TSUJI Yoshihisa

写真a

Affiliation

School of Medicine, Department of Community and General Medicine

Job title

Professor
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Degree 【 display / non-display 】

  • 医学博士

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Research Areas 【 display / non-display 】

  • Life sciences   Gastroenterology  

  • Life sciences   Radiology  

  • Life sciences   Immunology  

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Affiliation 【 display / non-display 】

  • Shiga University of Medical Science   総合診療学講座   特任教授  

  • Sapporo Medical University   General Medicine   教授  

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Research Interests 【 display / non-display 】

  • Medical Education

  • Severe acute pancreatitis

  • Acute pancreatitis

  • Perfusion CT

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Papers 【 display / non-display 】

  • Gut microbiota and metabolites in patients with COVID-19 are altered by the type of SARS-CoV-2 variant.

    Yoshihiro Yokoyama, Tomoko Ichiki, Tsukasa Yamakawa, Yoshihisa Tsuji, Koji Kuronuma, Satoshi Takahashi, Eichi Narimatsu, Akio Katanuma, Hiroshi Nakase

    Frontiers in microbiology   15   1358530 - 1358530  2024  [International journal]

    　View Summary

    INTRODUCTION: Patients with COVID-19 have dysbiosis of the intestinal microbiota with altered metabolites in the stool. However, it remains unclear whether the differences among SARS-CoV-2 variants lead to differences in intestinal microbiota and metabolites. Thus, we compared the microbiome and metabolome changes for each SARS-CoV-2 variant in patients with COVID-19. MATERIALS AND METHODS: We conducted a multicenter observational study of patients with COVID-19 and performed fecal microbiome, metabolome, and calprotectin analyses and compared the results among the different SARS-CoV-2 variants. RESULTS: Twenty-one patients with COVID-19 were enrolled and stratified according to the SARS-CoV-2 strain: six with the Alpha, 10 with the Delta, and five with the Omicron variant. Fecal microbiome analysis showed that α-diversity was reduced in the order of the Omicron, Delta, and Alpha variants (p = 0.07). Linear discriminant analysis revealed differences in the abundance of short-chain fatty acid-producing gut microbiota for each SARS-CoV-2 variant. Fecal metabolome analysis showed that the Omicron and Delta variants had markedly reduced propionic and lactic acid levels compared to the Alpha strain (p < 0.05). CONCLUSION: The intestinal microbiota of patients with COVID-19 varies depending on the SARS-CoV-2 variant. Dysbiosis of the intestinal microbiota due to differences in SARS-CoV-2 variants causes a decrease in intestinal short-chain fatty acids.

    DOI PubMed

  • Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.

    Tomoko Ichiki, Valentina Cannone, Christopher G Scott, Seethalakshmi R Iyer, S Jeson Sangaralingham, Kent R Bailey, Jens P Goetze, Yoshihisa Tsuji, Richard J Rodeheffer, John C Burnett Jr

    American journal of physiology. Heart and circulatory physiology   325 ( 3 ) H545-H552  2023.09  [International journal]

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    Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are produced in the heart and secreted into the circulation. As hormones, both peptides activate the guanylyl cyclase receptor A (GC-A), playing a role in blood pressure (BP) regulation. A significant role for ANP and BNP includes favorable actions in metabolic homeostasis. Sex-based high prevalence of risk factors for cardiovascular disease in males compared with females is well established, but sex-based differences on cardiometabolic protection have not been investigated in relation to ANP (NPPA) and BNP (NPPB) gene variants. We included 1,146 subjects in the general population from Olmsted County, Minnesota. Subjects were genotyped for the ANP gene variant rs5068 and BNP gene variant rs198389. Cardiometabolic parameters and medical records were reviewed. In the presence of the minor allele of rs5068, diastolic BP, creatinine, body mass index (BMI), waist measurement, insulin, and prevalence of obesity and metabolic syndrome were lower, whereas HDL was higher in males with only trends observed in females. We observed no associations of the minor allele with echocardiographic parameters in either males or females. Regarding rs198389 genotype, the minor allele was not associated with any BP, metabolic, renal, or echocardiographic parameters in either sex. In the general community, the minor allele of the ANP gene variant rs5068 is associated with a favorable metabolic phenotype in males. No associations were observed with the BNP gene variant rs198389. These studies support a protective role of the ANP pathway on metabolic function and underscore the importance of sex in relationship to natriuretic peptide responses.NEW & NOTEWORTHY Males are characterized by lower ANP and BNP with greater prevalence of cardiometabolic disease. The ANP genetic variant rs5068 was associated with less metabolic dysfunction in males, whereas no metabolic profile was related to the BNP genetic variant rs198389 in the general population. ANP may play a more biological role in metabolic homeostasis compared with BNP in the general population with greater physiological metabolic actions in males compared with females.

    DOI PubMed

  • 差異に着目した地域医療教育のデザインとその実践報告

    神野 敦, 佐藤 健太, 風間 友江, 野村 和史, 三原 弘, 杉原 伸明, 中川 貴史, 真部 建郎, 市来 智子, 辻 喜久

    日本病院総合診療医学会雑誌 ( (一社)日本病院総合診療医学会 )  19 ( 臨増2 ) 172 - 172  2023.08

  • Impact of S‐1 adjuvant chemotherapy longer than 6 months on survival in patients with resected pancreatic cancer: a nationwide survey by the Japan Pancreas Society based on real‐world data

    Yoshito Tomimaru, Hidetoshi Eguchi, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Hideki Takami, Michiaki Unno, Tomohisa Yamamoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Satoshi Hattori, Tsutomu Fujii, Yoshiki Hirooka, Hisato Igarashi, Masayuki Kitano, Tamotsu Kuroki, Atsushi Masamune, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshihisa Tsuji, Hiroki Yamaue, Sohei Satoi, Yoshifumi Takeyama

    Cancer ( Wiley )  129 ( 5 ) 728 - 739  2022.12  [Refereed]

    DOI

  • Self-assessment scale for the community-based and emergency practice.

    Takao Wakabayashi, Yoshihisa Tsuji, Takeshi Yamamoto, Hitoshi Sohma, Wari Yamamoto

    BMC medical education   22 ( 1 ) 799 - 799  2022.11  [International journal]

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    BACKGROUND: For current medical education, community-based primary care for the elderly is an essential topic. This study aimed to establish a scale of community-based assessment for clinical and emergency practice (C-CEP). METHODS: A self-assessment scale for C-CEP was developed according to four steps. Initially, we reviewed publications from the societies of the United States, British, and Japan regarding educational goals. In addition, we searched MEDLINE for educational goals regarding attitude, skills, and knowledge. Getting together, we established 23 items as the educational goals of the C-CEP. Second, we collected responses for these 23 items from 5th-grade medical students (n = 195). Third, we conducted an exploratory factor analysis (EFA) using their responses to determine the fundamental structure of the self-assessment scale. Finally, a confirmatory factor analysis (CFA) was performed to assess the fitness of the self-assessment scale developing the EFA, resulting in modification of the items. RESULTS: In EFA and CFA results, C-CEP Scale consisted of four factors with 15 items: "Attitude and communication in emergency care," Basic clinical skills," "Knowledge of community healthcare," and "Knowledge of evidence-based medicine perseverance." The model fit indices were acceptable (Goodness of Fix Index = 0.928, Adjusted Goodness of Fit Index = 0.900, Comparative Fit Index = 0.979, and Root Mean Square Error of Approximation = 0.045). The values of McDonald's omega as an estimate of scale reliability were more than 0.7 in all four factors. As for test-retest reliability, the intraclass correlation coefficients were ≥ 0.58 for all factors. All four factors of the C-CEP Scale correlated positively with the Medical Professionalism Evaluation Scale subscales. CONCLUSIONS: We developed a valid and reliable self-assessment scale to assess student competence.

    DOI PubMed

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Misc 【 display / non-display 】

  • 【チーム医療で取り組む肝胆膵疾患の栄養マネジメント】急性膵炎の栄養管理とQOL維持 経腸栄養・食事開始のタイミングを含めて

    上野 真行, 辻 喜久, 宇座 徳光, 妹尾 浩

    肝胆膵 ( (株)アークメディア )  88 ( 1 ) 97 - 101  2024.01

  • 都市と僻地の差異から学ぶ地域医療教育について

    辻 喜久

    医学教育 ( (一社)日本医学教育学会 )  54 ( 5 ) 467 - 473  2023.10

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    我々は,北海道南部の南檜山地域(2次医療圏)をリソースとした地域医療教育に取り組んでいる.南檜山地域は(1万4千km2,人口2万3,000人,高齢化率41.6%)と僻地である.一方,近年,"地域"に求められる医師像が多様化し,高度にデザインされた医師養成プログラムが必要となった.そこで,我々は,"差異"の概念に基づき地域医療教育のデザインを試みている."差異"は都市-地方間だけではなく,異なった文化間に常に生じうる.ここでは南檜山と札幌を遠隔診療/教育のシステムでつなぐことで"差異"が生じ,差異を経験した学修者において,より地域医療への理解が深まることを期待した.(著者抄録)

  • 差異に着目した地域医療教育のデザインとその実践報告

    神野 敦, 佐藤 健太, 風間 友江, 野村 和史, 三原 弘, 杉原 伸明, 中川 貴史, 真部 建郎, 市来 智子, 辻 喜久

    日本病院総合診療医学会雑誌 ( (一社)日本病院総合診療医学会 )  19 ( 臨増2 ) 172 - 172  2023.08

  • 関節症状の乏しいリウマチ性髄膜炎の診断にエコー所見が有用であった一例

    岩倉 伸昂, 眞部 建郎, 安場 遥香, 仲 郁子, 中澤 隆, 辻 喜久

    日本病院総合診療医学会雑誌 ( (一社)日本病院総合診療医学会 )  19 ( 臨増2 ) 143 - 143  2023.08

  • 新モデルコアカリキュラム(令和4年)の目標達成のために各専門診療科臨床実習期間の1割から改革するエッセンス 各科実習中の症例および実習の振り返りを改革する重要性

    三原 弘, 元尾 伊織, 田尻 和人, 安田 一朗, 高村 昭輝, 神野 敦, 佐藤 健太, 市来 智子, 辻 喜久

    医学教育 ( (一社)日本医学教育学会 )  54 ( Suppl. ) 69 - 69  2023.07

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Research Projects 【 display / non-display 】

  • Development of natriuretic peptide-based novel diagnosis and therapy for non-alcoholic fatty liver disease

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2022.04
    -
    2025.03
     

    市来 智子, 辻 喜久, 沼田 泰尚, 佐々木 茂

  • Perfusion CT to evaluate pancreatic stroma in pancreatic cancer mice model

    Grant-in-Aid for Research Activity Start-up

    Project Year :

    2013.08
    -
    2015.03
     

    TSUJI Yoshihisa

    　View Summary

    In the present study, a significantly strong correlation was found between the imaging parameter (Fis) of perfusion CT, which targeted the contrast accumulation in the intstitial space and relects tumor-associated stroma in this model, and stromal density quantified using immunohistochemistry; this finding supported our hypothesis that perfusion CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed using histopathological analysis. In terms of the association between tumor hypoxia and tumor-associated stroma, FMISO uptake had a negative correlation with Fis and stromal density, as well as with vascular parameters. These results suggest that tumor hypoxia was complementarily localized to tumor-associated stroma and the vascular component.

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Committee Memberships 【 display / non-display 】

  • 2017.04
    -
    Now

      急性膵炎分科会委員

  • 2014.04
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    2016.04

      研究協力者

  • 2013.11
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    Now

      Member of DDW abstract review comitee

  • 　
    -
    Now

      膵疾患臨床研究促進委員会委員

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