Misc - 安田　満

ヒトアデノウイルス陽性男子尿道炎の臨床的特徴

伊藤 晋, 花岡 希, 安田 満, 高梨 真樹, 伊藤 貴子, 出口 隆

日本性感染症学会誌 ( (一社)日本性感染症学会 )  26 ( 2 ) 80 - 80  2015年10月

ALK Gene Translocation in Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report

Kimiaki Takagi, Manabu Takai, Koji Kameyama, Kengo Horie, Mina Kikuchi, Taku Kato, Kosuke Mizutani, Kensaku Seike, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Natsuko Suzui, Masahiro Nakano, Takashi Deguchi

Urology Case Reports ( Elsevier Inc. )  3 ( 5 ) 138 - 140  2015年09月

　概要を見る

A 26-year-old woman with gross hematuria was seen in a previous hospital. Magnetic resonance imaging (MRI) showed a tumor at the dome of the urinary bladder with invasion outside of the bladder wall. The patient underwent transurethral resection of the bladder tumor (TUR-BT). From the result of the pathological examination, the tumor was suggested to be carcinosarcoma of the bladder. The patient was then referred to our hospital for treatment. We performed radical cystectomy and ileal conduit diversion. Pathological examination of the excised specimen revealed an inflammatory myofibroblastic tumor as the basis for immunostaining of anaplastic lymphoma kinase (ALK).

DOI

Three patients with acute myocardial infarction associated with targeted therapy of sorafenib for metastatic renal cell carcinoma: Case report

Kimiaki Takagi, Manabu Takai, Kei Kawata, Kengo Horie, Mina Kikuchi, Taku Kato, Kosuke Mizutani, Kensaku Seike, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Masahiro Nakano, Hiroaki Ushikoshi, Tatsuhiko Miyazaki, Takashi Deguchi

Acta Urologica Japonica ( Editorial Board of Acta Urologica Japonica )  61 ( 9 ) 347 - 351  2015年09月

　概要を見る

Sorafenib is a tyrosine kinase inhibitor (TKI) of the vascular endothelial growth factor receptor (VEGFR) used for advanced renal cell carcinoma. Treatment with sorafenib prolongs progression-free survival in patients with advanced clear-cell renal cell carcinoma. However, in spite of its therapeutic efficacy, sorafenib causes a wide range of adverse events. Cardiovascular adverse events have been observed when sorafenib was used with targeted agents. Although these adverse events like hypertension, reduced left ventricular ejection fraction, cardiac ischemia or infarction were manageable with standard medical therapies in most cases, some had a poor clinical outcome. We report three cases of acute myocardial infarction associated with sorafenib in patients with metastatic renal cell carcinoma.

PubMed

Japanese nationwide surveillance in 2011 of antibacterial susceptibility patterns of clinical isolates from complicated urinary tract infection cases

Kiyohito Ishikawa, Ryoichi Hamasuna, Shinya Uehara, Mitsuru Yasuda, Shingo Yamamoto, Hiroshi Hayami, Satoshi Takahashi, Tetsuro Matsumoto, Shinichi Minamitani, Jun-ichi Kadota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Takashi Deguchi, Minori Matsumoto, Kazushi Tanaka, Soichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Hironobu Wakeda, Yoshinosuke Amemoto, Shoichi Onodera, Hirokazu Goto, Hisao Komeda, Masuo Yamashita, Tadasu Takenaka, Yoshinori Fujimoto, Masaya Tsugawa, Yoshito Takahashi, Hiroshi Maeda, Hiroyuki Onishi, Satoshi Ishitoya, Kazuo Nishimura, Kenji Mitsumori, Toru Ito, Yoshikazu Togo, Ichiro Nakamura, Noriyuki Ito, Sojun Kanamaru, Takaoki Hirose, Takashi Muranaka, Daisuke Yamada, Satoshi Ishihara, Hiroya Oka, Hisato Inatomi, Takashi Matsui, Makoto Kobuke, Yasuharu Kunishima, Takahiro Kimura, Takaharu Ichikawa, Ichiro Kagara, Masanori Matsukawa, Koichi Takahashi, Koji Mita, Masao Kato, Kazuhiro Okumura, Hiroaki Kawanishi, Takayuki Hashimura, Teruyoshi Aoyama, Masanobu Shigeta, Shuntaro Koda, Keisuke Taguchi, Yohei Matsuda

JOURNAL OF INFECTION AND CHEMOTHERAPY ( ELSEVIER SCIENCE BV )  21 ( 9 ) 623 - 633  2015年09月

　概要を見る

To investigate antimicrobial susceptibility patterns of various bacterial pathogens isolated from complicated urinary tract infection (UTI) cases, the Japanese Society of Chemotherapy, the Japanese Association of Infectious Disease, and the Japanese Society of Clinical Microbiology conducted the second nationwide surveillance from January to September 2011. With the cooperation of 42 medical institutions throughout Japan, 1036 strains belonging to 8 clinically relevant bacterial species were collected. Among methicillin-resistant Staphylococcus aureus (MRSA) strain, the vancomycin (VCM) MIC for 5.5% (3/55) of the strains was 2 mu g/mL. Ampicillin, VCM, and linezolid were relatively active against 209 Enterococcus faecalis strains. The proportion of fluoroquinolone (FQ)-resistant strains was >20%. The MIC90 of FQs against the 382 Escherichia coli strains was 2-64 mg/L and the proportion resistant to FQs was approximately 30%. However, susceptibility of E. coli to sitafloxacin was still high (MIC90 = 2 mg/L). Fifty-eight (15.2%) of 382 E. coli, 6 (4.5%) of 132 Klebsiella pneumoniae, 1 (2.4%) of 41 Klebsiella oxytoca and 4 (6.8%) of 59 Proteus mirabilis strains were suspected of producing extended-spectrum beta-lactamase. Of 93 Pseudomonas aeruginosa strains, the proportions resistant to imipenem, amikacin, and ciprofloxacin were 21.5%, 4.3%, and 20.4%, respectively. Four strains (4.3%) were found to be multidrug-resistant. In complicated UTI cases, all of MRSA and E. faecalis were susceptible to all anti-MRSA agents. Sitafloxacin was active against other FQ-resistant E. coli strains. The isolation of extended-spectrum betalactamase-producing and multidrug-resistant strains increased. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI

Re: Adrian Pilatz, Hamid Hossain, Rolf Kaiser, et al. Acute Epididymitis Revisited: Impact of Molecular Diagnostics on Etiology and Contemporary Guideline Recommendations. Eur Urol 2015;68:428-35

Takashi Deguchi, Mitsuru Yasuda, Shin Ito

EUROPEAN UROLOGY ( ELSEVIER SCIENCE BV )  68 ( 3 ) E59 - E60  2015年09月

速報，短報，研究ノート等（学術雑誌）  

DOI

転移性腎細胞癌に対してソラフェニブ内服治療中に心筋梗塞を発症した3例

高木 公暁, 高井 学, 河田 啓, 堀江 憲吾, 菊地 美奈, 加藤 卓, 水谷 晃輔, 清家 健作, 土屋 朋大, 安田 満, 横井 繁明, 仲野 正博, 牛越 博昭, 宮崎 龍彦, 出口 隆

泌尿器科紀要 ( 泌尿器科紀要刊行会 )  61 ( 9 ) 347 - 351  2015年09月

　概要を見る

症例1は69歳男で、左腎癌に対する左腎摘除術後、局所再発、骨・肝・肺転移出現のためソラフェニブ内服を開始した。転移巣の完全消失(CR)後も継続したが、心筋梗塞を発症し、左冠動脈回旋枝と右冠動脈に経皮的冠動脈ステントを留置した。ソラフェニブ内服は中止し、1年8ヵ月経過して腎癌はCRを維持している。症例2は69歳男で、右腎癌に対し右腎摘除術後、多発肺転移を認め、ソラフェニブを10ヵ月継続したが、急性心筋梗塞を発症した。右冠動脈および左冠動脈前下行枝に対しカテーテル治療を行ったが、心不全が進行し第10病日に死亡した。症例3は59歳男で、右腎癌に対し右腎摘除術後、肺転移を認め、ソラフェニブを8ヵ月間継続したが、心筋梗塞を発症した。右冠動脈および左冠動脈前下行枝に冠動脈ステントを留置した。ソラフェニブを中止しtemsirolimus投与を開始したが、副作用のため中止となり、その後緩和治療へ移行した。

Development and clinical application of an InvaderPlus® assay for the detection of genital mycoplasmas

Masaki Takanashi, Shin Ito, Hiroyuki Kaneto, Yoshikatsu Tanahashi, Masataka Kitanohara, Akira Yanagihara, Haruhiko Nakazima, Mitsuru Yasuda

Journal of Infection and Chemotherapy ( ELSEVIER SCIENCE BV )  21 ( 7 ) 516 - 519  2015年07月

　概要を見る

© 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. We developed a PCR-based assay involving Invader® technology for detection of the genital mycoplasmas of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum. We compared its performance with that of a PCR-microtiter plate hybridization assay, which we developed previously, in detecting genital mycoplasmas in first-voided urine (FVU) specimens from men with non-gonococcal urethritis. The tests targeting each of the genital mycoplasmas were specific for the respective species and could detect as few as 10 copies of the plasmids containing the target genes of each of the genital mycoplasmas per reaction. The assay using the InvaderPlus® method (InvaderPlus® assay) showed very similar performance to that of the PCR-microtiter plate hybridization assay for detecting the genital mycoplasmas in the FVU specimens. In addition, the PCR and endonuclease reaction in the InvaderPlus® assay were carried out simultaneously in one procedure, thus simplifying the assay, leading to time- and labor-savings and a decrease in the risk of specimen contamination. The In

DOI PubMed

Drug Resistance-Associated Mutations in Mycoplasma genitalium in Female Sex Workers, Japan

Takashi Deguchi, Mitsuru Yasuda, Kengo Horie, Kensaku Seike, Mina Kikuchi, Kohsuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Shinji Hoshina

EMERGING INFECTIOUS DISEASES ( CENTERS DISEASE CONTROL )  21 ( 6 ) 1062 - 1064  2015年06月

　概要を見る

Mycoplasma genitalium was detected in 21(14.1%) of 149 vaginal swab samples and in 1 (0.7%) of 149 throat washing samples from female sex workers during 2013-2014 in Japan. Prevalences of M. genitalium with macrolide resistance associated 23S rRNA mutations and fluoroquinolone resistance associated parC alterations were 47.1% and 36.8%, respectively.

DOI

The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Shinya Uehara, Hiroshi Hayami, Satoshi Takahashi, Tetsuro Matsumoto, Shingo Yamamoto, Shinichi Minamitani, Akira Watanabe, Satoshi Iwata, Mitsuo Kaku, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi Tanaka, Soichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Kentaro Kuroiwa, Hideo Hirayama, Harunori Narita, Takahide Hosobe, Shin Ito, Kenji Ito, Shuichi Kawai, Masayasu Ito, Hirofumi Chokyu, Masaru Matsumura, Masaru Yoshioka, Satoshi Uno, Koichi Monden, Kazuo Takayama, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Hitoshi Kadena, Takamasa Yamaguchi, Shinichi Maeda, Shohei Nishi, Hirofumi Nishimura, Takeshi Shirane, Mutsumasa Yoh, Kikuo Akiyama, Toshio Imai, Motonori Kano

JOURNAL OF INFECTION AND CHEMOTHERAPY ( ELSEVIER SCIENCE BV )  21 ( 5-6 ) 340 - 345  2015年05月

　概要を見る

Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 mu g/ml, and 11(10.7%) strains were considered less susceptible with an MIC of 0.125 mu g/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 mu g/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1 mu g/ml. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI

The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Shinya Uehara, Hiroshi Hayami, Satoshi Takahashi, Tetsuro Matsumoto, Shingo Yamamoto, Shinichi Minamitani, Akira Watanabe, Satoshi Iwata, Mitsuo Kaku, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi Tanaka, Soichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Kentaro Kuroiwa, Hideo Hirayama, Harunori Narita, Takahide Hosobe, Shin Ito, Kenji Ito, Shuichi Kawai, Masayasu Ito, Hirofumi Chokyu, Masaru Matsumura, Masaru Yoshioka, Satoshi Uno, Koichi Monden, Kazuo Takayama, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Hitoshi Kadena, Takamasa Yamaguchi, Shinichi Maeda, Shohei Nishi, Hirofumi Nishimura, Takeshi Shirane, Mutsumasa Yoh, Kikuo Akiyama, Toshio Imai, Motonori Kano

JOURNAL OF INFECTION AND CHEMOTHERAPY ( ELSEVIER SCIENCE BV )  21 ( 5-6 ) 340 - 345  2015年05月

　概要を見る

Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 mu g/ml, and 11(10.7%) strains were considered less susceptible with an MIC of 0.125 mu g/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 mu g/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1 mu g/ml. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI

マイコプラズマ、アデノウイルス、単純ヘルペスウイルス、腟トリコモナスを含む尿道炎起炎微生物の検討

伊藤 晋, 安田 満, 高梨 真樹, 花岡 希, 前田 真一, 出口 隆

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  103回   524 - 524  2015年04月

Sitafloxacin: Antimicrobial activity against ciprofloxacin-selected laboratory mutants of Mycoplasma genitalium and inhibitory activity against its DNA gyrase and topoisomerase IV

Takashi Deguchi, Mina Kikuchi, Mitsuru Yasuda, Shin Ito

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER JAPAN KK )  21 ( 1-2 ) 74 - 75  2015年01月

　概要を見る

A sitafloxacin regimen is highly effective on Myco plasma genitalium infections, including those caused by the mycoplasmas harboring mutant topoisomerase IV with a quinolone resistance-associated amino acid change in ParC. In this study, we evaluated sitafloxacin antimicrobial activities against M. genitalium, including the mycolasmas with decreased susceptibilities to quinolones, by determining minimum inhibitory concentrations (MICs) for the strain ATCC 33530 and its 3 ciprofloxacin-selected mutants, for which ciprofloxacin MICs were 8-16 times higher than that for their parent strain. We also evaluated inhibitory activities against the target enzymes of M. genitalium by determining concentrations required to inhibit 50% (IC50) of the supercoiling activity of the recombinant wild-type DNA gyrase and the decatenating activities of the recombinant wild-type topoisomerase IV and the 2 types of mutant topoisomerase IV with a single amino acid change in ParC. Sitafloxacin MICs were 0.125 for the parent strain and 0.125-0.25 mu g/ml for the mutants. Sitafloxacin IC50s were 3.12 for the supercoiling activity of the wild-type DNA gyrase and 2.98 mu g/ml for the decatenating activity of the wild-type topoisomerase IV. Its IC50s for the decatenating activity of the mutant topoisomerase IV harboring an amino acid change in ParC were 15.1 for Gly-81 -> Cys and 7.92 mu g/ml for Asp-87 -> Tyr. Sitafloxacin was highly active against ciprofloxacin-selected mutants of M. genitalium and possessed intense inhibitory activities not only against wild-type DNA gyrase and topoisomerase IV but also against mutant topoisomerase IV containing ParC with a quinolone resistance-associated amino acid change. Sitafloxacin could be a promising agent for M. genitalium infections. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI PubMed

Atazanavir-Induced Urine Crystals Demonstrated by Infrared Spectroscopic Analysis

Isao Inagaki, Mariko Adachi, Hiroyasu Ito, Mitsuru Yasuda, Hisashi Tsurumi, Takashi Deguchi, Mitsuru Seishima

UROLOGIA INTERNATIONALIS ( KARGER )  94 ( 1 ) 121 - 124  2015年

　概要を見る

Atazanavir sulfate, an azapeptide inhibitor of HIV protease, has been associated with urolithiasis. A 60-year-old man with atazanavir-induced urinary sediment crystals verified by infrared spectroscopic analysis is described. He had been receiving highly active antiretroviral therapy (HAART) for HIV infection and also had a history of urinary lithiasis and been undergoing urinalysis once every month. Needle-shaped crystals were seen in his urine sediment and infrared spectroscopic analysis revealed that these were atazanavir crystals. Because the presence of the crystals in urine do not always reveal an abnormality in the urinary test strip analysis, the urinary sediment needed to be observed microscopically in order to prevent future urolithiasis and renal failure in this HIV patient receiving atazanavir. (C) 2013 S. Karger AG, Basel

DOI PubMed

[Conservative management of symptomatic or asymptomatic urinoma after grade III blunt renal trauma: a report of three cases].

Mina Kikuchi, Koji Kameyama, Kengo Horie, Kosuke Mizutani, Kensaku Seike, Taku Kato, Takashi Sugawara, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi, Hiroshi Kondo, Yoji Moriyama, Hidetoshi Ehara

Hinyokika kiyo. Acta urologica Japonica   60 ( 12 ) 615 - 20  2014年12月   [ 国内誌 ]

　概要を見る

The management of urinoma after blunt renal trauma is still controversial, ranging from percutaneous drainage or ureteral stent placement for the symptomatic urinoma and waiting for spontaneous vanishment of the asymptomatic urinoma. We present two cases of symptomatic urinoma and a case of asymptomatic urinoma after renal laceration. All patients underwent selective renal arterial embolization for vascular complications, including active bleeding, pseudoaneurysm and arteriovenous fistula. Urinomas, which had been observed in all cases gradually reduced and vanished 1-24 months later. All cases were successfully managed without catheterization or percutaneous drainage for urinoma.

PubMed

Usefulness of quantifying leukocytes in first-voided urine to predict positivity for Chlamydia trachomatis in asymptomatic men at high risk for chlamydial infection

Shin Ito, Kengo Horie, Kensaku Seike, Mitsuru Yasuda, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER JAPAN KK )  20 ( 12 ) 748 - 751  2014年12月

　概要を見る

Chlamydia trachomatis causes acute non-gonococcal urethritis, but some infected men are asymptomatic. We examined leukocytes in uncentrifuged first-voided urine (FVU) from asymptomatic men at high risk for chlamydial infection by automated urine particle analyzers to assess whether the quantification of urinary leukocytes could predict chlamydial infection in these men. We enrolled 209 asymptomatic men, whose female sexual partners had been diagnosed as having a genital chlamydial infection. Their FVU specimens were examined for quantification of leukocytes with automated urine particle analyzers and tested for Neisseria gonorrhoeae, C. trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum by nucleotide acid amplification tests. Eleven men positive for N. gonorrhoeae or M. genitalium were excluded from further analysis. In the remaining 198 men, 84 positive for C. trachomatis (42.4%) had 1.8-1666.9 white blood cells (WBCs)/mu l (median, 43.3 WBCs/mu l) in their FVU, whereas 114 negative for C. trachomatis had 0.1-1378 WBCs/mu l (median, 4.8 WBCs/mu l). A receiver operating characteristic (ROC) curve was constructed to examine the sensitivity and specificity of leukocytes counts for predicting chlamydial infection. A cut-off point of leukocyte counts of 12.5 WBCs/mu l was determined from the ROC curve, resulting in a sensitivity of 86.9% and specificity of 88.6% for predicting chlamydial infection. Leukocyte quantification in FVU by automated urine particle analyzers showed good performance in predicting the positivity and negativity for chlamydial infection in asymptomatic men. This test could potentially develop into a relevant tool for preselecting asymptomatic men prior to C. trachomatis screening. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI PubMed

Usefulness of quantifying leukocytes in first-voided urine to predict positivity for Chlamydia trachomatis in asymptomatic men at high risk for chlamydial infection

Shin Ito, Kengo Horie, Kensaku Seike, Mitsuru Yasuda, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER JAPAN KK )  20 ( 12 ) 748 - 751  2014年12月

　概要を見る

Chlamydia trachomatis causes acute non-gonococcal urethritis, but some infected men are asymptomatic. We examined leukocytes in uncentrifuged first-voided urine (FVU) from asymptomatic men at high risk for chlamydial infection by automated urine particle analyzers to assess whether the quantification of urinary leukocytes could predict chlamydial infection in these men. We enrolled 209 asymptomatic men, whose female sexual partners had been diagnosed as having a genital chlamydial infection. Their FVU specimens were examined for quantification of leukocytes with automated urine particle analyzers and tested for Neisseria gonorrhoeae, C. trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum by nucleotide acid amplification tests. Eleven men positive for N. gonorrhoeae or M. genitalium were excluded from further analysis. In the remaining 198 men, 84 positive for C. trachomatis (42.4%) had 1.8-1666.9 white blood cells (WBCs)/mu l (median, 43.3 WBCs/mu l) in their FVU, whereas 114 negative for C. trachomatis had 0.1-1378 WBCs/mu l (median, 4.8 WBCs/mu l). A receiver operating characteristic (ROC) curve was constructed to examine the sensitivity and specificity of leukocytes counts for predicting chlamydial infection. A cut-off point of leukocyte counts of 12.5 WBCs/mu l was determined from the ROC curve, resulting in a sensitivity of 86.9% and specificity of 88.6% for predicting chlamydial infection. Leukocyte quantification in FVU by automated urine particle analyzers showed good performance in predicting the positivity and negativity for chlamydial infection in asymptomatic men. This test could potentially develop into a relevant tool for preselecting asymptomatic men prior to C. trachomatis screening. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI

Nationwide survey of urogenital tuberculosis in Japan

Keita Nakane, Mitsuru Yasuda, Takashi Deguchi, Satoshi Takahashi, Kazushi Tanaka, Hiroshi Hayami, Ryoichi Hamasuna, Shingo Yamamoto, Soichi Arakawa, Tetsuro Matsumoto

INTERNATIONAL JOURNAL OF UROLOGY ( WILEY-BLACKWELL )  21 ( 11 ) 1171 - 1177  2014年11月

　概要を見る

ObjectivesTo determine current epidemiology and treatment patterns of urogenital tuberculosis in Japan. MethodsA questionnaire was sent to the urological departments of 1203 Japanese hospitals. Clinical data was reviewed retrospectively; no time range was specified. ResultsOf the 1203 hospitals, 399 returned questionnaires with information about 355 urogenital tuberculosis patients. Of the 399, 153 institutions reported at least one patient, and 201 patients were identified between 2000 and 2007. Infections were located in the kidneys (n=242), ureter (n=96), bladder (n=100), epididymis or testes (n=81) and prostate (n=9). ConclusionsUrogenital tuberculosis is rare in Japan, but patients do exist, and we should not ignore them.

DOI

A single 2 g oral dose of extended-release azithromycin for treatment of gonococcal urethritis

Mitsuru Yasuda, Shin Ito, Akira Kido, Kiminari Hamano, Yutaka Uchijima, Noriyasu Uwatoko, Hiroyuki Kusuyama, Akiko Watanabe, Ryuzou Miyamura, Kazutoyo Miyata, Takashi Deguchi

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY ( OXFORD UNIV PRESS )  69 ( 11 ) 3116 - 3118  2014年11月

　概要を見る

We treated gonococcal urethritis in men with a single 2 g dose of azithromycin extended-release formulation (azithromycin-SR) to determine its microbiological outcomes and tolerability. We enrolled 189 Japanese men with gonococcal urethritis between April 2009 and December 2013. The patients were given a single 2 g dose of azithromycin-SR. Microbiological efficacy was evaluated by the results of the post-treatment molecular testing of Neisseria gonorrhoeae. MIC testing was performed only for pretreatment isolates of N. gonorrhoeae collected from the patients. We evaluated 130 patients for microbiological outcomes. Of these patients, 122 (93.8%) were judged to be microbiologically cured on the basis of negative test results. All isolates for which the azithromycin MICs were a parts per thousand currency sign0.25 mg/L were eradicated, whereas 5 of 12 isolates for which the MICs were 1 mg/L persisted after the treatment. Forty-six adverse events occurred in 41 patients. However, all adverse events were classified as mild. The eradication rate of N. gonorrhoeae was 93.8% in men with gonococcal urethritis treated with a single 2 g dose of azithromycin-SR. The breakpoint MIC of a 2 g dose of azithromycin-SR for gonococcal urethritis associated with clinical treatment failures appeared to be 1 mg/L. With regard to side effects of higher doses of azithromycin, the 2 g dose of azithromycin-SR appeared to improve tolerability. However, the widespread use of a high-dose regimen of azithromycin might lead to the development of further resistance to azithromycin.

DOI PubMed

Small cell carcinoma of the prostate effectively treated for relatively long term: A case report

Kengo Horie, Koji Kameyama, Kosuke Mizutani, Takashi Sugawara, Kensaku Seike, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi, Natsuko Suzui, Yoshinobu Hirose

Acta Urologica Japonica ( Editorial Board of Acta Urologica Japonica )  60 ( 10 ) 517 - 521  2014年10月

　概要を見る

A 72-year-old Japanese man was referred to a hospital because of urinary retention. Digital rectal examination revealed a stony, hard nodule in the prostate. A high level of serum PSA was not detected. Prostatic biopsy was performed, and pathological examination indicated adenocarcinoma of the prostate. He was referred to our hospital for treatment. Imaging examinations revealed no metastases (T4N0M0), so we re-evaluated the biopsy specimens. Immunohistochemical examination revealed prostatic small cell carcinoma. His levels of neuron-specific enolase (NSE) and pro-gastrin-releasing peptide (Pro-GRP) were high. We treated him with combination chemotherapy comprising irinotecan and cisplatin, and the treatment was effective. After four courses of the chemotherapy, levels of NSE and Pro-GRP had decreased, and the prostatic mass had decreased in size. Needle rebiopsy of the prostate demonstrated no evidence of malignancy. Adjuvant external beam radiation therapy was also performed. The patient is still alive at 18 month after diagnosis with no evidence of relapse or metastasis of the disease. Key word: Prostatic small cell carcinoma.

PubMed

Erratum: Occurrence of infection following prostate biopsy procedures in Japan: Japanese Research Group for Urinary Tract Infection (JRGU) - A multi-center retrospective study (Journal of Infection and Chemotherapy (2014) 20 (232-237))

Yoshikazu Togo, Tatsuhiko Kubo, Rikiya Taoka, Yoshiki Hiyama, Teruhisa Uehara, Jiroh Hashimoto, Yuichiro Kurimura, Satoshi Takahashi, Taiji Tsukamoto, Jun Miyazaki, Hiroyuki Nishiyama, Shinichiro Kira, Hiroshi Kiyota, Satoshi Yazawa, Naoya Niwa, Hiroshi Hongo, Mototsugu Oya, Taku Kato, Mitsuru Yasuda, Takashi Deguchi, Kiyohito Ishikawa, Kiyotaka Hoshinaga, Minori Matsumoto, Katsumi Shigemura, Kazushi Tanaka, Soichi Arakawa, Masato Fujisawa, Koichiro Wada, Shinya Uehara, Toyohiko Watanabe, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Masahiro Matsumoto, Takehiko Sho, Ryoichi Hamasuna, Tetsuro Matsumoto, Hiroshi Hayami, Masayuki Nakagawa, Shingo Yamamoto

Journal of Infection and Chemotherapy ( Japanese Society for Cancer Chemotherapy )  20 ( 10 ) 660  2014年10月

DOI