WADA Nobuhiro

写真a

Affiliation

School of Medicine, Department of Anatomy (1)

Job title

Assistant Professor

Homepage URL

https://web.sapmed.ac.jp/anatomy1/index.html

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Degree 【 display / non-display 】

  • 東京大学   博士 (医学)

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Research Experience 【 display / non-display 】

  • 2022.04
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    Now

    札幌医科大学医学部医学科   解剖学第一講座   助教

  • 2019.04
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    2022.03

    国立研究開発法人医薬基盤・健康・栄養研究所 国立健康・栄養研究所   臨床栄養研究部   任期付研究員

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Professional Memberships 【 display / non-display 】

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    Now

    日本解剖学会

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    日本栄養・食糧学会

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    Now

    日本生化学会

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    Now

    日本DOHaD学会

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    Now

    日本糖尿病・肥満動物学会

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Research Areas 【 display / non-display 】

  • Life sciences   Nutrition and health science  

  • Life sciences   Metabolism and endocrinology  

  • Life sciences   Anatomy  

  • Life sciences   Physiology  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   Department of anatomy Ⅰ  

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Research Interests 【 display / non-display 】

  • 核内脂肪滴

  • DOHaD

  • 葉酸

  • 糖尿病

  • ガラニン様ペプチド (GALP)

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Papers 【 display / non-display 】

  • Associations of sleep quality with the skeletal muscle strength in patients with type 2 diabetes with poor glycemic control.

    Takanori Hayashi, Nobuhiro Wada, Tetsuya Kubota, Chie Koizumi, Yoshitaka Sakurai, Masakazu Aihara, Satoshi Usami, Toshimasa Yamauchi, Naoto Kubota

    Journal of diabetes investigation   14 ( 6 ) 801 - 810  2023.06  [Domestic journal]

    　View Summary

    AIMS/INTRODUCTION: Patients with type 2 diabetes mellitus are reported to be at a high risk for sarcopenia, and are known to have a poorer sleep quality. However, the association between sleep quality and skeletal muscle in patients with type 2 diabetes mellitus is not yet precisely understood. MATERIALS AND METHODS: A total of 110 inpatients with type 2 diabetes mellitus aged 40-90 years were enrolled. The sleep quality was assessed using the Pittsburgh sleep quality index (PSQI). Skeletal muscle mass was measured using bioelectrical impedance analysis. Muscle strength was evaluated by measuring the grip strength. We also performed dietary surveys and measurements of the plasma amino acid levels. RESULTS: A high total score on the PSQI was significantly associated with reduced muscle strength, and the association persisted even after adjustments for confounders. On the other hand, adjusted analysis did not reveal any significant associations between the PSQI total score and the skeletal muscle mass. In regard to the associations with subscores of the PSQI, the scores for sleep latency, sleep efficiency, and daytime dysfunction were significantly negatively associated with the muscle strength. Although poor sleep quality was associated with a high confectionery intake and low plasma arginine, citrulline, and ornithine levels, neither confectionery intake levels nor the plasma levels of these amino acids was associated with the muscle strength. CONCLUSIONS: Our study revealed a significant association between the sleep quality and muscle strength in patients with type 2 diabetes mellitus. These results suggest that poor sleep quality is an important risk factor for sarcopenia in patients with type 2 diabetes mellitus.

    DOI PubMed

  • Excessive folic acid supplementation in pregnant mice impairs insulin secretion and induces the expression of genes associated with fatty liver in their offspring

    Yuri Kintaka, Nobuhiro Wada, Seiji Shioda, Sadako Nakamura, Yuko Yamazaki, Kazuki Mochizuki

    Heliyon ( Elsevier {BV} )  6 ( 4 )  2020.04

    DOI

  • Effect of Intranasal Administration of Galanin-like Peptide (GALP) on Body Weight and Hepatic Lipids Accumulation in Mice with Diet-induced Obesity

    Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe, Seiji Shioda

    Current Pharmaceutical Design ( Bentham Science Publishers Ltd. )  23 ( 25 )  2017.09

    DOI

  • Behavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8

    Nobuhiro Wada, Satoru Yamanaka, Junko Shibato, R, eep Rakwal, Satoshi Hirako, Yuzuru Iizuka, Hyounju Kim, Akiyo Matsumoto, Ai Kimura, Fumiko Takenoya, Genta Yasunaga, Seiji Shioda

    Genomics Data ( Elsevier {BV} )  10   38 - 50  2016.12

    Authorship：   Lead author

    　View Summary

    This study investigates effects of dipeptide balenine, as a major component of whale meat extract (hereafter, WME), supplementation on senescence-accelerated mouse prone 8 (SAMP8), an Alzheimer's disease (AD) model at level of learning and memory formation and brain expression profiles genome-wide in brain. Mice fed experimental balenine (+ WME) supplemented diet for 26 weeks were subjected to four behavioral tests – open field, Y-maze, novel object recognition, and water-filled multiple T-maze – to examine effects on learning and memory. Brain transcriptome of SAMP8 mice-fed the WME diet over control low-safflower oil (LSO) diet-fed mice was delineated on a 4 × 44 K mouse whole genome DNA microarray chip. Results revealed the WME diet not only induced improvements in the learning and memory formation but also positively modulated changes in the brain of the SAMP8 mouse; the gene inventories are publically available for analysis by the scientific community. Interestingly, the SAMP8 mouse model presented many genetic characteristics of AD, and numerous novel molecules (Slc2a5, Treh, Fbp1, Aldob, Ppp1r1a, DNase1, Agxt2l1, Cyp2e1, Acsm1, Acsm2, and Pah) were revealed over the SAMR1 (senescence-accelerated mouse resistant 1) mouse, to be oppositely regulated/recovered under the balenine (+ WME) supplemented diet regime by DNA microarray and bioinformatics analyses. Our present study demonstrates an experimental strategy to understand the effects of dipeptide balenine, prominetly contained in meat diet, on SAMP8, providing new insight into whole brain transcriptome changes genome-wide. The gene expression data has been deposited into the Gene Expression Omnibus (GEO): GSE76459. The data will be a valuable resource in examining the effects of natural products, and which could also serve as a human model for further functional analysis and investigation.

    DOI CiNii

  • Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice

    Haruaki Kageyama, Kanako Shiba, Satoshi Hirako, Nobuhiro Wada, Satoru Yamanaka, Yukinori Nogi, Fumiko Takenoya, Naoko Nonaka, Tsutomu Hirano, Shuji Inoue, Seiji Shioda

    Scientific Reports ( Springer Science and Business Media {LLC} )  6 ( 1 )  2016.09

    DOI

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Books and Other Publications 【 display / non-display 】

  • Handbook of hormones : comparative endocrinology for basic and clinical research

    安東, 宏徳, Ukena, Kazuyoshi, Nagata, Shinji( Part： Contributor, Alarin)

    Academic Press  2021 ISBN: 9780323851947

  • Handbook of hormones : comparative endocrinology for basic and clinical research

    安東, 宏徳, Ukena, Kazuyoshi, Nagata, Shinji( Part： Contributor, Leptin)

    Academic Press  2021 ISBN: 9780323851947

  • Handbook of hormones : comparative endocrinology for basic and clinical research

    安東, 宏徳, Ukena, Kazuyoshi, Nagata, Shinji( Part： Contributor, Galanin peptide family)

    Academic Press  2021 ISBN: 9780323851947

  • The Lipid 第28巻4号

    泉田欣彦, 和田亘弘( Part： Contributor, 【第5回】 近親婚が同率で行われるコホートにおけるヒト・ノックアウトと表現型解析)

    メディカルレビュー社  2017

  • Handbook of hormones : comparative endocrinology for basic and clinical research

    竹井, 祥郎, 安東, 宏徳, 筒井, 和義( Part： Contributor, Leptin)

    Academic Press is an imprint of Elsevier  2016 ISBN: 9780128010280

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Misc 【 display / non-display 】

  • 2型糖尿病患者における睡眠と筋力・骨格筋量の関連の解析

    和田亘弘, 林高則, 小泉千恵, 窪田哲也, 窪田直人

    日本病態栄養学会誌(Web) ( (一社)日本病態栄養学会 )  24/25 ( Supplement ) S - 103  2022

    J-GLOBAL

  • 糖質・脂肪酸エネルギー基質動員に関する協調制御機構の解明

    和田亘弘, 和田亘弘, 泉田欣彦, 泉田欣彦, 矢作直也, 矢作直也, 武内謙憲, 武内謙憲, 升田紫, 升田紫, 李恩旭, 李恩旭, 沢田義一, 沢田義一, 呼延宜人, 呼延宜人, 島野仁, 門脇孝

    日本栄養・食糧学会大会講演要旨集 ( (一社)日本糖尿病学会 )  72nd ( Suppl.1 ) S - 164  2018

    J-GLOBAL

  • 妊娠期における葉酸の過剰摂取が仔の代謝障害誘導機構に及ぼす影響

    和田 亘弘, 根岸 りの, 金高 有里, 大埼 雄樹

    DOHaD研究 ( 一般社団法人 日本DOHaD学会 )  12 ( 3 ) 220 - 220  2024.10

    DOI

  • 核膜形態制御分子による核膜陥入構造と脂肪滴形成機序の解明

    和田 亘弘, 室松 悠希, 本城 愛子, 大崎 雄樹

    日本栄養・食糧学会大会講演要旨集 ( (公社)日本栄養・食糧学会 )  78回   231 - 231  2024.04

  • 胎生期人工性葉酸過剰摂取による出生仔の雌雄における代謝性疾患誘導とフラクトオリゴ糖摂取による影響の違い

    金高 有里, 和田 亘弘, 奥田 明日香, 田辺 賢一, 望月 和樹, 中山 敏幸, 竹嶋 伸之輔, 中村 禎子

    日本栄養・食糧学会大会講演要旨集 ( (公社)日本栄養・食糧学会 )  78回   287 - 287  2024.04

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Industrial Property Rights 【 display / non-display 】

  • 肝分泌型代謝制御因子阻害作用による肥満関連疾患治療剤

    泉田欣彦, 和田亘弘, 升田紫, 門脇孝

    Patent

  • 鯨筋肉抽出物からなる中長期記憶障害予防改善剤

    ShidaSeiji, WadaNobuhiro, HirakoSatoshi

    Patent

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Awards 【 display / non-display 】

  • 日本病態栄養学会 座長賞

    2022.01  

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Research Projects 【 display / non-display 】

  • 妊娠期の葉酸過剰摂取が仔の膵β細胞のエピゲノムに及ぼす影響の解明

    若手研究

    Project Year :

    2025.04
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    2028.03
     

    和田 亘弘

  • 周産期の葉酸過剰摂取が仔の膵β細胞のエピゲノムに及ぼす影響の解明

    個人研究奨励金

    Project Year :

    2024.07
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    2025.07
     

    和田 亘弘

  • 脂肪滴の細胞質および核内での生理機能解明

    基盤研究(B)

    Project Year :

    2024.04
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    2027.03
     

    大崎 雄樹, 和田 亘弘

  • 周産期の栄養環境が次世代のエピジェネティックな発現調節制御に及ぼす影響について

    Project Year :

    2022.10
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    2024.03
     

  • 神経ペプチドGALPによるへパトカインを介した新規代謝制御機構の解明

    基盤研究(C)

    Project Year :

    2025.04
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    2029.03
     

    平子 哲史

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Presentations 【 display / non-display 】

  • 核膜形態制御因子による脂肪滴形成への関与

    和田亘弘, 本城愛子, 室松悠希, 大﨑雄樹

    第77回日本栄養・食糧学会学術集会 

    Presentation date： 2023.05

    Event date：
    2023.05
    　
    　

  • 核膜形態制御分子の脂肪滴形成への関与

    和田亘弘, 本城愛子, 室松悠希, 大﨑雄樹

    第128回日本解剖学会学術集会・全国学術集会 

    Presentation date： 2023.03

    Event date：
    2023.03
    　
    　

  • ２型糖尿病患者における睡眠と筋力・骨格筋量の関連の解析

    和田亘弘, 林高則, 小泉千恵, 窪田哲也, 窪田直人

    第24・25回日本病態栄養学会年次学術集会 

    Presentation date： 2022.01

    Event date：
    2022.01
    　
    　

  • 糖尿病患者における睡眠と骨格筋の関連の解析

    和田亘弘, 林高則, 小泉千恵, 窪田哲也, 窪田直人

    第75回日本栄養・食糧学会年次学術集会 

    Presentation date： 2021.07

    Event date：
    2021.07
    　
    　

  • 糖質・脂肪酸エネルギーの基質動員に関する協調制御機構の解明

    和田亘弘, 泉田欣彦, 矢作直也, 武内謙憲, 升田紫, 李恩旭, 沢田義一, 呼延宜人, 島野仁, 門脇孝

    第72回日本栄養・食糧学会年次学術集会 

    Event date：
    2018.05
    　
    　

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Teaching Experience 【 display / non-display 】

  • 形態機能学実習Ⅱ  

    札幌保健医療大学  

    2024
    　
    　
     

  • 細胞・組織学Ⅱ（分担）  

    札幌医科大学  

    2023
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    Now
     

  • 医学英語Ⅲ（分担）  

    Sapporo Medical University  

    2022
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  • 細胞・組織学Ⅰ（分担）  

    Sapporo Medical University  

    2022
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  • 細胞・組織学実習  

    札幌医科大学  

    2022
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    Now
     

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Committee Memberships 【 display / non-display 】

  • 2024.09
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    Now

      幹事役員

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