Misc - 大西　浩文

糖尿病における動脈硬化進展指標としてのpulse wave velocity (PWV)の有用性に関する検討−端野・壮瞥研究より−

大西浩文, 斉藤重幸, 高木覚, 大畑純一, 磯部健, 菊地由佳, 竹内宏, 島本和明

糖尿病   45 ( 3 ) 195 - 198  2002年

　概要を見る

The usefulness of pulse wave velocity (baPWV) as an indicator of early-stage atherosclerosis in impaired fasting glucose was studied in 232 subjects randomly selected from a rural community in Japan. Body mass index (BMI), systolic blood pressure (SBP), fasting blood sugar (FBS), lipid parameters, ankle brachial pressure index (API), and baPWV were measured in each subject. API and baPWV were measured by ABI-form(BP-203 RPE Nihon Colin). Subjects were divided into 3 groups based on FBS : a healthy group of subjects with FBS< 110 mg/dl, an impaired fasting glucose (IFG) group of subjects with FBS of 110-125 mg/dl, and a diabetes mellitus(DM) group of subjects with FBS ≧ 126 mg/dl and subjects taking hypoglycemic agents. Parameters were compared among groups. We found that the higher the plasma glucose, the higher the baPWV. Significant differences were found between baPWV in the healthy and IFG groups (1518 cm/s vs. 1673 cm/s p = 0.01) and in the healthy and DM groups (1518 cm/s vs. 1771 cm/s p < 0.0001). Multiple regression analysis showed that FBS was closely related to baPWV, age, and SBP, suggesting that IFG be strictly controlled to prevent the progression of atherosclerosis. © 2002, THE JAPAN DIABETES SOCIETY. All rights reserved.

DOI CiNii

Relationship between insulin resistance and remnant-like particle cholesterol(RLP-C).

大西 浩文, 斉藤 重幸, 高木 覚, 大畑 純一, 磯部 健, 菊地 由佳, 竹内 宏, 島本 和明

日本循環器病予防学会誌 ( 社団法人 日本循環器管理研究協議会 )  37 ( 1 ) 19 - 23  2002年

　概要を見る

We investigated the relationship between insulin resistance and remnant-like particle cholesterol (RLP-C) using 472 subjects (174 men and 298 women) randomly selected from inhabitants of two rural communities in Japan, Tanno and Sobetsu. Fasting immunoreactive insulin (FIRI), fasting blood glucose (FBS), total cholesterol (TC), triglyceride (TG), HDL cholesterol, LDL cholesterol, and RLP-C were measured in each subject. HOMA-R was used as an indicator of insulin resistance. The subjects were divided into two groups according to the value of HOMA-R : an insulin-resistance (IR) group consisting of subjects with HOMA-R≥ 1.73 and a normal (NR) group consisting of subjects with HOMA-R < 1.73. There was a significant positive correlation between HOMA-R and RLP-C. The value of RLP-C was higher in the IR group than in the NR group (5.9 mg/dl vs. 3.6 mg/dl). The frequency of hyper RLP cholesterolemia (RLP-C ≥7.5mg/dl) was higher in the IR group than in the NR group (21.7% vs. 4.8%). The results of multiple regressionanalysis showed that HOMA-R was closely related to RLP-C. The results of this study suggest that RLP-C is closely associated with atherosclerosis in insulin-resistance syndrome.

DOI CiNii

インスリン抵抗性と血清脂質−一般住民からの検討：端野・壮瞥町研究−

大西 浩文, 斉藤 重幸, 高木 覚, 大畑 純一, 磯部 健, 菊地 由佳, 竹内 宏, 島本 和明

日本循環器病予防学会誌   37 ( 1 ) 19 - 23  2002年

DOI CiNii

Changes in the incidence of acute myocardial infarction in Obihiro City, Hokkaido, Japan, compared with 10 years ago.

竹内 宏, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 磯部 健, 藤原 禎, 島本 和明

日本循環器病予防学会誌 ( 社団法人 日本循環器管理研究協議会 )  37 ( 3 ) 181 - 185  2002年

　概要を見る

A survey was conducted to determine the incidence of acute myocardial infarction (AMI) during the period from January 1999 to December 2000 in Obihiro City, Hokkaido, Japan.<BR>A total of 137 new cases of AMI were registered over the 2-year period. The incidences of AMI were determined to be 51.5 cases per 100, 000 men per year and 13.7 cases per 100, 000 women per year. It was found that incidence of AMI has increased in men over 70 years of age compared to the incidence determined in a survey conducted for the period from Octber 1990 to September 1992.<BR>Considering the aging population structure in Japan, the results of the survey indicate the need for measures to reduce the incidence of AMI in elderly men.

DOI CiNii

10年間における急性心筋梗塞発症率の変化-北海道地方都市における循環器疾患登録研究

竹内 宏, 斎藤 重幸, 高木 覚, 大西 浩文, 大畑 純一, 磯部 健, 藤原 禎, 島本 和明

日本循環器病予防学会誌   37 ( 3 ) 181 - 185  2002年

DOI CiNii

糖尿病における動脈硬化進展指標としての Pulse Wave Velicity(PWV)の有用性に関する検討

大西 浩文, 斉藤 重幸, 高木 覚, 大畑 純一, 磯部 健, 菊地 由佳, 竹内 宏, 島本 和明

糖尿病 ( 日本糖尿病学会 )  45 ( 3 ) 195 - 198  2002年

　概要を見る

The usefulness of pulse wave velocity (baPWV) as an indicator of early-stage atherosclerosis in impaired fasting glucose was studied in 232 subjects randomly selected from a rural community in Japan. Body mass index (BMI), systolic blood pressure (SBP), fasting blood sugar (FBS), lipid parameters, ankle brachial pressure index (API), and baPWV were measured in each subject. API and baPWV were measured by ABI-form(BP-203 RPE Nihon Colin). Subjects were divided into 3 groups based on FBS : a healthy group of subjects with FBS< 110 mg/dl, an impaired fasting glucose (IFG) group of subjects with FBS of 110-125 mg/dl, and a diabetes mellitus(DM) group of subjects with FBS ≧ 126 mg/dl and subjects taking hypoglycemic agents. Parameters were compared among groups. We found that the higher the plasma glucose, the higher the baPWV. Significant differences were found between baPWV in the healthy and IFG groups (1518 cm/s vs. 1673 cm/s p = 0.01) and in the healthy and DM groups (1518 cm/s vs. 1771 cm/s p < 0.0001). Multiple regression analysis showed that FBS was closely related to baPWV, age, and SBP, suggesting that IFG be strictly controlled to prevent the progression of atherosclerosis. © 2002, THE JAPAN DIABETES SOCIETY. All rights reserved.

DOI CiNii

Usefulness of Pulse Wave Velocity as an Indicator of Early-stage Atherosclerosis in Impaired Fasting Glucose

Hirofumi Ohnishi, Shigeyuki Saitoh, Satoru Takagi, Junichi Ohhata, Takeshi Isobe, Yuka Kikuchi, Hiroshi Takeuchi, Kazuaki Shimamoto

Journal of the Japan Diabetes Society ( THE JAPAN DIABETES SOCIETY )  45 ( 3 ) 195 - 198  2002年

　概要を見る

The usefulness of pulse wave velocity (baPWV) as an indicator of early-stage atherosclerosis in impaired fasting glucose was studied in 232 subjects randomly selected from a rural community in Japan. Body mass index (BMI), systolic blood pressure (SBP), fasting blood sugar (FBS), lipid parameters, ankle brachial pressure index (API), and baPWV were measured in each subject. API and baPWV were measured by ABI-form(BP-203 RPE Nihon Colin). Subjects were divided into 3 groups based on FBS : a healthy group of subjects with FBS< 110 mg/dl, an impaired fasting glucose (IFG) group of subjects with FBS of 110-125 mg/dl, and a diabetes mellitus(DM) group of subjects with FBS ≧ 126 mg/dl and subjects taking hypoglycemic agents. Parameters were compared among groups. We found that the higher the plasma glucose, the higher the baPWV. Significant differences were found between baPWV in the healthy and IFG groups (1518 cm/s vs. 1673 cm/s p = 0.01) and in the healthy and DM groups (1518 cm/s vs. 1771 cm/s p < 0.0001). Multiple regression analysis showed that FBS was closely related to baPWV, age, and SBP, suggesting that IFG be strictly controlled to prevent the progression of atherosclerosis. © 2002, THE JAPAN DIABETES SOCIETY. All rights reserved.

DOI CiNii

本邦循環器疾患の疫学

斎藤 重幸, 大畑 純一, 大西 浩文, 島本 和明

日本老年医学会雑誌 ( 日本老年医学会 )  38 ( 5 ) 631 - 633  2001年09月

CiNii

循環器疾患死亡における高血圧及び高脂血症合併糖尿病の意義：1980年循環器疾患基礎調査追跡研究(NIPPON DATA 80)解析成績より

斎藤重幸, 高木覚, 小原史生, 大西浩文, 島本和明, 岡山明, 上島弘嗣

糖尿病   44・Suppl   S-130-S-130  2001年

研究発表ペーパー・要旨（全国大会，その他学術会議）  

糖尿病における早期の動脈硬化の指標としてのpulse wave velocity (PWV)の有用性に関する検討

Arterial Stiffness 動脈壁の硬化と老化   1   49 - 49  2001年

北海道における循環器疾患の変遷を通して

北海道公衆衛生学雑誌   14   116 - 119  2001年

肥満を伴った高血圧の心血管合併症

血圧   0   634 - 638  2001年

わが国における高血圧治療のガイドライン

分子心血管病   0   221 - 225  2001年

0496 正常血圧者におけるインスリン抵抗性と冠危険因子集積との関連 : 端野・壮瞥町研究

小原 史生, 斉藤 重幸, 高木 覚, 仲野 昌弘, 林 義人, 大西 浩文, 島本 和明

Japanese circulation journal ( 社団法人日本循環器学会 )  64 ( 4 ) 309 - 311  2000年04月

　概要を見る

Congestive heart failure (CHF) related to Sjogren's syndrome is extremely rare. This report concerns a patient who presented with CHF and severe thrombocytopenia (5,000/μl). Serum concentrations of K, Mg and digitoxin were 3.2 mmol/L, 1.4 mg/L and 57.2 ng/ml, respectively. Digitoxin intoxication was evident, seemingly evoked by hypokalemia, hypomagnesemia hepatorenal dysfunction and hypothyroidism. The severe thrombocytopenia was considered to have been caused by this intoxication, as it disappeared soon after the digitoxin was discontinued and potassium was supplemented.

DOI PubMed CiNii

Relationship between blood pressure level and mortality rate: an 18-year study conducted in two rural communities in Japan

S Takagi, S Saitoh, M Nakano, Y Hayashi, F Obara, H Onishi, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  18 ( 2 ) 139 - 144  2000年02月

　概要を見る

Background There have been very few studies on life prognosis of cardiovascular disease according to blood pressure stratification in the Japanese, Therefore, in Japan, although treatment of hypertension is possible, albeit at times difficult, due to the availability of various antihypertensive medications, the appropriate time at which treatment should be started remains a problem. Objective To investigate the long-term prognosis of cardiovascular disease in the Japanese general population according to blood pressure stratification in the Japanese. Design A community-based prospective cohort study of 1996 men and women between the ages of 40 and 64 years at the baseline examination was conducted over an 18-year period. Information on death was obtained from local public health nurses and death certificates, The causes of death were clarified by questionnaires sent to doctors in the hospital in which the deceased was hospitalized, and the causes of death were analysed in each blood pressure category at baseline examination. Results Mortality from cardiovascular disease increased with increases in the level of blood pressure and was significantly higher in greater than or equal to 140 mmHg group in systolic blood pressure and greater than or equal to 90 mmHg group in diastolic blood pressure, adjusted for age, sex and other cardiovascular risk factors in the Japanese general population. However, mortality risk from cardiovascular disease did not have a J-shaped relationship with systolic and diastolic blood pressure, Conclusion We conclude that the optimum time for starting treatment in Japanese people is when blood pressure is 140/90 mmHg or less. J Hypertens 2000, 18:139-144 (C) Lippincott Williams & Wilkins.

本態性高血圧症−臨床 疫学 日本人の場合

日本臨床   58   593 - 6  2000年

動脈硬化性疾患発症・進展とインスリン抵抗性/高インスリン血症−端野・壮瞥研究より

公益信託日本動脈硬化予防研究基金 平成12年度研究報告集    2000年

北海道における高血圧の疫学：端野・壮瞥研究

血圧   0   433 - 439  2000年

Cardiovascular mortality in elderly patients with hypertension in Japanese

S Takagi, S Saitoh, Y Hayashi, M Nakano, F Obara, H Onishi, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  18   S153 - S153  2000年

研究発表ペーパー・要旨（国際会議）  

[Epidemiology of hypertension in Japanese]

Nippon Rinsho.   58   593 - 6  2000年