Language：Japanese   Publisher：札幌医科大学保健医療学部  

Ichushi

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Language：Japanese   Publisher：札幌医科大学保健医療学部  

Ichushi

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Language：Japanese   Publisher：札幌医科大学保健医療学部  

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J05973&link_issn=&doc_id=20220426360013&doc_link_id=%2Ffc8hoken%2F2022%2F000011%2F013%2F0087-0091%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffc8hoken%2F2022%2F000011%2F013%2F0087-0091%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Ichushi

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Publishing type：Research paper (scientific journal)   Publisher：Scientific Research Publishing, Inc.  

DOI： 10.4236/ojn.2022.121002

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Despite a long average lifespan, increased life expectancy does not guarantee higher quality of life. METHODS: To contribute in understanding some determinants of healthy life expectancies in older Japanese individuals in a snowy winter region, we investigated the indicators of health. Local residents (n = 124) in the city of Iwamizawa volunteered for health examinations from January 2016 to March 2016. We recorded activity via daily steps for 2-week periods. In addition, we measured body composition, grip strength, and assessed nutritional status. RESULTS: Analysis of body composition and daily activity indicated that women who walked more than 4000 steps had lower fat mass and increased muscle mass. Men with >3.0 metabolic equivalents (METs) when walking had lower body fat. CONCLUSION: For healthy older Japanese individuals in this snowy winter region, walking >4000 steps daily for women and exercise of >3.0 METs for men may indicate health-promoting activities.

DOI： 10.3390/ijerph17155316

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred strains for evaluations of various parameters. In this study, experimental reproducibility in several parameters was compared between an outbred Wistar rat and Wistar King A Hokkaido (WKAH/HkmSlc) rat, the inbred strain that is originated from Wistar rats. METHODS: Difference of variations was investigated in parameters of body compositions and liver functions such as body weight, liver weight, liver triglycerides (TG), liver cholesterol and plasma alanine aminotransferase activity (ALT) between WKAH rats and outbred Wistar rats by using the coefficient of variation (CV). RESULTS: There was no difference in the CVs of body weight and relative liver weight between WKAH and Wistar rats. The CVs of body weight and relative liver weight were below 10% in both WKAH and Wistar rats. The CVs of TG, cholesterol, and ALT in Wistar rats were between 30 and 40%, whereas those in WKAH rats were between 10 and 25%. A low CV level of TG was observed in WKAH rats compared to that in Wistar rats regardless of the duration of the experimental period in those rat strains. CONCLUSION: The low CV values in metabolic parameters involved in liver functions in the inbred rats suggested an advantage of using inbred rather than outbred rats for the evaluation of liver lipid metabolism.

DOI： 10.1186/s12944-020-01320-9

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Publishing type：Research paper (scientific journal)   Publisher：Scientific Research Publishing, Inc.  

DOI： 10.4236/ojn.2020.102012

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Nurses are responsible for implementing appropriate measures to reduce hospital infections, especially with multidrug resistant bacteria, so nursing students should learn about microbiology. This helps them to understand bacterial dissemination and infectious disease control. Because of tight schedules, however, its teaching is limited in undergraduate nursing classes in Japan. We therefore tested whether a simple short practical session in a microbiology class could help to improve undergraduate nursing students' awareness of bacterial traits and how to prevent infections. METHODS: This study involved second-grade nursing students (n = 76). Two short practical sessions (a total of 3 h, across 2 days) were used to assess the effectiveness of washing or disinfection on hand bacteria in a 16-class microbiology course (total class time was 24 h, plus an exam). Hand bacteria were sampled on LB agar plates with orientation during the first half-day, and the plates examined for colonies with distinct color or morphological traits, and discussed, in the second session, a week later. Questionnaires before and after the exercise were used to assess changes in awareness of unseen bacteria inhabiting around us connecting bacterial traits and how to prevent infections. RESULTS: The results showed that the practical increased the nursing students' awareness of fomites (utensils) (p = 0.0115), fomites (contact-based) (p = 0.0016), habitats (body surface) (p = 0.0127), action facilitating hospital infection (p = 0.0166), and changes in physical condition caused by bacterial infections (p = 0.0136). There were no changes in word associations (p = 0.627) or habitats (inside body) (p = 0.308). Difficulty score, which is an element in questionnaire psychometric properties, tended to be close to the expected score through the practical, but not statistical significant. In addition, regardless of before or after practical, Cronbach α score, which is an indicator of the reliability among items of multi-choice questions, showed > 0.8, indicating validity of evaluation items. Thus, the student's awareness of unseen bacteria inhabiting around us was significantly increased as compared to those before practical in microbiology class. CONCLUSIONS: The simple short practical effectively improved nursing students' awareness of unseen bacteria inhabiting around us in microbiology course, useful for even tight teaching schedules.

DOI： 10.1186/s12909-019-1483-4

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Language：English   Publishing type：Research paper (scientific journal)  

We monitored the survival of human pathogenic bacteria [Escherichia coli (ATCC), extended-spectrum β-lactamase-producing E. coli (Clinical isolate), New Delhi metallo-β-lactamase-producing E. coli (clinical isolate), Staphylococcus aureus (ATCC)] on dry materials (vinyl chloride, aluminum, plastic, stainless steel) at distinct temperatures (room temperature or 15°C-37°C). These bacteria favored a lower temperature for their prolonged survival on the dry fomites, regardless of the material type. Interestingly, when mixed with S. aureus, E. coli survived for a longer time at a lower temperature. Cardiolipin, which can promote the survival of S. aureus in harsh environments, had no effect on maintaining the survival of E. coli. Although the trends remained unchanged, adjusting the humidity from 40% to 60% affected the survival of bacteria on dry surfaces. Scanning electron microscopic analysis revealed no morphological differences in these bacteria immediately before or after one day of dry conditions. In addition, ATP assessment, a method used to visualize high-touch surfaces in hospitals, was not effective at monitoring bacterial dynamics. A specialized handrail device fitted with a heater, which was maintained at normal human body core temperature, successfully prohibited the prolonged survival of bacteria [Enterococcus faecalis (ATCC), E. coli (ATCC), Pseudomonas aeruginosa (ATCC), S. aureus (ATCC), Acinetobacter baumannii (clinical isolate), and Serratia marcescens (clinical isolate)], with the exception of spore-forming Bacillus subtilis (from our laboratory collection) and the yeast-like fungus Candida albicans (from our laboratory collection)] on dry surfaces. Taken together, we concluded that the tested bacteria favor lower temperatures for their survival in dry environments. Therefore, the thermal control of dry fomites has the potential to control bacterial survival on high-touch surfaces in hospitals.

DOI： 10.1371/journal.pone.0226952

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Medical Internet Research  

DOI： 10.2196/ijmr.8555

PubMed

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Language：Japanese   Publisher：北海道公衆衛生学会  

Ichushi

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本未病学会  

Ichushi

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jiac.2017.03.016

PubMed

Web of Science

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1177/2333721417706854

PubMed

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Language：Japanese   Publisher：(一社)日本未病学会  

Ichushi

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Our previous study into assessing hospital cleanliness in Japan by two common methods, ATP bioluminescence and the stamp agar method, revealed considerable variability in the data of both methods (BMC Research Notes, 7: 121, 2014). To investigate the reason(s) for the variability, we reanalyzed the data (n = 752) from the point of view of the material surface properties of sampling sites. METHODS: Data obtained from surfaces with unknown properties and different purposes such as floor were omitted, and the remaining data (n = 488) were used for this study. The material surface properties on sampling sites were divided into six categories: melamine coated (n = 216), vinyl chloride (n = 16), stainless steel (n = 144), wood (n = 63), and acrylonitrile-butadiene styrene resin coated (n = 48). The data between individual material properties were compared. RESULTS: The ATP values of high-touch places were significantly different depending on the type of surface, but no significant difference in stamp values between material properties was seen, indicating that in contrast to stamp values, ATP-accumulation more depends on the physical properties of the material surface such as electronic charges or roughness. To confirm this, we assessed a degree of roughness on vinyl chloride material surface (disutilized floor samples actually used for each of the hospitals) by observation with scanning electron microscope (SEM). As a result, SEM observation similarly revealed considerable roughness on the materials, which may allow microbes to contaminate the materials without noticing it. CONCLUSION: Material properties must be considered when evaluating hospital cleanliness with ATP values, and provide a strong warning into evaluating hospital cleanliness.

DOI： 10.1186/s13104-015-1757-9

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier  

DOI： 10.1016/j.jiac.2015.08.016

PubMed

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Language：Japanese   Publisher：(一社)日本未病学会  

Ichushi

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Language：Japanese   Publisher：看護総合科学研究会  

Ichushi

J-GLOBAL

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DOI： 10.1177/1357633X15571998

PubMed

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Language：Japanese   Publisher：(一社)日本看護技術学会  

DOI： 10.18892/jsnas.13.3_211

CiNii Research

Ichushi

J-GLOBAL

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Hospital cleanliness in hospitals with a tendency toward long-term care in Japan remains unevaluated. We therefore visualized hospital cleanliness in Japan over a 2-month period by two distinct popular methods: ATP bioluminescence (ATP method) and the standard stamp agar method (stamp method). METHODS: The surfaces of 752 sites within nurse and patient areas in three hospitals located in a central area of Sapporo, Japan were evaluated by the ATP and stamp methods, and each surface was sampled 8 times in 2 months. These areas were located in different ward units (Internal Medicine, Surgery, and Obstetrics and Gynecology). Detection limits for the ATP and stamp methods were determined by spike experiments with a diluted bacterial solution and a wipe test on student tables not in use during winter vacation, respectively. Values were expressed as the fold change over the detection limit, and a sample with a value higher than the detection limit by either method was defined as positive. RESULTS: The detection limits were determined to be 127 relative light units (RLU) per 100 cm2 for the ATP method and 5.3 colony-forming units (CFU) per 10 cm2 for the stamp method. The positive frequency of the ATP and stamp methods was 59.8% (450/752) and 47.7% (359/752), respectively, although no significant difference in the positive frequency among the hospitals was seen. Both methods revealed the presence of a wide range of organic contamination spread via hand touching, including microbial contamination, with a preponderance on the entrance floor and in patient rooms. Interestingly, the data of both methods indicated considerable variability regardless of daily visual assessment with usual wiping, and positive surfaces were irregularly seen. Nurse areas were relatively cleaner than patient areas. Finally, there was no significant correlation between the number of patients or medical personnel in the hospital and organic or microbiological contamination. CONCLUSIONS: Ongoing daily hospital cleanliness is not sufficient in Japanese hospitals with a tendency toward long-term care.

DOI： 10.1186/1756-0500-7-121

PubMed

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Language：Japanese   Publisher：(一社)日本医療情報学会  

Ichushi

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Language：Japanese   Publisher：日本医療情報学会看護部会  

Ichushi

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Language：Japanese   Publisher：(公社)日本薬学会  

Ichushi

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Language：Japanese   Publisher：看護総合科学研究会  

Ichushi

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：Japanese   Publisher：(公社)日本薬学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本医療情報学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本医療情報学会  

Ichushi

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Language：Japanese   Publisher：(一社)日本医療情報学会  

Ichushi

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Language：Japanese   Publisher：山形大学  

Hypercholesterolemia is an important risk factor of coronary heart diseases, in which platelet aggregability is enhanced. It is suggested that platelet aggregation is inhibited by red wine polyphenolic compounds (RWPC) in vitro. We investigated the effect of chronic administration of RWPC on platelet aggregation, plasma lipid levels and lipid deposition in liver in hypercholesterolemic rats. Male F344 rats (2 month-old) were fed standard diet (Cont), 4% cholesterol-rich-diet (Cho), or 4% cholesterol-rich-diet plus 0.62% freeze-dried red wine extracts (RWPC + Cho) for 1 month. Platelet aggre...

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1440-1681.2006.04349.x

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Language：Japanese   Publisher：山形大学  

[Objective] It has been reported that hypercholesterolemia plays a role in progression of atherosclerosis. Watanabe heritable hyperlipidemic rabbits have been used widely as a model of familial hypercholesterolemia with atherosclerosis, while the emerging data raised a possibility of an important role of hypertriglyceridemia in the pathogenesis of atherosclerosis. We have recently segregated a new line with severely high (TGH) and moderately high (TGL) levels of plasma triglyceride. The hemodynamic parameters of TGH and TGL are not defined. The aim of present study was to examine the progre...

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Language：Japanese   Publisher：Yamagata University  

[Objective] The vasorelaxing effects of the red wine extracts were studied in rat thoracic aorta. [Methods] Aortas were isolated from young (2-3 months) and aged (27 months) F344 rats and the ring preparations with or without endothelium were mounted in Krebs-Henseleit solution to measure the developed tension. The polyphenolic substances were added cumulatively after the contraction with phenylephrine.[Results] Extracts of red wine relaxed the vessels concentration-dependently. These vasorelaxant effects were attenuated by endothelial removal. In young rat, vasorelaxation induced by RWPC was significantly inhibited by L-NNA (100 μM), diclofenac (10 μM) and 30mM KCl. In aged rat, the inhibition by L-NNA and diclofenac was less than that of young rat, and 30mM KCl potently decreased the relaxation. However, the vasorelaxant responses were preserved even in aged aorta.[Conclusion] RWPC induces vascular relaxation endothelium-dependently not only in young rat but also in aged rat. The relaxation was mediated via NO, prostacyclin and EDHF in young aorta, while EDHF may play an important role in aged aorta.

Other Link： http://www.lib.yamagata-u.ac.jp/kiyou/kiyoum/kiyoum-23-1/image/kiyoum-23-1-033to041.pdf

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Language：Japanese   Publisher：(一社)日本感染症学会  

Ichushi

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Language：Japanese   Publisher：日本医療薬学会  

J-GLOBAL

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Language：Japanese   Publisher：The Institute of Electronics, Information and Communication Engineers  

J-GLOBAL

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Language：Japanese   Publisher：日本医療情報学会看護部会  

Ichushi

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Language：English   Publishing type：Research paper, summary (international conference)  

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Web of Science

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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高速インターネットによる健康相談システムを開発し、遠隔健康相談ができるようになった。この遠隔健康相談記録の内容をテキストマイニング技法により、探索的検討を行った。分析対象期間は2010年3月から2012年6月であった。利用件数は354件(男性122名、女性230名、不明2名)であった。店舗ごとの相談件数は北海道内の4店舗はほぼ同数であり、僻地型、都市近郊型、都市型で差はなかった。利用者の年齢は10から90歳代であり、70歳代が最も多かった。相談内容は、健康相談、育児、排泄、栄養、生活習慣病、運動等であった。全相談のうち16%は、医療機関への受診が必要と判断し、利用者へ受診推奨をした。相談内容を分析すると、名詞では「薬」「受診」「血圧」の出現頻度が高く、形容詞では「高い」「悪い」「痛い」が頻度の上位を占めていた。各言語間の相関関係は明らかにならなかった。「受診」の頻度が高いのは受診すべきか否かを判断して欲しい利用者のニーズの現れであると考えられた。

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