Misc - 丹野　雅也

OE-312 Nuclear Localization of SIRT1, a Novel Mechanism of Cardiomyocyte Protection in Failing Hearts, is Achieved by PI3K/Akt Signaling(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Tanno Masaya, Sakamoto Jun, Miura Tetsuji, Shimamoto Kazuaki, Horio Yoshiyuki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  71   229 - 229  2007年03月

CiNii

PE-443 Role of Glycogen Synthase Kinase-3 β in Cardiomyocyte Protection by Erythropoietin(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Ohori Katsuhiko, Tanno Masaya, Miura Tetsuji, Miki Takayuki, Yano Toshiyuki, Naitoh Kazuyuki, Nishihara Masahiro, Satoh Takahiro, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  71   435 - 435  2007年03月

CiNii

Nuclear translocation of SIRT1 upregulates Mn-SOD and promotes cardiomyocyte survival in failing hearts.

Masaya Tanno, Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  103   62P - 62P  2007年

研究発表ペーパー・要旨（国際会議）  

Transcriptional activation of histone deacetylase SIRT1 by Notch1 signal

Yoshiyuki Horio, Umefumi Iguchi, Takafumi Ninomiya, Haruyuki Tatsumi, Shin Hisahara, Masaya Tanno, Haruo Takemura

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  103   105P - 105P  2007年

研究発表ペーパー・要旨（国際会議）  

Both gap junction-dependent and -independent mechanisms contribute to myocardial salvage by delta-opioid receptor activation

K. Naitoh, T. Miura, M. Nishihara, T. Yano, T. Miki, M. Tanno, K. Ohori, K. Shimamoto

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY ( ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD )  41 ( 6 ) 1055 - 1056  2006年12月

研究発表ペーパー・要旨（国際会議）  

DOI

GSK-3 beta signaling module in mitochondria leading to myocardial protection against infarction

Masahiro Nishihara, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Kazuyuki Naitoh, Katsuhiko Ohori, Akari Takahashi, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  114 ( 18 ) 242 - 242  2006年10月

研究発表ペーパー・要旨（国際会議）  

Increased nuclear translocation of SIRT1 and MnSOD up-regulation in failing hearts: A novel mechanism of the cardiomyocyte death suppression

Tanno Masaya, Tetsuji Miura, Jun Sakamoto, Kazuaki Shimamoto, Yoshiyuki Horio

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  12 ( 8 ) S159 - S160  2006年10月

研究発表ペーパー・要旨（国際会議）  

Contribution of gap junction-dependent and -independent mechanisms to myocardial salvage by delta-opioid receptor activation

Kazuyuki Naitoh, Masahiro Nishihara, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Katsuhiko Ohori, Akari Takahashi, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  114 ( 18 ) 311 - 311  2006年10月

研究発表ペーパー・要旨（国際会議）  

PJ-046 Predictors of Improvement of Exercise Capacity by Nitrates in Experimental Heart Failure(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Takahashi Akari, Miura Tetsuji, Miki Takayuki, Sakamoto Jun, Tanno Masaya, Kobayashi Hironori, Nishihara Masahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  70   500 - 500  2006年03月

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OE-026 Activation of ERK and Suppression of Calcineurin are Interacting Mechanisms of Cardioprotection Afforded by δ-opioid Receptor Activation(Myocardial ischemia-reperfusion, basic/clinical-1 (IHD) OE5,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Ikeda Yoshihiro, Miura Tetsuji, Sakamoto Jun, Tanno Masaya, Yano Toshiyuki, Naitoh Kazuyuki, Satoh Takahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  70   154 - 155  2006年03月

CiNii

PE-115 Activation of ERK Compensates Disrupted PI3K-Akt Signaling in EPO-induced Cardioprotection of Post-infarct Remodeled Hearts(Acute myocardial infarction, basic-3 (IHD) PE20,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Miki Takayuki, Miura Tetsuji, Sakamoto Jun, Tanno Masaya, Naitoh Kazuyuki, Nishihara Masahiro, Takahashi Akari, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  70   363 - 364  2006年03月

CiNii

PE-601 Molecular Mechanisms of Nucleo-cytoplasmic Shuttling of SIRT1, a Histone Deacetylase, and Its Pathopysicological Roles in Cardiomyocytes(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Tanno Masaya, Sakamoto Jun, Miura Tetsuji, Shimamoto Kazuaki, Horio Yoshiyuki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  70   482 - 483  2006年03月

CiNii

PE-268 Ischemic Preconditioning Modifies Interactions between Connexin43 and Protein Kinases during Myocardial Ischemia(Myocardial ischemia-reperfusion, basic/clinical-4 (IHD) PE45,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Naitoh Kazuyuki, Miura Tetsuji, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Ikeda Yoshihiro, Ohhori Katsuhiko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( 社団法人日本循環器学会 )  70   400 - 400  2006年03月

CiNii

The functional significance and mechanisms of nucleo-cytoplasmic shuttling of SIRT1 in failing hearts

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  100   87P - 87P  2006年

研究発表ペーパー・要旨（国際会議）  

Interaction between ERK and PP2B in development of anti-infarct tolerance of the myocardium

Y Ikeda, T Miura, T Miki, M Tanno, T Yano, H Kobayashi, M Nishihara, K Naitoh, K Oohori, K Shimamoto

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  11 ( 9 ) S316 - S316  2005年12月

研究発表ペーパー・要旨（国際会議）  

Response of silent information regulator 2 alpha (Sir2 alpha) to severe heart failure and its mechanism of nucleo-cytoplasmic shuttling

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  11 ( 9 ) S279 - S279  2005年12月

研究発表ペーパー・要旨（国際会議）  

Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3

AMN Kabir, XB Cao, DA Gorog, M Tanno, R Bassi, M Bellahcene, RA Quinlan, RJ Davis, RA Flavell, MJ Shattock, MS Marber

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY ( ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD )  39 ( 4 ) 709 - 717  2005年10月

　概要を見る

To examine the role of mitogen-activated protein kinase kinase 3 (MKK3) and p38 mitogen-activated protein kinase (p38-MAPK) in the cardioprotection afforded by antimycin A. Langendorff perfused murine hearts exposed to antimycin A or vehicle prior to global ischemia with p38-MAPK and HSP27 phosphorylation examined in the presence and absence of SB203580 or the presence (mkk3(+/+)) and absence (mkk3(-/-)) of MKK3. Infarct size was determined after 30 or 40 min of global ischemia and 2 h reperfusion. p38-MAPK dual phosphorylation in response to antimycin A was attenuated by co-administration of the antioxidant mercaptopropyonyl-glycine but unaffected by the absence of MKK3 or the presence of SB203580 at a concentration that inhibited the downstream phosphorylation of HSP27. Pre-ischemic exposure to antimycin A caused a significant reduction in subsequent infarction (I:R%) compared to vehicle on both the mkk3(-/-) and mkk3(-/-) background (23.7 +/- 2.9 and 22.8 +/- 4.6 compared to 50.7 +/- 4.0 and 49.6 +/- 5.4 P = 0.001, respectively). In C57B16 mice, antimycin A prior to ischemia reduced infarct size compared to vehicle (22.8 +/- 6.1 vs. 48.3 +/- 5.2 P = 0.01, respectively), an effect abolished by coincident SB203580. The cardiac protection initiated by antimycin A is dependent on the activation of p38-MAPK which occurs, at least in part, in response to oxygen-derived free radicals. The mechanism of this protective form of p38-MAPK activation is independent of the upstream kinase MKK3 and does not involve autophosphorylation. (c) 2005 Elsevier Ltd. All rights reserved.

DOI

Effects of ischemic preconditioning on interactions between Connexin43 and protein kinases during myocardial ischemia

K Naito, T Yano, T Miki, J Sakamoto, M Tanno, A Kuno, Y Ikeda, T Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  112 ( 17 ) U284 - U284  2005年10月

研究発表ペーパー・要旨（国際会議）  

Response of silent information regulator 2 alpha (Sir2 alpha) to severe heart failure and its mechanism of nucleo-cytoplasmic shuttling

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  112 ( 17 ) U360 - U360  2005年10月

研究発表ペーパー・要旨（国際会議）  

P38-MAPK mediates the early negative inotropic effect of tumour necrosis factor-alpha (TNF). Evidence of synergy between a direct negative inotropic effect and coronary constriction

M Bellahcene, XB Cao, J Layland, M Tanno, AM Kabir, RS Haworth, AM Shah, M Avkiran, MS Marber

HEART ( B M J PUBLISHING GROUP )  91   A57 - A57  2005年05月

研究発表ペーパー・要旨（国際会議）