Details of a Researcher - AKIYAMA Yuuji

Objective: Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the nontumorous gallbladder epithelium is maspin negative. We investigated maspin expression in non-tumorous gallbladder epithelium in patients with cholelithiasis. Methods: An immunohistochemical study of maspin expression was performed in 69 patients with cholelithiasis and 30 patients with gastric cancer without cholelithiasis. Results: Immunoreactivity for maspin was observed in focal and patchy regions of the gallbladder epithelium. Positive immunoreactivity for maspin was significantly associated with the presence of intestinal metaplasia in patients with cholelithiasis (p < 0.05). Conclusion: The high incidence of aberrant maspin expression in both intestinal metaplasia and carcinoma of the gallbladder supports the assumption that intestinal metaplasia of the gallbladder may predispose to gallbladder carcinoma.

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Comparison between laparoscopy-assisted colectomy and open colectomy for prognosis in patients with sigmoid and rectosigmoid carcinoma

Tarou Higuchi, Kouki Otsuka, Kentarou Fujisawa, Tetsuya Itabashi, Yuichirou Kawasaki, Yuji Akiyama, Hiroshi Asahi, Kazumi Okamoto, Kazuyoshi Saitou, Go Wakabayashi

Japanese Journal of Gastroenterological Surgery ( Japanese Society of Gastroenterological Surgery ) 39 ( 11 ) 1658 - 1665 2006

Purpose: The aim of this study was to compare the oncologic outcomes of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colorectal cancer. Subjects: This retrospective, non-randomized study examined 88 patients who were cured with no residual tumors after undergoing a colorectal resection with a D3-dissection between January 1996 and March 2005. The patients were divided into 2 groups, those receiving a LAC (n = 43) and those receiving an OC (n = 45). The groups were compared with regard to blood loss, duration of surgery, lymph node yield, postoperative hospital stay, complications, recurrence, and survival rates. Results: None of the patients in the LAC group required conversion to OC in this study. Intraoperative blood loss was significantly lower for the LAC group (18mL) than for the OC group (271mL, P < 0.0001), and the postoperative hospital stay was significantly shorter for the LAC group (13 days) than for the OC group (25 days, P < 0.0001). The duration of surgery and the number of dissected lymph nodes were very similar between the groups. No significant differences in the rate of complication (LAC, 9.3% OC, 22.2% P = 0.0976), the recurrence rate (LAC, 2.3% OC, 11.1% P = 0.1022), the overall 5-year survival rate (LAC, 100% OC, 93.2% P = 0.1064) or the disease-free 5-year survival rate (LAC, 95.2% OC, 86.6% P = 0.1793) were observed between the groups. No perioperative deaths occurred in either group. Conclusions: Our findings suggest that LAC offers not only the better short-term prognosis but also a very similar oncologic outcomes to that of OC with regard to the middle-to-long-term prognosis for sigmoid and rectosigmoid carcinoma. We therefore expect that LAC could be equally effective as traditional OC for sigmoid and rectosigoid resection with D3-dissection from an oncologic point of view. ©2006 The Japanese Society of Gastroenterological Surgery.

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症例後腹膜に発生した神経鞘腫の1例

秋山有史, 青木毅一, 中屋勉

外科 ( 南江堂 ) 67 ( 8 ) 966 - 969 2005.08

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術後13年目に発症した腎癌膵転移の1例(肝・胆・膵41, 第60回日本消化器外科学会総会)

青木毅一, 中屋勉, 大山健一, 秋山有史, 岩谷岳, 佐々木亮孝

日本消化器外科学会雑誌 ( 一般社団法人日本消化器外科学会 ) 38 ( 7 ) 1226 - 1226 2005.07

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システム化した腹腔鏡補助下直腸癌手術の手技と成績(第60回日本消化器外科学会定期学術総会)

大塚幸喜, 樋口太郎, 佐々木章, 秋山有史, 板橋哲也, 旭博史, 斎藤和好

日本消化器外科学会雑誌 ( 一般社団法人日本消化器外科学会 ) 38 ( 7 ) 1111 - 1111 2005.07

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リンパ節転移状況, 予後および再発形式よりみた胸部下部食道癌に対するリンパ節郭清の検討(食道4, 第60回日本消化器外科学会総会)

木村祐輔, 池田健一郎, 岩谷岳, 青木毅一, 佐藤信博, 飯島信, 秋山有史, 木村聡元, 石田薫, 斎藤和好

日本消化器外科学会雑誌 ( 一般社団法人日本消化器外科学会 ) 38 ( 7 ) 1026 - 1026 2005.07

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症例胃全摘術後4年目にRoux-en Y吻合部に発生した逆行性腸重積症の1例

秋山有史, 青木毅一, 中屋勉

外科 ( 南江堂 ) 67 ( 5 ) 587 - 589 2005.05

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臨床報告(1)イレウスを呈した穿孔性小腸憩室の1例

秋山有史, 青木毅一, 中屋勉

臨床外科 ( 医学書院 ) 60 ( 3 ) 395 - 398 2005.03

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TWO CASES OF PRIMARY SIGNET RING CELL CARCINOMA OF THE VERMIFORM APPENDIX

AKIYAMA Yuji, AOKI Kiichi, KIMURA Yusuke, IWAYA Takeshi, KOEDA Keisuke, SAITO Kazuyoshi

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 65 ( 11 ) 2958 - 2962 2004.11

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Fourth-Line TherapyとしてBi-weekly CPT-11/CDDP併用化学療法が有効であった胃癌肝転移再発の1例

藤原久貴, 青木毅一, 中屋勉, 秋山有史, 木村祐輔, 岩谷岳, 斉藤和好

癌と化学療法 ( (株)癌と化学療法社 ) 31 ( 12 ) 2035 - 2038 2004.11

症例は72歳,女性.1999年11月に残胃胃癌の診断にて胃全摘術を施行後(fStage IA,Cur A),2001年10月に腹部CTにて肝転移再発が認められた.以後,外来にて5'-DFUR/TXTおよびTS-1,TXLによる化学療法を継続施行していたが再燃・増悪が認められ,2002年8月に胃癌肝転移再発および閉塞性黄疸の診断にて当院入院となった.内外瘻化チューブ留置による減黄後,同時隔週投与のレジメンにてCPT-11(60mg/m2)およびCDDP(30mg/m2)を点滴静注し,28日間で1クールとする併用化学療法を施行した.1クール終了後,奏効度PRの腫瘍縮小効果(腫瘍縮小率69%)が認められ,抗腫瘍効果は以後の加療においても継続して認められた.本人希望により治療は計4クールにて終了したが,その後少なくとも3ヵ月間肝転移巣の再燃・増悪徴候は認められず,奏効期間は8.5ヵ月間であった.本療法施行中,grade 3以上の有害事象は血色素減少のみであり,他はすべてgrade 2以下であった.本療法は進行・再発胃癌患者においてQOLを損なうことなく,臨床的に有用性の高い併用療法であると思われた(著者抄録)

虫垂原発印環細胞癌の2例

秋山有史, 青木毅一, 中屋勉, 藤原久貴, 木村祐輔, 岩谷岳, 肥田圭介, 斎藤和好

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 65 ( 増刊 ) 771 - 771 2004.09

胸部食道癌周術期の経腸的グルタミン付加投与の検討

池田健一郎, 新田浩幸, 青木毅一, 大塚幸喜, 木村祐輔, 岩谷岳, 小川雅彰, 秋山有史, 木村聡元, 佐藤信博, 石田薫, 斎藤和好

外科と代謝・栄養 38 ( 3 ) 163 - 163 2004.06

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