Updated on 2025/08/22

写真a

 
YASUDA Mitsuru
 
Organization
School of Medicine Department of Clinical Laboratory Medicine Associate Professor
Title
Associate Professor
Profile
尿路性器感染症
External link

Degree

  • 医学博士

Research Interests

  • gyrA

  • 尿道炎

  • 性器感染症

  • 排尿障害

  • parC

  • MIC

  • 最小発育阻止濃度

  • 薬剤耐性

  • 淋菌

  • 尿路感染症

  • 尿路性器感染症

  • アジスロマイシン

  • penB

  • penA

  • mtrR

  • セフェム系抗菌剤

  • Mycoplasma genitalium

  • 遺伝子診断

  • 性感染症

  • 23S rRNA

Research Areas

  • Life Science / Urology  / 感染症学

  • Life Science / Urology

Education

  • Gifu University   School of Medicine

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Research History

  • Sapporo Medical University   Department of Infection Control & Laboratory Medicine   Associate Professor

    2021.7

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  • Gifu University   Center For Nutrition Support and Infection Control, University Hospital   Associate Professor

    2020.5 - 2021.6

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  • Gifu University   Center For Nutrition Support and Infection Control, University Hospital   Lecturer

    2018.5 - 2020.4

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  • Gifu University   Department of Urology, University Hospital   Lecturer

    2012.4 - 2018.4

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  • Gifu University   Department of Urology, University Hospital

    2006.11 - 2012.3

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  • Gifu University School of Medicine, Medical Course   Research Assistant

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Papers

  • Detection of Novel US <i>Neisseria meningitidis</i> Urethritis Clade Subtypes in Japan

    Hideyuki Takahashi, Masatomo Morita, Mitsuru Yasuda, Yuki Ohama, Yoshitomo Kobori, Munekado Kojima, Ken Shimuta, Yukihiro Akeda, Makoto Ohnishi

    Emerging Infectious Diseases   29 ( 11 )   2023.11

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    Publishing type：Research paper (scientific journal)   Publisher：Centers for Disease Control and Prevention (CDC)  

    DOI： 10.3201/eid2911.231082

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  • The third nationwide surveillance of antimicrobial susceptibility against Neisseria gonorrhoeae from male urethritis in Japan, 2016-2017. International journal

    Mitsuru Yasuda, Satoshi Takahashi, Jun Miyazaki, Koichiro Wada, Kanao Kobayashi, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Hiroyuki Nishiyama, Takahiro Kimura, Hiroki Yamada, Kazumasa Matsumoto, Kiyohito Ishikawa, Yoshikazu Togo, Kazushi Tanaka, Takuya Sadahira, Junichi Inokuchi, Ryoichi Hamasuna, Kenji Ito, Hideo Hirayama, Kenji Hayashi, Yuichiro Kurimura, Hitoshi Kadena, Shin Ito, Yutaka Shiono, Takahiro Maruyama, Masayasu Ito, Koichi Hatano, Hirofumi Chokyu, Hideari Ihara, Satoshi Uno, Koichi Monden, Teruhiko Yokoyama, Motonori Kano, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Takanori Tojo, Takahide Hosobe, Kazuhiko Naito, Shuichi Kawai, Hirofumi Nishimura, Masanobu Izumitani, Mutsumasa Yoh, Masaru Matsumura, Ryuji Fujita, Kazuo Takayama, Makoto Hara, Shohei Nishi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   29 ( 11 )   1011 - 1016   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea. To understand the trends of antimicrobial susceptibility of N. gonorrhoeae, the Surveillance Committee of the Japanese Society of Infectious Diseases, the Japanese Society for Chemotherapy, and the Japanese Society of Clinical Microbiology conducted the third nationwide antimicrobial susceptibility surveillance of N. gonorrhoeae isolated from male urethritis. The specimens were collected from male patients with urethritis at 30 facilities from May 2016 to July 2017. From the 159 specimens collected, 87 N. gonorrhoeae strains were isolated, and 85 were tested for susceptibility to 21 antimicrobial agents. All strains were non-susceptible to penicillin G. Seven strains (8.2%) were β-lactamase-producing strains. The rates of susceptibility to cefixime and cefpodoxime were 96.5% and 52.9%, respectively. Three strains were non-susceptible with a minimum inhibitory concentration (MIC) of 0.5 mg/L for cefixime. None of the strains were resistant to ceftriaxone or spectinomycin. The susceptibility rate for ciprofloxacin was 23.5% (20 strains), and no strains showed intermediate susceptibility. The susceptibility rate against azithromycin was 81.2%, with one strain isolated with a MIC of 8 mg/L against azithromycin. The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. It will be necessary to further expand the scale of the next surveillance to understand the current status of drug-resistant N. gonorrhoeae in Japan.

    DOI： 10.1016/j.jiac.2023.08.003

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  • AAUS guideline for chlamydial urethritis. International journal

    Yoshiki Hiyama, Satoshi Takahashi, Mitsuru Yasuda

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   28 ( 2 )   142 - 145   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Urogenital chlamydial infection is the most common sexually transmitted infection. Many cases of chlamydial infection are reported worldwide every year. Genital chlamydial infection in women can also cause obstetric issues, including infertility and miscarriage. For that purpose, appropriate care should be conducted with the latest knowledge. Only few guidelines come from Asian countries. The Asian Association of Urinary Tract Infection and Sexually Transmitted Infection (AAUS) belonging to the Urological Association of Asia (UAA) had developed the guidelines regarding chlamydial urethritis. We have collected the feedback and updated the guidelines which is now submitted for consideration of publication. In addition to the levels of evidence, the recommendation grades were defined using the modified GRADE methodology. Herein, we present the new edition of the UAA-AAUS guidelines for chlamydial urethritis.

    DOI： 10.1016/j.jiac.2021.11.024

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  • Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan: Comparison with the first surveillance report. International journal

    Satoshi Takahashi, Mitsuru Yasuda, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Kanao Kobayashi, Jun Miyazaki, Hiroshi Kiyota, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Shin Egawa, Hiroki Yamada, Kazumasa Matsumoto, Kiyohito Ishikawa, Shingo Yamamoto, Yoshikazu Togo, Kazushi Tanaka, Katsumi Shigemura, Shinya Uehara, Hiroyuki Kitano, Keijiro Kiyoshima, Ryoichi Hamasuna, Kenji Ito, Hideo Hirayama, Shuichi Kawai, Yutaka Shiono, Takahiro Maruyama, Shin Ito, Mutsumasa Yoh, Masayasu Ito, Koichi Hatano, Hideari Ihara, Satoshi Uno, Koichi Monden, Teruhiko Yokoyama, Kazuo Takayama, Toru Sumii, Hitoshi Kadena, Motoshi Kawahara, Takahide Hosobe, Masanobu Izumitani, Motonori Kano, Hirofumi Nishimura, Ryuji Fujita, Shinichi Kaji, Kenji Hayashi, Takanori Tojo, Masaru Matumura

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   28 ( 1 )   1 - 5   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    The Urogenital Sub-committee and the Surveillance Committee of the Japanese Society of Chemotherapy, The Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology conducted the second nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis. In this second surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 26 hospitals and clinics from May 2016 to July 2017. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 41 isolates; the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, azithromycin and solithromycin were 2 μg/ml (2 μg/ml), 1 μg/ml (0.5 μg/ml), 0.25 μg/ml (0.25 μg/ml), 0.125 μg/ml (0.063 μg/ml), 0.125 μg/ml (0.125 μg/ml), 0.25 μg/ml (0.25 μg/ml), 0.031 μg/ml (0.031 μg/ml), 0.25 μg/ml (0.125 μg/ml), and 0.016 μg/ml (0.008 μg/ml), respectively. In summary, this surveillance project did not identify any strains resistant to fluoroquinolone, tetracycline, or macrolide agents in Japan. In addition, the MIC of solithromycin was favorable and lower than that of other antimicrobial agents. However, the MIC of azithromycin had a slightly higher value than that reported in the first surveillance report, though this might be within the acceptable margin of error. Therefore, the susceptibility of azithromycin, especially, should be monitored henceforth.

    DOI： 10.1016/j.jiac.2021.09.012

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  • Guidelines for Infection Control in the Urological Field, including Urinary Tract Management (revised second edition). International journal

    Satoshi Takahashi, Soichi Arakawa, Kiyohito Ishikawa, Jun Kamei, Kanao Kobayashi, Katsumi Shigemura, Satoru Takahashi, Yoshiki Hiyama, Ryoichi Hamasuna, Hiroshi Hayami, Satoshi Yazawa, Mitsuru Yasuda, Yoshikazu Togo, Shingo Yamamoto, Koichiro Wada, Toyohiko Watanabe

    International journal of urology : official journal of the Japanese Urological Association   28 ( 12 )   1198 - 1211   2021.9

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    The Committee for the Development of Guidelines for Infection Control in the Urological Field, including Urinary Tract Management of the Japanese Urological Association, together with its systematic review team and external reviewers, have prepared a set of practice guidelines, an abridged version of which is published herein. These guidelines cover the following topics: (i) foundations of infection control, standard precautions, route-specific precautions, and occupational infection control (including vaccines); (ii) the relationship between urologists and infection control; (iii) infection control in urological wards and outpatient clinics; (iv) response to hepatitis B virus reactivation; (v) infection control in urological procedures and examinations; (vi) prevention of infections occurring in conjunction with medical procedures and examinations; (vii) responses to urinary tract tuberculosis and bacillus Calmette-Guérin; (viii) aseptic handling, cleaning, disinfection, and sterilization of urinary tract endoscopes (principles of endoscope manipulation, endoscope lumen cleaning, and disinfection); (ix) infection control in the operating room (principles of hand washing, preoperative rubbing methods, etc.); (x) prevention of needlestick and blood/bodily fluid exposure and response to accidental exposure; (xi) urinary catheter-associated urinary tract infection and purple urinary bag syndrome; and (xii) urinary catheter-associated urinary tract infections in conjunction with home care. In addressing these topics, the relevant medical literature was searched to the extent possible, and content was prepared for the purpose of providing useful information for clinical practice.

    DOI： 10.1111/iju.14684

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  • Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU). International journal

    Koichiro Wada, Teruhiko Yokoyama, Satoshi Uno, Motoo Araki, Takuya Sadahira, Yuki Maruyama, Herik Acosta, Hirochika Nakajima, Yoshiki Hiyama, Yasuharu Kunishima, Yoshikazu Togo, Takuhisa Nukaya, Hiroki Yamada, Katsumi Shigemura, Shin Ito, Masanobu Tanimura, Kanao Kobayashi, Hiroyuki Kitano, Jun Teishima, Mitsuru Yasuda, Shinya Uehara, Ryoichi Hamasuna, Toyohiko Watanabe, Tohru Nakagawa, Hiroshi Hayami, Jun Miyazaki, Satoshi Takahashi, Naoya Masumori, Kiyohito Ishikawa, Hiroshi Kiyota, Masato Fujisawa, Soichi Arakawa, Yasutomo Nasu, Shingo Yamamoto

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 8 )   1169 - 1180   2021.8

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    INTRODUCTION: The aim of this study was to monitor the development of drug-resistant bacteria isolated from acute uncomplicated cystitis (AUC) and to evaluate methodology of the survey conducted by collecting only clinical data. METHODS: We enrolled female patients at least 16 years of age diagnosed with AUC in 2018. Patient information including age, menopausal status, and results of bacteriological examination were collected and analyzed regardless of bacterial identification, antimicrobial susceptibility testing or extended-spectrum β-lactamase (ESBL) detection method. RESULTS: A total of 847 eligible cases were collected. Escherichia coli (E. coli) was the most frequently isolated bacterial species at about 70%, with proportions of fluoroquinolone-resistant E. coli (QREC) and ESBL-producing E. coli isolates at 15.6% and 9.5% of all E. coli isolates, respectively. The proportion of Staphylococcus saprophyticus (S. saprophyticus) was significantly higher in premenopausal women. Regarding the drug susceptibility of E. coli, isolates from Eastern Japan had significantly higher susceptibility to cefazolin, cefotiam and cefpodoxime and lower susceptibility to levofloxacin in postmenopausal women. ESBL-producing E. coli isolates had a high susceptibility to tazobactam-piperacillin, cefmetazole, carbapenems, aminoglycosides, and fosfomycin. In S. saprophyticus, the susceptibility to β-lactams including carbapenems was 40-60%. CONCLUSIONS: The proportions of QREC and ESBL-producing E. coli were increasing trends and lower susceptibility to LVFX in postmenopausal women was observed. Such surveillance, consisting of the collecting only clinical data, could be conducted easily and inexpensively. It is expected to be continuously performed as an alternative survey to conventional one collecting bacterial strains.

    DOI： 10.1016/j.jiac.2021.03.012

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  • 2019年にわが国で分離された淋菌の薬剤感受性報告

    安田 満, 志牟田 健, 中山 周一, 高橋 英之, 小林 寅哲, 大澤 佳代, 陳内 理生, 三宅 啓文, 大西 真

    日本性感染症学会誌   31 ( 2 )   93 - 93   2020.11

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    Language：Japanese   Publisher：(一社)日本性感染症学会  

    Ichushi

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  • Human Adenovirus B7d-Associated Urethritis after Suspected Sexual Transmission, Japan. International journal

    Nozomu Hanaoka, Shin Ito, Naomi Nojiri, Masami Konagaya, Mitsuru Yasuda, Takashi Deguchi, Tsuguto Fujimoto

    Emerging infectious diseases   26 ( 10 )   2444 - 2447   2020.10

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    Outbreaks of acute respiratory disease associated with human adenovirus (HAdV) B7d have been reported, including fatal cases in the United States. In 2018, we detected HAdV-B7d in a patient with urethritis, probably transmitted through sexual contact. Infectious HAdV-B7d was excreted in urine and gargle for >10 days after the disappearance of symptoms.

    DOI： 10.3201/eid2610.191538

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  • Characterization of two Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in 2015 and 2018 in Japan

    Ken Shimuta, Kenichi Lee, Mitsuru Yasuda, Keiichi Furubayashi, Chiaki Uchida, Shu-ichi Nakayama, Hideyuki Takahashi, Makoto Ohnishi

    Sexually Transmitted Diseases   Publish Ahead of Print ( 7 )   e85 - e87   2020.9

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    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    Abstract

    We identified and characterized the first 2 Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in Japan. These were in the clade of ceftriaxone- and azithromycin-resistant strains isolated in Australia and the United Kingdom. The multilocus sequence typing, N. gonorrhoeae multiantigen sequence typing, and N. gonorrhoeae sequence typing for antimicrobial resistance types of these strains were found in gonococci from eastern Asia.

    DOI： 10.1097/olq.0000000000001303

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  • The third national Japanese antimicrobial susceptibility pattern surveillance program: Bacterial isolates from complicated urinary tract infection patients. International journal

    Kanao Kobayashi, Shingo Yamamoto, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Koichiro Wada, Ryoichi Hamasuna, Hiroshi Hayami, Shinichi Minamitani, Tetsuya Matsumoto, Hiroshi Kiyota, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Hiroki Yamada, Shin Egawa, Takahiro Kimura, Hiroyuki Nishiyama, Jun Miyazaki, Kazumasa Matsumoto, Yukio Homma, Jun Kamei, Kiyohide Fujimoto, Kazumasa Torimoto, Kazushi Tanaka, Yoshikazu Togo, Shinya Uehara, Akio Matsubara, Koichi Shoji, Hirokazu Goto, Hisao Komeda, Toru Ito, Katsuhisa Mori, Koji Mita, Masao Kato, Yoshinori Fujimoto, Takako Masue, Hisato Inatomi, Yoshito Takahashi, Satoshi Ishihara, Kazuo Nishimura, Kenji Mitsumori, Noriyuki Ito, Sojun Kanamaru, Daisuke Yamada, Maeda Hiroshi, Masuo Yamashita, Masaya Tsugawa, Tadasu Takenaka, Koichi Takahashi, Yasuhiko Oka, Tomihiko Yasufuku, Shuji Watanabe, Yoshitomo Chihara, Kazuhiro Okumura, Hiroaki Kawanishi, Masanori Matsukawa, Masanobu Shigeta, Shuntaro Koda

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   26 ( 5 )   418 - 428   2020.5

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    The antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using national surveillance data. The data consisted of 881 bacterial strains from eight clinically relevant species. The data were collected for the third national surveillance project from January 2015 to March 2016 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology. Surveillance was undertaken with the cooperation of 41 medical institutions throughout Japan. Fluoroquinolone required a MIC90 of 2-64 mg/L to inhibit the 325 Escherichia coli strains tested and the proportion of levofloxacin resistant E. coli strains increased to 38.5% from 29.6% in 2011 and 28.6% in 2008. The proportion of levofloxacin resistant strains of Pseudomonas aeruginosa and Enterococcus faecalis decreased from previous reports and the proportion of multidrug-resistant P. aeruginosa and carbapenem-resistant Enterobacteriaceae remained low. Among methicillin-resistant Staphylococcus aureus (MRSA) strains, strains with reduced susceptibility to vancomycin (minimum inhibitory concentration, 2 μg/mL) increased to 14.7% from 5.5%. Bacterial strains that produced extended-spectrum β-lactamase included E. coli (79 of 325 strains, 24.3%), Klebsiella pneumoniae (9 of 177 strains, 7.7%), and Proteus mirabilis (6 of 55 strains, 10.9%). The proportion of extended-spectrum β-lactamase producing E. coli and K. pneumoniae strains increased from previous surveillance reports.

    DOI： 10.1016/j.jiac.2020.01.004

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  • The third national Japanese antimicrobial susceptibility pattern surveillance program: Bacterial isolates from complicated urinary tract infection patients

    Kanao Kobayashi, Shingo Yamamoto, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Koichiro Wada, Ryoichi Hamasuna, Hiroshi Hayami, Shinichi Minamitani, Tetsuya Matsumoto, Hiroshi Kiyota, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Hiroki Yamada, Shin Egawa, Takahiro Kimura, Hiroyuki Nishiyama, Jun Miyazaki, Kazumasa Matsumoto, Yukio Homma, Jun Kamei, Kiyohide Fujimoto, Kazumasa Torimoto, Kazushi Tanaka, Yoshikazu Togo, Shinya Uehara, Akio Matsubara, Koichi Shoji, Hirokazu Goto, Hisao Komeda, Toru Ito, Katsuhisa Mori, Koji Mita, Masao Kato, Yoshinori Fujimoto, Takako Masue, Hisato Inatomi, Yoshito Takahashi, Satoshi Ishihara, Kazuo Nishimura, Kenji Mitsumori, Noriyuki Ito, Sojun Kanamaru, Daisuke Yamada, Maeda Hiroshi, Masuo Yamashita, Masaya Tsugawa, Tadasu Takenaka, Koichi Takahashi, Yasuhiko Oka, Tomihiko Yasufuku, Shuji Watanabe, Yoshitomo Chihara, Kazuhiro Okumura, Hiroaki Kawanishi, Masanori Matsukawa, Masanobu Shigeta, Shuntaro Koda

    JOURNAL OF INFECTION AND CHEMOTHERAPY   26 ( 5 )   418 - 428   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jiac.2020.01.004

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  • Update on the treatment of sexually transmitted infections diseases-significance of a single 1 g dose of ceftriaxone and single 2 g dose of azithromycin for urethritis in Japan and comparison with guidelines from western countries

    Mitsuru Yasuda, Katsumi Shigemura, Shin Ito

    Japanese Journal of Chemotherapy   68 ( 2 )   186 - 197   2020.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Chemotherapy  

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  • Comparison of single- and multiple-dose cefazolin as prophylaxis for transurethral enucleation of prostate: A multicenter, prospective, randomized controlled trial by the Japanese Research Group for Urinary Tract Infection

    Yoshikazu Togo, Koji Fukui, Yasuo Ueda, Sojun Kanamaru, Yosuke Shimizu, Koichiro Wada, Takuya Sadahira, Yusuke Yamada, Masahiro Matsumoto, Ryoichi Hamasuna, Kiyohito Ishikawa, Manabu Takai, Yuka Maekawa, Mitsuru Yasuda, Koji Kokura, Nobuyuki Kondoh, Hidekazu Takiuchi, Shingo Yamamoto

    INTERNATIONAL JOURNAL OF UROLOGY   27 ( 3 )   244 - 248   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/iju.14181

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  • The resonance® metallic ureteral stent in the treatment of malignant ureteral obstruction: a prospective observational study. Reviewed International journal

    Jun Miyazaki, Mizuki Onozawa, Satoshi Takahashi, Yuka Maekawa, Mitsuru Yasuda, Koichiro Wada, Yuji Maeda, Takuro Masaki, Akito Yamaguchi, Masahiko Suzuki, Yasuyuki Sakai, Tomokazu Kimura, Manabu Takai, Kensaku Seike, Takahiko Hashimoto, Shingo Yamamoto

    BMC urology   19 ( 1 )   137 - 137   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: To study the outcomes and experiences of using metallic stents in treating patients with malignant ureteral obstruction (MUO), we examined the effects of metallic ureteral stenting using the Cook Resonance® stent in the treatment of MUO. METHODS: All patients who had a Resonance metallic stent inserted between April 2015 and March 2018 at one of multiple facilities were prospectively observed with a 1-year follow-up. The primary outcome was the patency rate of the metallic ureteral stent. The secondary outcomes included the complications (e.g., infection and fever). RESULTS: Although stent insertion was attempted in 50 patients, the stent could not be inserted as a ureteral stent in three patients due to severe ureteral stricture, and one ureteral cancer patient was excluded from the analysis. The remaining 46 patients' median age was 67 years (range 28-85 years) (16 males, 30 females). Twenty-four patients died during the study; their median survival time was 226 days. The median follow-up period for the censored patients was 355 days (range 16-372 days), and just seven patients were still alive without Resonance failure > 1 year later. The women's IPSS scores tended to be lower than those of the men. Regarding the OABSS score, although the women's total score tended to be low, the difference between the men's and women's scores was nonsignificant. The bacteria detected from urine culture after stent insertion were more gram-positive than gram-negative. CONCLUSION: Metallic ureteric stenting using the Resonance stent is safe and effective for treating MUO. Subjective symptoms were relatively less in the female patients.

    DOI： 10.1186/s12894-019-0569-y

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  • Evaluation of rapid immunochromatographic tests for adenovirs and herpe simplex virus ｗith urinary sediment from male urethritis Invited Reviewed

    Nozomu Hanaoka, Shin Ito, Tsuguto Fujimoto, Mitsuru Yasuda, Takashi Deguchi

    Japanese Journal of Sexually Transmitted Infections   30 ( 1 )   1 - 5   2019.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    J-GLOBAL

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  • 2018年にわが国で分離された淋菌の薬剤感受性報告

    安田 満, 志牟田 健, 中山 周一, 高橋 英之, 小林 寅哲, 大澤 佳代, 陳内 理生, 三宅 啓文, 大西 真

    日本性感染症学会誌   30 ( 2 )   228 - 228   2019.10

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    Language：Japanese   Publisher：(一社)日本性感染症学会  

    Ichushi

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  • クラミジア診断における3つの核酸増幅キット(APTIMA Combo2、Cobas4800、ProbeTec)の比較

    伊藤 晋, 高橋 聡, 花岡 希, 高梨 真樹, 桧山 佳樹, 安田 満, 出口 隆

    日本性感染症学会誌   30 ( 2 )   258 - 258   2019.10

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    Ichushi

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  • 本邦のAPTIMA Combo2クラミジア偽陰性株の解析

    伊藤 晋, 花岡 希, 高梨 真樹, 高橋 聡, 伊藤 貴子, 安田 満, 出口 隆

    日本性感染症学会誌   30 ( 2 )   257 - 257   2019.10

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  • アデノウイルス・単純ヘルペスウイルス性尿道炎診断における迅速免疫クロマトキットの有用性に関する検討(第2報) 尿沈渣検体ではアデノウイルスを高感度・高特異度に検出可能

    花岡 希, 伊藤 晋, 藤本 嗣人, 安田 満, 出口 隆

    日本性感染症学会誌   30 ( 1 )   45 - 49   2019.9

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  • Urinary exosome as a potential biomarker for urinary tract infection. Reviewed International journal

    Mizutani K, Kawakami K, Horie K, Fujita Y, Kameyama K, Kato T, Nakane K, Tsuchiya T, Yasuda M, Masunaga K, Kasuya Y, Masuda Y, Deguchi T, Koie T, Ito M

    Cellular microbiology   21 ( 7 )   e13020   2019.7

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    Unlike urinary tract infection (UTI), asymptomatic bacteriuria (ABU) should not be treated, with some exceptions such as pregnant women and patients who will undergo traumatic urologic interventions. However, there has been no clinically available marker for their differential diagnosis. Exosomes or small extracellular vesicles carry proteins contained in cells from which they are derived, thus having the potential as a biomarker of several diseases. On the basis of the hypothesis that the molecular signature of exosomes in urine may differ between UTI and ABU patients, we examined if urinary exosomes could serve as a marker for their differential diagnosis. Exosomes were isolated by ultracentrifugation or affinity-based method from cell culture medium of monocytic THP-1 and uroepithelial SV-HUC-1 cells and human urine. Protein expression was examined by Western blot analysis, ELISA, and CLEIA. The results showed that the levels of intracellular signalling molecules Akt and ERK and transcription factor NF-κB increased in exosomes isolated from THP-1 and SV-HUC-1 cells cocultured with Escherichia coli and/or treated with lipopolysaccharide. In urinary exosomes of UTI patients, Akt significantly diminished, and an exosomal marker CD9 showed a trend to decrease after treatment with antimicrobial agents. More importantly, Akt and CD9 levels in urinary exosomes were higher in UTI patients than in ABU patients, which was also observed after correction by urine creatinine. Collectively, these results suggest that Akt and CD9 in urinary exosomes could be useful markers for differential diagnosis of UTI and ABU.

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  • Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus Reviewed

    Hayami H, Takahashi S, Ishikawa K, Yasuda M, Yamamoto S, Wada K, Kobayashi K, Hamasuna R, Minamitani S, Matsumoto T, Kiyota H, Tateda K, Sato J, Hanaki H, Masumori N, Nishiyama H, Miyazaki J, Fujimoto K, Tanaka K, Uehara S, Matsubara A, Ito K, Hayashi K, Kurimura Y, Ito S, Takeuchi T, Narita H, Izumitani M, Nishimura H, Kawahara M, Hara M, Hosobe T, Takashima K, Chokyu H, Matsumura M, Ihara H, Uno S, Monden K, Sumii T, Kawai S, Kariya S, Sato T, Yoshioka M, Kadena H, Matsushita S, Nishi S, Hosokawa Y, Shirane T, Yoh M, Watanabe S, Makinose S, Uemura T, Goto H

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   25 ( 6 )   413 - 422   2019.6

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  • 非淋菌性尿道炎の治療効果判定における初尿白血球濃度の有用性

    伊藤 晋, 安田 満, 花岡 希, 出口 隆

    日本泌尿器科学会総会   107回   AOP - 037   2019.4

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  • 2015〜2017年にわが国で分離された淋菌の薬剤感受性について

    安田 満, 籏崎 恭子, 小林 寅哲, 大澤 佳代, 濱砂 良一, 荒川 創一, 志牟田 健, 中山 周一, 大西 真, 陳内 理生, 三宅 啓文

    日本化学療法学会雑誌   67 ( Suppl.A )   240 - 240   2019.3

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  • 2017年に男子淋菌性尿道炎患者より分離された淋菌の薬剤感受性について Reviewed

    安田 満, 伊東 晋, 楊 睦正, 伊藤 雅康, 西村 昌宏, 川原 元司, 平山 英雄, 宮田 和豊, 出口 隆, 田中 香お里, 村上 啓雄, 旗崎 恭子, 鷺山 和幸, 小島 宗門, 松木 孝和, 成田 晴紀, 木戸 雅人, 伊東 健治, 川井 修一, 上床 典康, 花井 俊典, 重原 一慶, 中嶋 一史, 沼崎 進, 内田 千秋, 竹内 敏視, 佐藤 嘉一, 楠山 弘之, 岩澤 晶彦, 野口 武俊, 土屋 博, 川野 尚, 小林 峰男, 山田 拓己, 内島 豊, 宮村 隆三, 米田 尚生, 久保田 恵章, 伊藤 康久, 岡野 学, 濱野 公成, 増栄 成泰

    感染症学雑誌   93 ( 2 )   235 - 236   2019.3

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  • A real-time PCR assay for detecting a penA mutation associated with ceftriaxone resistance in Neisseria gonorrhoeae. Reviewed

    Shimuta K, Igawa G, Yasuda M, Deguchi T, Nakayama SI, Ohnishi M

    Journal of global antimicrobial resistance   19   46 - 49   2019.2

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    DOI： 10.1016/j.jgar.2019.02.011

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  • Etiological role of human papillomavirus infection in the development of penile cancer. International journal

    Jiro Sakamoto, Kazuyoshi Shigehara, Kazufumi Nakashima, Shohei Kawaguchi, Takao Nakashima, Masayoshi Shimamura, Mitsuru Yasuda, Taku Kato, Toru Hasegawa, Yoshitomo Kobori, Hiroshi Okada, Takashi Deguchi, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   78   148 - 154   2019.1

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    OBJECTIVE: To examine the association between human papillomavirus (HPV) infection and penile cancer among Japanese patients. METHODS: Thirty-four patients with penile cancer were enrolled in this study. DNA was extracted from paraffin-embedded tumor tissue samples, and HPV-DNA tests and genotyping were performed. For all of the samples, in situ hybridization (ISH) was performed to locate HPV-DNA in tumor tissue. Furthermore, expression levels of p16-INK4a, mini-chromosome maintenance protein 7(mcm-7), HPV-L1, and Ki-67 were analyzed using immunohistochemical methods. RESULTS: HPV and high-risk (HR)-HPV were detected in 14 (41.1%; 95% confidence interval (CI) 24.6-57.7%) and 12 (35.2%; 95% CI 19.2-51.4%) cases, respectively. HPV16 was the most frequently detected HPV type. Among the HR-HPV-positive cases, a punctate HR-HPV-DNA signal pattern was detected by ISH in tumor cell nuclei. P16-INK4a was expressed in 66.7% (95% CI 42.8-90.1%) of HR-HPV-positive cases and was significantly more frequent and stronger in HR-HPV-positive cases than in HPV-negative cases. There was no significant difference in the occurrence or distribution of mcm-7 or Ki-67 expression between HPV-positive and HPV-negative cases. HPV-L1 expression was not observed in any of the cases examined. CONCLUSIONS: HPV infection may have had an etiological role in 41% of the examined cases of penile cancer in Japan.

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  • Infectious human adenoviruses are shed in urine even after disappearance of urethral symptoms. International journal

    Nozomu Hanaoka, Shin Ito, Masami Konagaya, Naomi Nojiri, Mitsuru Yasuda, Tsuguto Fujimoto, Takashi Deguchi

    PloS one   14 ( 3 )   e0212434   2019

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    BACKGROUND: Urethritis is a common sexually transmitted disease, and human adenoviruses (HAdVs) have been found to be associated with nonchlamydial nongonococcal urethritis. However, the level and viability of HAdV in the urine of patients with urethritis remain unclear. METHODS: Male patients with urethritis and an asymptomatic group were screened using their First-void urine (FVU) for urethritis-related pathogens to identify those with HAdV DNA. FVU and gargle fluid were collected from all patients including from those in the asymptomatic group. A swab of eye discharge was also collected from patients with eye symptoms. The pharyngeal and/ or ocular fluid was also screened only in cases in which FVU was positive for HAdV DNA. HAdVs were isolated using A549 cell lines and typed by sequencing, and viral shedding during 2 years was quantified using real-time PCR. The prevalence of HAdV was assessed in the urethritis and asymptomatic groups, and viral load, isolated HAdV types, and urethral symptoms were compared between the groups. RESULTS: The positive detection rate of HAdV DNA was significantly higher in the urethritis group than in the asymptomatic group. Of 398 patients with urethritis, HAdV was isolated in all 32 cases (23 cases in which only HAdV DNA was detected with a mean of 2 × 109 copies/mL in urine samples). Of 124 control cases, one had HAdV monoinfection. The most frequently detected HAdV type was 56, followed by types 37 and 64. Regarding the relationship between symptoms and isolated HAdVs, the virus was isolated for up to 12 days after urethritis symptoms disappeared. CONCLUSIONS: HAdVs were significantly detected and isolated from the FVU of patients with urethritis. Furthermore, high levels of infectious HAdVs are excreted in urine for a long period even after urethritis symptoms disappear.

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  • Surveillance of the prevalence of macrolide and/or fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Japan

    Takashi Deguchi, Shin Ito, Mitsuru Yasuda, Yuko Sato, Chiaki Uchida, Masayuki Sawamura, Kazushi Manda, Masaki Takanashi, Hiroshi Kiyota

    Journal of Infection and Chemotherapy   24 ( 11 )   861 - 867   2018.11

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    DOI： 10.1016/j.jiac.2018.08.009

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  • 尿道炎原因微生物の診断に関する検討 原因微生物と排尿痛の程度

    伊藤 晋, 伊藤 貴子, 花岡 希, 安田 満, 出口 隆

    日本性感染症学会誌   29 ( 2 )   240 - 240   2018.10

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  • 2015〜2017年にわが国で分離された淋菌の薬剤感受性報告

    安田 満, 志牟田 健, 中山 周一, 小林 寅哲, 大澤 佳代, 陣内 理生, 三宅 啓文, 濱砂 良一, 荒川 創一, 大西 真

    日本性感染症学会誌   29 ( 2 )   239 - 239   2018.10

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  • 尿道炎原因微生物の診断に関する検討 迅速免疫クロマトキットを用いたヒトアデノウイルスおよび単純ヘルペスウイルスの検出

    伊藤 晋, 花岡 希, 伊藤 貴子, 安田 満, 出口 隆

    日本性感染症学会誌   29 ( 2 )   241 - 241   2018.10

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  • 尿道炎原因微生物の診断に関する検討 原因微生物と潜伏期間

    伊藤 晋, 伊藤 貴子, 花岡 希, 安田 満, 出口 隆

    日本性感染症学会誌   29 ( 2 )   240 - 240   2018.10

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  • Corrigendum: Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages. International journal

    Koji Yahara, Shu-Ichi Nakayama, Ken Shimuta, Ken-Ichi Lee, Masatomo Morita, Takuya Kawahata, Toshiro Kuroki, Yuko Watanabe, Hitomi Ohya, Mitsuru Yasuda, Takashi Deguchi, Xavier Didelot, Makoto Ohnishi

    Microbial genomics   4 ( 9 )   2018.9

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    DOI： 10.1099/mgen.0.000215

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  • Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages. Reviewed International journal

    Koji Yahara, Shu-Ichi Nakayama, Ken Shimuta, Ken-Ichi Lee, Masatomo Morita, Takuya Kawahata, Toshiro Kuroki, Yuko Watanabe, Hitomi Ohya, Mitsuru Yasuda, Takashi Deguchi, Xavier Didelot, Makoto Ohnishi

    Microbial genomics   4 ( 8 )   2018.8

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    The first extensively drug resistant (XDR) Neisseria gonorrhoeae strain with high resistance to the extended-spectrum cephalosporin ceftriaxone was identified in 2009 in Japan, but no other strain with this antimicrobial-resistance profile has been reported since. However, surveillance to date has been based on phenotypic methods and sequence typing, not genome sequencing. Therefore, little is known about the local population structure at the genomic level, and how resistance determinants and lineages are distributed and evolve. We analysed the whole-genome sequence data and the antimicrobial-susceptibility testing results of 204 strains sampled in a region where the first XDR ceftriaxone-resistant N. gonorrhoeae was isolated, complemented with 67 additional genomes from other time frames and locations within Japan. Strains resistant to ceftriaxone were not found, but we discovered a sequence type (ST)7363 sub-lineage susceptible to ceftriaxone and cefixime in which the mosaic penA allele responsible for reduced susceptibility had reverted to a susceptible allele by recombination. Approximately 85 % of isolates showed resistance to fluoroquinolones (ciprofloxacin) explained by linked amino acid substitutions at positions 91 and 95 of GyrA with 99 % sensitivity and 100 % specificity. Approximately 10 % showed resistance to macrolides (azithromycin), for which genetic determinants are less clear. Furthermore, we revealed different evolutionary paths of the two major lineages: single acquisition of penA X in the ST7363-associated lineage, followed by multiple independent acquisitions of the penA X and XXXIV in the ST1901-associated lineage. Our study provides a detailed picture of the distribution of resistance determinants and disentangles the evolution of the two major lineages spreading worldwide.

    DOI： 10.1099/mgen.0.000205

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  • Macrolide and fluoroquinolone resistance is uncommon in clinical strains of Chlamydia trachomatis. Reviewed

    Deguchi T, Hatazaki K, Ito S, Kondo H, Horie K, Nakane K, Mizutani K, Tsuchiya T, Yasuda M, Yokoi S, Nakano M

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   24 ( 8 )   610 - 614   2018.8

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  • Oral administration of cernitin pollen extract (Cernilton<sup>®</sup> ) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study. Reviewed International journal

    Togo Y, Ichioka D, Miyazaki J, Maeda Y, Kameyama K, Yasuda M, Hiyama Y, Takahashi S, Nagae H, Hirota S, Yamamoto S, Japanese Research Group for Urinary Tract Infection (JRG

    International journal of urology : official journal of the Japanese Urological Association   25 ( 5 )   479 - 485   2018.5

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    OBJECTIVES: To assess the effect of cernitin pollen extract on serum prostate-specific antigen level prostate biopsy candidates, and to develop an ideal protocol to avoid an unnecessary biopsy procedure. METHODS: A total of 61 patients were administrated cernitin pollen extract tablets (two tablets t.i.d.) for 30 days, and then underwent a prostate biopsy with ≥12 systematic and targeted biopsy cores obtained. Serum prostate-specific antigen levels were examined before and after administration of the pollen extract, and the change in serum prostate-specific antigen and the rate of change were analyzed in relation to negative and positive biopsy results for cancer. RESULTS: The mean change in serum prostate-specific antigen and rate of change after administration of cernitin pollen extract in all patients were -0.6 ± 1.4 ng/mL and -7.6 ± 16.1%, respectively, which were significantly different from the baseline values (P = 0.0003 and P = 0.0005, respectively). When prostate-specific antigen change values and rates were compared between patients negative and positive for cancer, a significant difference between those groups was observed (P = 0.04 and P = 0.03, respectively). CONCLUSIONS: The present study is the first to show that an ideal protocol using cernitin pollen extract has the potential to avoid an unnecessary prostate biopsy procedure in patients with elevated prostate-specific antigen, possibly caused by inflammation. Additional studies with greater numbers of participants are required to confirm our findings and develop an ideal protocol.

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  • GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. Reviewed

    Kondo H, Ito S, Hatazaki K, Horie K, Nakane K, Mizutani K, Tsuchiya T, Yasuda M, Yokoi S, Nakano M, Deguchi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   24 ( 3 )   232 - 235   2018.3

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  • 'Haemophilus quentini' in the urethra of men complaining of urethritis symptoms Reviewed

    Kengo Horie, Shin Ito, Kyoko Hatazaki, Mitsuru Yasuda, Masahiro Nakano, Kyojiro Kawakami, Yasunori Fujita, Masafumi Ito, Takayuki Ezaki, Takashi Deguchi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   24 ( 1 )   71 - 74   2018.1

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    DOI： 10.1016/j.jiac.2017.08.007

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  • Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis. Reviewed International journal

    Soda M, Ito S, Matsumaru N, Nakamura S, Nagase I, Takahashi H, Ohno Y, Yasuda M, Yamamoto M, Tsukamoto K, Itoh Y, Deguchi T, Kitaichi K

    Antimicrobial agents and chemotherapy   62 ( 1 )   2018.1

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    The objective of this study was to analyze the relationship between the pharmacokinetic (PK)/pharmacodynamic (PD) parameters of a single 2-g dose of extended-release formulation of azithromycin (AZM-SR) and its microbiological efficacy against gonococcal urethritis. Fifty male patients with gonococcal urethritis were enrolled in this study. In 36 patients, the plasma AZM concentrations were measured using liquid chromatography-tandem mass spectrometry, the AZM MIC values for the Neisseria gonorrhoeae isolates were determined, and the microbiological outcomes were assessed. AZM-SR monotherapy eradicated N. gonorrhoeae in 30 (83%) of the 36 patients. AZM MICs ranged from 0.03 to 2 mg/liter. The mean value of the area under the concentration-time curve (AUC), estimated by population PK analysis using a two-compartment model, was 20.8 mg · h/liter. Logistic regression analysis showed that the PK/PD target value required to predict an N. gonorrhoeae eradication rate of ≥95% was a calculated AUC/MIC of ≥59.5. The AUC/MIC value was significantly higher in patients who achieved microbiological cure than in patients who achieved microbiological failure. Monte Carlo simulation using this MIC distribution revealed that the probability that AZM-SR monotherapy would produce an AUC/MIC exceeding the AUC/MIC target of 59.5 was 47%. Furthermore, the MIC distribution for strains isolated in this study was mostly consistent with that for strains currently circulating in Japan. In conclusion, in Japan, AZM-SR monotherapy may not be effective against gonococcal urethritis. Therefore, use of a single 2-g dose of AZM-SR either with or without other antibiotics could be an option to treat gonococcal urethritis if patients are allergic to ceftriaxone and spectinomycin or are diagnosed to be infected with an AZM-sensitive strain.

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  • Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis Reviewed

    Takashi Deguchi, Shin Ito, Kyoko Hatazaki, Kengo Horie, Mitsuru Yasuda, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Nozomu Hanaoka, Ken Shimuta, Makoto Ohnishi, Tetsuro Muratani, Masahiro Nakano

    JOURNAL OF INFECTION AND CHEMOTHERAPY   23 ( 11 )   804 - 807   2017.11

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    DOI： 10.1016/j.jiac.2017.05.009

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  • Clinical courses of herpes simplex virus-induced urethritis in men Reviewed

    Shin Ito, Mitsuru Yasuda, Hiromi Kondo, Yoshiteru Yamada, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   23 ( 10 )   717 - 719   2017.10

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  • Emergence of Mycoplasma genitalium with clinically significant fluoroquinolone resistance conferred by amino acid changes both in GyrA and ParC in Japan Reviewed

    Takashi Deguchi, Shin Ito, Mitsuru Yasuda, Hiromi Kondo, Yoshiteru Yamada, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano

    JOURNAL OF INFECTION AND CHEMOTHERAPY   23 ( 9 )   648 - 650   2017.9

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  • 陰茎癌におけるHPV感染の役割と発癌のメカニズムについての検討

    坂本 次郎, 重原 一慶, 中嶋 一史, 川口 昌平, 中嶋 孝夫, 島村 正喜, 安田 満, 長谷川 徹, 小堀 善友, 岡田 弘, 出口 隆, 並木 幹夫, 溝上 敦

    日本性感染症学会誌   28 ( 1 )   85 - 91   2017.9

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  • Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities Reviewed

    Shin Ito, Kyoko Hatazaki, Ken Shimuta, Hiromi Kondo, Kosuke Mizutani, Mitsuru Yasuda, Keita Nakane, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Makoto Ohinishi, Takashi Deguchi

    SEXUALLY TRANSMITTED DISEASES   44 ( 4 )   205 - 210   2017.4

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  • Antimicrobial Susceptibility of Neisseria gonorrhoeae in Japan from 2000 to 2015 Reviewed

    Mitsuru Yasuda, Kyoko Hatazaki, Shin Ito, Masataka Kitanohara, Mutsumasa Yoh, Munekado Kojima, Harunori Narita, Akira Kido, Kazutoyo Miyata, Takashi Deguch

    SEXUALLY TRANSMITTED DISEASES   44 ( 3 )   149 - 153   2017.3

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  • Remarkable increase of Neisseria gonorrhoeae with decreased susceptibility of azithromycin and increase in the failure of azithromycin therapy in male gonococcal urethritis in Sendai in 2015 Reviewed

    Mitsuru Yasuda, Shin Ito, Kyoko Hatazaki, Takashi Deguchi

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 12 )   841 - 843   2016.12

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  • 単純ヘルペスウイルスが原因と考えられ症状が遷延した後淋菌性尿道炎の2例

    伊藤 晋, 伊藤 貴子, 花岡 希, 山田 壮一, 安田 満, 出口 隆

    日本性感染症学会誌   27 ( 2 )   259 - 259   2016.11

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  • Essential Japanese guidelines for the prevention of perioperative infections in the urological field: 2015 edition

    Shingo Yamamoto, Katsumi Shigemura, Hiroshi Kiyota, Koichiro Wada, Hiroshi Hayami, Mitsuru Yasuda, Satoshi Takahashi, Kiyohito Ishikawa, Ryoichi Hamasuna, Soichi Arakawa, Tetsuro Matsumoto

    INTERNATIONAL JOURNAL OF UROLOGY   23 ( 10 )   814 - 824   2016.10

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  • Japanese guideline for clinical research of antimicrobial agents on urogenital infections: Second edition Reviewed

    Mitsuru Yasuda, Tetsuro Muratani, Kiyohito Ishikawa, Hiroshi Kiyota, Hiroshi Sakata, Katsumi Shigemura, Satoshi Takahashi, Ryoichi Hamasuna, Hiroshi Hayami, Hiroshige Mikamo, Shingo Yamamoto, Toyohiko Watanabe, Soichi Arakawa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 9-10 )   651 - 661   2016.9

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    DOI： 10.1016/j.jiac.2016.07.018

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  • 単純ヘルペスウイルス1型が原因と考えられ症状が遷延した後淋菌性尿道炎の1例

    伊藤 晋, 花岡 希, 山田 壮一, 安田 満, 出口 隆

    泌尿器外科   29 ( 9 )   1499 - 1499   2016.9

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  • Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis. Reviewed

    Ito S, Yasuda M, Hatazaki K, Mizutani K, Tsuchiya T, Yokoi S, Nakano M, Deguchi T

    The Journal of antimicrobial chemotherapy   71 ( 9 )   2559 - 2562   2016.9

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  • Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated between 2000 and 2014 in Japan. Reviewed

    Seike K, Yasuda M, Hatazaki K, Mizutani K, Yuhara K, Ito Y, Fujimoto Y, Ito S, Tsuchiya T, Yokoi S, Nakano M, Deguchi T

    The Journal of antimicrobial chemotherapy   71 ( 9 )   2466 - 2470   2016.9

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  • Postoperative infectious complications in patients undergoing holmium laser enucleation of the prostate: Risk factors and microbiological analysis Reviewed

    Mina Kikuchi, Koji Kameyama, Mitsuru Yasuda, Shigeaki Yokoi, Takashi Deguchi, Kosei Miwa

    INTERNATIONAL JOURNAL OF UROLOGY   23 ( 9 )   791 - 796   2016.9

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    DOI： 10.1111/iju.13139

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  • 尿路性器感染症に関する臨床試験実施のためのガイドライン(第2版) ガイドラインの改訂にあたって

    荒川 創一, 石川 清仁, 清田 浩, 坂田 宏, 重村 克巳, 高橋 聡, 濱砂 良一, 速見 浩士, 三鴨 廣繁, 村谷 哲郎, 安田 満, 山本 新吾, 渡邉 豊彦, 公益社団法人日本化学療法学会尿路性器感染症に関する臨床試験実施のためのガイドライン改訂委員会

    日本化学療法学会雑誌   64 ( 3 )   479 - 493   2016.5

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  • 2014年に収集された複雑性尿路感染症分離菌の薬剤感受性について

    安田 満, 亀山 紘司, 山田 佳輝, 江原 英俊, 原田 吉将, 小出 卓也, 小林 覚, 米田 尚生, 高橋 義人, 林 秀治, 篠田 育男, 石原 哲, 武田 明久, 岡野 学, 伊藤 康久, 藤本 佳則, 藤広 茂, 出口 隆, 旗崎 恭子, 増栄 孝子, 藤本 祥太, 中井 千愛, 川瀬 紘太

    日本化学療法学会雑誌   64 ( 2 )   360 - 360   2016.3

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  • Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan Reviewed International journal

    Takahashi, Satoshi, Hamasuna, Ryoichi, Yasuda, Mitsuru, Ishikawa, Kiyohito, Hayami, Hiroshi, Uehara, Shinya, Yamamoto, Shingo, Minamitani, Shinichi, Kadota, Junichi, Iwata, Satoshi, Kaku, Mitsuo, Watanabe, Akira, Sato, Junko, Hanaki, Hideaki, Masumori, Naoya, Kiyota, Hiroshi, Egawa, Shin, Tanaka, Kazushi, Arakawa, Soichi, Fujisawa, Masato, Kumon, Hiromi, Wada, Koichiro, Kobayashi, Kanao, Matsubara, Akio, Matsumoto, Tetsuro, Eto, Masatoshi, Tatsugami, Katsunori, Kuroiwa, Kentaro, Ito, Kenji, Hosobe, Takahide, Hirayama, Hideo, Narita, Harunori, Yamaguchi, Takamasa, Ito, Shin, Sumii, Toru, Kawai, Shuichi, Kanokogi, Mototsugu, Kawano, Hiromi, Chokyu, Hirofumi, Uno, Satoshi, Monden, Koichi, Kaji, Shinichi, Kawahara, Motoshi, Takayama, Kazuo, Ito, Masayasu, Yoshioka, Masaru, Kano, Motonori, Konishi, Takatoshi, Kadena, Hitoshi, Nishi, Shohei, Nishimura, Hirofumi, Yamauchi, Takamine, Maeda, Shinichi, Horie, Masanobu, Ihara, Hideari, Matsumura, Masaru, Shirane, Takeshi, Takeyama, Koh, Akiyama, Kikuo, Takahashi, Koichi, Ikuyama, Toshihiro, Inatomi, Hisato, Yoh, Mutsumasa

    JOURNAL OF INFECTION AND CHEMOTHERAPY   22 ( 9-10 )   581 - 586   2016

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    Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 mu g/ml and 1 mu g/ml, 0.5 mu g/ml and 0.5 mu g/ml, 0.125 mu g/ml and 0.125 mu g/ml, 0.063 mu g/ml and 0.063 mu g/ml, 0.125 mu g/ml and 0.125 mu g/ml, 0.125 mu g/ml and 0.125 mu g/ml, 0.016 mu g/ml and 0.016 mu g/ml, and 0.063 mu g/ml and 0.063 mu g/ml, respectively. In summary, this surveillance project did

    DOI： 10.1016/j.jiac.2016.06.010

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  • MLVAによって見出されたNG-MAST ST1407型淋菌の遺伝学的特徴

    中西 典子, 田中 忍, 志牟田 健, 石原 朋子, 中山 周一, 大澤 佳代, 吉田 弘之, 重村 克巳, 荒川 創一, 安田 満, 出口 隆, 岩本 朋忠, 大西 真

    日本性感染症学会誌   26 ( 2 )   72 - 72   2015.10

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  • 男性性器感染症に対する治療を考える 前立腺生検に伴う尿路性器感染症の発生頻度の検討 後ろ向き多施設共同研究 UTI共同研究会

    東郷 容和, 安田 満, 宮崎 淳, 高橋 聡, 速見 浩士, 田中 一志, 石川 清仁, 濱砂 良一, 山本 新吾, 清田 浩, 荒川 創一, 松本 哲朗

    感染症学雑誌   89 ( 1 )   123 - 123   2015.1

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  • 男性性器感染症に対する治療を考える 前立腺生検に伴う尿路性器感染症の発生頻度の検討 後ろ向き多施設共同研究 UTI共同研究会

    東郷 容和, 安田 満, 宮崎 淳, 高橋 聡, 速見 浩士, 田中 一志, 石川 清仁, 濱砂 良一, 山本 新吾, 清田 浩, 荒川 創一, 松本 哲朗

    日本化学療法学会雑誌   63 ( 1 )   76 - 77   2015.1

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  • 泌尿器科領域 2012年における淋菌の薬剤感受性サーベイランス

    安田 満, 濱砂 良一, 上原 慎也, 高橋 聡, 速見 浩士, 石川 清仁, 山本 新吾, 松本 哲朗, 門田 淳一, 渡辺 彰, 三学会合同抗菌薬感受性サーベイランス委員会

    日本臨床微生物学雑誌   25 ( Suppl.1 )   150 - 150   2014.12

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  • 集学的治療にて比較的長期予後を得られている前立腺小細胞癌の1例

    堀江 憲吾, 亀山 紘司, 水谷 晃輔, 菅原 崇, 清家 健作, 土屋 朋大, 安田 満, 横井 繁明, 仲野 正博, 出口 隆, 酒々井 夏子, 広瀬 善信

    泌尿器科紀要   60 ( 10 )   517 - 521   2014.10

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  • 尿道炎におけるアデノウイルスについて

    花岡 希, 伊藤 晋, 高梨 真樹, 安田 満, 出口 隆, 山岸 拓也, 藤本 嗣人

    日本性感染症学会誌   25 ( 2 )   64 - 64   2014.10

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  • 2012年における淋菌の薬剤感受性サーベイランス(3学会合同サーベイランス報告)

    濱砂 良一, 安田 満, 上原 慎也, 高橋 聡, 速見 浩士, 石川 清仁, 山本 新吾, 松本 哲朗, 門田 淳一, 3学会合同サーベイランス委員会

    感染症学雑誌   88 ( 5 )   735 - 735   2014.9

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  • 2012年における淋菌の薬剤感受性サーベイランス(3学会合同サーベイランス報告)

    濱砂 良一, 安田 満, 上原 慎也, 高橋 聡, 速見 浩士, 石川 清仁, 山本 新吾, 松本 哲朗, 門田 淳一, 3学会合同サーベイランス委員会

    日本化学療法学会雑誌   62 ( Suppl.A )   227 - 227   2014.5

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  • 泌尿器科領域における抗癌化学療法に伴う発熱性好中球減少症に関する多施設共同調査

    和田 耕一郎, 谷本 竜太, 能勢 宏幸, 上原 慎也, 渡辺 豊彦, 速見 浩士, 永井 真吾, 安田 満, 出口 隆, 茂田 啓介, 矢澤 聰, 菊地 栄次, 大家 基嗣, 橋本 次朗, 上原 央久, 栗村 雄一郎, 桧山 佳樹, 高橋 聡, 塚本 泰司, 庄 武彦, 濱砂 良一, 宮崎 淳, 東郷 容和, 田岡 利宜也, 中尾 篤, 山本 新吾, 小林 加直, 松原 昭郎, 石川 清仁, 公文 裕巳, 松本 哲朗

    日本化学療法学会雑誌   62 ( 3 )   374 - 381   2014.5

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  • 陰茎-尿道海綿体シャント術で勃起機能を温存しえたLow-flow型持続勃起症の1例

    亀山 紘司, 清家 健作, 堀江 憲吾, 菊地 美奈, 水谷 晃輔, 菅原 崇, 土屋 朋大, 安田 満, 横井 繁明, 仲野 正博, 出口 隆, 加藤 博基, 近藤 浩史, 小林 覚

    泌尿器科紀要   60 ( 4 )   202 - 202   2014.4

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  • 複雑性尿路感染症由来株の抗菌薬感受性サーベイランス報告

    石川 清仁, 山本 新吾, 上原 慎也, 高橋 聡, 浜砂 良一, 安田 満, 速見 浩士, 松本 哲朗, 門田 淳一

    日本泌尿器科学会総会   102回   553 - 553   2014.4

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  • 尿管ステントの長期留置に関するアンケート調査

    和田 耕一郎, 山本 新吾, 松崎 純一, 麦谷 荘一, 山田 仁, 安田 満, 宮崎 淳, 高橋 聡, 山口 秋人, 奴田原 紀久雄

    Japanese Journal of Endourology   27 ( 1 )   79 - 83   2014

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    Other Link： https://jlc.jst.go.jp/DN/JALC/10036464578?from=CiNii

    DOI： 10.11302/jsejje.27.79

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  • 三学会合同抗菌薬感受性サーベイランス委員会報告 泌尿器科領域 複雑性尿路感染症

    石川 清仁, 山本 新吾, 上原 慎也, 高橋 聡, 濱砂 良一, 安田 満, 速見 浩士, 松本 哲朗, 門田 淳一

    感染症学雑誌   87 ( 4 )   532 - 532   2013.7

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  • 「泌尿器科領域における周術期感染予防ガイドライン」に関する多施設共同研究

    和田 耕一郎, 上原 慎也, 吉良 慎一郎, 松本 正広, 庄 武彦, 栗村 雄一郎, 橋本 次朗, 上原 央久, 山根 隆史, 金丸 聰淳, 東郷 容和, 田岡 利宜也, 高橋 彰, 山田 祐介, 横溝 晃, 安田 満, 田中 一志, 濱砂 良一, 高橋 聡, 速見 浩士, 渡邉 豊彦, 門田 晃一, 清田 浩, 出口 隆, 内藤 誠二, 塚本 泰司, 荒川 創一, 藤澤 正人, 山本 新吾, 公文 裕巳, 松本 哲朗, UTI共同研究会

    日本泌尿器科学会雑誌   104 ( 3 )   505 - 512   2013.5

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  • 再発を繰り返す尿路感染症患者に対するクランベリー果汁飲料の再発予防効果

    高橋 聡, 濱砂 良一, 安田 満, 荒川 創一, 田中 一志, 石川 清仁, 清田 浩, 速見 浩士, 山本 新吾, 松本 哲朗, UTI共同研究会

    日本化学療法学会雑誌   60 ( Suppl.A )   272 - 272   2012.3

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  • PP-949 急性精巣上体炎におけるMycoplasma genitaliumの起炎菌としての意義は明白ではない(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

    伊藤 晋, 安田 満, 前田 真一, 出口 隆

    日本泌尿器科学会雑誌   102 ( 2 )   563 - 563   2011

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    DOI： 10.5980/jpnjurol.102.563_5

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  • めざせ3 座長のメッセージ(研究のすゝめ-研究で世界一になる必要があるんでしょうか?臨床だけじゃダメなんでしょうか?-,めざせ!泌尿器科の星3,第99回日本泌尿器科学会総会)

    安田 満, 高橋 聡, 山本 新吾

    日本泌尿器科学会雑誌   102 ( 2 )   271 - 271   2011

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    DOI： 10.5980/jpnjurol.102.271

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  • OP-133 岐阜大学病院における腹腔鏡下ドナー腎採取術の経験(腎移植2,一般演題口演,第99回日本泌尿器科学会総会)

    伊藤 慎一, 横井 繁明, 石田 健一郎, 三輪 好生, 中根 慶太, 佐藤 啓美, 清家 健作, 安田 満, 仲野 正博, 出口 隆

    日本泌尿器科学会雑誌   102 ( 2 )   363 - 363   2011

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    DOI： 10.5980/jpnjurol.102.363_1

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  • OP-109 男子淋菌性尿道炎患者より分離された淋菌の薬剤感受性について(感染症1,一般演題口演,第99回日本泌尿器科学会総会)

    安田 満, 中根 慶太, 清家 健作, 楊 睦正, 原田 吉将, 石原 哲, 斉藤 昭弘, 藤本 佳則, 前田 真一, 藤広 茂, 堀江 正宣, 伊藤 晋, 出口 隆

    日本泌尿器科学会雑誌   102 ( 2 )   359 - 359   2011

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    DOI： 10.5980/jpnjurol.102.359_1

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  • VP-015 腹腔鏡下左副腎摘除術 : 当院における工夫(副腎・尿管・腹部,一般演題ビデオ,第99回日本泌尿器科学会総会)

    横井 繁明, 三輪 好生, 中根 慶太, 佐藤 啓美, 加藤 卓, 清家 健作, 石田 健一郎, 安田 満, 伊藤 慎一, 仲野 正博, 出口 隆

    日本泌尿器科学会雑誌   102 ( 2 )   397 - 397   2011

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    DOI： 10.5980/jpnjurol.102.397_3

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  • 小児泌尿器科周術期感染予防のための抗菌薬投与に関するアンケート調査結果について

    石川 清仁, 松本 哲朗, 村谷 哲郎, 山田 陽司, 塚本 泰司, 松川 雅則, 小野寺 昭一, 清田 浩, 安田 満, 石原 哲, 出口 隆, 山本 新吾, 荒川 創一, 田中 一志, 門田 晃一, 上原 慎也, 公文 裕巳, 江頭 稔久, 野村 博之

    尿路感染症研究会記録集   21回   35 - 35   2010.10

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    Ichushi

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  • 尿路感染症主要原因菌の各種抗菌薬に対する感受性

    松本 哲朗, 濱砂 良一, 石川 清仁, 高橋 聡, 安田 満, 速見 浩士, 田中 一志, 清田 浩, 村谷 哲郎, 門田 晃一, 荒川 創一, 山本 新吾

    日本化学療法学会雑誌   58 ( 4 )   466 - 482   2010.7

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  • 尿路性器結核症の全国的調査

    中根 慶太, 安田 満, 石原 哲, 出口 隆, 高橋 聡, 田中 一志, 速見 浩士, 石川 清仁, 門田 晃一, 濱砂 良一, 山本 新吾, 荒川 創一, 松本 哲朗

    日本泌尿器科学会雑誌   101 ( 2 )   237 - 237   2010.2

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  • OP-014 ヨウ素125密封小線源永久挿入療法における抗菌剤の予防投与に関する検討(感染症2,一般演題口演,第98回日本泌尿器科学会総会)

    仲野 正博, 南館 謙, 佐藤 啓美, 輪 好生, 安田 満, 横井 繁明, 出口 隆, 大宝 和博, 林 真也, 宇野 裕己

    日本泌尿器科学会雑誌   101 ( 2 )   236 - 236   2010

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    DOI： 10.5980/jpnjurol.101.236_2

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  • PP-624 非クラミジア性非淋菌性尿道炎の起炎菌に関する検討(発表・討論,一般演題ポスター,第98回日本泌尿器科学総会)

    伊藤 晋, 安田 満, 前田 真一, 出口 隆

    日本泌尿器科学会雑誌   101 ( 2 )   524 - 524   2010

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    DOI： 10.5980/jpnjurol.101.524_4

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  • OP-373 当院における新規生体腎移植患者におけるグラセプターの使用経験 : 1日用量はプログラフと々でいいのか?(腎移植3,一般演題口演,第98回日本泌尿器科学会総会)

    石田 健一郎, 佐藤 啓美, 菊地 美奈, 中根 慶太, 土屋 朋大, 三輪 好生, 南舘 譲, 安田 満, 横井 繁明, 伊藤 慎一, 仲野 正博, 出口 隆

    日本泌尿器科学会雑誌   101 ( 2 )   326 - 326   2010

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    DOI： 10.5980/jpnjurol.101.326_1

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  • 尿路性器感染症に関する臨床試験実施のためのガイドライン(第1版)

    松本 哲朗, 高橋 聡, 清田 浩, 安田 満, 石川 清仁, 高橋 彰, 山本 新吾, 荒川 創一, 門田 晃一, 村谷 哲郎, 濱砂 良一, 速水 浩士, 公文 裕巳, 渡辺 豊彦, 上原 慎也, 川原 元司, 中川 昌之, 山根 隆史, 石原 哲, 出口 隆, 菊池 達也, 内藤 誠二, 野村 博之, 平賀 紀行, 金丸 聰淳, 小川 修, 守殿 貞夫, 重村 克巳, 田中 一志, 中野 雄造, 藤澤 正人, 三浦 徹也, 国島 康晴, 塚本 泰司, 松川 雅則, 山田 陽司, 赤坂 聡一郎, 小野寺 昭一, 島 博基, 繁田 正信, 星長 清隆, 長田 幸夫, 和田 耕一郎, 日本化学療法学会UTI薬効評価基準見直しのための委員会

    日本化学療法学会雑誌   57 ( 6 )   511 - 525   2009.11

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  • 膀胱炎由来キノロン耐性大腸菌株のキノロン耐性決定領域変異と系統分類・病原因子の相関

    高橋 彰, 山本 新吾, 村谷 哲郎, 石川 清仁, 安田 満, 高橋 聡, 門田 晃一, 清田 浩, 荒川 創一, 松本 哲朗

    尿路感染症研究会記録集   19回   66 - 66   2009.10

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  • Retrospective cohort chart review study of factors associated with the development of thrombocytopenia in adult Japanese patients who received intravenous linezolid therapy. Reviewed

    Niwa Takashi, Suzuki Akio, Sakakibara Seiji, Kasahara Senji, Yasuda Mitsuru, Fukao Ayumi, Matsuura Katsuhiko, Goto Chitoshi, Murakami Nobuo, Itoh Yoshinori

    Clinical therapeutics   31 ( 10 )   2126 - 33   2009.10

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    Linezolid is an oxazolidinone antibiotic agent active against Gram-positive bacteria. It has been associated with hematologic adverse effects such as thrombocytopenia. Little is known about the mechanism underlying thrombocytopenia in patients who receive intravenous linezolid.

    DOI： 10.1016/j.clinthera.2009.10.017

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  • 泌尿器科領域における感染制御ガイドライン

    松本 哲朗, 荒川 創一, 高橋 聡, 濱砂 良一, 山本 新吾, 矢内原 仁, 石川 悟, 石川 清仁, 石原 哲, 上原 慎也, 江田 晋一, 小野寺 昭一, 金丸 聰淳, 守殿 貞夫, 菊池 達也, 清田 浩, 公文 裕巳, 栗村 雄一郎, 島 博基, 高橋 彰, 田中 一志, 谷村 正信, 塚本 泰司, 出口 隆, 内藤 誠二, 中野 雄造, 速見 浩士, 平賀 紀行, 藤澤 正人, 三浦 徹也, 村谷 哲郎, 門田 晃一, 安田 満, 安福 富彦, 渡辺 豊彦, 和田 耕一郎, 日本泌尿器科学会泌尿器科領域における感染制御ガイドライン作成委員会

    日本泌尿器科学会雑誌   100 ( 4 )   np1,np2,1 - 27   2009.5

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  • 尿路性器感染症に関する臨床試験実施のためのガイドライン 第1版 最終案

    松本 哲朗, 荒川 創一, 村谷 哲郎, 安田 満, 高橋 彰, 公文 裕巳, 門田 晃一, 渡辺 豊彦, 上原 慎也, 川原 元司, 中川 昌之, 速見 浩士, 山根 隆史, 石原 哲, 出口 隆, 菊池 達也, 内藤 誠二, 野村 博之, 平賀 紀行, 金丸 聰淳, 小川 修, 守殿 貞夫, 重村 克巳, 田中 一志, 中野 雄造, 藤澤 正人, 三浦 徹也, 国島 康晴, 高橋 聡, 塚本 泰司, 松川 雅則, 山田 陽司, 赤坂 聡一郎, 小野寺 昭一, 清田 浩, 島 博基, 山本 新吾, 繁田 正信, 石川 清仁, 星長 清隆, 濱砂 良一, 長田 幸夫, 日本化学療法学会臨床評価法制定委員会

    日本化学療法学会雑誌   57 ( 2 )   np1 - 20   2009.3

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  • PP-320 非淋菌性尿道炎治療後のMycoplasma genitalium除菌は初尿白血球数で推定可能か?(感染症2,一般演題ポスター,第97回日本泌尿器科学会総会)

    伊藤 晋, 前田 真一, 安田 満, 出口 隆

    日本泌尿器科学会雑誌   100 ( 2 )   396 - 396   2009

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    DOI： 10.5980/jpnjurol.100.396_4

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  • 尿路由来キノロン耐性大腸菌株の系統分類、保有病原因子検討

    高橋 彰, 山本 新吾, 石川 清仁, 安田 満, 高橋 聡, 門田 晃一, 村谷 哲郎, 清田 浩, 荒川 創一, 松本 哲朗

    日本泌尿器科学会雑誌   99 ( 2 )   460 - 460   2008.2

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  • 尿路由来キノロン耐性大腸菌株の系統分類、保有病原因子検討

    高橋 彰, 山本 新吾, 石川 清仁, 安田 満, 高橋 聡, 門田 晃一, 村谷 哲郎, 清田 浩, 荒川 創一, 松本 哲朗

    尿路感染症研究会記録集   ( 16 )   22 - 24   2008.2

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  • PP-332 尿道分泌物を認める男子症例における初尿白血球数と淋菌、クラミジア、マイコプラズマの検出率について(感染症/基礎/尿道、前立腺、性器1,一般演題ポスター,第96回日本泌尿器科学会総会)

    伊藤 晋, 前田 真一, 安田 満, 出口 隆

    日本泌尿器科学会雑誌   99 ( 2 )   460 - 460   2008

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    DOI： 10.5980/jpnjurol.99.460_4

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  • PP-220 夜間頻尿は睡眠時無呼吸症候群の治療で改善するのか(第95回日本泌尿器科学会総会)

    守山 洋司, 三輪 好生, 安田 満, 出口 隆, 藤広 茂, 西野 好則

    日本泌尿器科学会雑誌   98 ( 2 )   451 - 451   2007

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    DOI： 10.5980/jpnjurol.98.451_4

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  • PP-274 前立腺肥大症にともなう pelvic pain syndrome に対するエビプロスタットの有効性の検討(第95回日本泌尿器科学会総会)

    三輪 好生, 守山 洋司, 増栄 孝子, 西野 好則, 加藤 成一, 安田 満, 宇野 雅博, 米田 尚生, 岡野 学, 竹内 敏視, 藤本 佳則, 坂 義人, 出口 隆

    日本泌尿器科学会雑誌   98 ( 2 )   465 - 465   2007

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    DOI： 10.5980/jpnjurol.98.465_2

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  • 泌尿器科領域における周術期感染予防ガイドライン

    松本 哲朗, 村谷 哲郎, 山田 陽司, 塚本 泰司, 松川 雅則, 小野寺 昭一, 清田 浩, 頴川 晋, 星長 清隆, 石川 清仁, 出口 隆, 安田 満, 石原 哲, 小川 修, 山本 新吾, 藤澤 正人, 荒川 創一, 田中 一志, 公文 裕巳, 門田 晃一, 上原 慎也, 内藤 誠二, 江頭 稔久, 野村 博之, UTI共同研究会周術期感染予防ガイドライン作成ワーキンググループ

    日本泌尿器科学会雑誌   97 ( 6 )   np1,1 - 35   2006.9

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  • S3-4 男子尿道炎におけるマイコプラズマ感染症について(シンポジウム3「性感染症の現状と対策」,第94回日本泌尿器科学会総会)

    出口 隆, 安田 満, 横井 繁明, 仲野 正博, 伊藤 慎一, 江原 英俊, 高橋 義人, 久保田 恵章, 前田 慎一

    日本泌尿器科学会雑誌   97 ( 2 )   136 - 136   2006

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    DOI： 10.5980/jpnjurol.97.136_1

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  • APP-018 免疫組織化学的手法による腎細胞癌(clear cell carcinoma)の予後因子の検討(総会賞応募ポスター,第94回日本泌尿器科学会総会)

    ウェン フック・バ, 江原 英俊, 萩原 徳康, 安田 満, 横井 繁明, 伊藤 慎一, 仲野 正博, 山本 直樹, 高橋 義人, 出口 隆

    日本泌尿器科学会雑誌   97 ( 2 )   231 - 231   2006

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    DOI： 10.5980/jpnjurol.97.231_2

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  • MP-194 当科における最近5年間の腎移植の臨床的検討(一般演題ポスター,第94回日本泌尿器科学会総会)

    土屋 朋大, 伊藤 慎一, 萩原 徳康, 久保田 恵章, 亀井 信吾, 安田 満, 横井 繁明, 仲野 正博, 山田 徹, 江原 英俊, 高橋 義人, 出口 隆

    日本泌尿器科学会雑誌   97 ( 2 )   415 - 415   2006

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    DOI： 10.5980/jpnjurol.97.415_2

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  • In vitro activity of fluoroquinolones against Mycoplasma genitalium and their bacteriological efficacy for treatment of m. genitalium-positive nongonococcal urethritis in men

    M. Yasuda, S. Maeda, Takashi Deguchi

    Clinical Infectious Diseases   41 ( 9 )   1357 - 1359   2005.11

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    DOI： 10.1086/496983

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  • 髄膜炎菌が分離された男子尿道炎の1例

    林 美佳, 萩原 徳康, 安田 満, 山羽 正義, 堀江 正宣, 大楠 清文, 江崎 孝行, 出口 隆

    日本性感染症学会誌   16 ( 2 )   51 - 51   2005.11

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  • Efficacy of 1-day prophylaxis medication with fluoroquinolone for prostate biopsy

    K Shigemura, K Tanaka, M Yasuda, S Ishihara, T Muratani, T Deguchi, T Matsumoto, S Kamidono, Y Nakano, S Arakawa, M Fujisawa

    WORLD JOURNAL OF UROLOGY   23 ( 5 )   356 - 360   2005.11

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    DOI： 10.1007/s00345-005-0024-4

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  • Neisseria meningitidis(髄膜炎菌)Y群による男子尿道炎の1例

    大楠 清文, 安田 満, 大塚 喜人, 河村 好章, 江崎 孝行, 出口 隆

    感染症学雑誌   79 ( 9 )   797 - 797   2005.9

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  • Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones

    M Takei, Y Yamaguchi, H Fukuda, M Yasuda, T Deguchi

    JOURNAL OF CLINICAL MICROBIOLOGY   43 ( 9 )   4321 - 4327   2005.9

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    DOI： 10.1128/JCM.43.9.4321-4327.2005

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  • Polymerase chain reaction-based subtyping of Ureaplasma parvum and Ureaplasma urealyticum in first-pass urine samples from men with or without urethritis

    T Yoshida, H Ishiko, M Yasuda, Y Takahashi, Y Nomura, Y Kubota, M Tamaki, S Maeda, T Deguchi

    SEXUALLY TRANSMITTED DISEASES   32 ( 7 )   454 - 457   2005.7

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    DOI： 10.1097/01.olq.0000158932.78183.95

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  • Neisseria meningitidis(髄膜炎菌)Y群による男子尿道炎の1例

    大楠 清文, 安田 満, 大塚 喜人, 河村 好章, 江崎 孝行, 出口 隆

    感染症学雑誌   79 ( 臨増 )   307 - 307   2005.3

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  • A Clinical Isolate of Leclercia adecarboxylata from a Patient of Pyelonephritis

    SAWAMURA Haruki, KAWAMURA Yoshiaki, YASUDA Mitsuru, OHKUSU Kiyofumi, TAKAHASHI Yoshito, ISHIHARA Satoshi, DEGUCHI Takashi, EZAKI Takayuki

    Journal of the Japanese Association for Infectious Diseases   79 ( 10 )   831 - 835   2005.1

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    Other Link： https://jlc.jst.go.jp/DN/JALC/00271379058?from=CiNii

    DOI： 10.11150/kansenshogakuzasshi1970.79.831

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  • 泌尿器科系感染症Neisseria meningitidis（髄膜炎菌）Serogroup Yによる男子尿道炎の一例

    大楠 清文, 萩原 徳康, 河村 好章, 安田 満, 大塚 喜人, 江崎 孝行, 出口 隆

    症例から学ぶ感染症診療のポイント   137 - 142   2005.1

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  • 尿膜管臍瘻に対する腹腔鏡下手術

    高橋 義人, 横井 繁明, 安田 満, 出口 隆

    手術   59   1591 - 1597   2005.1

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  • Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan

    M Ito, T Deguchi, KS Mizutani, M Yasuda, S Yokoi, SI Ito, Y Takahashi, S Ishihara, Y Kawamura, T Ezaki

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   49 ( 1 )   137 - 143   2005.1

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    DOI： 10.1128/AAC.49.1.137-143.2005

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  • 腎不全症例に対する鏡視下腎摘除術の経験(第93回日本泌尿器科学会総会)

    横井 繁明, 中根 慶太, 加藤 卓, 水谷 晃輔, 萩原 徳康, 安田 満, 仲野 正博, 伊藤 慎一, 江原 英俊, 高橋 義人, 石原 哲, 出口 隆

    日本泌尿器科学会雑誌   96 ( 2 )   348 - 348   2005

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    DOI： 10.5980/jpnjurol.96.348_3

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  • Mycoplasma genitalium urethritis in men

    S Ishihara, M Yasuda, S Ito, S Maeda, T Deguchi

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   24   S23 - S27   2004.9

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    DOI： 10.1016/j.ijantimicag.2004.02.006

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  • Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones

    M Ito, M Yasuda, S Yokoi, SI Ito, Y Takahashi, S Ishihara, SI Maeda, T Deguchi

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   48 ( 8 )   3185 - 3187   2004.8

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    DOI： 10.1128/AAC.48.8.3185-3187.2004

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  • Association of Ureaplasma urealyticum (Biovar 2) with nongonococcal urethritis

    T Deguchi, T Yoshida, T Miyazawa, M Yasuda, M Tamaki, H Ishiko, SI Maeda

    SEXUALLY TRANSMITTED DISEASES   31 ( 3 )   192 - 195   2004.3

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    DOI： 10.1097/01.OLQ.0000114653.26951.71

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  • 血清CA19とCAEが異常高値を示した尿管癌の1例

    加藤 成一, 安田 満, 仲野 正博, 江原 英俊, 石原 哲, 出口 隆, 坂田 佳子, 森, 秀樹, 下川 邦泰

    泌尿器科紀要   50   99 - 102   2004.1

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  • 泌尿器科周術期における抗菌薬の使用方法についてのアンケート報告

    山本 新吾, 竹山 康, 塚本 泰司, 清田 浩, 小野寺 昭一, 頴川 晋, 門田 晃一, 公文 裕巳, 江頭 稔久, 内藤 誠二, 田中 一志, 金丸 聰淳, 荒川 創一, 守殿 貞夫, 安田 満, 石原 哲, 出口 隆, 山田 陽司, 村谷 哲郎, 松本 哲朗, 小川 修, 石川 清仁, 星長 清隆, 岩村 正嗣, 斉藤 威文, 馬場 志郎, 松川 雅則

    泌尿器科紀要   50   779 - 786   2004.1

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  • マイコプラズマ

    出口 隆, 安田 満, 前田 真一

    性感染症 STD   160 - 168   2004.1

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  • 非淋菌性尿道炎難治例におけるマイコプラズマの関与

    前田 真一, 久保田 恵章, 玉木 正義, 安田 満, 出口 隆, 吉田 隆史, 石古 博昭

    日本性感染症学会誌   15   139 - 143   2004.1

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  • APP-114 ペニシリン結合蛋白2のモザイク様構造変化を有する淋菌臨床分離株の出現(総会賞応募(ポスター))

    安田 満, 水谷 晃輔, 石原 哲, 篠田 育男, 林 秀治, 斉藤 昭弘, 藤本 佳則, 前田 真一, 藤広 茂, 蟹本 雄右, 堀江 正宣, 説田 修, 出口 隆

    日本泌尿器科学会雑誌   95 ( 2 )   343 - 343   2004

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.95.343_2

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  • PP4-016 タクロリムス,バシリキシマブ併用療法におけるCD25陽性細胞数の推移に関する検討(一般演題(ポスター))

    伊藤 慎一, 萩原 徳康, 増栄 成泰, 水谷 晃輔, 安田 満, 横井 繁明, 江原 英俊, 高橋 義人, 石原 哲, 出口 隆

    日本泌尿器科学会雑誌   95 ( 2 )   534 - 534   2004

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    DOI： 10.5980/jpnjurol.95.534_2

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  • PP3-185 複雑性尿路感染症起因菌の耐性率の変化(一般演題(ポスター))

    石原 哲, 水谷 晃輔, 亀井 信吾, 増栄 成泰, 後藤 高広, 萩原 徳康, 安田 満, 横井 繁明, 仲野 正博, 伊藤 慎一, 江原 英俊, 高橋 義人, 出口 隆

    日本泌尿器科学会雑誌   95 ( 2 )   520 - 520   2004

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    DOI： 10.5980/jpnjurol.95.520_1

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  • PP3-217 腹腔鏡手術の開腹移行例の検討(一般演題(ポスター))

    高橋 義人, 横井 繁明, 安田 満, 亀井 信吾, 伊藤 慎一, 江原 英俊, 水谷 晃輔, 中根 慶太, 加藤 卓, 宇野 裕巳, 玉木 正義, 前田 真一, 出口 隆

    日本泌尿器科学会雑誌   95 ( 2 )   528 - 528   2004

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    DOI： 10.5980/jpnjurol.95.528_1

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  • 外来診療のすべて改訂第3版

    安田 満, 出口 隆

    124 - 125   2003.1

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  • 尿路感染症の薬物治療 細菌感染症のトピックス

    安田 満, 出口 隆

    MEDICAMENT NEWS   1764   1 - 3   2003.1

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  • Mycoplasma genitaliumと尿道炎

    安田 満, 出口 隆

    日本マイコプラズマ学会誌   30   52 - 55   2003.1

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  • 男子淋菌性尿道炎に対するセフィキシム400mg，分2，3日間投与の細菌学的効果の検討

    前田 真一, 久保田 恵章, 玉木 正義, 安田 満, 出口 隆

    日本性感染症学会誌   14   121 - 124   2003.1

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  • Treatment of uncomplicated gonococcal urethritis by double-dosing of 200mg cefixime at a 6-h interval

    Takashi Deguchi, Mitsuru Yasuda, Shigeaki Yokoi, Ken-Ichiro Ishida, Masayasu Ito, Satoshi Ishihara, Ken Minamidate, Yoshimasa Harada, Kanhin Tei, Kentaro Kojima, Masayoshi Tamaki, Shin-Ichi Maeda

    Journal of Infection and Chemotherapy   9 ( 1 )   35 - 39   2003

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Japan  

    DOI： 10.1007/s10156-002-0204-8

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  • Grade3表在性膀胱癌の臨床的検討

    楊 睦正, 土屋 朋大, 亀井 信吾, 山田 徹, 安田 満, 西野 好則, 西田 泰幸, 谷口 光宏, 永井 司, 竹内 敏視, 出口 隆

    日本泌尿器科学会雑誌   94 ( 2 )   266 - 266   2003

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.94.266_1

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  • 膀胱全摘除症例における術前化学療法の有用性の検討

    土屋 朋大, 亀井 信吾, 山田 徹, 安田 満, 楊 睦正, 西野 好則, 西田 泰幸, 谷口 光宏, 永井 司, 竹内 敏視, 出口 隆

    日本泌尿器科学会雑誌   94 ( 2 )   213 - 213   2003

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    DOI： 10.5980/jpnjurol.94.213_2

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  • Association of mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis Reviewed

    S Maeda, M Tamaki, K Kojima, T Yoshida, H Ishiko, M Yasuda, T Deguchi

    SEXUALLY TRANSMITTED DISEASES   28 ( 8 )   472 - 476   2001.8

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    Web of Science

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  • 上部尿路上皮内癌におけるBCG灌流療法の検討

    西野 好則, 安田 満, 横井 繁明, 江原 英俊, 山本 直樹, 原田 吉將, 米田 尚生, 高橋 義人, 石原 哲, 竹内 敏視, 酒井 俊助, 鄭 漢彬, 出口 隆

    日本泌尿器科学会雑誌   91 ( 3 )   400 - 400   2000

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.91.400_2

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  • 1998年に当科で分離された尿路由来緑膿菌の抗菌剤耐性関連遺伝子の状況について

    石原 哲, 安田 満, 横井 繁明, 西野 好則, 江原 英俊, 山本 直樹, 高橋 義人, 出口 隆

    日本泌尿器科学会雑誌   91 ( 3 )   198 - 198   2000

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.91.198_1

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  • 腎細胞癌におけるcentrosomal kinase AIK1およびAIK3発現の免疫組織化学的検討

    江原 英俊, 横井 繁明, 山田 徹, 玉木 正義, 安田 満, 西野 好則, 山本 直樹, 高橋 義人, 石原 哲, 出口 隆, 木村 正志, 岡野 幸雄

    日本泌尿器科学会雑誌   91 ( 3 )   395 - 395   2000

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.91.395_1

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  • Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins Reviewed

    T Deguchi, M Yasuda, T Kawamura, M Nakano, S Ozeki, E Kanematsu, Y Nishino, Y Kawada

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   41 ( 11 )   2544 - 2546   1997.11

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  • Detection of mutations in the gyrA and parC genes in quinolone-resistant clinical isolates of Enterobacter cloacae Reviewed

    T Deguchi, M Yasuda, M Nakano, S Ozeki, E Kanematsu, Y Nishino, S Ishihara, Y Kawada

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   40 ( 4 )   543 - 549   1997.10

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  • Development of a rapid assay for detecting gyrA mutations in Escherichia coli and determination of incidence of gyrA mutations in clinical strains isolated from patients with complicated urinary tract infections Reviewed

    S Ozeki, T Deguchi, M Yasuda, M Nakano, T Kawamura, Y Nishino, Y Kawada

    JOURNAL OF CLINICAL MICROBIOLOGY   35 ( 9 )   2315 - 2319   1997.9

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  • In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae with quinolone resistance-associated alterations in GyrA and ParC Reviewed

    T Deguchi, M Yasuda, S Ishihara, Y Takahashi, E Okezaki, O Nagata, Saito, I, Y Kawada

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   40 ( 3 )   437 - 439   1997.9

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  • Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citrobacter freundii Reviewed

    Y Nishino, T Deguchi, M Yasuda, T Kawamura, M Nakano, E Kanematsu, S Ozeki, Y Kawada

    FEMS MICROBIOLOGY LETTERS   154 ( 2 )   409 - 414   1997.9

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  • In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections Reviewed

    T Deguchi, T Kawamura, M Yasuda, M Nakano, H Fukuda, H Kato, N Kato, Y Okano, Y Kawada

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   41 ( 7 )   1609 - 1611   1997.7

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  • Comparison of in vitro antimicrobial activity of AM-1155 with those of tosufloxacin and fleroxacin against clinical isolates of Neisseria gonorrhoeae harboring quinolone resistance alterations in GyrA and ParC Reviewed

    T Deguchi, M Yasuda, M Nakano, S Ozeki, E Kanematsu, H Fukuda, S Maeda, Saito, I, Y Kawada

    CHEMOTHERAPY   43 ( 4 )   239 - 244   1997.7

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  • Fluoroquinolone treatment failure in gonorrhea - Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones Reviewed

    T Deguchi, Saito, I, M Tanaka, K Sato, K Deguchi, M Yasuda, M Nakano, Y Nishino, E Kanematsu, S Ozeki, Y Kawada

    SEXUALLY TRANSMITTED DISEASES   24 ( 5 )   247 - 250   1997.5

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  • Prevalence of Mycoplasma genitalium in asymptomatic men in Japan Reviewed

    M Uno, T Deguchi, A Saito, M Yasuda, H Komeda, Y Kawada

    INTERNATIONAL JOURNAL OF STD & AIDS   8 ( 4 )   259 - 260   1997.4

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  • Rapid screening of point mutations of the Neisseria gonorrhoeae parC gene associated with resistance to quinolones Reviewed

    T Deguchi, M Yasuda, M Nakano, E Kanematsu, S Ozeki, Y Nishino, T Ezaki, S Maeda, Saito, I, W Kawada

    JOURNAL OF CLINICAL MICROBIOLOGY   35 ( 4 )   948 - 950   1997.4

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  • Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae Reviewed

    T Deguchi, A Fukuoka, M Yasuda, M Nakano, S Ozeki, E Kanematsu, Y Nishino, S Ishihara, Y Ban, Y Kawada

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   41 ( 3 )   699 - 701   1997.3

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  • Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV Reviewed

    T Deguchi, M Yasuda, M Nakano, E Kanematsu, S Ozeki, S Ishihara, Saito, I, Y Kawada

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   39 ( 2 )   247 - 249   1997.2

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  • Prevalence of Mycoplasma genitalium in men with gonococcal urethritis Reviewed

    M Uno, T Deguchi, H Komeda, M Yasuda, M Tamaki, S Maeda, Saito, I, Y Kawada

    INTERNATIONAL JOURNAL OF STD & AIDS   7 ( 6 )   443 - 444   1996.10

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  • Rapid detection of point mutations of the Neisseria gonorrhoeae gyrA gene associated with decreased susceptibilities to quinolones Reviewed

    T Deguchi, M Yasuda, M Nakano, S Ozeki, T Ezaki, SI Maeda, Saito, I, Y Kawada

    JOURNAL OF CLINICAL MICROBIOLOGY   34 ( 9 )   2255 - 2258   1996.9

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  • Comparison among performances of a ligase chain reaction-based assay and two enzyme immunoassays in detecting Chlamydia trachomatis in urine specimens from men with nongonococcal urethritis Reviewed

    T Deguchi, M Yasuda, M Uno, K Tada, H Iwata, H Komeda, S Maeda, Latila, V, Saito, I, Y Kawada

    JOURNAL OF CLINICAL MICROBIOLOGY   34 ( 7 )   1708 - 1710   1996.7

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  • Quinolone-resistant Neisseria gonorrhoeae: Correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles Reviewed

    T Deguchi, M Yasuda, M Nakano, S Ozeki, T Ezaki, Saito, I, Y Kawada

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   40 ( 4 )   1020 - 1023   1996.4

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  • 腎細胞癌におけるProgesterone receptorの発現に関する免疫組織学的検討

    楊 睦正, 江原 英俊, 出口 隆, 仲野 正博, 安田 満, 土屋 博, 河田 幸道

    日本泌尿器科学会雑誌   87 ( 2 )   390 - 390   1996

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    Language：Japanese   Publisher：一般社団法人 日本泌尿器科学会  

    DOI： 10.5980/jpnjurol.87.390_2

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  • Detection of <I>Mycoplasma genitalium</I> from Male Patients with Non-Gonococcal Urethritis by Polymerase Chain Reaction

    KOMEDA Hisao, DEGUCHI Takashi, YASUDA Mitsuru, TADA Kouji, IWATA Hideki, ISHIHARA Satoshi, BAN Yoshihito, KAWADA Yukimichi, ESAKI Takayuki, SAITO Isao

    Journal of the Japanese Association for Infectious Diseases   68 ( 11 )   1376 - 1380   1994

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    Publisher：The Japanese Association for Infectious Diseases  

    <I>Mycoplasma genitalium</I> causes urethritis in non-human primates, but studies on its pathogenicity in man have been hampered by the difficulty in isolating this oragnism in culture. We have used a specific polymerase chain reaction to examine the role of <I>M. genitalium</I> in nongonococcal urethritis (NGU). Oligonucleotide primers were used to amplify a 281 bp of 140-KDa adhesin gene of <I>M. genitalium</I>. A characteristic PCR product was amplified, when <I>M. genitalium</I> DNA was template for the PCR. No amplified product was detected in <I>Mycoplasma pneumoniae</I> DNA, <I>Mycoplasma hominis</I> DNA or other bacterial DNAs. <I>M. genitalium</I> DNA was detected in urethral swabs from 17 (14.9%) of 114 men with NGU. Three (9.1%) of the 33 men with <I>Chlamydia</I>-positive NGU and 14 (17.3%) of the 81 with <I>Chlamydia</I>-negative NGU were positive for <I>M. genitalium</I> DNA, but 29 men without urethritis were negative. The prevalence of <I>M. genitalium</I> in NGU and in <I>Chlamydia</I>-negative NGU was significantly higher than that in the normal control. These findings suggest that <I>M. genitalium</I> would be a cause of NGU.

    Other Link： https://jlc.jst.go.jp/DN/JALC/00081008476?from=CiNii

    DOI： 10.11150/kansenshogakuzasshi1970.68.1376

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MISC

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Presentations

  • 「Mycoplasma genitaliumと尿道炎」

    安田 満

    第30回日本マイコプラズマ学会学術集会  2003.10 

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    Presentation type：Oral presentation (general)  

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  • 「Mycoplasma genitaliumと男子非淋菌性尿道炎」

    安田 満

    第53回日本泌尿器科学会中部総会  2003.11 

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    Presentation type：Oral presentation (general)  

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  • Multidisciplinary studies on the human diseases caused by mycoplasmas. Mycoplasma genitalium and Ureaplasma urealyticum in urethritis

    安田 満

    oint congress of The 1st Meeting of The Asian Organization for Mycoplasmology and The 31st Meeting of the Japanese Society of Mycoplasmology  2004.10 

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    Presentation type：Oral presentation (general)  

    Venue：Tokyo  

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  • Epidemiology and Treatumeut for STIs. Neisseria gonorrhoeae intection International conference

    安田 満

    Joint Meeting of International Disease Management Symposium and 3rd Asian UTI/STD Fourm  2005.5 

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Research Projects

  • 淋菌薬剤感受性サーベイランスによる薬剤耐性淋菌に対する有効な抗菌化学療法の検討

    Grant number：22K09533  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安田 満, 高橋 聡, 佐藤 勇樹

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Drug-resistant Neisseria gonorrhoeae detection by gonococcal antimicrobial susceptibility surveillance and study of drug resistance mechanism and molecular type

    Grant number：18K09163  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yasuda Mitsuru

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    From 2018 to 2020, 2,131 strains (608 strains in 2018, 654 strains in 2019, 869 strains in 2020) of Neisseria gonorrhoeae were isolated and preserved from clinical specimens. Of these, drug susceptibility tests were conducted on all strains in 2018 and 2019 and 414 strains in 2020. Almost strains were susceptible to CTRX and SPCM recommended in Japan. 30% were susceptible to CPFX and 90% were susceptible to CFIX. It was considered that these drugs could be used as initial therapeutic agents if they were guaranteed to be susceptible to CPFX and CFIX.

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  • 淋菌咽頭感染の効果的な治療法の確立

    2014.4 - 2017.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安田満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\2210000 （ Direct Cost: \1700000 、 Indirect Cost：\510000 ）

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  • 淋菌咽頭感染の効果的な治療法の確立

    2014.4 - 2017.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安田満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1430000 （ Direct Cost: \1100000 、 Indirect Cost：\330000 ）

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  • 淋菌咽頭感染の効果的な治療法の確立

    2014 - 2016

    文部科学省  科学研究費補助金(基盤研究(C))  基盤研究(C)

    安田 満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

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  • 淋菌咽頭感染の効果的な治療法の確立

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安田 満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1430000 （ Direct Cost: \1100000 、 Indirect Cost：\330000 ）

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  • Surveillance of antimicrobial susceptibility of pathogens of male urethritis

    Grant number：25462509  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Deguchi Takaashi, YSUDA Mitsuru

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    We examined clinical isolates of Neisseria gonorrhoeae for antimicrobial susceptibility and Mycoplasma genitalium DNAs for macrolide and quinolone resistance-associated mutations. We observed some isolates with decreased susceptibility to cefixime, with resistance to levofloxacin, and with resistance to azithromycin. We isolated a strain (GU140106) with decreased to ceftriaxone in 2014 but found that all other isolates were susceptible to ceftriaxone. We detected macrolide resistance-associated and/or quinolone resistance-associated mutations in M. genitalium DNAs. The presence of M. genitalium DNAs harboring both mutations suggested that some strains of M. genitalium might be evolving into multi-drug resistant ones. We should continue to pay attention to the antimicrobial susceptibility of these pathogens.

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  • Survey of chronological changes of azithromycin resistance and analyses of azithromycin resistance mechanisms in clinical strains of Neisserira gonorrhoeae

    Grant number：22591788  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    DEGUCHI Takashi

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    Clinical strains of Neisseria gonorrhoeae isolated in 2010, 2011 and 2012 were examined for antimicrobial susceptibility to azithromycin. The MIC50 and MIC90, which were defined as minimum concentrations inhibiting the growth of 50% and 90% of the isolates, were 0.25 μg/ml and 0.5 μg/ml, 0.5 μg/ml and 1 μg/ml, and 0.25 μg/ml and 1 μg/ml for the isolates in 2010, 2011, and 2012, respectively. The 23S rRNA genes in the strains were examined for the presence of azxithromycin resistance-associated mutations. Our current study demonstrated that some clinical strains with intermediate resistance to azithromycin have emerged in Japan and that the resistance was associated with the mutation in the 23S rRNA gene.

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  • 分子生物学的手法を用いた淋菌のセフェム系抗菌剤耐性機構の解析

    2004.1

    科学研究費補助金若手研究(B) 

    安田 満

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    Authorship：Principal investigator  Grant type：Competitive

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  • 分子生物学的手法を用いた淋菌のセフェム系抗菌剤耐性機構の解析

    2004 - 2005

    文部科学省  科学研究費補助金(若手研究(B))  若手研究(B)

    安田 満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\3400000 （ Direct Cost: \3400000 ）

    岐阜大学医学部附属病院およびその関連病院泌尿器科に来院した淋菌性男子尿道炎が疑われる患者から尿道分泌物を採取し、分離培養および同定を行った。得られた淋菌臨床分離株は、専用の保存培地に懸濁後-70℃にて各施設にて冷凍保存を行っており一部については当教室に送付され、当教室にて保存を行った。また淋菌臨床分離株の保存を行った淋菌性尿道炎患者より感染源、治療内容など疫学的・臨床的背景を収集した。-70℃にて保存してある淋菌臨床分離菌株のうち当大学に送付・保存された菌株についてはβラクタマーゼ産生の有無を確認の上penicillin G、ampicillin、cefodizime、ceftriaxone、cefpodoxime proxetil、cefxime、cefdinir、levofloxacin、azithromycin、tetracycline、spectinomycin等の抗菌剤のMimimal Inhibitory Concentration(MIC)をCLSI(Clinical and Laboratory Standards Institute)法に準じ寒天平板希釈法にて測定した。感受性測定結果の一部についてはすでに学会にて報告を行っている。またMICを測定した菌株について

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  • Development of rapid and comprehensive molecular diagnosis system for genitourinary infections

    Grant number：16591590  2004 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    DEGUCHI Takashi, YASUDA Mitsuru

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    Grant amount：\3600000 （ Direct Cost: \3600000 ）

    We have designed universal primers which can amplified the 16S rRNA genes of all possible pathogens causing genitourinary tract infections. We have amplified the DNA fragments of the 16s rRNA genes by PCR with the universal primers, and then hybridized the PCR products with each of the oligonucleotides fixed on the plate to identify the pathogens. We have aimed for the establishment of a rapid and comprehensive diagnosis system for genitourinary tract infections.
    To amplify DNA fragments from other microorganisms, including virus and protozoan, we have also designed the primers specific for human papilloma virus, herpes simplex virus, and Trichomonas vaginalis. We have developed the multiplex PCR system to efficiently amplify respective DNA fragment specific for the microorganisms in one tube.
    Neisseria gonorrohoeae, Chlamydia trachomatis, Mycoplasma genitalium, and Ureaplasma urealyticum are recognized as pathogens causing sexually transmitted infections. To detect these pathogens rapidly, therefore, we have developed the real-time PCR-based assay with the primers specific for each pathogen. This assay allows quantitative detection of each pathogen in urine samples.
    Emergence and increase of antibiotics-resistant N. gonorrhoeae is a clinical concern in Japan. In clinical settings, rapid detection of drug susceptibilities to antibiotics is needed for optimal chemotherapy for gonococcal infections. We are developing the molecular diagnosis system for detecting some mutations associated with resistance to fluoroquinolones and beta-lactams.

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  • クラミジア・トラコマティスにおけるニューキノロン耐性機構の分子生物学的解析

    2000

    文部科学省  科学研究費補助金(奨励研究(A))  奨励研究(A)

    安田 満

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1100000 （ Direct Cost: \1100000 ）

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  • 尿路性器感染症、排尿障害

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    Grant type：Competitive

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Social Activities

  • 非常勤講師

    Role(s)： Lecturer

    愛知医科大学  非常勤講師  愛知医科大学  2018.4 - 2019.3

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    Audience： College students,　Graduate students

    2

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  • 非常勤講師

    Role(s)： Lecturer

    愛知医科大学  非常勤講師  2018.4 - 2019.3

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  • 非常勤講師

    愛知医科大学  愛知医科大学  2016.9 - 2017.3

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  • 非常勤講師

    愛知医科大学  愛知医科大学  2016.4 - 2017.3

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  • 非常勤講師

    愛知医科大学  愛知医科大学  2015.9 - 2016.3

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    愛知医科大学  愛知医科大学  2015.4 - 2016.3

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    愛知医科大学  愛知医科大学  2014.4 - 2015.3

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  • 非常勤講師

    ネットワーク大学コンソーシアム岐阜  ネットワーク大学コンソーシアム岐阜  2013.10 - 2014.3

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  • M, genitalium由来の非淋菌性尿道炎にGFLXが有用

    Medical Tribune  Medical Tribune  2005.1

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