Education 【 display / non-display 】

Education 【 display / non-display 】

• 2010

  -

  2014

  京都大学大学院医学研究科 博士課程  

• 1995

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  2001

  高知医科大学医学科  

Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 医学博士

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2022

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  Now

  Shiga University of Medical Science   総合診療学講座   特任教授（クロスアポイントメント）

• 2020

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  Now

  Sapporo Medical University   臨床研修医師キャリア支援センター   センター長

• 2020

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  Now

  Sapporo Medical University   総合診療医学講座   教授

• 2020

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  Now

  Sapporo Medical University   病院長補佐  

• 2022

  -

  Now

  Shiga University of Medical Science   IR室   客員教授

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Gastroenterology  

• Life sciences   Radiology  

• Life sciences   Immunology  

• Life sciences   Healthcare management, medical sociology  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Shiga University of Medical Science   総合診療学講座   特任教授  

• Sapporo Medical University   General Medicine   教授  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Acute pancreatitis

• Severe acute pancreatitis

• Medical Education

• Perfusion CT

• 地域医療

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025: Supported and Endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society

  Andrea Párniczky, Alexandra Mikó, Aliye Uc, Anand Narayan Singh, Anshuman Elhence, Ashok Saluja, Atsushi Masamune, Barham K. Abu Dayyeh, Brian Davidson, Charles Mel Wilcox, Chris Forsmark, David Whitcomb, Deepak Gunjan, Dhiraj Yadav, Djuna Cahen, D. Nageshwar Reddy, Douglas Adler, Douglas Pleskow, En-Qiang Mao, Enrique de-Madaria, Enver Zerem, Federico Bolado, Fredrick Gorelick, Georgios Papachristou, Greg Cote, Guru Trikudanathan, Hana Alguel, Hjalmar Santvoort, James Buxbaum, Jens Werner, Ji Young Bang, John Neoptolemos, John Windsor, Julia Mayerle, Jun-Ho Choi, Kasper Overbeek, Kazuhiro Kikuta, Katsuya Kitamura, Luca Frulloni, Madhusudan K, Marc Besselink, Marco Bruno, Mark Lowe, Markus Lerch, Martin Freeman, Matthias Löhr, Morihisa Hirota, Mouen Khashab, Nicholas Zyromski, Nalini Guda, Namrata Singh, Niladri Baneerjee, Olaf J. Bakker, Panu Mentula, Peter Banks, Peush Sahni, Peter Hegyi, Peter Szatmary, Pramod Garg, Rajesh Gupta, Raju Sharma, Rakesh Kochhar, Robert Sutton, Rodrigo Cartin-Ceba, Rupjyoti Talukdar, Samagra Agarwal, Sohail Husain, Santhi Vege, Shuji Isaji, Shyam Varadarajulu, Shivanand Gamanagatti, Soumya Jagannath, Surinder Rana, Stefan Bouwense, Steve Pandol, Subodh Kumar, Sudipta Dhar Chowdhury, Sundeep Lakhtakia, Suresh Chari, Takao Itoi, Thilo Hackert, Thomas Bollen, Thomas Gress, Timothy Gardner, Vijay Singh, Vikas Dudeja, Vikesh Singh, Vinciane Rebours, Walter Park, Wei Huang, Wen-Hua He, Yi-No Kang, Yoshihisa Tsuji, Yoshifumi Takeyama

  Pancreatology ( Elsevier BV )   2025.07  [Refereed]

  DOI

• Three Molecular Developmental Pathways of Remnant Pancreatic Cancer After Resection: A Nationwide Project Study of Japan Pancreas Society.

  Shuji Suzuki, Yuko Omori, Yusuke Ono, Katsuya Hirose, Taito Itoh, Hidenori Karasaki, Mitsugi Shimoda, Yuichi Nagakawa, Ryota Higuchi, Itaru Endo, Toshiki Rikiyama, Michiaki Unno, Tsutomu Fujii, Yuki Sunagawa, Hidetoshi Eguchi, Hideki Sasanuma, Takahiro Akahori, Keiichi Okano, Masaji Tani, Satoshi Hirano, Yasuhiro Shimizu, Minoru Kitago, Shugo Mizuno, Tomohisa Yamamoto, Masayuki Furukawa, Masayuki Ohtsuka, Motokazu Sugimoto, Akira Matsushita, Kenichi Hakamada, Hisato Igarashi, Tamotsu Kuroki, Satoshi Tanno, Yoshihisa Tsuji, Atsushi Masamune, Kazuhiro Mizumoto, Yoshiki Hirooka, Hiroki Yamaue, Kazuichi Okazaki, Sohei Satoi, Yoshifumi Takeyama, Yusuke Mizukami, Toru Furukawa

  Annals of surgery   281 ( 6 ) 1015 - 1025  2025.06  [Refereed]  [International journal]

  　View Summary

  OBJECTIVE: To clarify the molecular mechanism of remnant pancreatic cancer (PC) development after primary PC resection. BACKGROUND: Molecular mechanisms of the development of remnant PCs after primary PC resection are largely unknown. METHODS: Forty-three patients undergoing remnant PC resection after primary PC resection between 2001 and 2017 at 26 institutes were retrospectively analyzed. Clinicopathologic features and molecular alterations detected by targeted amplicon sequencing of 36 PC-associated genes were evaluated. RESULTS: These patients showed significantly lower body mass indices and higher hemoglobin A1c values at remnant PC resection than at primary PC resection. A comparison of the molecular features between primary and remnant PCs indicated that remnant PCs were likely to develop through 3 different molecular pathways: successional, showing identical and accumulated alterations (n = 14); phylogenic, showing identical and distinct alterations (n = 26); and distinct, showing independent distinctive alterations (n = 3). The similarity of gene alterations was associated with time to the remnant PC development ( r = 0.384, P = 0.0173). Phylogenic pathways were significantly associated with the intraductal spread of carcinoma ( P = 0.007). Patient survival did not differ significantly depending on these molecular pathways. CONCLUSIONS: Molecular profiling uncovered 3 pathways for the development of remnant PCs, namely, successional, phylogenic, and distinct pathways. The vast majority of remnant PCs are likely to be molecularly associated with primary PCs either in the successional or phylogenic way. This information could impact the design of a strategy for monitoring and treating remnant PCs.

  DOI PubMed

• Participation-based clinical clerkships contribute to increased medical student confidence in community emergency care: a cohort study.

  Hiroshi Mihara, Atsushi Jinno, Kenta Sato, Kazuhito Nomura, Takao Wakabayashi, Yoshihisa Tsuji

  BMC medical education   25 ( 1 ) 734 - 734  2025.05  [Refereed]  [International journal]

  　View Summary

  BACKGROUND: The Community-based assessment for Clinical and Emergency Practice (C-CEP) scale is a validated tool comprising 15 items across four components: "Attitude and Communication in Emergency Medicine," "Basic Clinical Skills," "Knowledge about Community Medicine," and "Knowledge in Evidence-Based Medicine." The C-CEP scale enables medical students' self-assessment of their confidence in clinical and emergency care. This study aimed to evaluate whether a two-week comprehensive general practice clerkship would improve C-CEP scores and to identify the specific training elements contributing to increased confidence in primary care, particularly in emergency responses. METHODS: After obtaining ethical approval and written informed consent, fifth-year medical students at Sapporo Medical University who participated in two-week off-campus clerkships at external healthcare facilities (hospitals) during the 2023 academic year were included. Pre- and post-clerkship C-CEP scores were collected. Changes in the baseline and average scores were analyzed across facilities accepting more than four trainees. Text mining was conducted on students' reflective portfolios from the facilities with significant findings to identify frequent and co-occurring words related to confidence-building activities. RESULTS: Out of 115 eligible participants, 97 students were included in the analysis (84.3% participation rate). The data from seven facilities accepting more than four trainees, representing 74 students in total, were analyzed. These facilities averaged 243 beds, were located 147 km from the medical school, and had an emergency admission rate of 84.6%. C-CEP scores showed significant improvement across all components post-clerkship (p < 0.05). Although pre-clerkship scores did not differ significantly across facilities, post-clerkship score increases varied. Multivariate analysis identified Facilities D and F as exhibiting significant differences in confidence improvement compared with the other facilities (R² = 0.20, p = 0.0379). Text mining highlighted that Facility F emphasized active learning activities such as "interviews," "examinations," and "conferences," whereas Facility D focused on passive activities such as "observation", which were associated with limited impact on trainee confidence. CONCLUSION: The C-CEP effectively measured confidence improvements in primary care and emergency responses among fifth-year medical students following their clinical clerkships. The C-CEP scale's ability to detect inter-facility differences highlights its potential to inform and refine clinical education programs, ensuring more targeted and effective training.

  DOI PubMed

• 急性膵炎患者における長期入院の予測因子

  上野 真行, 羽田 綾子, 辻 喜久

  胆膵の病態生理   41 ( 1 ) 65 - 69  2025.05  [Refereed]

• Diagnostic accuracy of endoscopic ultrasonographic shear wave elastography for assessing early chronic pancreatitis using the Japanese diagnostic criteria 2019.

  Shuhei Shintani, Osamu Inatomi, Takuya Okamoto, Kosuke Hiroe, Takaaki Eguchi, Yuki Tomozawa, Akitoshi Inoue, Hidenori Kimura, Atsushi Nishida, Yoshihisa Tsuji, Yoshiyuki Watanabe, Akira Andoh

  DEN open   5 ( 1 ) e387  2025.04  [Refereed]  [International journal]

  　View Summary

  BACKGROUND AND AIM: Endoscopic ultrasound shear wave elastography (EUS-SWE) can facilitate an objective evaluation of pancreatic fibrosis. Although it is primarily applied in evaluating chronic pancreatitis, its efficacy in assessing early chronic pancreatitis (ECP) remains underinvestigated. This study evaluated the diagnostic accuracy of EUS-SWE for assessing ECP diagnosed using the Japanese diagnostic criteria 2019. METHODS: In total, 657 patients underwent EUS-SWE. Propensity score matching was used, and the participants were classified into the ECP and normal groups. ECP was diagnosed using the Japanese diagnostic criteria 2019. Pancreatic stiffness was assessed based on velocity (Vs) on EUS-SWE, and the optimal Vs cutoff value for ECP diagnosis was determined. A practical shear wave Vs value of ≥50% was considered significant. RESULTS: Each group included 22 patients. The ECP group had higher pancreatic stiffness than the normal group (2.31 ± 0.67 m/s vs. 1.59 ± 0.40 m/s, p < 0.001). The Vs cutoff value for the diagnostic accuracy of ECP, as determined using the receiver operating characteristic curve, was 2.24m/s, with an area under the curve of 0.82 (95% confidence interval: 0.69-0.94). A high Vs was strongly correlated with the number of EUS findings (rs = 0.626, p < 0.001). Multiple regression analysis revealed that a history of acute pancreatitis and ≥2 EUS findings were independent predictors of a high Vs. CONCLUSIONS: There is a strong correlation between EUS-SWE findings and the Japanese diagnostic criteria 2019 for ECP. Hence, EUS-SWE can be an objective and invaluable diagnostic tool for ECP diagnosis.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Direct electrohydraulic lithotripsy with a novel peroral cholangioscope through the overtube for surgically-altered anatomy.

  Kosuke Hiroe, Shuhei Shintani, Takuya Okamoto, Hidenori Kimura, Takaaki Eguchi, Yoshihisa Tsuji, Osamu Inatomi

  Endoscopy   56 ( S 01 ) E644-E645  2024.12  [International journal]

  DOI PubMed

• 膵癌腫瘍内血流速度による術前治療戦略(会議録)

  前平 博充, 辻 喜久, 森 治樹, 新田 信人, 前川 毅, 石川 原, 竹林 克士, 貝田 佐知子, 三宅 亨, 新谷 修平, 稲富 理, 谷 眞至

  日本消化器外科学会雑誌   57 ( 2 ) 379  2024.11

• 急性膵炎に対する早期からの栄養開始が入院期間および治療費に与える影響(会議録)

  上野 真行, 辻 喜久, 竹山 宜典

  日本消化器病学会雑誌   121 ( 臨 ) A488  2024.10

• 膵癌における術前化学療法に対する腫瘍内血流速度の臨床的意義(会議録/英語)

  前平 博充, 辻 喜久, 森 治樹, 新田 信人, 前川 毅, 石川 原, 竹林 克士, 小島 正継, 貝田 佐知子, 三宅 亨, 新谷 修平, 稲富 理, 谷 眞至

  日本癌治療学会学術集会抄録集62回   62nd   O48-3  2024.10

  J-GLOBAL

• 急性膵炎発症が生活の質に及ぼす影響についての多施設共同前向きコホート研究

  上野 真行, 辻 喜久, 江口 考明, 福田 晃久, 栗田 裕介, 高山 敬子, 石田 悦嗣, 山上 裕機, 正宗 淳, 里井 壯平, 竹山 宜典, 水野 元夫

  膵臓 ( (一社)日本膵臓学会 )  39 ( 3 ) A149 - A149  2024.07

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 平成30年度 ベストティーチャー賞

  2019   滋賀医科大学  

• 奨励賞

  2018   第31回 日本消化器病学会  

• Poster Distinction

  2013   Pancreas Club 2013（オーランド、米国）  

• Travel Award

  2012   National Pancreas Foundation（アトランタ、米国）  

• 研究奨励賞

  2007   膵臓財団  

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 非救急医の救急診療スキル向上のための遠隔教育プログラムの開発と教育効果の検証

  基盤研究(C)

  Project Year :

  2025.04

  -

  2029.03

   

  神野 敦, 辻喜久

  Authorship： Coinvestigator(s)

• A system for training doctors for gastrointestinal cancer screening in Palau

  Project Year :

  2025.04

  -

  2026.03

   

  Authorship： Principal investigator

• Development of natriuretic peptide-based novel diagnosis and therapy for non-alcoholic fatty liver disease

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2022.04

  -

  2025.03

   

  市来 智子, 辻 喜久, 沼田 泰尚, 佐々木 茂

• Perfusion CT to evaluate pancreatic stroma in pancreatic cancer mice model

  Grant-in-Aid for Research Activity Start-up

  Project Year :

  2013.08

  -

  2015.03

   

  TSUJI Yoshihisa

  　View Summary

  In the present study, a significantly strong correlation was found between the imaging parameter (Fis) of perfusion CT, which targeted the contrast accumulation in the intstitial space and relects tumor-associated stroma in this model, and stromal density quantified using immunohistochemistry; this finding supported our hypothesis that perfusion CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed using histopathological analysis. In terms of the association between tumor hypoxia and tumor-associated stroma, FMISO uptake had a negative correlation with Fis and stromal density, as well as with vascular parameters. These results suggest that tumor hypoxia was complementarily localized to tumor-associated stroma and the vascular component.

• Perfusion CTによる重症膵炎早期膵虚血と血管透過性亢進についての研究

  特別研究員奨励費

  Project Year :

  2010

  -

  2012

   

  辻 喜久

  　View Summary

  研初年度は、各参加施設問で共通の重症急性膵炎患者登録データベースを作成した。ついで、各参加施設での倫理委員会の承認を経て多施設共同研究を開始し、UMINに登録、StudyDesignを公開した。研究期間を通して臨床データは採取し続け(膵局所血流障害の診断、血管透過性亢進の評価)は各症例にて、毎回評価しデータベースに登録を継続し、2012年12月78例の登録され、統計学的に十分なサンプル数であったため症例の集積は終了し、現在、解析中である。 また、1年目の目標であったヒト重症急性膵炎患者における局所(膵実質)血流障害の有無と血清Angiopoietin(ANG)2値の上昇が関係の検討を行ったところ、両者の間に有意な差を認めず、むしろ、Perfusion CTによって診断された全身性の血流異常とANG2との間で有意な相関を得た。ANG1、VEGF-A,VEGF-Bは、局所(膵実質)血流異常および全身性の血流異常のどちらとも相関を認めなかった(Watanabe T, Tsuji Y et a1. Am J Gastroenterol. 2011)。また、高ANG2を伴った重症急性膵炎患者における全身循環不全は実際に多臓器不全と有意に関係することを論文発表した(Watanabe T, Tsuji Y et al. Pancreas 2013)。 重症急性膵炎における全身性血流異常は多臓器不全の原因となり、これを改善するために一日6-10Lもの輸液を要すると治療ガイドラインにも指摘されている。こうした大量輸液はともすると輸液過剰になり、生命予後の悪化の一因にもなりうる。適切な輸液量を決めるために、全身性の血流異常を簡便に評価する必要があるが、有用なマーカーが存在せず積年の問題であった。一方、我々の結果では、Ang-2が全身性の血流異常の評価の指標となりうる可能性が示唆された。

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Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2024

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  Now

    大学ネットワーク委員会 副委員長

• 2024

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  Now

    評議員

• 2024

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  Now

    北海道地区幹事

• 2024

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  Now

    Academic Editor

• 2024

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  Now

    評議員

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