Updated on 2025/08/22

写真a

 
NAKATA Kei
 
Organization
School of Medicine Department of Public Health Assistant Professor
Title
Assistant Professor
ORCID ID
0000-0003-0747-7103
External link

Degree

  • Doctor of Philosophy ( 2017.3   Sapporo Medical University )

Research Interests

  • Heart failure diabetes Cardiac MRI sarcopenia sleep apnea

Research Areas

  • Life Science / Cardiology  / Cardiac MRI

  • Life Science / Metabolism and endocrinology  / diabetes mellitus

Research History

  • Sapporo Medical University   Public Health and Cardiovascular, renal and metabolic medicine   Assistant Professor

    2022.8

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    Country:Japan

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  • Harvard University Beth Israel Deaconess Medical center   Cardiovascular division   Research fellow

    2021.1 - 2022.7

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    Country:United States

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  • Mie University Hospital   Radiology

    2019.4 - 2021.12

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  • Hokkaido Esashi hosipital   Cardiology

    2018.10 - 2019.3

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    Country:Japan

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  • Sapporo Medical University Hospital   Cardiovascular, Renal and Metabolic medicine   Assistant Professor

    2018.4 - 2018.9

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    Country:Japan

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  • Otaru General hospital   Cardiology

    2017.4 - 2018.3

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    Country:Japan

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  • Sapporo Medical University Hospital   Cardiovascular, Renal and Metabolic medicine

    2015.4 - 2017.3

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    Country:Japan

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  • Steel Memorial Muroran Hospital   cardiology

    2014.4 - 2015.3

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    Country:Japan

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  • Sapporo Medical University Hospital   Cardiovascular, Renal and Metabolic medicine

    2013.4 - 2014.3

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    Country:Japan

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  • KKR Sapporo Medical center   Junior resident

    2011.4 - 2013.3

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    Country:Japan

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Professional Memberships

  • The Japan Diabetes Society

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  • The Japanese Circulation Society

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  • Japanease Society of Sleep Research

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  • Japanese Association of Cardiovascular Intervention and Therapeutics

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  • Society for Cardiovascular Magnetic Resonance

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  • The Japanese Society of Internal Medicine

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Papers

  • Incorporation of Metabolic Dysfunction‐Associated Steatotic Liver Disease in the Health Stage of Cardiovascular‐Kidney‐Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population

    Wataru Kawaharata, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Hiroki Aida, Rie Matsumori, Kei Nakata, Keitaro Nishizawa, Toru Suzuki, Hidemichi Kouzu, Nagisa Hanawa, Masato Furuhashi

    Journal of the American Heart Association   2025.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.125.043173

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  • Pathological Analysis of T1 Pseudonormalization in the Advanced Stage of Female Fabry Cardiomyopathy

    Hiroki Aida, Ryo Nishikawa, Toshiyuki Yano, Kei Nakata, Naoto Murakami, Atsuko Muranaka, Masato Furuhashi

    Circulation: Heart Failure   2025.5

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    DOI: 10.1161/CIRCHEARTFAILURE.124.012234

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  • Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Is an Independent Risk Factor for the Development of Ischemic Heart Disease ― A 10-Year Cohort Study ―

    Toshifumi Ogawa, Tatsuya Sato, Marenao Tanaka, Yukinori Akiyama, Kei Nakata, Hidemichi Kouzu, Kazuma Mori, Hiroki Aida, Wataru Kawaharata, Itaru Hosaka, Toru Suzuki, Nagisa Hanawa, Masato Furuhashi

    Circulation Reports   2025.4

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    DOI: 10.1253/circrep.cr-25-0019

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  • High Level of Estimated Small Dense Low-Density Lipoprotein Cholesterol as an Independent Risk Factor for the Development of Ischemic Heart Disease Regardless of Low-Density Lipoprotein Cholesterol Level ― A 10-Year Cohort Study ―

    Keisuke Endo, Marenao Tanaka, Tatsuya Sato, Masafumi Inyaku, Kei Nakata, Wataru Kawaharata, Hiroki Aida, Itaru Hosaka, Yukinori Akiyama, Nagisa Hanawa, Masato Furuhashi

    Circulation Journal   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    DOI: 10.1253/circj.cj-24-0770

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  • Elevated urinary fatty acid-binding protein 4 level predicts future renal dysfunction and poor prognosis in Japanese patients with diabetes: a longitudinal cohort study

    Marenao Tanaka, Tatsuya Sato, Tomohito Gohda, Nozomu Kamei, Maki Murakoshi, Erika Ishiwata, Kei Nakata, Yukinori Akiyama, Keisuke Endo, Wataru Kawaharata, Hiroki Aida, Toru Suzuki, Mitsunobu Kubota, Michiyoshi Sanuki, Yusuke Suzuki, Masato Furuhashi

    Clinical Kidney Journal   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Background

    Fatty acid-binding protein 4 (FABP4) is an adipokine secreted from adipocytes and macrophages and is also expressed in injured, but not normal, glomerular endothelial cells. Elevated levels of urinary FABP4 (U-FABP4) have been reported to be associated with glomerular damage and increased proteinuria.

    Methods

    The associations of levels of U-FABP4 at baseline with future events including renal dysfunction defined by a 30% decline in estimated glomerular filtration rate (eGFR) and all-cause death were investigated in 660 patients with diabetes (type 1/2: 57/603).

    Results

    During a follow-up period (median: 62 months), 90 patients (13.6%) developed renal dysfunction, and 66 patients (10.0%) died (median follow-up period: 65 months). Kaplan-Meier survival curves showed that there were significant differences in cumulative incidences for a 30% decline in eGFR and all-cause death in patients divided by the tertiles of U-FABP4 level. Furthermore, multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard ratios for a 30% decline in eGFR and all-cause death increased with a higher level of logarithmically transformed (Log) U-FABP4 after adjustment for age, sex, type of diabetes, body mass index, current smoking habit, duration of diabetes, comorbidities of hypertension and dyslipidemia, eGFR and the categorical classification of urinary albumin-creatinine ratio. The addition of Log U-FABP4 to traditional risk factors significantly increased the discriminatory capacities for renal dysfunction in net reclassification improvement (NRI) and integrated discrimination improvement and for all-cause death in NRI.

    Conclusion

    U-FABP4 is a predictive biomarker for future renal dysfunction and poor prognosis in patients with diabetes.

    DOI: 10.1093/ckj/sfaf056

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  • Urinary fatty acid‐binding protein 4 is a promising biomarker for glomerular damage in patients with diabetes mellitus

    Marenao Tanaka, Tatsuya Sato, Tomohito Gohda, Nozomu Kamei, Maki Murakoshi, Erika Ishiwata, Keisuke Endo, Wataru Kawaharata, Hiroki Aida, Kei Nakata, Yukinori Akiyama, Mitsunobu Kubota, Michiyoshi Sanuki, Toru Suzuki, Yusuke Suzuki, Masato Furuhashi

    Journal of Diabetes Investigation   2024.12

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    ABSTRACT

    Aims/Introduction

    Fatty acid‐binding protein (FABP) 4, which acts as an adipokine secreted by adipocytes, macrophages, and capillary endothelial cells, is expressed in injured glomerular cells. It has been reported that urinary (U‐) FABP4 is associated with renal dysfunction and proteinuria in several glomerular kidney diseases. However, the clinical significance of U‐FABP4 in diabetic kidney disease (DKD) remains undetermined.

    Materials and Methods

    Immunohistological analyses of FABP4 and FABP1 (liver‐type FABP), an established biomarker for impaired proximal tubules, were performed in the kidneys of patients with DKD and nonobese diabetic mice (KK‐Ta/Akita mice). The associations between U‐FABP4 and U‐FABP1 with kidney function and metabolic indices were also investigated in patients with type 1 diabetes (n = 57, mean age: 61 years) and patients with type 2 diabetes (n = 608, mean age: 65 years).

    Results

    In both patients with diabetes and diabetic mice, FABP4 was expressed in injured glomeruli with increased markers of endoplasmic reticulum stress in addition to peritubular capillaries, whereas FABP1 was mainly expressed in proximal tubules. Levels of U‐FABP4 and U‐FABP1 were independently associated with each other, and both levels were independently associated with estimated glomerular filtration rate (eGFR) and urinary albumin‐to‐creatinine ratio (UACR) after adjustment of age, sex, type of diabetes, duration of diabetes, and systolic blood pressure in patients with diabetes.

    Conclusions

    Urinary level of FABP4 derived from injured glomeruli with increased endoplasmic reticulum stress is independently associated with eGFR and UACR, suggesting a promising biomarker for glomerular damage in patients with diabetes.

    DOI: 10.1111/jdi.14388

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  • セマグルチド注射薬により20年間のインスリン強化療法から離脱できた2型糖尿病の1例

    寺沢 誠, 中田 圭, 大久保 武志, 小川 俊史, 隅田 健太郎, 佐藤 達也, 神津 英至, 矢野 俊之, 古橋 眞人

    糖尿病   67 ( 12 )   511 - 511   2024.12

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    Language:Japanese   Publisher:(一社)日本糖尿病学会  

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  • 腹腔鏡下胃スリーブ状切除術によりインスリン抵抗性-インスリン必要量増加-体重増加の悪循環を脱し、肥満関連合併症の改善が得られた1例

    小川 俊史, 佐藤 達也, 大久保 武志, 寺沢 誠, 中田 圭, 隅田 健太郎, 神津 英至, 矢野 俊之, 矢島 諒人, 伊東 竜哉, 竹政 伊知朗, 古橋 眞人

    日本内分泌学会雑誌   100 ( 4 )   805 - 805   2024.12

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  • Metabolic dysfunction-associated steatotic liver disease (SLD) and alcohol-associated liver disease, but not SLD without metabolic dysfunction, are independently associated with new onset of chronic kidney disease during a 10-year follow-up period. International journal

    Kazuma Mori, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo, Toshifumi Ogawa, Toru Suzuki, Hiroki Aida, Wataru Kawaharata, Kei Nakata, Itaru Hosaka, Araya Umetsu, Nagisa Hanawa, Masato Furuhashi

    Hepatology research : the official journal of the Japan Society of Hepatology   2024.8

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    AIMS: The new nomenclature of steatotic liver disease (SLD) including metabolic dysfunction-associated SLD (MASLD), MASLD and increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD) has recently been proposed. We aimed to elucidate the relationship between each category of SLD and chronic kidney disease (CKD). METHODS: We investigated the effects of various SLDs on the development of CKD, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or positive for urinary protein, during a 10-year period in 12 138 Japanese subjects (men / women, 7984/4154; mean age, 48 years) who received annual health examinations including abdominal ultrasonography. RESULTS: The prevalences of SLD without metabolic dysfunction (SLD-MD[-]), MASLD, MetALD, and ALD were 1.7%, 26.3%, 4.9%, and 1.9%, respectively. During the follow-up period, 1963 subjects (16.2%) (men / women, 1374 [17.2%]/589 [14.2%]) had new onset of CKD. Multivariable Cox proportional hazard model analyses after adjustment of age, sex, eGFR, current smoking habit, diabetes mellitus, hypertension, and dyslipidemia showed that the hazard ratios (HR [95% confidence interval]) for the development of CKD in subjects with MASLD (1.20 [1.08-1.33], p = 0.001) and those with ALD (1.41 [1.05-1.88], p = 0.022), but not those with MetALD (1.11 [0.90-1.36], p = 0.332), were significantly higher than the HR in subjects with non-SLD. Interestingly, subjects with SLD-MD[-] had a significantly lower HR (0.61 [0.39-0.96], p = 0.034) than that in subjects with non-SLD. The addition of the novel classification of SLDs into traditional risk factors for the development of CKD significantly improved the discriminatory capacity. CONCLUSIONS: MASLD and ALD, but not SLD-MD[-], are independently associated with the development of CKD.

    DOI: 10.1111/hepr.14097

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  • Small dense LDLコレステロールの推定式の検証と臨床的意義の検討

    遠藤 圭佑, 田中 希尚, 佐藤 達也, 秋山 幸功, 小林 亮, 田中 真輝人, 保坂 到, 古橋 眞人, 中田 圭, 小山 雅之, 大西 浩文, 高橋 聡

    日本動脈硬化学会総会プログラム・抄録集   56回   233 - 233   2024.6

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  • Tirzepatide ameliorates eating behaviors regardless of prior exposure to glucagon-like peptide receptor agonists in Japanese patients with type 2 diabetes mellitus. International journal

    Toru Suzuki, Tatsuya Sato, Marenao Tanaka, Keisuke Endo, Kei Nakata, Toshifumi Ogawa, Itaru Hosaka, Yukinori Akiyama, Araya Umetsu, Masato Furuhashi

    Journal of diabetes and its complications   38 ( 7 )   108779 - 108779   2024.5

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    AIMS: To investigate effects of tirzepatide, a dual receptor agonist for glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1), on eating behaviors. METHODS: Eating behaviors were evaluated by using a validated questionnaire survey in 33 Japanese patients with type 2 diabetes mellitus (T2DM) (mean age: 51.8 years) who were treated with tirzepatide (2.5 mg/week for 4 weeks and then 5.0 mg/week) for 6 months (M). RESULTS: Treatment with tirzepatide significantly decreased median hemoglobin A1c (HbA1c) (baseline/3 M/6 M: 7.3 %/6.0 %/5.8 %), mean body weight (BW) (baseline/3 M/6 M: 87.7 kg/82.0 kg/79.6 kg) and mean relative score of eating behaviors (baseline/3 M/6 M: 57.0/50.7/45.9). In the GLP-1 receptor agonist (GLP-1RA) naïve group (n = 20, men/women: 13/7), HbA1c and BW were continuously decreased up to 6 M. Changes in eating behaviors were mainly observed in the first 3 M. In the GLP-1RA non-naïve group (n = 13, men/women: 8/5), reductions in HbA1c and BW were predominant in the first 3 M, and changes in eating behaviors were observed up to 6 M. There were no significant correlations of changes in scores of eating behaviors with changes in glycemic control or those in BW. CONCLUSIONS: Tirzepatide ameliorates eating behaviors as well as glycemic management and obesity in Japanese patients with T2DM, and the patterns of improvement are partially dependent on prior exposure to GLP-1RAs.

    DOI: 10.1016/j.jdiacomp.2024.108779

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  • Sampsonの式あるいは人工知能を用いて推定したsmall dense LDLコレステロール値の精度の検証

    大久保 武志, 遠藤 圭佑, 田中 希尚, 佐藤 達也, 小林 亮, 田中 真輝人, 秋山 幸功, 保坂 到, 中田 圭, 小山 雅之, 大西 浩文, 高橋 聡, 古橋 眞人

    糖尿病   67 ( Suppl.1 )   S - 251   2024.4

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  • Cardiac MR Characterization of Myocardial Tissue Injury in a Miniature Swine Model of Cancer Therapy-related Cardiovascular Toxicity. International journal

    Kei Nakata, Selcuk Kucukseymen, Xiaoying Cai, Tuyen Yankama, Jennifer Rodriguez, Eiryu Sai, Patrick Pierce, Long Ngo, Shiro Nakamori, Nadine Tung, Warren J Manning, Reza Nezafat

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance   101033 - 101033   2024.3

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    BACKGROUND: Left ventricular ejection fraction (LVEF) is the most commonly clinically used imaging parameter for assessing cancer therapy-related cardiac dysfunction (CTRCD). However, LVEF declines may occur late, after substantial injury. This study sought to investigate cardiovascular magnetic resonance (CMR) imaging markers of subclinical cardiac injury in a miniature swine model. METHODS: Female Yucatan miniature swine (n=14) received doxorubicin (2mg/kg) every 3 weeks for 4 cycles. CMR, including cine, tissue characterization via T1 and T2 mapping, and late gadolinium enhancement (LGE) was performed on the same day as doxorubicin administration and three weeks after the final chemotherapy cycle. In addition, MR spectroscopy (MRS) was performed during the 3 weeks after the final chemotherapy in 7 pigs. A single CMR and MRS exam was also performed in three Yucatan miniature swine that were age- and weight-matched to the final imaging exam of the doxorubicin-treated swine to serve as controls. CTRCD was defined as histological early morphologic changes, including cytoplasmic vacuolization and myofibrillar loss of myocytes, based on post-mortem analysis of humanely euthanized pigs after the final CMR exam. RESULTS: Of 13 swine completing five serial CMR scans, 10 (77%) had histological evidence of CTRCD. Three animals had neither histological evidence nor changes in LVEF from baseline. No absolute LVEF <40% or LGE were observed. Native T1, extracellular volume (ECV), and T2 at 12 weeks were significantly higher in swine with CTRCD than those without CTRCD (1178 ms vs. 1134 ms, p=0.002, 27.4% vs. 24.5%, p=0.03, and 38.1 ms vs. 36.4 ms, p=0.02, respectively). There were no significant changes in strain parameters. The temporal trajectories in native T1, ECV, and T2 in swine with CTRCD showed similar and statistically significant increases. At the same time, there were no differences in their temporal changes between those with and without CTRCD. MRS myocardial triglyceride content substantially differed among controls, swine with and without CTRCD (0.89%, 0.30%, 0.54%, respectively, ANOVA, p=0.01), and associated with the severity of histological findings and incidence of vacuolated cardiomyocytes. CONCLUSIONS: Serial CMR imaging alone has a limited ability to detect histologic CTRCD beyond LVEF. Integrating MRS myocardial triglyceride content may be useful for detection of early potential CTRCD.

    DOI: 10.1016/j.jocmr.2024.101033

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  • Scanner-Independent MyoMapNet for Accelerated Cardiac MRI T1 Mapping Across Vendors and Field Strengths. International journal

    Amine Amyar, Ahmed S Fahmy, Rui Guo, Kei Nakata, Eiryu Sai, Jennifer Rodriguez, Julia Cirillo, Karishma Pareek, Jiwon Kim, Robert M Judd, Frederick L Ruberg, Jonathan W Weinsaft, Reza Nezafat

    Journal of magnetic resonance imaging : JMRI   59 ( 1 )   179 - 189   2024.1

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    BACKGROUND: In cardiac T1 mapping, a series of T1 -weighted (T1 w) images are collected and numerically fitted to a two or three-parameter model of the signal recovery to estimate voxel-wise T1 values. To reduce the scan time, one can collect fewer T1 w images, albeit at the cost of precision or/and accuracy. Recently, the feasibility of using a neural network instead of conventional two- or three-parameter fit modeling has been demonstrated. However, prior studies used data from a single vendor and field strength; therefore, the generalizability of the models has not been established. PURPOSE: To develop and evaluate an accelerated cardiac T1 mapping approach based on MyoMapNet, a convolution neural network T1 estimator that can be used across different vendors and field strengths by incorporating the relevant scanner information as additional inputs to the model. STUDY TYPE: Retrospective, multicenter. POPULATION: A total of 1423 patients with known or suspected cardiac disease (808 male, 57 ± 16 years), from three centers, two vendors (Siemens, Philips), and two field strengths (1.5 T, 3 T). The data were randomly split into 60% training, 20% validation, and 20% testing. FIELD STRENGTH/SEQUENCE: A 1.5 T and 3 T, Modified Look-Locker inversion recovery (MOLLI) for native and postcontrast T1 . ASSESSMENT: Scanner-independent MyoMapNet (SI-MyoMapNet) was developed by altering the deep learning (DL) architecture of MyoMapNet to incorporate scanner vendor and field strength as inputs. Epicardial and endocardial contours and blood pool (by manually drawing a large region of interest in the blood pool) of the left ventricle were manually delineated by three readers, with 2, 8, and 9 years of experience, and SI-MyoMapNet myocardial and blood pool T1 values (calculated from four T1 w images) were compared with conventional MOLLI T1 values (calculated from 8 to 11 T1 w images). STATISTICAL TESTS: Equivalency test with 95% confidence interval (CI), linear regression slope, Pearson correlation coefficient (r), Bland-Altman analysis. RESULTS: The proposed SI-MyoMapNet successfully created T1 maps. Native and postcontrast T1 values measured from SI-MyoMapNet were strongly correlated with MOLLI, despite using only four T1 w images, at both field-strengths and vendors (all r > 0.86). For native T1 , SI-MyoMapNet and MOLLI were in good agreement for myocardial and blood T1 values in institution 1 (myocardium: 5 msec, 95% CI [3, 8]; blood: -10 msec, 95%CI [-16, -4]), in institution 2 (myocardium: 6 msec, 95% CI [0, 11]; blood: 0 msec, [-18, 17]), and in institution 3 (myocardium: 7 msec, 95% CI [-8, 22]; blood: 8 msec, [-14, 30]). Similar results were observed for postcontrast T1 . DATA CONCLUSION: Inclusion of field strength and vendor as additional inputs to the DL architecture allows generalizability of MyoMapNet across different vendors or field strength. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 2.

    DOI: 10.1002/jmri.28739

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  • Science behind children's handwashing: action study of 9- to 10-years-old elementary school students in Japan. International journal

    Asae Oura, Yukiko Naito, Hiroko Yako-Suketomo, Kei Nakata, Masayuki Koyama, Hirofumi Ohnishi

    Frontiers in public health   12   1425646 - 1425646   2024

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    BACKGROUND: Hand washing instructions for children have been implemented in school education to establish good lifestyle habits. However, repeated hand washing through education from early childhood was common for both teachers and children. If this continues, children might assume they already know how to wash their hands, stop taking handwashing instructions seriously, and become increasingly lax about washing their hands. PURPOSE: This study aimed to develop a new handwashing education method for children. METHODS: We applied the adenosine triphosphate (ATP) test to health education on hand washing in elementary schools. This study was conducted as part of a class for elementary school students in October 2023, in Hokkaido, Japan. The subjects were 157 third-grade (9-10 years old) elementary school students. After excluding absent pupils, 147 were included in the analysis. RESULTS: Both pre- and post-education, ATP values after handwashing were lower than those before handwashing. Following the education, children's handwashing behavior improved, with an increase in the number of point washed and appropriate timing of handwashing. CONCLUSION: The new handwashing education program utilizing the ATP-test succeeded in promoting handwashing behavior among many children. Visualizing handwashing using ATP values was effective in motivating children.

    DOI: 10.3389/fpubh.2024.1425646

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  • Validation of Estimated Small Dense Low-Density Lipoprotein Cholesterol Concentration in a Japanese General Population.

    Keisuke Endo, Ryo Kobayashi, Makito Tanaka, Marenao Tanaka, Yukinori Akiyama, Tatsuya Sato, Itaru Hosaka, Kei Nakata, Masayuki Koyama, Hirofumi Ohnishi, Satoshi Takahashi, Masato Furuhashi

    Journal of atherosclerosis and thrombosis   2023.12

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    AIM: A high level of directly measured small dense low-density lipoprotein cholesterol (sdLDL-C) is a strong risk factor for atherosclerotic cardiovascular disease. A method for estimating sdLDL-C by using Sampson's equation that includes levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C and triglycerides (TG) has recently been proposed. We investigated the validation and exploration of estimated sdLDL-C level. METHODS: The associations between measured and estimated sdLDL-C levels were investigated in 605 Japanese subjects (men/women: 280/325; mean age: 65±15 years) who received annual health check-ups in the Tanno Sobetsu Study, a population-based cohort. RESULTS: Estimated sdLDL-C level was highly correlated with measured sdLDL-C level in all subjects (R2 =0.701), nondiabetic subjects without any medication (n=254, R 2=0.686) and subjects with diabetes mellitus (n=128, R2=0.721). Multivariable regression analysis showed that levels of non-HDL-C, TG and γ-glutamyl transpeptidase (γGTP) were independent predictors of measured sdLDL-C level. In a stratification of the LDL window, all of the subjects with a combination of high non-HDL-C (≥ 170 mg/dL) and high TG (≥ 150 mg/dL) had high levels of measured and estimated sdLDL-C (≥ 35 mg/dL). Furthermore, machine learning-based estimation of sdLDL-C level by artificial intelligence software, Prediction One, was substantially improved by using components of Sampson's equation (R2=0.803) and by using those components with the addition of γGTP and deletion of TC (R2=0.929). CONCLUSIONS: sdLDL-C level estimated by Sampson's equation can be used instead of measured sdLDL-C level in general practice. By building multiple machine learning models of artificial intelligence, a more accurate and practical estimation of sdLDL-C level might be possible.

    DOI: 10.5551/jat.64578

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  • Microvascular Dysfunction in Patients with Idiopathic Dilated Cardiomyopathy: Quantitative Assessment with Phase Contrast Cine MR Imaging of the Coronary Sinus.

    Masafumi Takafuji, Masaki Ishida, Satoshi Nakamura, Kei Nakata, Haruno Ito, Takanori Kokawa, Kensuke Domae, Suguru Araki, Shiro Nakamori, Junko Ishiura, Kaoru Dohi, Hajime Sakuma

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   2023.9

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    PURPOSE: The purposes of this study were to compare global coronary flow reserve (CFR) between patients with idiopathic dilated cardiomyopathy (DCM) and risk-matched controls using cardiac MRI (CMR), and to evaluate the relationship between global CFR and CMR left ventricular (LV) parameters. METHODS: Twenty-six patients with DCM and 26 risk-matched controls who underwent comprehensive CMR examination, including stress-rest coronary sinus flow measurement by phase contrast (PC) cine CMR were retrospectively studied. LV peak global longitudinal, radial, and circumferential strains (GLS, GRS, and GCS) were determined by feature tracking. RESULTS: Patients with DCM had significantly lower global CFR compared with the risk-matched controls (2.87 ± 0.86 vs. 4.03 ± 1.47, P = 0.001). Among the parameters, univariate linear regression analyses revealed significant correlation of global CFR with LV end-diastolic volume index (r = -0.396, P = 0.045), LV mass index (r = -0.461, P = 0.018), GLS (r = -0.558, P = 0.003), and GRS (r = 0.392, P = 0.047). Multiple linear regression analysis revealed GLS as the only independent predictor of global CFR (standardized β = -0.558, P = 0.003). CONCLUSION: Global CFR was significantly impaired in patients with idiopathic DCM and independently associated with LV GLS, suggesting that microvascular dysfunction may contribute to deterioration of LV function in patients with idiopathic DCM.

    DOI: 10.2463/mrms.mp.2023-0018

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  • Comparison of DeepStrain and Feature Tracking for Cardiac MRI Strain Analysis. International journal

    Manuel A Morales, Julia Cirillo, Kei Nakata, Selcuk Kucukseymen, Long H Ngo, David Izquierdo-Garcia, Ciprian Catana, Reza Nezafat

    Journal of magnetic resonance imaging : JMRI   57 ( 5 )   1507 - 1515   2023.5

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    BACKGROUND: Myocardial feature tracking (FT) provides a comprehensive analysis of myocardial deformation from cine balanced steady-state free-precession images (bSSFP). However, FT remains time-consuming, precluding its clinical adoption. PURPOSE: To compare left-ventricular global radial strain (GRS) and global circumferential strain (GCS) values measured using automated DeepStrain analysis of short-axis cine images to those calculated using manual commercially available FT analysis. STUDY TYPE: Retrospective, single-center. POPULATION: A total of 30 healthy subjects and 120 patients with cardiac disease for DeepStrain development. For evaluation, 47 healthy subjects (36 male, 53 ± 5 years) and 533 patients who had undergone a clinical cardiac MRI (373 male, 59 ± 14 years). FIELD STRENGTH/SEQUENCE: bSSFP sequence at 1.5 T (Phillips) and 3 T (Siemens). ASSESSMENT: Automated DeepStrain measurements of GRS and GCS were compared to commercially available FT (Circle, cvi42) measures obtained by readers with 1 year and 3 years of experience. Comparisons were performed overall and stratified by scanner manufacturer. STATISTICAL TESTS: Paired t-test, linear regression slope, Pearson correlation coefficient (r). RESULTS: Overall, FT and DeepStrain measurements of GCS were not significantly different (P = 0.207), but measures of GRS were significantly different. Measurements of GRS from Philips (slope = 1.06 [1.03 1.08], r = 0.85) and Siemens (slope = 1.04 [0.99 1.09], r = 0.83) data showed a very strong correlation and agreement between techniques. Measurements of GCS from Philips (slope = 0.98 [0.98 1.01], r = 0.91) and Siemens (slope = 1.0 [0.96 1.03], r = 0.88) data similarly showed a very strong correlation. The average analysis time per subject was 4.1 ± 1.2 minutes for FT and 34.7 ± 3.3 seconds for DeepStrain, representing a 7-fold reduction in analysis time. DATA CONCLUSION: This study demonstrated high correlation of myocardial GCS and GRS measurements between freely available fully automated DeepStrain and commercially available manual FT software, with substantial time-saving in the analysis. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 3.

    DOI: 10.1002/jmri.28374

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  • Complementary prognostic value of stress perfusion imaging and global coronary flow reserve derived from cardiovascular magnetic resonance: a long-term cohort study. International journal

    Satoshi Nakamura, Masaki Ishida, Kei Nakata, Masafumi Takafuji, Shiro Nakamori, Tairo Kurita, Haruno Ito, Kaoru Dohi, Hajime Sakuma

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance   25 ( 1 )   20 - 20   2023.3

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    BACKGROUND: Phase-contrast cine cardiovascular magnetic resonance (CMR) quantifies global coronary flow reserve (CFR) by measuring blood flow in the coronary sinus (CS), allowing assessment of the entire coronary circulation. However, the complementary prognostic value of stress perfusion CMR and global CFR in long-term follow-up has yet to be investigated. This study aimed to investigate the complementary prognostic value of stress myocardial perfusion imaging and global CFR derived from CMR in patients with suspected or known coronary artery disease (CAD) during long-term follow-up. METHODS: Participants comprised 933 patients with suspected or known CAD who underwent comprehensive CMR. Major adverse cardiac events (MACE) comprised cardiac death, non-fatal myocardial infarction, unstable angina, hospitalization for heart failure, stroke, ventricular arrhythmia, and late revascularization. RESULTS: During follow-up (median, 5.3 years), there were 223 MACE. Kaplan-Meier curve analysis revealed a significant difference in event-free survival among tertile groups for global CFR (log-rank, p < 0.001) and between patients with and without ischemia (p < 0.001). The combination of stress perfusion CMR and global CFR enhanced risk stratification (p < 0.001 for overall), and prognoses were comparable between the subgroup with ischemia and no impaired CFR and the subgroup with no ischemia and impaired CFR (p = 0.731). Multivariate Cox proportional hazard regression analysis showed that impaired CFR remained a significant predictor for MACE (hazard ratio, 1.6; p = 0.002) when adjusted for coronary risk factors and CMR predictors, including ischemia. The addition of impaired CFR to coronary risk factors and ischemia significantly increased the global chi-square value from 88 to 109 (p < 0.001). Continuous net reclassification improvement and integrated discrimination with the addition of global CFR to coronary risk factors plus ischemia improved to 0.352 (p < 0.001) and 0.017 (p < 0.001), respectively. CONCLUSIONS: During long-term follow-up, stress perfusion CMR and global CFR derived from CS flow measurement provided complementary prognostic value for prediction of cardiovascular events. Microvascular dysfunction or diffuse atherosclerosis as shown by impaired global CFR may play a role as important as that of ischemia due to epicardial coronary stenosis in the risk stratification of CAD patients.

    DOI: 10.1186/s12968-023-00930-3

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  • Long-term prognostic value of whole-heart coronary magnetic resonance angiography. International journal

    Satoshi Nakamura, Masaki Ishida, Kei Nakata, Yasutaka Ichikawa, Shinichi Takase, Masafumi Takafuji, Haruno Ito, Shiro Nakamori, Tairo Kurita, Kaoru Dohi, Hajime Sakuma

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance   23 ( 1 )   56 - 56   2021.5

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    BACKGROUND: Coronary magnetic resonance angiography (CMRA) allows non-ionizing visualization of luminal narrowing in coronary artery disease (CAD). Although a prior study showed the usefulness of CMRA for risk stratification in short-term follow-up, the long-term prognostic value of CMRA remains unclear. The purpose of this study was to evaluate the long-term prognostic value of CMRA. METHODS: A total of 506 patients without history of myocardial infarction or prior coronary artery revascularization underwent free-breathing whole-heart CMRA between 2009 and 2015. Images were acquired using a 1.5 T or 3 T scanner and visually evaluated as the consensus decisions of two observers. Obstructive CAD on CMRA was defined as luminal narrowing of ≥ 50% in at least one coronary artery. Major adverse cardiac events (MACE) comprised cardiac death, nonfatal myocardial infarction, and unstable angina. RESULTS: Obstructive CAD on CMRA was observed in 214 patients (42%). During follow-up (median, 5.6 years), 31 MACE occurred. Kaplan-Meier curve analysis revealed a significant difference in event-free survival between patients with and without obstructive CAD for MACE (log-rank, p = 0.003) and cardiac death (p = 0.012). Annualized event rates for MACE in patients with no obstructive CAD, 1-vessel disease, 2-vessel disease, and left-main or 3-vessel disease were 0.6%, 1.5%, 2.3%, and 3.6%, respectively (log-rank, p = 0.003). Cox proportional hazard regression analysis showed that, among obstructive CAD on CMRA and clinical risk factors (age, sex, hypertension, diabetes, dyslipidemia, smoking, and family history of CAD), obstructive CAD and diabetes were significant predictors of MACE (hazard ratios, 2.9 [p = 0.005] and 2.2 [p = 0.034], respectively). In multivariate analysis, obstructive CAD remained an independent predictor (adjusted hazard ratio, 2.6 [p = 0.010]) after adjusting for diabetes. Addition of obstructive CAD to clinical risk factors significantly increased the global chi-square result from 8.3 to 13.8 (p = 0.022). CONCLUSIONS: In long-term follow-up, free breathing whole heart CMRA allows non-invasive risk stratification for MACE and cardiac death and provides incremental prognostic value over conventional risk factors in patients without a history of myocardial infarction or prior coronary artery revascularization. The presence and severity of obstructive CAD detected by CMRA were associated with worse prognosis. Importantly, patients without obstructive CAD on CMRA displayed favorable prognosis.

    DOI: 10.1186/s12968-021-00749-w

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  • Isolated Right Ventricular Apical Hypoplasia: A Case Report with 18 Years of Follow Up

    Takashi Oya, Kakuya Kitagawa, Takanori Kokawa, Hiroshi Nakajima, Shiro Nakamori, Yoshito Ogihara, Kei Nakata, Masaki Ishida, Yasutaka Ichikawa, Hajime Sakuma

    Cardiovascular Imaging Asia   2021

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    DOI: 10.22468/cvia.2021.00066

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  • Serial cardiac magnetic resonance imaging in wet beriberi.

    Hiroaki Murakami, Naoki Fujimoto, Keishi Moriwaki, Kei Nakata, Masaki Ishida, Ryuji Okamoto, Masaaki Ito, Kaoru Dohi

    Journal of cardiology cases   22 ( 3 )   100 - 102   2020.9

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    A 69-year-old woman with previous pancreaticoduodenectomy was admitted for evaluation of chest discomfort on effort and leg edema for a few months. Oral flosemide before admission for 1 week failed to relieve her symptoms. Her blood pressure was 105/51 mmHg and heart rate was 76 beats/min. Chest X-ray revealed an enlarged heart and mild pulmonary congestion. Echocardiography demonstrated normal left ventricular ejection fraction and diastolic dysfunction with no left ventricular hypertrophy. Cardiac catheterization showed normal coronary arteries, high cardiac index, and elevated intracardial pressures. Myocardial biopsy from the right ventricular septum revealed nearly normal findings. Cardiac magnetic resonance imaging (CMRI) showed both ventricles enlarged and increased global extracellular volume fraction (ECV) of 37%, but normal native T1 and T2 values. As she had pancreaticoduodenectomy, beriberi was suspected. Vitamin B1 significantly increased urine output and lowered intracardiac pressures and cardiac index. After 3 months of vitamin B1, CMRI exhibited that the right ventricle had decreased in size and the global ECV value had been lowered. Our case highlights that chronic beriberi may be associated with little myocardial damage. The increased ECV suggests that the diffuse expansion of extracellular space unrelated to myocardial edema might have been reversed by vitamin B1treatment. Morphological changes in the ventricles and myocardial damage by wet beriberi can be demonstrated by CMRI. <Learning objective: Chronic wet beriberi can occur in patients with previous pancreaticoduodenectomy although they eat regularly and never drink alcohol. Morphological changes in the ventricles and myocardial damage by wet beriberi can be demonstrated by cardiac magnetic resonance imaging.>.

    DOI: 10.1016/j.jccase.2020.05.010

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  • Reply to the comment of Hirota et al. on "Accuracy of flash glucose monitoring in insulin-treated patients with type 2 diabetes".

    Tatsuya Sato, Hiroto Oshima, Kei Nakata, Yukishige Kimura, Toshiyuki Yano, Masato Furuhashi, Masaya Tannno, Takayuki Miki, Tetsuji Miura

    Journal of diabetes investigation   11 ( 1 )   256 - 256   2020.1

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    DOI: 10.1111/jdi.13163

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  • mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation. International journal

    Koki Abe, Toshiyuki Yano, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Tatsuya Sato, Hidemichi Kouzu, Kei Nakata, Wataru Ohwada, Yukishige Kimura, Hirohito Sugawara, Satoru Shibata, Yusuke Igaki, Shoya Ino, Tetsuji Miura

    Biochimica et biophysica acta. Molecular basis of disease   1865 ( 12 )   165552 - 165552   2019.12

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    Accumulating evidence indicates that necroptosis contributes to cardiovascular diseases. We recently reported suppression of autophagy by necroptotic signals in cardiomyocytes and protective action of rapamycin. Here we examined the mechanism by which mTORC1 inhibition protects cardiomyocytes from necroptosis. Necroptosis of H9c2 cells was induced by treatment with tumor necrotic factor-α (TNF) and z-VAD-fmk (zVAD), and the extent of necroptosis was determined as the level of LDH release (as % of total). TNF/zVAD increased RIP1-RIP3 interaction and LDH release from 3.4 ± 1.3% to 46.1 ± 2.3%. The effects of TNF/zVAD were suppressed by an mTORC1 inhibitor, rapamycin, and an mTORC1/2 inhibitor, Ku-0063794, but not by a p70s6K inhibitor, PF-4708671. Protection by rapamycin was not abolished by inhibitors of TAK1, IKKα/β, and cIAP, endogenous necroptosis suppressors upstream of RIP1. Rapamycin and Ku-0063794 suppressed TNF/zVAD-induced RIP1-Ser166 phosphorylation and increased phosphorylation of RIP1-Ser320, an inhibitory phosphorylation site, though such an effect on RIP1-Ser320 was not observed for PF-4708671. Protective effects of rapamycin on TNF/zVAD-induced RIP1-RIP3 binding and necroptosis were undetected in cells transfected with RIP1-S320A. In TNF/zVAD-treated cells, rapamycin and a RIP1 inhibitor, necrostatin-1, increased nuclear localization of transcriptional factor EB (TFEB) and promoted autolysosome formation from autophagosomes in a TFEB-dependent manner. Knockdown of TFEB expression attenuated rapamycin-induced protection from necroptosis in TNF/zVAD-treated cells. The results suggest that mTORC1 inhibition promotes autophagy and protects cardiomyocytes from necroptosis by a TFEB-dependent mechanism and that inhibition of RIP1 by increased phosphorylation at Ser320 is crucial in the cardiomyocyte protection afforded by mTORC1 inhibition.

    DOI: 10.1016/j.bbadis.2019.165552

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  • Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.

    Yukishige Kimura, Atsushi Kuno, Masaya Tanno, Tatsuya Sato, Kouhei Ohno, Satoru Shibata, Kei Nakata, Hirohito Sugawara, Koki Abe, Yusuke Igaki, Toshiyuki Yano, Takayuki Miki, Tetsuji Miura

    Journal of diabetes investigation   10 ( 4 )   933 - 946   2019.7

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    AIMS/INTRODUCTION: Type 2 diabetes mellitus is a risk factor of acute kidney injury after myocardial infarction (MI), a form of cardiorenal syndrome. Recent clinical trials have shown that a sodium-glucose cotransporter 2 (SGLT2) inhibitor improved both cardiac and renal outcomes in patients with type 2 diabetes mellitus, but effects of an SGLT2 inhibitor on cardiorenal syndrome remain unclear. MATERIALS AND METHODS: Type 2 diabetes mellitus (Otsuka Long-Evans Tokushima Fatty rats [OLETF]) and control (Long-Evans Tokushima Otsuka rats [LETO]) were treated with canagliflozin, an SGLT2 inhibitor, for 2 weeks. Renal tissues were analyzed at 12 h after MI with or without preoperative fasting. RESULTS: Canagliflozin reduced blood glucose levels in OLETF, and blood β-hydroxybutyrate levels were increased by canagliflozin only with fasting. MI increased neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 protein levels in the kidney by 3.2- and 1.6-fold, respectively, in OLETF, but not in LETO. The renal messenger ribonucleic acid level of Toll-like receptor 4 was higher in OLETF than in LETO after MI, whereas messenger ribonucleic acid levels of cytokines/chemokines were not significantly different. Levels of lipid peroxides, nicotinamide adenine dinucleotide phosphate oxidase (NOX)2 and NOX4 proteins after MI were significantly higher in OLETF than in LETO. Canagliflozin with pre-MI fasting suppressed MI-induced renal expression of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in OLETF, together with reductions in lipid peroxides and NOX proteins in the kidney. Blood β-hydroxybutyrate levels before MI were inversely correlated with neutrophil gelatinase-associated lipocalin protein levels in OLETF. Pre-incubation with β-hydroxybutyrate attenuated angiotensin II-induced upregulation of NOX4 in NRK-52E cells. CONCLUSIONS: The findings suggest that SGLT2 inhibitor treatment with a fasting period protects kidneys from MI-induced cardiorenal syndrome, possibly by β-hydroxybutyrate-mediated reduction of NOXs and oxidative stress, in type 2 diabetic rats.

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  • Accuracy of flash glucose monitoring in insulin-treated patients with type 2 diabetes.

    Tatsuya Sato, Hiroto Oshima, Kei Nakata, Yukishige Kimura, Toshiyuki Yano, Masato Furuhashi, Masaya Tanno, Takayuki Miki, Tetsuji Miura

    Journal of diabetes investigation   10 ( 3 )   846 - 850   2019.5

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    The present study evaluated the accuracy of interstitial glucose measurements by flash glucose monitoring (FGM) and continuous glucose monitoring (CGM). Five diabetes patients simultaneously underwent FGM (FreeStyle Libre Pro) and CGM (iPro™2), and their glucose levels were compared with venous blood and capillary blood glucose levels. The range of daily venous blood glucose levels (30 measurements) was 70-245 mg/dL, with a median of 138 mg/dL. There were good correlations of glucose levels measured by FGM (r2  = 0.90, mean absolute relative difference 8.2 ± 5.6%), CGM (r2  = 0.86, mean absolute relative difference 9.2 ± 9.1%) and capillary blood (r2  = 0.87, mean absolute relative difference 7.2 ± 7.2%) with venous blood glucose levels. The accuracy of FGM measurements was also shown against CGM, with 99.9% of the FGM values (1,279 measurements) being within the Parkes error grid zones A and B. The results suggest that the accuracy of FGM is similar to that of CGM, and that FGM is a useful tool for determining daily glucose profile.

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  • Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats. International journal

    Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada, Tetsuji Miura

    The Journal of pharmacology and experimental therapeutics   368 ( 3 )   524 - 534   2019.3

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    The mechanism by which SGLT2 inhibitors reduce cardiac events in diabetic patients remains unclear. Here, we examined the effects of an SGLT2 inhibitor on the acute survival rate after myocardial infarction (MI) in an animal model of type 2 diabetes mellitus (DM) and the possible involvement of modification of cardiac metabolomes and antioxidative proteins. MI was induced in DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Long-Evans Tokushima Otsuka (LETO) control rats. Treatment with empagliflozin (10 mg/kg per day, 14 days) before MI reduced blood glucose and increased blood and myocardial β-hydroxybutyrate (βOHB) levels in OLETF. Survival rate at 48 hours after MI was significantly lower in OLETF rats than in LETO rats (40% vs. 84%), and empagliflozin significantly improved the survival rate in OLETF rats to 70%, although the sizes of MI were comparable. Patterns of metabolomes and gene expression in the noninfarcted myocardium of OLETF rats were consistent with increased fatty acid oxidation and decreased glucose oxidation. The patterns were modified by empagliflozin, suggesting both increased glucose oxidation and ketone utilization in OLETF rats. Empagliflozin prevented reduction of ATP level in the noninfarcted myocardium after MI and significantly increased myocardial levels of Sirt3 and superoxide dismutase 2 in OLETF rats. Administration of βOHB partially mimicked the effects of empagliflozin in OLETF rats. The results suggest that empagliflozin prevents DM-induced increase in post-MI mortality, possibly by protective modification of cardiac energy metabolism and antioxidant proteins.

    DOI: 10.1124/jpet.118.253666

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  • Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts. International journal

    Masashi Mizuno, Atsushi Kuno, Toshiyuki Yano, Takayuki Miki, Hiroto Oshima, Tatsuya Sato, Kei Nakata, Yukishige Kimura, Masaya Tanno, Tetsuji Miura

    Physiological reports   6 ( 12 )   e13741   2018.6

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    To explore mechanisms by which SGLT2 inhibitors protect diabetic hearts from heart failure, we examined the effect of empagliflozin (Empa) on the ultrastructure of cardiomyocytes in the noninfarcted region of the diabetic heart after myocardial infarction (MI). OLETF, a rat model of type 2 diabetes, and its nondiabetic control, LETO, received a sham operation or left coronary artery ligation 12 h before tissue sampling. Tissues were sampled from the posterior ventricle (i.e., the remote noninfarcted region in rats with MI). The number of mitochondria was larger and small mitochondria were more prevalent in OLETF than in LETO. Fis1 expression level was higher in OLETF than in LETO, while phospho-Ser637-Drp1, total Drp1, Mfn1/2, and OPA1 levels were comparable. MI further reduced the size of mitochondria with increased Drp1-Ser616 phosphorylation in OLETF. The number of autophagic vacuoles was unchanged after MI in LETO but was decreased in OLETF. Lipid droplets in cardiomyocytes and tissue triglycerides were increased in OLETF. Empa administration (10 mg/kg per day) reduced blood glucose and triglycerides and paradoxically increased lipid droplets in cardiomyocytes in OLETF. Empa suppressed Fis1 upregulation, increased Bnip3 expression, and prevented reduction in both mitochondrial size and autophagic vacuole number after MI in OLETF. Together with the results of our parallel study showing upregulation of SOD2 and catalase by Empa, the results indicate that Empa normalizes the size and number of mitochondria in diabetic hearts and that diabetes-induced excessive reduction in mitochondrial size after MI was prevented by Empa via suppression of ROS and restoration of autophagy.

    DOI: 10.14814/phy2.13741

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  • Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes. International journal

    Shingo Muratsubaki, Atsushi Kuno, Masaya Tanno, Takayuki Miki, Toshiyuki Yano, Hirohito Sugawara, Satoru Shibata, Koki Abe, Satoko Ishikawa, Kouhei Ohno, Yukishige Kimura, Yuki Tatekoshi, Kei Nakata, Wataru Ohwada, Masashi Mizuno, Tetsuji Miura

    Scientific reports   7 ( 1 )   5311 - 5311   2017.7

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    Diabetes mellitus is a major risk factor for acute kidney injury (AKI). Here, we hypothesized that suppression of autophagic response underlies aggravation of renal ischemia/reperfusion (I/R) injury by type 2 diabetes mellitus (T2DM). In OLETF, a rat model of T2DM, and its non-diabetic control, LETO, AKI was induced by unilateral nephrectomy and 30-min occlusion and 24-h reperfusion of the renal artery in the contralateral kidney. Levels of serum creatinine and blood urea nitrogen and tubular injury score after I/R were significantly higher in OLETF than in LETO. Administration of chloroquine, a widely used autophagy inhibitor, aggravated I/R-induced renal injury in LETO, but not in OLETF. In contrast to LETO, OLETF exhibited no increase in autophagosomes in the proximal tubules after I/R. Immunoblotting showed that I/R activated the AMPK/ULK1 pathway in LETO but not in OLETF, and mTORC1 activation after I/R was enhanced in OLETF. Treatment of OLETF with rapamycin, an mTORC1 inhibitor, partially restored autophagic activation in response to I/R and significantly attenuated I/R-induced renal injury. Collectively, these findings indicate that suppressed autophagic activation in proximal tubules by impaired AMPK/ULK1 signaling and upregulated mTORC1 activation underlies T2DM-induced worsening of renal I/R injury.

    DOI: 10.1038/s41598-017-05667-5

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  • Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways. International journal

    Makoto Ogasawara, Toshiyuki Yano, Masaya Tanno, Koki Abe, Satoko Ishikawa, Takayuki Miki, Atsushi Kuno, Toshiyuki Tobisawa, Shingo Muratsubaki, Kouhei Ohno, Yuki Tatekoshi, Kei Nakata, Wataru Ohwada, Tetsuji Miura

    Journal of molecular and cellular cardiology   108   203 - 213   2017.7

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    BACKGROUND: The role of necroptosis in myocardial injury has not been fully characterized. Here we examined roles of mitochondrial permeability transition pore (mPTP) and autophagy in necroptosis of cardiomyocytes. METHODS AND RESULTS: In H9c2 cells, necroptosis was induced by treatment with TNF-α (TNF) and z-VAD-fmk (zVAD) for 24h, and necroptotic death was determined by LDH release (as % of total). TNF/zVAD increased LDH release from 16.6±4.3% to 60.6±2.7%, and the LDH release was suppressed by necrostatin-1 (29.4±4.0%), a RIP1 inhibitor, and by siRNA-mediated knockdown of RIP3 (27.7±2.0%), confirming RIP1-RIP3-dependent necroptosis. TNF/zVAD-induced necroptosis was not attenuated by mPTP inhibitors or GSK-3β inhibitors. TNF/zVAD increased LC3-II level, but the change was not further enhanced by bafilomycin A1. The increase of LC3-II by TNF/zVAD was associated with suppression of both autophagic flux and LC3-LAMP1 co-localization. TNF/zVAD did not modify phosphorylation of Akt, p70s6K, AMPK, ULK1 or VASP but significantly increased RIP1-p62 binding and conversely reduced p62-LC3 binding. Rapamycin inhibited RIP1-p62 and RIP1-RIP3 interactions induced by TNF/zVAD and partly restored autophagic flux and suppressed LDH release in TNF/zVAD-treated cells. The effect of rapamycin on LDH release was reduced by knockdown of Atg5 expression. Knockdown of p62 by siRNA augmented LDH release by TNF/zVAD. CONCLUSION: Suppression of autophagic flux contributes to RIP1-RIP3 interaction and necroptosis of cardiomyocytes, and sequestration of p62 from its interaction with LC3-II by p62-RIP1 interaction possibly underlies the suppressed autophagy. The mPTP is unlikely to play a major role in execution of necroptosis in cardiomyocytes.

    DOI: 10.1016/j.yjmcc.2017.06.008

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  • Distinct impacts of sleep-disordered breathing on glycemic variability in patients with and without diabetes mellitus. International journal

    Kei Nakata, Takayuki Miki, Masaya Tanno, Hirofumi Ohnishi, Toshiyuki Yano, Atsuko Muranaka, Tatsuya Sato, Hiroto Oshima, Yuki Tatekoshi, Masashi Mizuno, Koki Abe, Tetsuji Miura

    PloS one   12 ( 12 )   e0188689   2017

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    BACKGROUND: Sleep-disordered breathing (SDB) is highly prevalent in patients with diabetes mellitus (DM) and heart failure (HF) and contributes to poor cardiovascular outcomes. Enlarged glycemic variability (GV) is a risk factor of cardiac events independently of average blood glucose level, but the influence of SDB on GV is uncertain. In this study, we examined whether the impact of SDB on GV is modified by the presence of DM with or without HF. METHODS AND RESULTS: Two hundred three patients (67.5±14.1 [SD] years old, 132 males) who were admitted to our institute for examination or treatment of DM and/or HF underwent continuous glucose monitoring and polysomnography. Both HbA1c (8.0±2.0 vs. 5.7±0.4%) and mean amplitude of glycemic excursion (MAGE, median: 95.5 vs. 63.5 mg/dl) were significantly higher in a DM group (n = 100) than in a non-DM group (n = 103), but apnea-hypopnea index (AHI: 29.0±22.7 vs. 29.3±21.5) was similar in the two groups. AHI was correlated with log MAGE in the non-DM group but not in the DM group, and multivariate regression analysis revealed that AHI was an independent variable for log MAGE in the non-DM group but not in the DM group. We then divided the non-DM patients into two subgroups according to BNP level (100 pg/ml). AHI was positively correlated with log MAGE (r = 0.74, p<0.001) in the non-DM low-BNP subgroup, but such a correlation was not found in the non-DM high-BNP subgroup. Continuous positive airway pressure (CPAP) reduced MAGE from 75.3 to 53.0 mg/dl in the non-DM group but did not reduce MAGE in the DM group. CONCLUSION: Severity of SDB was associated with higher GV, but DM as well as HF diminished the contribution of SDB to GV. Treatment with CPAP was effective for reduction of GV only in patients without DM.

    DOI: 10.1371/journal.pone.0188689

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Books

  • 血糖だけにこだわらない!糖尿病治療薬の考え方・使い方

    野見山 崇( Role: Contributor第4章-5 糖尿病患者が高血圧症になったら)

    日本医事新報社  2023.12  ( ISBN:9784784903740

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  • Text of Clinical Cardiology

    Kei Nakata, Hajime Sakuma( Role: ContributorChapter 14 Diagnosis and Examination MRI p.774-780)

    Bunked  2021.3  ( ISBN:9784830619670

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MISC

  • 機械学習による新規糖尿病発症予測モデルの構築

    田中 希尚, 遠藤 圭佑, 川原田 航, 合田 大樹, 中田 圭, 佐藤 達也, 塙 なぎさ, 古橋 眞人

    日本内科学会雑誌   114 ( 臨増 )   172 - 172   2025.2

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    Ichushi

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  • 日本の医療系学生の実態を捉えたSCOPH-Japanの活動とその意義

    木原 花野, 中野渡 康太朗, 高橋 侑里, 工藤 祐奈, 久保田 真央, 中田 圭, 大西 浩文

    日本公衆衛生学会総会抄録集   83回   375 - 375   2024.10

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  • デジタル技術は血圧を低下させるか? 成人血圧に対するウェアラブルデバイスの直接的および間接的介入効果

    小山 雅之, 親谷 佳佑, 中田 圭, 樋室 伸顕, 篠原 由紀子, 有馬 久富, 大西 浩文

    日本高血圧学会総会プログラム・抄録集   46回   631 - 631   2024.10

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  • Sampsonの式あるいは人工知能を用いて推定したsmall dense LDLコレステロール値の精度の検証

    大久保 武志, 遠藤 圭佑, 田中 希尚, 佐藤 達也, 小林 亮, 田中 真輝人, 秋山 幸功, 保坂 到, 中田 圭, 小山 雅之, 大西 浩文, 高橋 聡, 古橋 眞人

    糖尿病   67 ( Suppl.1 )   S - 251   2024.4

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  • Association of Snacking Habits with Other Lifestyle Habits: Baseline Survey of Dental Education Activities for Preschool Children in the After-COVID-19

    大岩大祐, 大岩大祐, 大浦麻絵, 中田圭, 中田真由, 林二士, 小野智史, 大西浩文

    北海道公衆衛生学雑誌   37 ( 2 )   33 - 38   2024.3

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  • 子ども達から子ども達へ伝えるピア健康教育の実践 病気の予防プロジェクト2022

    大浦 麻絵, 大西 浩文, 中田 真由, 小山 雅之, 中田 圭, 長多 好恵, 長谷川 準子, 助友 裕子, 森 満

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  • 児童の手洗いを科学するアクションリサーチ ATPを用いた可視化の検討

    大浦 麻絵, 中田 圭, 内藤 由紀子, 大岩 大祐, 小山 雅之, 長多 好恵, 助友 裕子, 大西 浩文

    北海道公衆衛生学雑誌   37 ( 2 )   65 - 69   2024.3

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  • 肥満減量術後慢性期の血糖コントロール悪化にセマグルチドが著効した2型糖尿病の症例

    赤澤 史子, 小川 俊史, 中田 圭, 佐藤 達也, 伊東 竜哉, 竹政 伊知朗, 古橋 眞人

    糖尿病   67 ( 1 )   37 - 37   2024.1

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  • チルゼパチドが著効した後腹膜滑膜肉腫合併の若年肥満2型糖尿病の症例

    大久保 武志, 佐藤 達也, 小川 俊史, 中田 圭, 大和田 渉, 隅田 健太郎, 神津 英至, 矢野 俊之, 古橋 眞人

    糖尿病   67 ( 1 )   38 - 38   2024.1

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  • 日本人2型糖尿病患者においてペマフィブラートの12ヵ月投与が血中脂質と脂肪肝指数に与える影響の検討

    鈴木亨, 鈴木亨, 佐藤達也, 佐藤達也, 田中希尚, 田中希尚, 遠藤圭佑, 中田圭, 小川俊史, 小川俊史, 保坂致, 秋山幸功, 梅津新矢

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   56th   2024

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    中田圭, 佐藤達也, 小川俊史, 大和田渉, 隅田健太郎, 神津英至, 矢野俊之, 古橋眞人

    糖尿病(Web)   67 ( 1 )   2024

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    赤澤史子, 小川俊史, 中田圭, 佐藤達也, 伊東竜哉, 竹政伊知朗, 古橋眞人

    糖尿病(Web)   67 ( 1 )   2024

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    大久保武志, 佐藤達也, 小川俊史, 中田圭, 大和田渉, 隅田健太郎, 神津英至, 矢野俊之, 古橋眞人

    糖尿病(Web)   67 ( 1 )   2024

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    若松淳, 若松淳, 中田圭, 上村修二, 小山雅之, 中山龍一, 原正浩, 大西浩文

    日本臨床救急医学会雑誌   27 ( 3 )   2024

  • 脂肪肝指数(FLI)と高血圧発症との関連:日本人における大規模データベースを用いた過去起点コホート研究

    親谷佳佑, 親谷佳佑, 小山雅之, 小山雅之, 中田圭, 中田圭, 樋室伸顕, 古橋眞人, 岡山明, 大西浩文, 大西浩文

    日本疫学会学術総会講演集(Web)   34th   2024

  • A Survey of the Patients with Hypertensive Disorders of Pregnancy in Hokkaido: NDB-based all-inclusive survey

    前田尚美, 前田尚美, 小山雅之, 高塚伸太朗, 親谷佳佑, 中田圭, 樋室伸顕, 大西浩文

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   45回   415 - 415   2023.9

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  • 心不全に罹患した高齢者に対する多職種介入の効果に関する研究

    栗林 美優, 中田 圭, 加藤 ちえ, 釜江 直也, 平松 知子, 福田 茉莉, 室谷 智子, 小山 雅之, 平田 匠, 宮本 恵宏

    日本循環器病予防学会誌   58 ( 2 )   144 - 144   2023.5

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    牧田靖子, 大浦麻絵, 中田圭, 助友裕子, 手塚崇子, 河村洋子, 林二士, 森満, 大西浩文

    北海道公衆衛生学雑誌   37 ( 1 )   2023

  • COVID-19流行前における保護者のインフルエンザワクチン接種に対する意識と予防行動に関する調査

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    北海道公衆衛生学雑誌   37 ( 1 )   2023

  • 全身麻酔下に歯科治療を受けた小児患者のうち障がいの有無と移動距離との関連性に関する検討

    大岩大祐, 大岩大祐, 大浦麻絵, 中田圭, 中田真由, 大西浩文

    北海道公衆衛生学雑誌   37 ( 1 )   2023

  • 【一般内科医が知っておきた最新の心筋症診療】心筋症の診断と治療 現状と今後の展望 心臓MRI検査

    中田 圭, 石田 正樹, 佐久間 肇

    診断と治療   109 ( 4 )   471 - 475   2021.4

  • 心筋T1 mappingを用いて予測した拡張型心筋症患者の左室リバースリモデリング 組織学的組織性状との比較(Myocardial T1 Mapping for Prediction of Left Ventricular Reverse Remodeling in Patients with Dilated Cardiomyopathy: A Comparison with Histological Tissue Characterization)

    石浦 純子, 中森 史朗, 今中 恭子, 廣江 道昭, 中田 圭, 石田 正樹, 森脇 啓至, 藤本 直紀, 佐久間 肇, 土肥 薫

    日本循環器学会学術集会抄録集   85回   OJ44 - 3   2021.3

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  • Q&A(第10回) 睡眠呼吸障害と血糖変動の関係について教えてください

    中田 圭

    Calm   7 ( 2 )   74 - 78   2020.7

  • SAP療法下に多量飲酒を誘因に発症した糖尿病性ケトアシドーシスの1例

    東浦 幸村, 中田 圭, 西川 諒, 矢野 俊之, 古橋 眞人, 三木 隆幸, 三浦 哲嗣

    糖尿病   62 ( 12 )   776 - 776   2019.12

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  • 3Fr CAGおよびバーチャル3Fr PCIによる標準手技は橈骨動脈合併症を低減させる

    中田 圭, 古川 哲章, 高川 芳勅

    日本心血管インターベンション治療学会抄録集   28回   [MO81 - 004]   2019.9

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  • 重症冠動脈病変の検出における心筋全体の血流予備能評価の有用性 O-15水PETによる検討

    中田 圭, 市川 泰崇, 高藤 雅史, 石田 正樹, 永田 幹紀, 北川 覚也, 佐久間 肇

    日本心臓核医学会ニュースレター   21 ( 2 )   24 - 24   2019.6

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  • 重症冠動脈病変の検出における心筋全体の血流予備能評価の有用性 O-15水PETによる検討

    中田 圭, 市川 泰崇, 高藤 雅史, 石田 正樹, 永田 幹紀, 北川 覚也, 佐久間 肇

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  • 糖尿病薬以外のポリファーマシーが糖尿病教育入院患者の退院後血糖コントロールに及ぼす影響

    石郷 友之, 近藤 蕗, 中田 圭, 伊野 祥哉, 北川 学, 木明 智子, 中田 浩雅, 三木 隆幸, 三浦 哲嗣, 宮本 篤

    糖尿病   62 ( Suppl.1 )   S - 110   2019.4

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  • 糖尿病の外来診療における慢性合併症評価実態の検討

    伊野 祥哉, 中田 圭, 東浦 幸村, 佐藤 達也, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三木 隆幸, 斎藤 重幸, 三浦 哲嗣

    糖尿病   62 ( Suppl.1 )   S - 306   2019.4

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  • 【血糖変動評価で変わる新たな糖尿病治療】血糖変動と睡眠時無呼吸症候群

    中田 圭

    Progress in Medicine   39 ( 3 )   257 - 262   2019.3

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  • JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは 心血管イベントリスクの高い糖尿病患者を検出するためのECG検査の重要性とSGLT2阻害薬によって得られる利点(Importance of ECG Examination to Detect High Risk Diabetic Patients for Cardiovascular Events and Their Benefit Afforded by SGLT2 Inhibitors)

    三木 隆幸, 佐藤 達也, 大西 浩文, 矢野 俊之, 中田 圭, 丹野 雅也, 三浦 哲嗣

    日本循環器学会学術集会抄録集   83回   SY12 - 3   2019.3

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  • SAP療法下に多量飲酒を誘因に発症した糖尿病性ケトアシドーシスの1例

    東浦幸村, 中田圭, 西川諒, 矢野俊之, 古橋眞人, 三木隆幸, 三浦哲嗣

    糖尿病(Web)   62 ( 12 )   2019

  • 糖尿病の外来診療における慢性合併症評価実態の検討

    伊野祥哉, 中田圭, 東浦幸村, 佐藤達也, 矢野俊之, 古橋眞人, 丹野雅也, 三木隆幸, 斎藤重幸, 三浦哲嗣

    糖尿病(Web)   62 ( Suppl )   2019

  • 糖尿病薬以外のポリファーマシーが糖尿病教育入院患者の退院後血糖コントロールに及ぼす影響

    石郷友之, 近藤蕗, 中田圭, 伊野祥哉, 北川学, 木明智子, 中田浩雅, 三木隆幸, 三浦哲嗣, 宮本篤

    糖尿病(Web)   62 ( Suppl )   2019

  • SDB治療フロンティア 陽圧換気療法の新展開(第9回) 睡眠呼吸障害と血糖変動

    中田 圭, 小川 俊史

    睡眠医療   12 ( 3 )   409 - 417   2018.9

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  • Fallot四徴症および重症肺高血圧合併の糖尿病性ネフローゼ症候群にempaglifrozinが著効した一例

    中田 圭, 古川 哲章, 高川 芳勅

    糖尿病   61 ( Suppl.1 )   S - 178   2018.4

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  • Flash Glucose Monitoringを用いた血糖値予測妥当性の検討

    青山 ちひろ, 三木 隆幸, 大島 洸人, 中田 圭, 佐藤 達也, 矢野 俊之, 古橋 眞人, 齋藤 重幸, 三浦 哲嗣

    糖尿病   61 ( Suppl.1 )   S - 191   2018.4

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  • Flash Glucose Monitoringを用いた血糖値予測妥当性の検討

    青山ちひろ, 三木隆幸, 大島洸人, 中田圭, 佐藤達也, 矢野俊之, 古橋眞人, 齋藤重幸, 三浦哲嗣

    糖尿病(Web)   61 ( Suppl )   2018

  • Fallot四徴症および重症肺高血圧合併の糖尿病性ネフローゼ症候群にempaglifrozinが著効した一例

    中田圭, 古川哲章, 高川芳勅

    糖尿病(Web)   61 ( Suppl )   2018

  • 冠疾患危険因子の管理目標達成率が冠動脈病変に与える影響

    中田圭, 村上直人, 青山ちひろ, 鎌田祐介, 能登貴弘, 国分宜明, 丹野雅也, 三木隆幸, 三浦哲嗣

    糖尿病(Web)   61 ( Suppl )   2018

  • SGLT2阻害薬は2型糖尿病患者の心室筋再分極障害を改善させる

    佐藤 達也, 三木 隆幸, 山下 智久, 中田 圭, 高田 明典, 大野 紘平, 矢野 俊之, 土田 哲人, 齋藤 重幸, 三浦 哲嗣

    糖尿病   60 ( Suppl.1 )   S - 269   2017.4

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  • 多腺性自己免疫症候群3A型に房室ブロックを合併した一例 抗Ro/SS-A抗体との関連

    中田 圭, 矢野 俊之, 大島 洸人, 古橋 眞人, 丹野 雅也, 斎藤 重幸, 三木 隆幸, 三浦 哲嗣

    糖尿病   60 ( Suppl.1 )   S - 452   2017.4

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  • 抗Ro/SS-A抗体陽性多腺性自己免疫症候群3A型に房室ブロックを合併した1例

    中田圭, 大島洸人, 青山ちひろ, 舘越勇輝, 矢野俊之, 古橋眞人, 三木隆幸, 三浦哲嗣

    糖尿病(Web)   60 ( 3 )   2017

  • SGLT2阻害薬は2型糖尿病患者の心室筋再分極障害を改善させる

    佐藤達也, 三木隆幸, 山下智久, 中田圭, 高田明典, 大野紘平, 矢野俊之, 土田哲人, 齋藤重幸, 三浦哲嗣

    糖尿病(Web)   60 ( Suppl )   2017

  • 多腺性自己免疫症候群3A型に房室ブロックを合併した一例:抗Ro/SS-A抗体との関連

    中田圭, 矢野俊之, 大島洸人, 古橋眞人, 丹野雅也, 斎藤重幸, 三木隆幸, 三浦哲嗣

    糖尿病(Web)   60 ( Suppl )   2017

  • Increased Renal Susceptibility to AKI after Myocardial Infarction in Type 2 Diabetes is Mediated by Augmented Activation of Toll-like Receptors

    大野紘平, 久野篤史, 三木隆幸, 丹野雅也, 矢野俊之, 大和田渉, 木村幸滋, 安部功記, 中田圭, 舘越勇輝, 三浦哲嗣

    日本循環器学会学術集会(Web)   81st   2017

  • ポリファーマシーが血糖コントロールに与える影響

    石郷友之, 中田圭, 木明智子, 中田浩雅, 野田師正, 宮本篤

    日本医療薬学会年会講演要旨集(Web)   27   2017

  • ROS-Induced Mitochondrial Translocation of Phosphatases Cancels Cell-Protective Signals Activated by Phosphorylation of Mitochondrial Protective Kinases

    Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Atsushi Kuno, Takayuki Miki, Satoko Ishikawa, Yuki Tatekoshi, Koki Abe, Kouhei Ohno, Masashi Mizuno, Kei Nakata, Tetsuji Miura

    CIRCULATION   134   2016.11

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  • Upregulation of AMP deaminase activity in diabetic hearts by decreased interaction with phosphoglucomutase-1 and depletion of fructose 1,6-diphosphate: a novel mechanism for diabetic cardiomyopathy

    Y. Tatekoshi, M. Tanno, H. Kouzu, T. Miki, A. Kuno, S. Ishikawa, T. Yano, W. Ohwada, K. Ohno, M. Mizuno, K. Nishizawa, K. Nakata, T. Miura

    EUROPEAN HEART JOURNAL   37   1037 - 1038   2016.8

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  • 睡眠呼吸障害が血糖変動に与える影響の検討

    中田 圭, 丹野 雅也, 矢野 俊之, 小笠原 淳, 赤坂 憲, 古橋 眞人, 三木 隆幸, 三浦 哲嗣

    糖尿病   59 ( Suppl.1 )   S - 191   2016.4

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    Language:Japanese   Publisher:(一社)日本糖尿病学会  

    Ichushi

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  • 糖尿病が腎虚血再灌流障害に及ぼす影響:オートファジーとの関連

    村椿真悟, 久野篤史, 大野紘平, 丹野雅也, 矢野俊之, 水野雅司, 西沢慶太郎, 大和田渉, 舘越勇輝, 中田圭, 三木隆幸, 三浦哲嗣

    日本腎臓学会誌   58 ( 3 )   2016

  • 睡眠呼吸障害が血糖変動に与える影響の検討

    中田圭, 丹野雅也, 矢野俊之, 小笠原淳, 赤坂憲, 古橋眞人, 三木隆幸, 三浦哲嗣

    糖尿病(Web)   59 ( Suppl )   2016

  • 薬剤選択の分岐点 DPP-4阻害薬かSGLT-2阻害薬かの選択

    三木 隆幸, 中田 圭, 舘越 勇輝

    循環器内科   78 ( 6 )   616 - 622   2015.12

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    J-GLOBAL

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  • 心不全と糖尿病が,睡眠呼吸障害と血糖変動の関連へ与える影響

    藤田雄吾, 中田圭, 丹野雅也, 鈴木洋平, 長南新太, 舘越勇輝, 能登貴弘, 瀬野結, 三木隆幸, 三浦哲嗣

    日本循環器学会北海道地方会(Web)   114th   2015

  • 肺動静脈瘻に伴う心不全に対して外科的切除が奏功した一例

    三俣兼人, 坂本健一, 高橋弘, 中村裕一, 岡崎雄介, 中田圭, 西川諒, 山内一暁, 松木高雪

    日本循環器学会北海道地方会(Web)   112th   2014

  • Klebsiella pneumoniaeによる肝膿瘍に多発肺膿瘍を合併した1例

    中田 圭, 有賀 伸, 松薗 絵美, 横山 文明, 石橋 陽子, 菅井 望, 関 英幸, 三浦 淳彦, 藤田 淳, 鈴木 潤一

    KKR札幌医療センター医学雑誌   9 ( 1 )   67 - 70   2012.10

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Presentations

Awards

  • The 23rd Society of Cardiovascular Magnetic Resonance Annual Scientific Sessions Travel Award

    2020.1   Society of Cardiovascular Magnetic Resonance  

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  • Poster Award

    2021.3   Beyond Angiography Japan   A case of cardiac MRI and pathological evaluation of the course of myocarditis induced by immune checkpoint inhibitors

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  • The 29th The Japanese Society of Nuclear Cardiology Young Investigators Award

    2019.7   The JapaneseJ Society of Nuclear Cardiology  

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  • Japan Heart Foundation Philips Heart Failure Positive Pressure Treatment Research Encouragement Award Research Presentation Award

    2017.2   Japan Heart Foundation  

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Research Projects

  • 組織粘弾性イメージングを用いたサルコペニア併存心不全の骨格筋粘弾性評価

    Grant number:25K10715  2025.4 - 2029.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    長岡 凌平, 片野唆敏, 矢野俊之, 谷口圭吾, 中田圭, 河合誠

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 保育従事者の離職を抑制する要因の解明

    Grant number:18K02445  2018.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    大浦 麻絵, 大西 浩文, 米谷 光弘, 森 満, 助友 裕子, 手塚 崇子, 河村 洋子, 中田 圭

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    女性の社会進出のみならず療養中など社会のサポートが必要な家庭を支えている保育施設は重要な社会資源の一つです。その一方で保育者の離職率の高さ、勤続年数の短さは大きな社会問題です。今、日本の子育ては大きな転換期を迎えております。この転換期で安全・安心な通常の保育教育を実施しながら、子ども達の関わりに心を配り、更には過大な事務仕事等にも追われながら、多くの先生が疲弊しているのではないかと危惧されています。保育者の負担軽減は子ども達の質の高い保育へと繋がっていきます。そして保育という仕事を長期的に続けることが出来ると考えております。以上より私たちは保育者の処遇改善は公衆衛生学的な喫緊の課題と考え、2015年度から調査を行っております。
    コロナ禍においては、保育者研修会などが中止、オンライン実施になり対面での研究活動が困難な中、これまでの研究フィールドとの信頼関係から、会員園にご理解を頂き、郵送法による調査票研究実施まで実現することが出来ました。
    2023年1月から、北海道私立幼稚園協会の会員園に所属する保育士を対象とした質問紙調査を実施し現在回収中です。(4月12日時点において600人近くの調査票を回収。)現在、2019年夏、2020年冬、2021年秋に実施した調査研究の分析作業を行っています。また、2023年度以降も調査は継続しますが、一旦現在の調査が終了し次第、横断研究の繰り返し調査として論文発表を行っていきます。

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