Updated on 2026/10/28

写真a

 
MIHARA Hiroshi
 
Organization
Medical Development Center Dean Department of Educational Development Associate Professor
Title
Associate Professor
Profile

Hiroshi Mihara is an Associate Professor at Sapporo Medical University. His work spans medical education, general internal medicine, and gastroenterology. His research interests include AI-based simulated patients, clinical reasoning education, simulation-based assessment, professional identity formation, and whole person care. He also investigates gastrointestinal sensory mechanisms and disorders of gut–brain interaction.

ORCID ID
0000-0002-8427-2868
External link

Degree

  • Doctor of Philosophy in Medicine ( 2011.3   University of Toyama )

Research Interests

  • Medical education

  • Clinical reasoning

  • Generative AI

  • Whole person care

  • Objective structured clinical examination (OSCE)

  • Gastroenterology

  • Simulated patients

Research Areas

  • Humanities & Social Sciences / Education

  • Life Science / General internal medicine

  • Life Science / Gastroenterology

Education

  • University of Toyama   Graduate School of Medicine and Pharmaceutical Sciences, Doctoral Program   Medical Life Science

    2007.4 - 2011.3

      More details

    Notes: Completed; Ph.D. in Medicine awarded

    researchmap

  • Toyama Medical and Pharmaceutical University   Faculty of Medicine   School of Medicine

    1996.4 - 2002.3

      More details

    Notes: Graduated

    researchmap

Research History

  • Sapporo Medical University   Division of Educational Development and Research, Center for Medical Education   Associate Professor

    2022.9

      More details

  • University of Toyama   Center for Medical Education, Faculty of Medicine   Assistant Professor

    2015.7 - 2022.8

      More details

  • Toyama University Hospital   Third Department of Internal Medicine   Clinical Assistant

    2012.4 - 2015.6

      More details

  • Toyama University Hospital   Third Department of Internal Medicine   Physician

    2010.10 - 2012.3

      More details

  • National Institute for Physiological Sciences   Division of Cell Physiology, Okazaki Institute for Integrative Bioscience   Research Fellow

    2008.5 - 2010.9

      More details

  • Toyama University Hospital   Third Department of Internal Medicine   Physician

    2007.4 - 2008.4

      More details

  • Takaoka City Hospital   Department of Gastroenterology   Physician

    2005.4 - 2007.3

      More details

  • Toyama City Hospital   Department of Internal Medicine   Physician

    2004.4 - 2005.3

      More details

  • Toyama Medical and Pharmaceutical University Hospital   Third Department of Internal Medicine   Resident Physician

    2002.5 - 2004.3

      More details

▼display all

Professional Memberships

  • 日本Whole Person Care研究会

    2024.4

      More details

  • Japanese Society for Abdominal Emergency Medicine

    2012.7

      More details

  • Japan Society for Medical Education

    2007.7

      More details

  • Japanese Society of Internal Medicine

    2002.5

      More details

  • Japanese Society of Gastroenterology

    2002.5

      More details

  • Japan Gastroenterological Endoscopy Society

    2002.5

      More details

▼display all

Papers

▼display all

Books

MISC

▼display all

Awards

  • Award for Excellence (Silver Prize), 71st Toyama Prefectural Medical Congress

    2017.1   Comparison of Third-Year Medical Students’ Awareness of Career-Path Milestones at the University of Toyama

    Hiroshi Mihara

     More details

    Award type:Award from Japanese society, conference, symposium, etc. 

    Award date: January 29, 2017.

    researchmap

Research Projects

  • Development of a distance learning program to improve the emergency medical skills for non-emergency physicians and verification of the educational outcome

    Grant number:25K13417  2025.4 - 2029.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    researchmap

  • Research for induction or normalization factor for colonic TRPV4 methylation aiming at curing constipation

    Grant number:19K08366  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Mihara Hiroshi

      More details

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    TRPV4 ion channel, a receptor for stretching and microinflammation, was highly expressed in the epithelium in constipated patients from the small intestine to the rectum and was associated with decreased stool frequency and duration of disease. When colon epithelial cell lines and bacteria were co-cultured, bacteria was divided into those that transiently decreased, those that remained constant, and those that increased TRPV4 expression. ; K.oxytoca, E.faecalis, and E.coli increased TRPV4 expression; the bacteria themselves did not increase the expression, but culture components did. Butyrate, a short-chain fatty acid, and TNF-α inhibitors suppressed increased expression, and constipation symptoms were associated with the ratio of E.faecalis in the colonic mucosa of constipated patients, suggesting that maintaining butyrate-producing bacteria and suppressing the TNF-α pathway may prevent or treat chronic constipation.

    researchmap

  • TRP ion channel related to the pathogenic mechanism of small intestinal ulceration induced by NSAIDs use

    Grant number:15K08947  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Sugiyama Toshiro

      More details

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    NSAIDs-induced small intestinal ulcerations are rapidly increasing, however the effective prevention has not been established. As the ulcerations are prevented by the use of broad spectrum antibiotics, the intestinal inflammation by intestinal flora or the metabolites should be attributed. However, the molecular mechanism related to increased permeability of small intestinal epithelial cells by NSAIDs use is not elucidated.
    By the permeability experiment with small intestinal epithelial cells, NSAIDs accelerated the permeability via the accumulation of 8, 9 EET, which is the metabolites of membrane arachidonic acids and activated TRPV4. The activated TRPV4 is attributed to the increase of permeability. By this assay system, one candidate drug was selected, which showed the inhibition of TRPV4 activation and inhibited the increased permeability of intestinal epithelial cells induced by NSAIDs. Clinical trials are planning to confirm the preventing effect of the candidate.

    researchmap

  • Molecular mechanism of luminal pressure reception and ATP release in gastrointestinal epithelium

    Grant number:26870214  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Mihara Hiroshi, NISHIZONO Hirofumi, SUGIYAMA Toshiro, TOMINAGA Makoto, TABUCHI Yoshiaki, WATANABE Shiro, UCHIDA Kunitoshi, KOIZUMI Schuichi, Boudaka Ammar, YAMAWAKI Hidemoto, SUZUKI Nobuhiro, Muhammad Jibran Sualeh, KOZAWA Toyomi, Fujinami Haruka, ANDO Takayuki, NANJO Sohachi

      More details

    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    Approximately 15% of Japanese people have chronic abdominal pain of unknown origin and hypersensitivity to gastrointestinal pressure is one of possible causes. The esophagus senses a tension with mechano-sensitive TRPV4 ion channel and releases bag-like adenosine triphosphate (ATP) using its transporter (VNUT). As a result of the study, TRPV4 and VNUT are present not only in the esophagus but also from the stomach to the rectum, and ATP is released via VNUT by TRPV4 stimulation, including stretch stimuli. Mice lacking TRPV4 have gastric motor abnormality and Helicobacter pylori infection decreases TRPV4 (gene methylation). It has also succeeded in quantifying the TRPV4 stimulating component synthesized in the gastrointestinal tract and so the possibility of quantifying invisible abdominal pain has come out.

    researchmap

Teaching Experience

  • Comprehensive Lectures I and Integrative Medicine (Year 4)

    2024.4 Institution:School of Medicine, Sapporo Medical University

     More details

  • Course Director: Joint Seminar in Community Medicine III (Year 6)

    2024.4 Institution:School of Medicine, Sapporo Medical University

     More details

  • Introduction to Medicine and Basic Clinical Skills (Medical Interviewing, Venipuncture, etc.)

    2023.4 Institution:School of Medicine, Sapporo Medical University

     More details

  • Clinical Clerkship in General Medicine and Community-Based Comprehensive Care (Years 5 and 6)

    2022.9 Institution:School of Medicine, Sapporo Medical University

     More details

  • Introduction to Clinical Medicine and Clinical Epidemiology (Year 3)

    2022.9 Institution:School of Medicine, Sapporo Medical University

     More details

  • Clinical Clerkship in Gastroenterology, Basic Clinical Skills, and Medical English

    2020.4 - 2022.8 Institution:Faculty of Medicine, University of Toyama

     More details

  • Course Director: Preclinical Clerkship and Integrated Clinical Courses (Years 3, 4, and 6)

    2020.4 - 2022.3 Institution:Faculty of Medicine, University of Toyama

     More details

▼display all

Social Activities

  • Promotion of Regional Collaboration in Healthcare Education as President of the 13th Meeting of the Japan Whole Person Care Study Group in Sapporo

    Role(s): Planner

    2026.2

     More details

    Type:Other

    researchmap

  • Online Seminars on Whole Person Care for Healthcare Professionals and Community Members

    Role(s): Planner

    2025.6

     More details

    Type:Seminar, workshop

    researchmap

  • Support for Digital Transformation in Regional Healthcare Education through an AI Simulated Patient Team Competition in Hokkaido

    Role(s): Planner

    2024.4

     More details

    Type:Other

    researchmap

  • Organization of Mindfulness Reading and Practice Groups to Promote Well-Being and Prevent Burnout among Healthcare Professionals and Medical Students

    Role(s): Planner

    2023.4

     More details

    Type:Seminar, workshop

    researchmap

  • Facilitation of Joint Seminars for Community Healthcare Professionals and Interprofessional Education

    Role(s): Organizing member

    2021.4

     More details

    Type:Seminar, workshop

    researchmap

  • Public Lectures and Health Education on Chronic Constipation and Lifestyle-Related Gastrointestinal Disorders

    Role(s): Lecturer

    2018.4

     More details

    Type:Lecture

    researchmap

▼display all

Academic Activities

  • Peer Review for Health Professions Education Journals, Including Journal of General and Family Medicine

    Role(s): Peer review

    2025.4

     More details

    Type:Peer review 

    researchmap

  • Peer Reviewer, Medical Education (Japan)

    Role(s): Peer review

    Japan Society for Medical Education  2025.1

     More details

    Type:Peer review 

    researchmap

  • Working Group Collaborator, External Review and AGREE II Appraisal, 2025 Revision of the Clinical Practice Guidelines for Acute Abdomen

    Role(s): Review, evaluation

    2024.10

     More details

    Type:Scientific advice/Review 

    researchmap

  • Guest Editor, Chiryo, August 2024: Preventing Drug-Induced Constipation During Disease Treatment

    Role(s): Planning, management, etc.

    Nanzando Co., Ltd.  2024.8 - 2024.9

     More details

  • Editorial Board Member and Issue Editor, Rp.+ (Recipe Plus), Spring 2022

    Role(s): Planning, management, etc.

    Nanzando Co., Ltd.  2022.4 - 2022.6

     More details

  • Peer Review for International Journals, Including BMC Medical Education, Advances in Health Sciences Education, and PLOS Digital Health

    Role(s): Peer review

    2021.1

     More details

    Type:Peer review 

    researchmap

▼display all