Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by the involvement of multiple organs. Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in SLE patients. Hence, designing effective drugs is pivotal for treating individuals with LN. Fisetin plays a senolytic role by specifically eliminating senescent cells, inhibiting cell proliferation, and exerting anti-inflammatory, anti-oxidant, and anti-tumorigenic effects. However, limited research has been conducted on the utility and therapeutic mechanisms of fisetin in chronic inflammation. Similarly, whether the effects of fisetin depend on cell type remains unclear. In this study, we found that LN-prone MRL/lpr mice demonstrated accumulation of Ki-67-positive myofibroblasts and p15INK4B-positive senescent tubular epithelial cells (TECs) that highly expressed transforming growth factor β (TGF-β). TGF-β stimulation induced senescence of NRK-52E renal TECs and proliferation of NRK-49F renal fibroblasts, suggesting that TGF-β promotes senescence and proliferation in a cell type-dependent manner, which is inhibited by fisetin treatment in vitro. Furthermore, fisetin treatment in vivo reduced the number of senescent TECs and myofibroblasts, which attenuated kidney fibrosis, reduced senescence-associated secretory phenotype (SASP) expression, and increased TEC proliferation. These data suggest that the effects of fisetin vary depending on the cell type and may have therapeutic effects in complex and diverse LN pathologies.

DOI： 10.3389/fimmu.2022.960601

PubMed

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

Neuropsychiatric manifestations targeting the central, peripheral, and autonomic nervous system are common in systemic lupus erythematosus (SLE); collectively, these symptoms are termed neuropsychiatric SLE (NPSLE). Among a wide variety of neuropsychiatric symptoms, depression is observed in about 24-39% of SLE patients. Several cytokines and chemokines have been identified as biomarkers or therapeutic targets of NPSLE; in particular, the levels of type 1 interferons, TNFs, and IL-6 are elevated in SLE patient’s cerebrospinal fluid (CSF), and these factors contribute to the pathology of depression. Here, we show that senescent neural cells accumulate in the hippocampal cornu ammonis 3 (CA3) region in MRL/lpr SLE model mice with depressive behavior. Furthermore, oral administration of fisetin, a senolytic drug, reduced the number of senescent neural cells and reduced depressive behavior in the MRL/lpr mice. In addition, transcription of several senescence and senescence-associated secretory phenotype (SASP) factors in the hippocampal region also decreased after fisetin treatment in the MRL/lpr mice. These results indicate that the accumulation of senescent neural cells in the hippocampus plays a role in NPSLE pathogenesis, and therapies targeting senescent cells may represent a candidate approach to treat NPSLE.

DOI： 10.3389/fimmu.2021.692321

PubMed

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Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction. Cellular senescence, a state of irreversible cell cycle arrest, acts during normal embryonic development and remodeling after tissue damage; when these processes are complete, the senescent cells are eliminated. However, the accumulation of senescent cells is a hallmark of aging tissues or pathological contexts and may lead to progressive tissue degeneration. The mechanisms responsible for the effects of senescent cells have not been fully elucidated. Here, we review current knowledge about the beneficial and detrimental effects of senescent cells in tissue repair, regeneration, aging, and age-related disease, especially in skeletal muscle. We also discuss how senescence of muscle stem cells and muscle-resident fibro-adipogenic progenitors affects muscle pathologies or regeneration, and consider the possibility that immunosenescence leads to muscle pathogenesis. Finally, we explore senotherapy, the therapeutic targeting of senescence to treat age-related disease, from the standpoint of improving muscle regeneration.

DOI： 10.3389/fphar.2021.739510

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Authorship：Lead author   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s41467-020-14734-x

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Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/s12891-019-2819-2

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier {BV}  

DOI： 10.1016/j.ebiom.2019.05.012

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Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media {SA}  

DOI： 10.3389/fimmu.2019.00241

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Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Nature  

DOI： 10.1038/s41598-017-16443-w

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Authorship：Corresponding author  

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Language：Japanese   Publisher：(株)羊土社  

Ichushi

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: In the general population, the flexor hallucis longus (FHL) often has tendinous slips to lesser toes and the number of FHL slips varies between individuals. The purpose of this study was to investigate the relationship between the number of FHL tendinous slips in an individual foot and its toe flexor strength. METHODS: Forty healthy men were included in the study. The FHL branch test was used to assess each subject for the number of FHL tendinous slips. Toe flexor strength in each toe was measured using a force gauge. A two-way ANOVA was used to compare toe flexor strength between groups classified according to the number of FHL slips. RESULTS: The group of subjects with FHL branching to the second toe was the most common (20/40). The toe flexor strength ratio of the third toe was significantly lower in feet lacking FHL branching to the third toe than in those feet which did have branching to the third toe (P = 0.005). CONCLUSIONS: Toe flexor strength was affected by FHL tendinous slips. Considering the number of the FHL tendinous slips an individual foot has may be useful in clinical practice for rehabilitation or training of toe flexor muscles.

DOI： 10.1016/j.fas.2020.11.002

PubMed

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.bbih.2020.100149

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: High-force eccentric contractions (ECCs) have traditionally been excluded from rehabilitation programs of patients with idiopathic inflammatory myopathies (IIMs) due to unverified fear of causing muscle damage and inflammation. Here, we used an IIM animal model, experimental autoimmune myositis (EAM) mice, to investigated whether ECC training can be safely and effectively used to counteract muscle weakness in IIM. METHODS: EAM was induced in Balb/c mice by immunization with three injections of myosin emulsified in complete Freund's adjuvant. Control (CNT: n=12) and EAM (n=12) mice were exposed to an acute bout of 100 ECCs or 4 weeks of ECC training (20 ECCs every other day). To induce ECCs, plantar flexor muscles were electrically stimulated while the ankle was forcibly dorsiflexed. RESULTS: Less cell damage, as assessed by Evans blue dye uptake, was observed in EAM than in CNT muscles after an acute bout of 100 ECCs (P < 0.05). Maximum Ca2+ -activated force was decreased in skinned gastrocnemius muscle fibers from EAM mice and this was accompanied by increased expression of the endoplasmic reticulum (ER) stress proteins glucose-regulated protein 78 and 94 (P < 0.05). ECC training prevented the force decrease and the increase in ER stress proteins, and also enhanced the expression and myofibrillar binding of small heat shock proteins (sHSP) (P < 0.05), which can stabilize myofibrillar structure and function. CONCLUSION: ECC training protected against the reduction in myofibrillar force generating capacity in an IIM mouse model and this occurred via inhibition of ER stress responses and sHSP-mediated myofibrillar stabilization.

DOI： 10.1002/art.41594

PubMed

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Language：Japanese   Publisher：(一社)日本臨床スポーツ医学会  

Ichushi

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Language：English   Publishing type：Research paper (scientific journal)  

STUDY DESIGN: This is a basic science research. INTRODUCTION: Isolating excursion of the flexor digitorum profundus (FDP) in zones I and II is common practice in the current management after flexor tendon repair. During this procedure, the proximal interphalangeal joint is sometimes fully extended with unmeasured external forces at the middle phalanx when the distal interphalangeal joint is actively flexed. PURPOSE OF THE STUDY: The purpose of the study was to investigate the incremental effect of external force with palmar blocking versus lateral blocking and increased angles of flexion on internal tendon forces at the repair site for a safer application of force by the treating therapist. METHODS: Eight human cadaveric fingers were studied. To simulate palmar or lateral finger blocking, a compression force of blocking was applied from 5N (510 grams) to 25N (2,550 grams) on the skin surface of the palmar or the lateral aspect of each of these middle phalanges in 5N increments. The tensile load on the FDP tendon during distal interphalangeal joint flexion from 0° to 60° was measured in 10° increments. RESULTS: During palmar blocking, the tensile load was significantly increased with increases in palmar blocking force. However, no significant increase in the tensile load on the FDP tendon was observed at any lateral blocking. DISCUSSION: Lateral blocking exercise can be performed with less tensile force on the FDP tendon when performing blocking exercise after flexor tendon injury repair. CONCLUSIONS: This study supports the concept that lateral blocking with incremental joint angles allows a safer application of force for the healing tendon.

DOI： 10.1016/j.jht.2020.07.004

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) ameliorates diabetes-induced cognitive impairment by transferring exosomes derived from these cells into astrocytes. Here, we show that intracerebroventricularly injected BM-MSCs improve cognitive impairment in AD model mice by ameliorating astrocytic inflammation as well as synaptogenesis. Although AD model mice showed an increase in NF-κB in the hippocampus, BM-MSC-treated AD model mice did not show this increase but showed an increase in levels of microRNA (miR)-146a in the hippocampus. Intracerebroventricularly injected BM-MSCs were attached to the choroid plexus in the lateral ventricle, and thus, BM-MSCs may secrete exosomes into the cerebrospinal fluid. In vitro experiments showed that exosomal miR-146a secreted from BM-MSCs was taken up into astrocytes, and an increased level of miR-146a and a decreased level of NF-κB were observed in astrocytes. Astrocytes are key cells for the formation of synapses, and thus, restoration of astrocytic function may have led to synaptogenesis and correction of cognitive impairment. The present study indicates that exosomal transfer of miR-146a is involved in the correction of cognitive impairment in AD model mice.

DOI： 10.1038/s41598-020-67460-1

PubMed

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier {BV}  

DOI： 10.1016/j.fas.2019.08.003

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Language：Japanese   Publisher：金原出版(株)  

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00767&link_issn=&doc_id=20180613120018&doc_link_id=10.18888%2Fse.0000000518&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fse.0000000518&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Ichushi

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Language：Japanese   Publisher：北海道整形災害外科学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本足の外科学会  

Ichushi

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Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media {LLC}  

DOI： 10.1038/srep24805

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Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

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Language：Japanese   Publisher：(一社)日本臨床スポーツ医学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(株)文光堂  

Ichushi

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Language：Japanese   Publisher：(有)科学評論社  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)北海道作業療法士会  

Other Link:： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J03831&link_issn=&doc_id=20171116340002&doc_link_id=%2Fcr8occup%2F2017%2F003403%2F003%2F0119-0123%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcr8occup%2F2017%2F003403%2F003%2F0119-0123%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

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Language：Japanese   Publisher：(一社)日本手外科学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本手外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：公益社団法人 日本理学療法士協会  

<p>【はじめに，目的】</p><p></p><p>多発性筋炎に対する運動は炎症の助長や異所性組織を形成させるリスクがある。本研究では，骨格筋の炎症と再生，異所性組織形成において中心的な役割を果たす骨格筋間葉系前駆細胞（Mesenchymal Progenitor Cell：MPC）を中心として，運動刺激と炎症の助長および異所性組織形成のメカニズムを解明する。</p><p></p><p></p><p>【方法】</p><p></p><p>8週齢のBalb/cマウス（メス）に精製したBalb/c由来ミオシンと完全フロイトアジュバントをリンパ節付近に免疫し実験的自己免疫性筋炎（Experimental Autoimmune Myositis：EAM）を作成した。免疫後5週の時点で運動介入（17m/min，-20度傾斜，30分）を実施し，24時間後に腓腹筋を採取した。MPCはLineage陰性α7-integrin陰性PDGFRα陽性の細胞を単離した。単離後のMPCにて遺伝子発現解析（筋再生関連遺伝子Follistatin，IGF-1；抗炎症関連遺伝子TSG-6，IL-1Ra，IL-33；細胞周期阻害遺伝子p16^ink4a；線維化関連遺伝子αSMA，TGFβ）を実施した。Control（Con）群，Controlに運動介入をしたControl-Exercise（Con-Ex）群，EAM群，EAMに運動介入をしたEAM-Exercise（EAM-Ex）群の4群で比較検討した。</p><p></p><p></p><p>【結果】</p><p></p><p>片側腓腹筋あたりのMPC細胞数はCon群（mean，0.37*10⁵ cells；95% CI，0.24-0.50）と比較してEAM群（mean，2.02 *10⁵ cells；95% CI，1.58-2.46）で有意に増加した（<i>P</i>＜0.001）。Con群ではEx介入によってMPC細胞数は有意に増加したが（mean，0.70 *10⁵ cells；95% CI，0.56-0.84；<i>P</i>=0.02），EAM群ではEx介入で細胞数に有意差はなかった（mean，1.52 *10⁵ cells；95% CI，1.90-1.14；<i>P</i>=0.132）。MPCの遺伝子発現解析の結果，Con-Ex群では筋再生関連，抗炎症関連および細胞周期阻害遺伝子の発現量増加を認めたが（<i>P</i>＜0.05），EAM-Ex群減少（<i>P</i>＜0.05），もしくは変化しなかった。さらに，EAM-Ex群では線維化関連遺伝子の発現が増加した（<i>P</i>＜0.05）。</p><p></p><p></p><p></p><p></p><p>【結論】</p><p></p><p>正常マウスと筋炎マウスのMPCでは運動刺激に対する反応が異なることを明らかにした。慢性炎症状態の骨格筋に対する運動刺激は，本来MPCがもつ抗炎症能力や筋サテライト細胞ニッチとしての働きを減弱させること，MPCにおけるαSMAやTGFβの発現が亢進させて骨格筋線維化の原因となる可能性を示唆した。また，間葉系細胞におけるp16^ink4aの発現低下は様々な組織における線維化や再生不良に寄与することが報告されている。今回，筋炎モデルでは運動介入によってp16^ink4a発現低下を認め，正常モデルでは発現亢進した。以上より，p16^ink4aは適切な運動刺激のバイオマーカーとなるかもしれない。</p>

DOI： 10.14900/cjpt.2016.0455

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Language：Japanese   Publisher：(一社)日本足の外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

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Language：Japanese   Publisher：日本基礎理学療法学雑誌編集委員会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本手外科学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本糖尿病学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本手外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：公益社団法人 日本理学療法士協会  

【はじめに，目的】滑膜下結合組織（Subsynovial Connective Tissues，SSCT）の線維化が特発性手根管症候群（Carpal Tunnel Syndrome，CTS）の原因とされている。近年，線維性疾患においてPlatelet-derived Growth Factor Receptor alpha（PDGFRα）陽性の間葉系細胞の過剰増殖が組織線維化の要因の一つとして注目されている。本研究では，CTS及びコントロールのSSCTにおけるPDGFRα陽性間葉系細胞と間葉系細胞の超微細形態について検討を行った。【方法】CTS患者2名（77歳女性，45歳女性），コントロール1名（47歳男性）および2遺体標本（86歳男性，94歳男性）の手根管よりSSCTを採取した。超微細形態観察のため，オスミウム固定後，超薄切片を作製し，電子染色を施した。免疫組織学的解析のため，凍結切片を作製しPDGFRα，Cadherin-11抗体で免疫組織染色を行い，1視野あたりの細胞密度，TGFβ1，CTGF陽性細胞の割合を算出した。結果の解析はCTS患者のSSCTをCTS群，コントロールおよび遺体標本のSSCT対象群とし，One way ANOVA及びTukey-Kramer testを用いて群間比較をした（α＝0.05）。【結果】CTS群における間葉系細胞の超微細形態所見では細胞質内の豊富な筋フィラメントと細胞質周囲に大量のコラーゲン様線維産生を認めた。CTS群におけるPDGFRα陽性細胞の割合は対象群より有意に高値を示したが，Cadherin-11陽性細胞の割合は有意に低値を示した。さらにPDGFRα陽性かつCadherin-11陽性細胞の割合がCTS群にて有意に低値を示した。【結論】CTS群においてPDGFRα陽性間葉系細胞の過剰増殖を認め，同時に正常な滑膜線維芽細胞のマーカーであるCadherin-11を発現する細胞が減少した。これらの結果から，CTSにおけるSSCTの線維化にはPDGFRα陽性間葉系細胞の関与が示唆された。

DOI： 10.14900/cjpt.2015.0680

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Language：Japanese   Publisher：(公社)日本整形外科学会  

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：公益社団法人 日本理学療法士協会  

DOI： 10.14900/cjpt.2013.0803

Ichushi

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Language：Japanese   Publisher：公益社団法人 日本理学療法士協会  

DOI： 10.14900/cjpt.2013.1412

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

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Language：Japanese   Publisher：(公社)日本理学療法士協会  

Other Link:： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J01747&link_issn=&doc_id=20140716481514&doc_link_id=10.14900%2Fcjpt.2012.0.48101075.0&url=https%3A%2F%2Fdoi.org%2F10.14900%2Fcjpt.2012.0.48101075.0&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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Language：Japanese   Publisher：公益社団法人 日本理学療法士協会  

【はじめに、目的】下肢関節損傷の中で高頻度に認められる足関節捻挫は、日常生活動作（Activities of Daily Living, ADL）において最も損傷を受けやすく、特に、不整地での歩行や走行の着地時に受傷する。また、足関節はADL上の繰り返し負荷によって起こるオーバーユース障害（足底腱膜炎やアキレス腱炎など）を生じやすい。そのため、ADL上において足関節に加わる負荷は膝関節・股関節よりも大きいと推測されるが、その詳細は明らかでない。本研究の目的は、異なる高さからの着地時に受ける足関節のエネルギー量と膝・股関節のエネルギー量を比較することで、足関節のエネルギー吸収の割合を求め、足関節への負担を明らかにすることである。【方法】健常成人男性16 名を対象とした。年齢は21.1 歳（18-23 歳）、身長172.4cm（166-178cm）、体重62.6kg（52-74kg）であった。被験者は20cm, 40cm, 60cmの台から飛び降り、両脚着地を行った。飛び降りの際、できるだけ台の端に立ち、前方、上方に飛ばないように指示した。動作中の身体の空間座標の計測には、モーションキャプチャーカメラ（Vicon512, Oxford Metrics, UK）7 台と床反力計（Advanced Mechanical Technology Inc.,USA）2 枚をサンプリング周波数60Hzで同期させた3 次元動作解析装置システムを用いた。臨床歩行分析研究会が推奨するマーカーの貼付方法を採用して、直径25mmの赤外線マーカーを肩峰部、股関節部、膝関節部、足関節部、第5 中足骨部の左右10 か所に貼付し、身体を7 リンク剛体モデルに定義した。着地の瞬間から重心が最下点に達するまでの運動学、運動力学的データを計測した。今回指標とするエネルギー量は関節モーメントに関節運動の角速度を乗じてそのパワーを計算し、さらにその値を時間積分することによって得られた。統計処理にはエネルギー量およびエネルギー量の割合においてそれぞれTwo-way Repeated-Mesears ANOVAを行いpost-hocとしてTukey's multiple comparison testを行った。有意水準はα=0.05 と設定した。【倫理的配慮、説明と同意】本研究は学内研究倫理委員会の承認を受けたのち、事前に研究の内容を被験者に十分に説明し、書面で同意を得た。【結果】各関節におけるエネルギー量（Joule, J）を体重で正規化した。足関節は20cmからの着地で1.1 ± 0.3J、40cmで1.6 ± 0.4J、60cmで1.8 ± 0.5Jと、20cmと60cmの間で有意差を認めた（p=0.001）。膝関節は20cmからの着地で0.7 ± 0.5J、40cmで1.8 ± 0.7J、60cmで2.7 ± 0.6Jと、20cmと60cmの間で有意差を認めた（p<0.001）。股関節は20cmで0.06 ± 0.05J、40cmで0.3 ± 0.2J、60cmで0.6 ± 0.5Jと有意差を認めなかった。各関節におけるエネルギー量の割合は、20cmからの着地で、足関節は60.7%、膝関節は36.4%と足関節が有意に高かった（p<0.0001）。40cmでは足関節は44.5%、膝関節は47.5%であり、足関節と膝関節の間に有意差を認めなかった（p=0.99）。60cmでは足関節は36.0%、膝関節は53.5%であり、膝関節が有意に高かった（p=0.02）。股関節は20cm、40cm、60cmでそれぞれ2.9%、6.0%、10.5%と他の関節に比して有意に低い割合を示した（p<0.0001）。【考察】足関節は低い高さからの着地時に、近位関節である膝関節、股関節よりも大きなエネルギー吸収の役割を果たした。一方でより高い位置からの着地では、近位関節へ加わる負荷が増大する。これらのことから、より低い位置からの着地、例えば降段や歩行、ジョギングなどのADL活動によって、足関節は膝関節、股関節よりも大きな繰り返し負荷を受けている可能性が示唆された。ADL上の活動で頻発する足関節捻挫やオーバーユース障害の予防には、膝関節、股関節によるエネルギー吸収の割合を増加させることが有効かもしれない。【理学療法学研究としての意義】下肢損傷に対する理学療法では、関節への負荷量のコントロールが必要となる。本研究の結果から、特に足関節・足部の損傷に対して着地練習を実施する時は、低い高さからの着地であっても足関節に対する負担が大きいことを留意しなければならない。また、足関節とは異なり、膝関節に対する負荷量は飛び降りの位置が高くなるにつれて増加する。このことは、例えば前十字靭帯損傷の術後の患者に対する着地練習など、膝関節に対する負荷量をコントロールするための基礎的情報として理学療法に寄与するかもしれない。

DOI： 10.14900/cjpt.2012.0.48101075.0

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Language：English   Presentation type：Symposium, workshop panel (public)  

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