーヒーポリフェノール・クロロゲン酸の認知症予防機序の解明

    2019

    全日本コーヒー協会  研究助成 

    板垣 史郎

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    Authorship:Principal investigator 

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  • 病院看護職のメンタルヘルスケアに貢献する光触媒型・病院臭気脱臭装置の開発

    2018

    ヘルス・サイエンス・センター  研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 病室不快臭の科学分析に基づく入院高齢者の生活環境改善に関する基礎研究

    2018

    三井住友海上福祉財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • ライフスタイルに発症起因する難治性肺疾患の征圧基盤:肺投与型DDSがその扉を開く

    2017 - 2020

    日本学術振興会  科学研究費補助金 基盤研究B 

    丁野 純男

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    Grant type:Competitive

    研究分担者

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  • 糖尿病患者の健やかな老いを創出・支援する介入的アルツハイマー病併発予防法の開発

    2014 - 2017

    日本学術振興会  科学研究費補助金 若手研究A 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 膵臓がん組織の抗がん剤反応性を予測するバイオマーカーの探索

    2013

    政策医療振興財団  研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 認知症の治療へ向けた脳インスリン応答性ペプチダーゼの記憶制御における役割の解明

    2012

    医科学応用研究財団  研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • アンジオテンシン変換酵素を標的とした大豆由来内臓脂肪型肥満症改善物質の探索

    2012

    不二たん白質研究振興財団  若手研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 大豆の認知能増強効果の実験的検証とその機構解明

    2012

    飯島記念食品科学振興財団  学術研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • アンジオテンシンⅡを介した脂肪細胞の分化・増殖機構の解明

    2012

    唐牛記念医学研究基金  助成金B 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 食品機能成分による新規大腸癌抑制遺伝子の制御

    2011 - 2012

    日本学術振興会  科学研究費補助金 挑戦的萌芽研究 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 脳インスリン応答性ペプチダーゼを介した記憶制御機構の解明

    2011

    武田科学振興財団  薬学系研究奨励 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • タマネギの虚血性腸管障害予防作用に関する研究

    2010

    食生活研究会  研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 肺がん組織に高発現するトランスポータLAT1を標的とした抗がん剤感受性増強戦略

    2010

    弘前大学  若手研究者支援事業 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 母集団パラメータ解析に基づく小児バンコマイシン血中濃度の予測精度向上

    2010

    臨床薬理研究振興財団  研究奨励金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 第9回 生体異物研究に関する国際会議

    2010

    金原一郎記念医学医療振興財団  研究交流助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 2010年 世界薬学会議/北米薬学会年会 合同会議

    2010

    薬学研究奨励財団  海外派遣助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 致死的薬剤誘発性肺炎の予防

    2010

    上原記念生命科学財団  研究奨励金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 食品機能成分の体内動態特性に基づく薬剤性肺障害の予防

    2009 - 2011

    文部科学省  科学研究費補助金 若手研究A 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • ルテインの化学的特性を利用した薬剤性肺障害予防法の確立

    2009

    旗影会  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 大豆ポリフェノールの抗酸化作用に基づく虚血・再灌流障害予防法の構築

    2009

    不二たん白質研究振興財団  若手研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 消化管トランスポータOATPを標的とした胆汁酸成分吸収促進技術の開発

    2009

    持田記念医学薬学振興財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • In vitro妊娠進行モデルを活用した、妊婦栄養指導プログラムの策定

    2009

    花王健康科学協会  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • コーヒーの虚血性腸管障害予防作用に関する研究

    2009

    すかいらーくフードサイエンス研究所  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • ハスカップを用いたがん治療に伴う重篤な副作用、口内炎の治療法

    2008

    ノーステック財団基盤的研究開発育成事業  スタートアップ研究補助金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • トランスポータ発現変動を反映した小腸虚血再灌流障害患者への適切な薬物投与指針の構築に関する研究

    2008

    中冨健康科学振興財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • In vitro肺胞上皮モデルを用いた薬物肺移行メカニズムの解析

    2008

    北海道大学重点配分経費  若手研究者自立支援 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 食生活に応じた適切なOTC薬選択基準の確立に向けた薬物動態学的研究

    2008

    一般用医薬品セルフメディケーション振興財団  調査研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 薬物動態因子の発現変動を反映した肝切除患者に対する薬物治療の最適化に関する研究

    2008

    政策医療振興財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 国際薬物動態学会 第15回北米年会

    2008

    伊藤医薬学術交流財団  海外交流助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • ダッタンそばの機能性成分であるルチンに着目した酸化ストレス性疾患の予防に関する多面的研究

    2008

    東和食品研究振興会  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 抗がん剤の重篤な副作用である口内炎に対する豆類ポリフェノールの治療効果

    2008

    タカノ農芸化学研究助成財団  若手研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 天然食用色素ルテインの生理的有用性に関する多角的検証

    2008

    旗影会  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 日本人に高頻度に発現する薬剤性肺障害の予防に関する研究

    2008

    薬学研究奨励財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 日本人に高頻度に発現する薬剤性肺障害の予防

    2007

    北海道大学重点配分経費  若手研究者の研究支援 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 小腸虚血再灌流による多臓器トランスポータ発現変動機構の解明

    2007

    ノーステック財団  基盤的研究開発育成事業(若手研究補助金) 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 第3回世界薬学会議

    2007

    加藤記念バイオサイエンス研究振興財団  加藤記念国際交流助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • トランスポータ発現変動を反映した肝切除・肝移植患者への適切な薬物投与指針の構築に関する研究

    2007

    栗林育英学術財団  研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 機能性食品の開発に貢献する新しい吸収改善理論の確立と新規配合剤の開発

    2007

    浦上食品・食文化振興財団  研究助成金 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 腎有機アニオントランスポータ欠損モデルラットの確立

    2005 - 2006

    文部科学省  科学研究費補助金 若手研究B 

    板垣 史郎, 内定後辞退

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    Authorship:Principal investigator  Grant type:Competitive

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  • 塩酸イリノテカンの副作用回避のための基礎的研究:消化管透過機構からのアプローチ

    2004

    秋山記念生命科学振興財団  奨励研究助成 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • 腎有機アニオントランスポータ欠損モデル動物の確立

    2004

    ノーステック財団  基盤的研究開発育成事業(若手研究補助金) 

    板垣 史郎

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    Authorship:Principal investigator  Grant type:Competitive

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  • Prevention of adverse-effects of drugs

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    Grant type:Competitive

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