Misc - 大西　浩文

Contribution of interleukin-6 to insulin resistance and atherosclerosis - Association with age

N Moniwa, Y Takagawa, N Ura, S Saitoh, K Higashiura, S Takagi, H Ohnishi, J Ohata, D Yoshida, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  22   S169 - S169  2004年02月

研究発表ペーパー・要旨（国際会議）  

Correlations of adiponectin with insulin resistance, lipid metabolism and atherosclerosis in general male populations

H Higashiura, N Ura, J Ohata, H Ohnishi, S Takagi, S Saitoh, Y Takagawa, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  22   S47 - S47  2004年02月

研究発表ペーパー・要旨（国際会議）  

Adiponectin levels and coronary risk factors in the elderly

磯部 健, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 竹内 宏, 藤原 禎, 東浦 勝浩, 浦 信行, 島本 和明

日本老年医学会雑誌 ( 社団法人 日本老年医学会 )  41 ( 3 ) 328 - 333  2004年

　概要を見る

[Aim] To determine the relationship between adiponectin level and coronary risk factors in men.[Methods] The subjects were 395 elderly men in two rural communities (Tanno, Sobetsu) in Japan. Blood pressure in the sitting position (SBP/DBP), after overnight fasting, plasma glucose level (FPG), total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL) and serum adiponectin were measured. The subjects were divided into two adiponectin level groups, a high adiponectin level (≥7.94μg/ml) group (H-Adipo group) and a normal adiponectin level (<7.94μg/ml) group (N-Adipo group), and into two age groups, 70 years of age or older (70 or older group) and less than 70 years of age (under 70 group).[Results] Adiponectin showed negative correlations with BMI, FPG, TC and TG and positive correlations with age, SBP and HDL. In multiple regression analysis using adiponectin as a dependent variable, BMI, SBP, FPG, TG and HDL were selected as independent variables. Age and HDL in the H-Adipo group were significantly higher than those in the N-Adipo group, and BMI, FPG, TC and TG in the H-Adipo group were significantly lower than those in the N-Adipo group. In the 70 or older group, SBP and adiponectin were significantly higher and BMI, DBP, FPG, TC and TG were significantly lower than those in the under 70 group. The mean number of total coronary risk factors in the 70 or older group (1.71) was significantly lower than that in the under 70 group (2.06).[Conclusions] Coronary risk factors other than systolic blood pressure were significantly reduced in the older subjects.

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日本人男性における Metabolic Syndrome とインスリン抵抗性の検討 : 端野・壮瞥研究

竹内 宏, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 磯部 健, 藤原 禎, 赤坂 憲, 島本 和明

糖尿病 ( 日本糖尿病学会 )  46 ( 9 ) 739 - 744  2003年09月

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基調講演 IT技術を用いた北海道における僻地遠隔医療支援

明石 浩史, 大西 浩文, 戸倉 一

へき地・離島救急医療研究会誌 ( へき地・離島救急医療研究会 )  4   8 - 15  2003年09月

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Insulin Resistance and Cardiac Disease in Japanese Males : Usefulness of Metabolic Syndrome Proposed by NCEP-ATP3, Tanno-Soubetsu Study

Takeuchi Hiroshi, Saitoh Shigeyuki, Takagi Satoru, Ohnishi Hirofumi, Ohhata Junichi, Isobe Takeshi, Fujiwara Tadashi, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  67   120 - 120  2003年03月

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Relationship between Pulse Wave Velosity and Risk Factors in Community Based Epidemiological Study

Ohhata Junichi, Saitoh Shigeyuki, Takagi Satoru, Ohnishi Hirofumi, Takeuchi Hiroshi, Isobe Takeshi, Fujiwara Tadashi, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  67   560 - 560  2003年03月

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高血圧からみた糖尿病性臓器障害

大西 浩文, 斉藤 重幸, 島本 和明

ホルモンと臨牀   51 ( 1 ) 7 - 13  2003年01月

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IT技術を用いた北海道における僻地遠隔医療支援

へき地、離島救急医療研究会誌   4   16 - 23  2003年

Metabolic Syndrome and Insulin Resistance in Japanese Males-Tanno-Soubestu Study

竹内 宏, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 磯部 健, 藤原 禎, 赤坂 憲, 島本 和明

糖尿病 ( 一般社団法人 日本糖尿病学会 )  46 ( 9 ) 739 - 744  2003年

　概要を見る

According to the American NCEP-ATP III (National Cholesterol Education Program-Adult Treatment Panel III) criteria, metabolic syndrome is characterized by an abnormal abdominal circumference (AO), high blood pressure (HT), high fasting glucose (HFPG), high triglyceride level (HTG) and low HDL cholesterol level (LHDL). The present study investigated the concept of metabolic syndome with regand to insulin resistance in Japanese males. The subjects consisted of 808 males (60±12years) living in two rural communities in Hokkaido, Japan, who had undergone health screening examinations and a 75g oral glucose tolerance test. The subjects were divided into a metabolic syndrome (MS) group (24.4%) and a non-MS group (75.6%) based on the NCEP-ATP III criteria (but with the criterion for AO being 85cm). The overall percentages of patients with an AO, HTG, LHDL, HT and HFPG were each 42.7%, 34.1%, 16.7%, 59.1% and 13.5%, respectively. As the number of risk factors increased from 0 to 5, the level of 120-IRI, HOMAR increased significantly. A multiple regression analysis showed that 120-IRI and HOMA-R were significantrisk factors in a model that included BMI and age. The presence of metabolic syndrome may be useful for predicting insulin resistance in Japanese males.

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老年者男性における高血圧と耐糖能異常の動脈硬化への影響PWVを用いた検討 : 端野・壮瞥町研究

磯部 健, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 竹内 宏, 藤原 禎, 赤坂 憲, 島本 和明

日本老年医学会雑誌 ( 日本老年医学会 )  40 ( 6 ) 610 - 614  2003年

　概要を見る

Hypertension and diabetes are risk factors for arteriosclerosis and have a synergistic effect on the progression of arteriosclerosis. The aim of this study was to determine the correlation between complications of hypertension and diabetes and arteriosclerosis as assessed by pulse wave velocity (PWV) in elderly subjects. The subjects of this study were 186 people aged 60 years or older (mean age: 68.8 ± 5.8 years) who were scheduled to undergo health examinations. PWV, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG) and HDL cholesterol (HDL) were measured in each subject. The patients were divided according to the American Diabetes Association (ADA) diagnostic criteria for diabetes based on fasting blood sugar level into the following three groups: a normal (NGT) group (FBS< 110mg/dl), an impaired fasting glucose (IFG) group (110≤FBS< 126mg/dl) and a diabetes mellitus (DM) group (FBS≥126mg/dl or receiving treatment for diabetes). Based on the JNC-VI and WHO/ISH diagnostic criteria, subjects who had a SBP of 140mmHg or higher or a DBP of 90mmHg or higher or who had been taking hypotensive drugs were assigned to the hypertension (HT) group, and the other subjects were assigned to the normotenskm (NT) group. PWV showed significant positive correlations with SBP and FBS (r = 0.499 and r = 0.300, respectively). The effects of hypertension on PWV were significantly higher in subjects with HT than in subjects with NT in all of the glucose tolerance groups (all p< 0.01). Moreover, in the subjects with HT, PWV started to increase from the IFG stage, and PWV was significantly higher in the DM groups than in the NGT group (p< 0.01). In multiple regression analysis using PWV as an objective variable, SBP and FBS were selected as significant explanatory variables. The results of this study indicate the need for stricter management of elderly people with slight glucose tolerance impairment and hypertension in order to prevent the occurrence of arteriosclerosis.

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Relationship between insulin resistance and accumulation of coronary risk factors

H Ohnishi, S Saitoh, N Ura, S Takagi, F Obara, H Akasaka, H Oimatsu, K Shimamoto

DIABETES OBESITY & METABOLISM ( BLACKWELL PUBLISHING LTD )  4 ( 6 ) 388 - 393  2002年11月

　概要を見る

We examined correlations between the frequency of insulin resistance and the accumulation of coronary risk factors in residents of rural comities in Japanese, using simple criteria for determination of insulin resistance based on evaluation by the euglycaemic-hyperinsulinaemic glucose clamp [GC) method. The subjects were 376 men and 589 women living in two rural communities in Japan. We measured body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), HDL cholesterol (HDL), and homeostasis model assessment (HOMA-R). Correlations between HOMA-R and those parameters were examined. To assess the existence of insulin resistance in these subjects, we used a practical index based on the GC method. The subjects with value of HOMA-R greater than or equal to 1.73 have insulin resistance. In addition, the HOMA-R was divided into five quantiles based on the frequency distribution (0.60 or below, from 0.61 to 0.82, from 0.83 to 1.18, from 1.19 to 1.69, and 1.70 or higher), to examine the concentration of risk factors in each group. In total, 74 (19.6%) of the men and 119 (20.3%) of the women had insulin resistance (HOMA-R greater than or equal to 1.73). It was found that the higher the HOMA-R, the higher was the number of coronary risk factors, such as hypertension, obesity, hypertriglyceridaemia and hypo HDL cholesterolaemia. The number of coronary risk factors was particular high in subjects with HOMA-R greater than or equal to 1.70. HOMA-R in the case of no glucose loading is a useful and practical index for evaluation of insulin resistance and coronary risk factors in the epidemiological study.

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10年間における急性心筋梗塞発症率の変化北海道地方都市における循環器疾患登録研究

竹内 宏, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 磯部 健, 藤原 禎, 島本 和明

日本循環器病予防学会誌 = Japanese journal of cardiovascular disease prevention   37 ( 3 ) 181 - 185  2002年10月

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Relationship between insulin-resistance and remnant-like particle cholesterol

H Ohnishi, S Saitoh, S Takagi, J Ohata, T Isobe, Y Kikuchi, H Takeuchi, K Shimamoto

ATHEROSCLEROSIS ( ELSEVIER SCI IRELAND LTD )  164 ( 1 ) 167 - 170  2002年09月

　概要を見る

We investigated the relationship between insulin-resistance (IR) and remnant-like particle cholesterol (RLP-C) using 472 subjects (174 men and 298 women) randomly selected from inhabitants of two rural communities in Japan, Tanno and Sobetsu. The level of fasting immunoreactive insulin (FIRI), fasting blood glucose (FBS), total cholesterol (TC), triglyceride (TG), HDL cholesterol, LDL cholesterol, and RLP-C were measured in each subject. Homeostasis model assessment (HOMA-R) was used as an indicator of IR. The subjects were divided into two groups according to the value of HOMA-R: an IR group of subjects with HOMA-R greater than or equal to 1.73 and a normal (NR) group of subjects with HOMA-R < 1.73. There was a significant positive correlation between HOMA-R and RLP-C. The value of RLP-C was higher in the IR group than in the NR group (7.1 vs. 3.9 mg/dl in men and 5.3 vs. 3.6 mg/dl in women). The frequency of hyper RLP cholesterolemia (RLP-C &GE; 7.5 mg/dl) was higher in the IR than in the NR group (23.7 vs. 6.6% in men and 20.3 vs. 6.6% in women). The results of multiple regression analysis showed that HOMA-R was closely related to RLP-C. The results of this study suggest that RLP-C is closely associated with IR syndrome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Relationship between insulin resistance and atherosclerotic cardiovascular disease

S Takagi, S Saitoh, H Onishi, J Ohata, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  20   S316 - S316  2002年06月

研究発表ペーパー・要旨（国際会議）  

An epidemiological cross-sectional study on the relationships between atherosclerosis pulse pressure and the high-sensitivity C-reactive protein

S Saitoh, S Takagi, J Ohata, H Onishi, Y Kikuchi, H Takeuchi, K Ishobe, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  20   S139 - S139  2002年06月

研究発表ペーパー・要旨（国際会議）  

Effect of hypertension on the development of atherosclerosis due to impaired fasting glucose: Tanno and Sobetsu study

H Ohnishi, S Saitoh, S Takagi, J Ohata, T Isobe, Y Kikuchi, H Takeuchi, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  20   S138 - S138  2002年06月

研究発表ペーパー・要旨（国際会議）  

Is measurement of pulse wave velocity useful for management of atherosclerotic risk factors? The Tanno-Soubetsu study

Takagi Satoru, Saitoh Shigeyuki, Ohnishi Hirofumi, Ohhata Junichi, Takeuchi Hiroshi, Kikuchi Yuka, Isobe Takeshi, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  66   823 - 823  2002年03月

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インスリン抵抗性と血清脂質 : 一般住民からの検討 : 端野・壮瞥町研究

大西 浩文, 斉藤 重幸, 高木 覚, 大畑 純一, 磯部 健, 菊地 由佳, 竹内 宏, 島本 和明

日本循環器病予防学会誌 = Japanese journal of cardiovascular disease prevention   37 ( 1 ) 19 - 23  2002年01月

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地域集団における動脈硬化の検出 : 高感度C反応性蛋白(CRP)と大動脈脈派伝播速度(PWV)の可能性-端野・壮瞥町研究より

大畑 純一, 斎藤 重幸, 高木 覚, 大西 浩文, 菊池 由佳, 磯部 健, 竹内 宏, 藤原 禎, 赤坂 憲, 島本 和明

Journal of epidemiology   12 ( 1 ) 190 - 190  2002年01月

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