Details of a Researcher - HASHIMOTO Eri

Papers - HASHIMOTO Eri

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The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and I-123-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies

Seiju Kobayashi, Kanae Makino, Shigeki Hatakeyama, Takao Ishii, Masaru Tateno, Tomo Iwamoto, Hanako Tsujino, Kazuhito Kawasaki, Kouhei Mikuni, Wataru Ukai, Tomonori Murayama, Eri Hashimoto, Kumiko Utsumi, Chiaki Kawanishi

PSYCHOGERIATRICS ( WILEY ) 17 ( 4 ) 247 - 255 2017.07 [Refereed]

Background: Current diagnostic criteria recommend neuroimaging as a diagnostic support tool for the clinical diagnosis of dementia with Lewy bodies (DLB). Because DLB causes characteristic impairments and disabilities, such as neuroleptic hypersensitivity, which may significantly increase morbidity and mortality, its prompt and correct diagnosis is very important. The aim of this study was to evaluate the extent to which diagnostic accuracy can be increased by using different combinations of brain perfusion single-photon emission computed tomography (bp-SPECT), (123) I-metaiodobenzylguanidine myocardial scintigraphy (MIBG scintigraphy), and DAT-SPECT. Taking finances and patient burden into consideration, we compared the tests to determine priority. Methods: Thirty-four patients with probable DLB (75.0 +/- 8.3 years old; 14 men, 20 women) underwent bp-SPECT, MIBG scintigraphy, and DAT-SPECT. Results: Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) and Dopamine-transporter (DAT) SPECT (79%) had better sensitivity for characteristic abnormalities in DLB than bp-SPECT (53%). The combination of the three modalities could increase sensitivity for diagnosis of DLB to 100%. Additionally, the ratio of patients with rapid eye movement sleep behaviour disorder was significantly higher in the positive finding group on MIBG scintigraphy than in the negative finding group. Conclusions: In terms of stand-alone diagnostic means, priority should be placed on MIBG scintigraphy or DAT-SPECT for the diagnosis of DLB. However, our results suggest that the combination of bp-SPECT, MIBG scintigraphy, and DAT-SPECT increased the accuracy of the clinical diagnosis of DLB.

DOI PubMed

【うつ疾患の診断と鑑別-双極性障害を中心に】双極性障害の自殺リスクと予防

橋本恵理, 田山真矢, 古瀬研吾, 河西千秋

カレントテラピー ( (株)ライフメディコム ) 35 ( 5 ) 457 - 461 2017.05

精神科領域の新薬 (専門医講習会テキストシリーズ知っておきたい関連領域のトピックス)

橋本恵理

日本耳鼻咽喉科学会会報 ( 日本耳鼻咽喉科学会 ) 119 ( 11 ) 1451 - 1453 2016.11

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Relationship between social support and stress response, QOL, functional impairment among adult Female To Male GID persons

安藤孟梓, 池田官司, 針間克己, 橋本恵理, 齋藤利和, 坂野雄二, 中野倫仁

日本性科学会雑誌 ( 日本セックス・カウンセラー・セラピスト協会 ) 34 ( 1 ) 21 - 31 2016.07

本研究の目的は、成人のFemale To Male(FTM)75名を対象に、ソーシャルサポートとストレス反応、QOL、機能障害との関連を検討することであった。質問紙調査を行いて分析した結果、何らかの身体的手術を行った群は、ストレス反応、QOL、機能障害が良好であった。また、治療方法を統制してもソーシャルサポートはストレス反応、QOL、機能障害の下位尺度と相関関係にあることが示された。一方で主観的パス度との関連は限定的であった。次に、家族の中でカミングアウトをもっとも多く受けていたのは母親(86.77%)であり、カミングアウトの結果、家族の中で理解が得られた割合がもっとも高かったのは兄弟・姉妹(90.02%)であった。友人にカミングアウトをした結果、理解が得られた割合は93.22%であった。本研究の結果から、家族や友人からのソーシャルサポートがストレス反応、QOL、機能障害に関連していることが明らかになった。今後は対象をMTFや未成年のGID当事者に広げて検討していく必要がある。(著者抄録)

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アルコール性障害が関与する難治性うつ病の病態基盤血中・脳中BDNF値の変動解析から

古瀬研吾, 木川昌康, 辻野華子, 石井貴男, 田山真矢, 鵜飼渉, 橋本恵理, 齋藤利和, 河西千秋

アルコールと医学生物学 ( (株)響文社 ) 34 29 - 30 2016.06

Pathological analysis of refractory depression using fetal alcohol and adolescent corticosterone double stress model

Kengo Furuse, Hanako Tsujino, Yoshiyasu Kigawa, Masaya Tayama, Wataru Ukai, Takao Ishii, Tomo Iwamoto, Masaki Shiraishi, Seiju Kobayashi, Eri Hashimoto, Chiaki Kawanishi

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY ( OXFORD UNIV PRESS ) 19 119 - 120 2016.06 [Refereed]

Epigenetic status of LINE-1 promoters in neurons and non-neurons

Risa Watanabe, Miki Bundo, Eri Hashimoto, Takao Ishii, Kazuya Iwamoto, Kiyoto Kasai, Tadafumi Kato, Yui Murata, Masaki Nishioka, Yutaka Sawai, Siro Simizu, Junko Ueda, Wataru Ukai

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY ( OXFORD UNIV PRESS ) 19 230 - 230 2016.06 [Refereed]

【DSM-5の新機軸と課題(2)-今後の研究対象とされた病態-】出生前のアルコール曝露

木川昌康, 橋本恵理

臨床精神医学 ( (株)アークメディア ) 45 ( 3 ) 309 - 313 2016.03

Prenatal alcohol exposure

木川昌康, 橋本恵理

臨床精神医学 ( アークメディア ) 45 ( 3 ) 309 - 313 2016.03

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The effect of APOE ϵ4 allele on brain perfusion SPECT in late onset Alzheimer's disease by an automated program, 3DSRT

Seiju Kobayashi, Takao Ishii, Masaru Tateno, Hitoshi Sohma, Yasuo Kokai, Yoichi M. Ito, Tomo Iwamoto, Kengo Furuse, Hanako Tsujino, Hidetoshi Morii, Wataru Ukai, Eri Hashimoto, Kumiko Utsumi, Chiaki Kawanishi

Neuropsychiatry ( Future Medicine Ltd. ) 6 ( 2 ) 55 - 63 2016 [Refereed]

Aim: The Apolipoprotein E (APOE) ϵ4 allele is a risk factor for developing Alzheimer's disease (AD), however its impact on cerebral functional changes in AD remains controversial. Previous studies reported conflicting results or failed to confirm any association, possibly because they failed to consider either the effect of patient age at onset or that of clinical stage. We performed functional neuroimaging studies using current improved techniques to re-examine the effect of APOE ϵ4 allele, taking both the age at onset and clinical stage into account. Methods: 111 late onset AD (LOAD) subjects were divided into 3 subgroups based on Clinical Dementia Rating (CDR). We investigated the influence of ϵ4 allele on functional cerebral changes in each group of LOAD by using cutting-edge analysis software, 3DSRT. Results: The APOE ϵ4 allele was significantly associated with relatively preserved cerebral blood flow in the cerebral cortices. The influence of APOE ϵ4 allele is not apparent in the mild stage, but is significantly demonstrable in the moderate stage. Conclusion: Dividing AD subjects into subgroups based on the severity as well as the age at onset is important for precise outcomes. This study may help resolve the uncertainties of previous studies which reported conflicting results or failed to confirm any association. We believe this is the first study focused on the effect of APOE ϵ4 allele on functional cerebral changes at each stage of AD.

DOI

One case of the manic type general paralysis that manic state was improved with olanzapine, but cognitive function decline remained in

高平充, 清水剛, 小野澤淳, 姫野大作, 木村永一, 橋本恵理, 齋藤利和

精神科治療学 ( (株)星和書店 ) 30 ( 6 ) 831 - 836 2015.06

梅毒感染による進行麻痺の病態は多彩であり、認知機能障害、躁状態、幻覚妄想状態等の精神症状をきたすことも数多く報告されている。今回、著しい躁状態を呈したため内因性躁病も鑑別に挙げられたが、入院後に梅毒感染が判明し、進行麻痺と診断された症例を経験した。多弁多動や精神運動興奮状態は、olanzapineにて消退した。また、残存した認知機能障害に対してPCG、CTRXによる駆梅療法を施行したところ、認知機能障害は若干の改善がみられた。進行麻痺の精神症状は多彩であり、時として内因性精神疾患との鑑別を要することがある。一般身体疾患による精神症状の治療が遅れないよう的確な診断が重要であることを再認識した。(著者抄録)

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胎児期アルコール曝露と成長後のストレスを組み合わせた難治性うつ病モデルにおける神経幹細胞移植療法の有効性

鵜飼渉, 木川昌康, 石井貴男, 古瀬研吾, 辻野華子, 岩本倫, 田山真矢, 白石将毅, 橋本恵理, 河西千秋, 齋藤利和

アルコールと医学生物学 ( (株)響文社 ) 33 39 - 44 2015.03

Influence of comorbid alcohol use disorder on treatment response of depressive patients

Eri Hashimoto, Masaya Tayama, Hiromi Ishikawa, Megumi Yamamoto, Toshikazu Saito

JOURNAL OF NEURAL TRANSMISSION ( SPRINGER WIEN ) 122 ( 2 ) 301 - 306 2015.02 [Refereed]

Patients with major depressive disorder (MDD) frequently also have alcohol use disorder (AUD) and they are more likely to experience symptomatic recurrence and resist treatment. How the two disorders interrelate has not yet been fully examined in Japanese subjects. The treatment response of 47 MDD patients was followed for 12 weeks. Depressive symptoms were rated by the 17-item Hamilton Rating Scale for Depression (HAM-D) and those whose HAM-D score was less than 16 were excluded. The MDD patients were divided into a non-alcohol use disorder (NAUD) and an alcohol use disorder (AUD) group according to the Alcohol Use Disorder Identification Test (AUDIT). We applied a cutoff score of 12 in the AUDIT scale. After 8 weeks, HAM-D NAUD group scores were significantly lower compared with AUD patients. The NAUD group, 23 individuals, prescribed therapeutic doses of antidepressant (equivalent to more than 150 mg of imipramine per day) significantly improved their HAM-D scores but no improvement occurred in the AUD subjects. Correlation analysis in all subjects revealed a significant negative correlation between AUDIT score and improved HAM-D score at endpoint. Moreover, a significant negative correlation was found between total alcohol consumption during the study period and improvement of HAM-D score at endpoint in AUD patients. These results suggest that co-occurrence of MDD and AUD is associated with a lower response to antidepressant treatment and it may reflect an inhibitory effect of ethanol on antidepressants action in the brain.

DOI PubMed

Stem Cell Therapy as a Candidate Treatment Approach for Neural Plasticity Change in Refractory Depression

Toshikazu Saito, Wataru Ukai, Yoshiyasu Kigawa, Takao Ishi, Kengo Furuse, Hanako Tsujino, Masaya Tayama, Eri Hashimoto

NEUROPSYCHOPHARMACOLOGY ( NATURE PUBLISHING GROUP ) 39 S292 - S293 2014.12 [Refereed]

Stem cell therapy: a new approach to the treatment of refractory depression

Yoshiyasu Kigawa, Eri Hashimoto, Wataru Ukai, Takao Ishii, Kengo Furuse, Hanako Tsujino, Tomohiro Shirasaka, Toshikazu Saito

JOURNAL OF NEURAL TRANSMISSION ( SPRINGER WIEN ) 121 ( 10 ) 1221 - 1232 2014.10 [Refereed]

To better understand the relationship of repeated exposure to adversity during early development as a risk factor for refractory depression, we exposed pregnant female rats to ethanol and the resulting pups to corticosterone during adolescence. A stressful forced swim test was then used to induce depression-like behavior. The adolescent rat brains were examined for the possible therapeutic benefit of a combination of sertraline, an antidepressant, and neural stem cells (NSCs) complexed with atelocollagen in relation to the level of GABAergic interneuron and synaptic protein density in different brain regions. The combined exposures of prenatal and adolescent stress resulted in a reduction in parvalbumin (PV)-positive phenotype of GABAergic interneurons and reduced postsynaptic density protein 95 (PSD-95) levels in the anterior cingulate cortex, amygdala, and hippocampus. Treatments with sertraline and NSCs reversed the reductions in PV-positive cells and PSD-95 levels. Furthermore, the combined treatment of sertraline and NSCs resulted in reduced depressive-like behaviors. These experiments underscore a potentially important role for synaptic remodeling and GABAergic interneuron genesis in the treatment of refractory depression and highlight the therapeutic potential of stem cell and pharmacological combination treatments for refractory depression.

DOI PubMed

統合失調症と多発性硬化症の鑑別に苦慮した1例

坂田太, 小坂優, 吉川徹, 畠山茂樹, 橋本恵理

精神科 ( (有)科学評論社 ) 24 ( 5 ) 596 - 600 2014.05

統合失調症の診断で治療経過中に歩行障害が生じ、精査の結果、多発性硬化症(MS)の確定診断に至った33歳の女性の症例を報告した。主訴は足がしびれる、歩きにくい、というものであった。8年前に近医精神科で統合失調症と診断され、オランザピン、リスペリドン、パリペリドン、アリピプラゾール等を主剤とする薬物療法が行われたが、内服薬への拘り、拒絶が強く、症状の再燃と寛解を繰り返していた。6月頃、視力の低下、両下肢の筋力低下、歩行困難が出現したため、薬剤性パーキンソニズムを疑い抗精神病薬を減量したが、改善が認められなかった。9月に近医神経内科を受診したところ、MSの疑いで精査加療が必要と診断され、札幌医科大学附属病院神経精神科へ紹介、入院となった。画像所見と髄液検査の結果MSと診断され、ステロイドパルス療法が施行された。ステロイドパルス療法は2クールでMS急性期治療は終了したが、精神症状に対しては引き続き入院加療が必要と判断し、前医へ転院した。

Characteristics of Attempted Suicide by Patients with Schizophrenia Compared with Those with Mood Disorders: A Case-Controlled Study in Northern Japan

Takao Ishii, Eri Hashimoto, Wataru Ukai, Yohei Kakutani, Ryuji Sasaki, Toshikazu Saito

PLOS ONE ( PUBLIC LIBRARY SCIENCE ) 9 ( 5 ) e96272 2014.05 [Refereed]

Recent reports suggest a lifetime suicide risk for schizophrenia patients of approximately 5%. This figure is significantly higher than the general population suicide risk consequently, detection of those at risk is clinically important. This study was undertaken to define the characteristics of suicide attempts by schizophrenia patients compared with attempts by patients with mood disorders. All patients were diagnosed using the ICD-10 criteria. The study population comprised 65 patients with F2 disorders (schizophrenia, schizotypal and delusional disorders), i.e., "the F2 group'', and 94 patients with F3 disorders (mood disorders), i.e., "the F3 group'', who presented in the clinical setting of consultation-liaison psychiatry. The F2 group had a significantly younger mean age and significantly higher ratios of 'past/present psychiatric treatment' and 'more than 3 months interruption of psychiatric treatment'. In contrast, the ratios of 'physical disorder comorbidity', 'alcohol intake at suicide attempt' and 'suicide note left behind' were significantly higher in the F3 group. The F2 group attempted suicide by significantly more serious methods. Furthermore, 'hallucination-delusion' was the most prevalent motive in the F2 group and was the only factor that showed a significant association with the seriousness of the method of suicide attempt (OR = 3.36, 95% CI: 1.05-11.33).

DOI PubMed

抗うつ効果とBipolarityの診断の糸口を求めて血小板BDNF遊離機能の個体差のメカニズム解析から

橋本恵理, 鵜飼渉, 石井貴男, 木川昌康, 古瀬健吾, 辻野華子, 齋藤利和

精神薬療研究年報 ( (公財)先進医薬研究振興財団 ) ( 46 ) 50 - 51 2014.03

Tips for the medical care of alcoholism by physician

齋藤利和, 橋本恵理

Frontiers in alcoholism = アルコーリズム : アルコール依存症と関連問題 ( メディカルレビュー社 ) 2 ( 1 ) 94 - 98 2014.01

アルコール依存症の為の診療技術の第一はアルコール依存症を知ることから始まる。飲酒に対する強い渇望が依存の中心であるが、そのことを基盤にした症状に注意を払う必要がある。内科には多くのアルコール依存症が、依存症の診断を受けることなく存在する。アルコール依存症を疑い、適切に対処するために飲酒様式、離脱症状に注意し、AUDITなどのスクリーニングテストや血液生化学的検査などを活用する必要がある。内科医でも軽症例においては簡易介入を行い飲酒量の低減を図ることや自助グループと連携し抗渇望薬を使用して断酒の指導をすることは可能である。但し、連続飲酒発作を繰り返す重篤例、振戦せん妄などの重篤な離脱や精神科併存症が疑われる症例は精神科医との緊密な連携が必要である。(著者抄録)

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末梢血血小板からの神経栄養因子遊離に及ぼす抗うつ薬の効果とアルコールの影響について

石井貴男, 鵜飼渉, 橋本恵理, 渡邊公彦, 金田博雄, 木川昌康, 白坂知彦, 五十嵐健史, 吉永敏弘, 館農勝, 齋藤利和

アルコールと医学生物学 ( (株)響文社 ) 32 144 - 144 2014.01

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Papers - HASHIMOTO Eri