研究者詳細 - 秋山　有史

論文 - 秋山　有史

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術前HCCとの鑑別が困難であったParagangliomaの一例

畑中智貴, 高原武志, 新田浩幸, 長谷川康, 眞壁健二, 梅邑晃, 板橋英教, 秋山有史, 岩谷岳, 大塚幸喜, 肥田圭介, 佐々木章

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 77 ( 増刊 ) 821 - 821 2016年10月

食道肺瘻合併進行食道癌に対しバイパス手術が有効であった1例

遠藤史隆, 岩谷岳, 秋山有史, 塩井義裕, 天野総, 木村祐輔, 佐々木章

日本食道学会学術集会プログラム・抄録集 ( (NPO)日本食道学会 ) 70回 208 - 208 2016年07月

DCF療法(docetacel/cisplatin/5-FU併用療法)とBi-weekly DCF療法における有害事象に関する検討

塩井義裕, 岩谷岳, 秋山有史, 遠藤史隆, 木村祐輔, 大塚幸喜, 新田浩幸, 肥田圭介, 水野大, 佐々木章

日本消化器外科学会総会 ( (一社)日本消化器外科学会 ) 71回 P3 - 5 2016年07月

当院におけるERASに基づく胸部食道癌周術期管理

遠藤史隆, 岩谷岳, 秋山有史, 塩井義裕, 新田浩幸, 大塚幸喜, 肥田圭介, 水野大, 木村祐輔, 佐々木章

日本消化器外科学会総会 ( (一社)日本消化器外科学会 ) 71回 P3 - 1 2016年07月

Downregulation of TMPRSS11B in squamous cell carcinoma

Suburu Amano, Takeshi Iwaya, Satoshi Nishizuka, Kohei Kume, Chie Ito, Yuji Akiyama, Yoshihiro Shioi, Fumitaka Endo, Akira Sasaki

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH ) 76 2016年07月 [査読有り]

DOI

胸腔鏡下食道切除術における合併症軽減のための工夫

秋山有史, 岩谷岳, 遠藤史隆, 塩井義裕, 高原武志, 大塚幸喜, 新田浩幸, 肥田圭介, 木村祐輔, 佐々木章

日本消化器外科学会総会 ( (一社)日本消化器外科学会 ) 71回 P2 - 2 2016年07月

進行食道癌に対する導入DCF療法後後治療に関する検討

岩谷岳, 秋山有史, 塩井義裕, 遠藤史隆, 木村祐輔, 大塚幸喜, 新田浩幸, 肥田圭介, 水野大, 佐々木章

日本消化器外科学会総会 ( (一社)日本消化器外科学会 ) 71回 P3 - 3 2016年07月

Multiple genes on chromosome 17q25 were involved in sporadic esophageal squamous cell carcinoma development

Takeshi Iwaya, Suburu Amano, Fumitaka Endo, Yuji Akiyama, Yoshihiro Shioi, Kohei Kume, Satoshi Nishizuka, Chie Ito, Akira Sasaki, Koshi Mimori

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH ) 76 2016年07月 [査読有り]

DOI

食道癌に対する周術期の多職種チーム医療介入の成果

秋山有史, 岩谷岳, 遠藤史隆, 塩井義裕, 肥田圭介, 木村祐輔, 佐々木章

日本食道学会学術集会プログラム・抄録集 ( (NPO)日本食道学会 ) 70回 76 - 76 2016年07月

Intracorporeal reconstruction after laparoscopic pylorus-preserving gastrectomy for middle-third early gastric cancer: a hybrid technique using linear stapler and manual suturing.

Koeda K, Chiba T, Noda H, Nishinari Y, Segawa T, Akiyama Y, Iwaya T, Nishizuka S, Nitta H, Otsuka K, Sasaki A

Langenbeck's archives of surgery 401 ( 3 ) 397 - 402 2016年05月 [査読有り] [国際誌]

PURPOSE: Laparoscopy-assisted pylorus-preserving gastrectomy has been increasingly reported as a treatment for early gastric cancer located in the middle third of the stomach because of its low invasiveness and preservation of pyloric function. Advantages of a totally laparoscopic approach to distal gastrectomy, including small wound size, minimal invasiveness, and safe anastomosis, have been recently reported. Here, we introduce a new procedure for intracorporeal gastro-gastrostomy combined with totally laparoscopic pylorus-preserving gastrectomy (TLPPG). METHODS: The stomach is transected after sufficient lymphadenectomy with preservation of infrapyloric vessels and vagal nerves. The proximal stomach is first transected near the Demel line, and the distal side is transected 4 to 5 cm from the pyloric ring. To create end-to-end gastro-gastrostomy, the posterior wall of the anastomosis is stapled with a linear stapler and the anterior wall is made by manual suturing intracorporeally. We retrospectively assessed the postoperative surgical outcomes via medical records. The primary endpoint in the present study is safety. RESULTS: Sixteen patients underwent TLPPG with intracorporeal reconstruction. All procedures were successfully performed without any intraoperative complications. The mean operative time was 275 min, with mean blood loss of 21 g. With the exception of one patient who had gastric stasis, 15 patients were discharged uneventfully between postoperative days 8 and 11. CONCLUSIONS: Our novel hybrid technique for totally intracorporeal end-to-end anastomosis was performed safely without mini-laparotomy. This technique requires prospective validation.

DOI PubMed

食道悪性腫瘍手術における周術期管理チームが周術期に与える効果

塩井義裕, 岩谷岳, 秋山有史, 鴻巣正史, 遠藤史隆, 木村祐輔, 大塚幸喜, 新田浩幸, 柏葉匡寛, 肥田圭介, 水野大, 佐々木章

日本外科学会定期学術集会抄録集 ( (一社)日本外科学会 ) 116回 PS - 2 2016年04月

進行食道癌に対する一次化学療法に関する検討

岩谷岳, 秋山有史, 塩井義裕, 遠藤史隆, 木村祐輔, 鴻巣正史, 天野総, 大塚幸喜, 新田浩幸, 柏葉匡寛, 肥田圭介, 水野大, 佐々木章

日本外科学会定期学術集会抄録集 ( (一社)日本外科学会 ) 116回 PS - 2 2016年04月

食道癌に対する腹臥位胸腔鏡下食道切除術の手術成績

秋山有史, 岩谷岳, 塩井義裕, 遠藤史隆, 千葉丈広, 大塚幸喜, 新田浩幸, 柏葉匡寛, 肥田圭介, 水野大, 木村祐輔, 佐々木章

日本外科学会定期学術集会抄録集 ( (一社)日本外科学会 ) 116回 PS - 8 2016年04月

食道扁平上皮癌におけるTransmembrane Protease Serine 11Bの発現異常

天野総, 岩谷岳, 西塚哲, 伊藤千絵, 秋山有史, 塩井義裕, 遠藤史隆, 木村祐輔, 鴻巣正史, 杉立彰夫, 伊勢一哉, 大塚幸喜, 新田浩幸, 柏葉匡寛, 肥田圭介, 水野大, 佐々木章

日本外科学会定期学術集会抄録集 ( (一社)日本外科学会 ) 116回 OP - 6 2016年04月

当科における食道癌肉腫症例の検討

遠藤史隆, 岩谷岳, 秋山有史, 塩井義裕, 天野総, 鴻巣正史, 木村祐輔, 西塚哲, 新田浩幸, 大塚幸喜, 柏葉匡寛, 肥田圭介, 水野大, 佐々木章

日本外科学会定期学術集会抄録集 ( (一社)日本外科学会 ) 116回 PS - 3 2016年04月

Successfully treated advanced esophageal cancer with left axillary lymph node metastasis and synchronous right breast cancer: a case report.

Akiyama Y, Iwaya T, Shioi Y, Endo F, Ishida K, Kashiwaba M, Otsuka K, Nitta H, Koeda K, Mizuno M, Kimura Y, Sasaki A

Surgical case reports 1 ( 1 ) 94 - 94 2015年12月 [査読有り] [国際誌]

The incidence of double cancer of the esophagus and breast is rare, and axillary lymph node metastasis (ALM) in esophageal cancer is also very rare. We report a case of advanced esophageal cancer with left ALM and synchronous right breast cancer. A 64-year-old woman was admitted to our hospital with dysphagia. The clinical diagnosis was esophageal cancer (T3N0M1 stage IV) and right breast cancer (T1cN0M0 stage I). She was initially treated with triple chemotherapy with docetaxel, cisplatin, and 5-fluorouracil. The primary lesion in the esophagus achieved almost complete response as assessed by esophageal endoscopy. A computed tomography scan showed that the left ALM reduced in size and that stable disease was achieved for the right breast cancer. She underwent partial mastectomy of the right breast and bilateral axillary lymph node dissection. The histopathological diagnosis of the breast cancer was T1cN1M0 stage IIA. The lymph nodes from the left axilla contained metastatic cells from the squamous cell carcinoma of the esophagus. Complete response was achieved for the primary lesion in the esophagus following chemoradiotherapy (CRT), and the patient has been relapse free 2 years after treatment. Thus, we report the successful treatment of synchronous double cancers of the esophagus with left ALM and right breast by combination therapy with chemotherapy, CRT, and surgery.

DOI PubMed

Totally laparoscopic total gastrectomy for gastric cancer: literature review and comparison of the procedure of esophagojejunostomy.

Umemura A, Koeda K, Sasaki A, Fujiwara H, Kimura Y, Iwaya T, Akiyama Y, Wakabayashi G

Asian journal of surgery 38 ( 2 ) 102 - 12 2015年04月 [査読有り] [国際誌]

There has been a recent increase in the use of totally laparoscopic total gastrectomy (TLTG) for gastric cancer. However, there is no scientific evidence to determine which esophagojejunostomy (EJS) technique is the best. In addition, both short- and long-term oncological results of TLTG are inconsistent. We reviewed 25 articles about TLTG for gastric cancer in which at least 10 cases were included. We analyzed the short-term results, relationships between EJS techniques and complications, long-term oncological results, and comparative study results of TLTG. TLTG was performed in a total of 1170 patients. The mortality rate was 0.7%, and the short-term results were satisfactory. Regarding EJS techniques and complications, circular staplers (CSs) methods were significantly associated with leakage (4.7% vs. 1.1%, p < 0.001) and stenosis (8.3% vs. 1.8%, p < 0.001) of the EJS as compared with the linear stapler method. The long-term oncological prognosis was acceptable in patients with early gastric cancers and without metastases to lymph nodes. Although TLTG tended to increase surgical time compared with open total gastrectomy and laparoscopy-assisted total gastrectomy, it reduced intraoperative blood loss and was expected to shorten postoperative hospital stay. TLTG is found to be safer and more feasible than open total gastrectomy and laparoscopy-assisted total gastrectomy. At present, there is no evidence to encourage performing TLTG for patients with advanced gastric cancer from the viewpoint of long-term oncological prognosis. Although the current major EJS techniques are CS and linear stapler methods, in this review, CS methods are significantly associated with leakage and stenosis of the EJS.

DOI PubMed

Thoracoscopic enucleation of esophageal benign tumors

Yusuke Kimura, Akira Sasaki, Toru Obuchi, Takeshi Iwaya, Yuji Akiyama, Masafumi Konosu, Fumitaka Endo, Koki Otsuka, Hiroyuki Nitta, Keisuke Koeda, Go Wakabayashi

Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice ( Springer International Publishing ) 177 - 181 2015年01月 [査読有り]

Benign esophageal tumors are rare, with a prevalence of 0.005–5.1 %, based on autopsy results, and account for < 1–10 % of all esophageal neoplasms. Leiomyomas constitute 70–80 % of these benign esophageal neoplasms. Other benign esophageal tumors, such as granular cell tumors or schwannomas, are extremely rare. Esophageal leiomyomas are usually detected in patients between 20 and 50 years of age, with a twofold male predominance, and most commonly occur in the lower third of the esophagus. At least 50 % of patients with esophageal leiomyomas are asymptomatic in symptomatic individuals, dysphagia is the most commonly reported symptom, followed by chest tightness and pain. These tumors are usually discovered, incidentally, during esophagography or endoscopic examination of the upper gastrointestinal tract for unrelated reasons. The treatment strategy for esophageal benign tumors, such as leiomyomas, involves continued monitoring of smaller tumors and surgical resection of larger or symptomatic tumors. Conventional, open thoracotomy for enucleation of this tumor type has been gradually replaced by less invasive thoracoscopic or laparoscopic approaches. In the present report, we describe our experience with patients undergoing surgical enucleation of esophageal leiomyomas via thoracoscopic or laparoscopic approaches.

DOI

Curative two-stage resection for synchronous triple cancers of the esophagus, colon, and liver: Report of a case.

Akiyama Y, Iwaya T, Konosu M, Shioi Y, Endo F, Katagiri H, Nitta H, Kimura T, Otsuka K, Koeda K, Kashiwaba M, Mizuno M, Kimura Y, Sasaki A

International journal of surgery case reports 13 1 - 4 2015年 [査読有り] [国際誌]

INTRODUCTION: Cases of synchronous triple cancers of the esophagus and other organs curatively resected are rare. PRESENTATION OF CASE: A 73-year-old man was admitted to our hospital with bloody feces. He was diagnosed with synchronous triple cancers of the esophagus, colon, and liver. We selected a two-stage operation to safely achieve curative resection for all three cancers. The first stage of the operation comprised a laparoscopy-assisted sigmoidectomy and partial liver resection via open surgery. The patient was discharged without complications. Thirty days later, he was readmitted and thoracoscopic esophagectomy was performed. Although pneumonia-induced pulmonary aspiration occurred as a postoperative complication, it was treated conservatively. The patient was discharged on postoperative day 24. DISCUSSION: Esophagectomy is a highly invasive procedure; thus, simultaneous surgery for plural organs, including the esophagus, may induce life-threatening, severe complications. Two-stage surgery is useful in reducing surgical stress in high-risk patients. For synchronous multiple cancers, the planning of two-stage surgery should be considered for each cancer to maintain organ function and reduce the stress and difficulty of each stage. CONCLUSION: We successfully treated synchronous triple cancers, including esophageal cancer, by a two-stage operation.

DOI PubMed

Effectiveness of neoadjuvant chemotherapy with cisplatin and irinotecan followed by surgery on small-cell carcinoma of the esophagus: A case report.

Akiyama Y, Iwaya T, Shioi Y, Endo F, Chiba T, Otsuka K, Nitta H, Koeda K, Mizuno M, Uesugi N, Kimura Y, Sasaki A

International journal of surgery case reports 17 121 - 5 2015年 [査読有り] [国際誌]

INTRODUCTION: Small-cell carcinoma of the esophagus (SCCE) is a rare disease with aggressive progression and a poor prognosis. A standard treatment strategy for SCCE is yet to be established. PRESENTATION OF CASE: A 40-year-old woman with dysphagia was admitted to our hospital. A clinical diagnosis of SCCE (T3N1N0 stage IIIA) was established. She was initially treated with chemotherapy using cisplatin (CDDP) and irinotecan (CPT-11). After two courses of treatment, the primary lesion in the esophagus was not detectable by esophageal endoscopy. Likewise, swelling of the right recurrent nerve lymph node present prior to treatment could not be detected. The chemotherapy resulted in a complete response. One month after the conclusion of chemotherapy, radical esophagectomy with three-field lymph node dissection was performed. Histopathological examination of the excised specimen revealed no residual tumor or lymph node metastasis. The patient was discharged from hospital 29 days after surgery with no complications. The patient is alive and has remained cancer-free for 48 months after the surgery. DISCUSSION: Systemic chemotherapy for SCCE in combination with surgery was treated after surgery in most reports. Neoadjuvant chemotherapy is advantageous from three viewpoints, namely achievement of downstaging, increasing complete resection rates, and a better completion of treatment compared with postoperative chemotherapy. Neoadjuvant chemotherapy following esophagectomy could be a useful treatment option for patients with limited disease (LD) of SCCE. CONCLUSION: We report a case of SCCE achieving a pathologically complete response with neoadjuvant chemotherapy using CDDP and CPT-11, and long-term survival followed by surgery.

DOI PubMed

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