Misc - 安田　満

Serotyping of quinolone-resistant neisseria gonorrhoeae isolates with alterations in GyrA and ParC [2]

T. Deguchi, M. Yasuda, S. I. Maeda, I. Saito, Y. Kawada

Journal of Antimicrobial Chemotherapy   41 ( 3 ) 418 - 420  1998年

速報，短報，研究ノート等（学術雑誌）  

DOI PubMed

Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Pseudomonas aeruginosa with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV

Masahiro Nakano, Takashi Deguchi, Mitsuru Yasuda, Shigehiko Ozeki, Yoshinori Nishino, Satoshi Ishihara, Yukimichi Kawada

Journal of Infection and Chemotherapy ( Springer Japan )  4 ( 3 ) 142 - 144  1998年

　概要を見る

The in vitro antimicrobial activity of DU-6859a, a new fluoroquinolone, was tested against 22 clinical isolates of Pseudomonas aeruginosa, including strains with fluoroquinolone resistance-associated alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV. The MICs of DU-6859a for 10 isolates with both altered GyrA and ParC and for 7 isolates with altered GyrA alone ranged from 1.56 to 25 μg/mL and from 0.78 to 6.25 μg/mL, respectively. The MIC of DU-6859a at which 90% of the strains were inhibited (MIC90) of these 17 isolates was 12.5 μg/mL. However, there was no significant difference between DU-6859a and the other quinolones tested against 5 strains which did not have any alterations of either GyrA or ParC. Based on the MIC90s, DU-6859a exhibited 8- to 32-fold greater activity than the currently available fluoroquinolones against strains having alterations in DNA gyrase and topoisomerase IV. © JSC/CLJ 1998.

DOI

尿路性器感染症における Mycoplasma genitalium の病原的意義

出口 隆, 安田 満, 宇野 雅博

日本マイコプラズマ学会雑誌 = Japanese Journal of Mycoplasmology   24   37 - 40  1997年12月

CiNii

In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Klebsiella pneumoniae and Enterobacter cloacae with fluoroquinolone resistance-associated amino acid alterations in GyrA and ParC

T Deguchi, M Yasuda, T Kawamura, Y Takahashi, E Okezaki, O Nagata, H Kato, Y Kawada

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY ( OXFORD UNIV PRESS )  40 ( 6 ) 907 - 909  1997年12月

速報，短報，研究ノート等（学術雑誌）  

尿由来緑膿菌におけるgyrA遺伝子変異の臨床的意義に関する研究

河田 幸道, 出口 隆, 仲野 正博, 安田 満

日本化学療法学会雜誌 = Japanese journal of chemotherapy   45 ( 9 ) 750 - 756  1997年09月

CiNii

Quinolone-Resistant Neisseria gonorrhoeae

DEGUCHI Takashi, YASUDA Mitsuru, SAITO Isao, KAWADA Yukimichi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   3 ( 2 ) 73 - 84  1997年06月

CiNii

Uncommon occurrence of mutations in the gyrB gene associated with quinolone resistance in clinical isolates of Neisseria gonorrhoeae

T Deguchi, M Yasuda, M Nakano, S Ozeki, E Kanematsu, Y Kawada, T Ezaki, Saito, I

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY ( AMER SOC MICROBIOLOGY )  40 ( 10 ) 2437 - 2438  1996年10月

速報，短報，研究ノート等（学術雑誌）  

陰嚢内平滑筋肉腫の1例

尾関 茂彦, 安田 満, 仲野 正博, 石原 哲, 出口 隆, 坂 義人, 河田 幸道, 武田 明久

泌尿器科紀要 ( 泌尿器科紀要刊行会 )  42 ( 3 ) 229 - 231  1996年03月

　概要を見る

A case of leiomyosarcoma of the scrotum is reported. A 44-year-old man referred to our hospital with the complaint of swelling of the left scrotal contents. The lesion was about 3 cm in diameter, isolated from testis, epididymis and spermatic cord. Ultrasonography revealed hypoechoic and slightly heterogenic area in the lesion. Surgical resection was easily done. Histological examination showed leiomyosarcoma. Adjuvant therapy was not performed. Three years after the resection, he is alive without any sign of recurrence or metastasis.

CiNii

淋菌におけるキノロン耐性遺伝子変異の簡易検査法

出口 隆, 安田 満, 宇野 雅博, 仲野 正博, 尾関 茂彦, 河田 幸道

日本性感染症学会誌 = Japanese archives of sexually transmitted diseases   6 ( 2 ) 77 - 77  1995年11月

CiNii

男子尿道炎の7年間の臨床統計

前田 真一, 玉木 正義, 安田 満, 仲野 正博, 出口 隆, 坂 義人, 河田 幸道

日本性感染症学会誌 = Japanese archives of sexually transmitted diseases   6 ( 2 ) 28 - 28  1995年11月

CiNii

PCR法による男子非淋菌性尿道炎患者からの Mycoplasma genitalium の検出

米田 尚生, 出口 隆, 安田 満, 多田 晃司, IWATA HIDEKI, 石原 哲, 坂 義人, 河田 幸道, 江崎 孝行, 斉藤 功

日本マイコプラズマ学会雑誌 = Japanese Journal of Mycoplasmology   21   73 - 74  1995年10月

CiNii

複雑性尿路感染症由来Enterococcus faecalisの臨床的検討と薬剤感受性について

石原 哲, 安田 満, 多田 晃司, 米田 尚生, 伊藤 康久, 斉藤 昭弘, 出口 隆, 栗山 学, 坂 義人, 河田 幸道

日本化学療法学会雜誌 = Japanese journal of chemotherapy   43 ( 4 ) 451 - 456  1995年04月

CiNii

DNA GYRASE MUTATIONS IN QUINOLONE-RESISTANT CLINICAL ISOLATES OF NEISSERIA-GONORRHOEAE

T DEGUCHI, M YASUDA, M ASANO, K TADA, H IWATA, H KOMEDA, T EZAKI, SAITO, I, Y KAWADA

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY ( AMER SOC MICROBIOLOGY )  39 ( 2 ) 561 - 563  1995年02月

記事・総説・解説・論説等（学術雑誌）  

　概要を見る

Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.

Mycoplasma genitalium in non-gonococcal urethritis [2]

T. Deguchi, H. Komeda, M. Yasuda, K. Tada, H. Iwata, M. Asano, T. Ezaki, Y. Kawada

International Journal of STD and AIDS   6   144 - 145  1995年01月

PubMed

Macrolide resistance-associated 23s rRNA mutation in Mycoplasma Genitalium, Japan

Yasushi Shimada, Yasushi Shimada, Takashi Deguchi, Keita Nakane, Mitsuru Yasuda, Shigeaki Yokoi, Shin Ichi Ito, Masahiro Nakano, Shin Ito, Hiroaki Ishiko

Emerging Infectious Diseases   17   1148 - 1149  1978年

DOI PubMed