研究者詳細 - 馬場　剛

Misc - 馬場　剛

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長尾沙智子, 玉手雅人, 金美善, 杉尾明香, 松浦基樹, 明石祐史, 馬場剛, 田中綾一, 齋藤豪

産科と婦人科 ( (株)診断と治療社 ) 83 ( 12 ) 1475 - 1479 2016年12月

腹腔内の癒着は、目的とする手術を完遂するうえで妨げとなる。とくに視野の限られた腹腔鏡手術においては、手術時間を延長し、出血や合併症の危険性を上昇させる場合もある。複数回の手術や重症内膜症などの炎症と治癒を繰り返す病態は、癒着を形成する原因である。今回、当院で腹腔鏡手術を行った症例のなかで手術既往を持つ119症例を後方視的に検討し、癒着の有無や手術を完遂するうえで妨げとなった要因について考察した。(著者抄録)

腹腔鏡下卵巣子宮内膜症性嚢胞核出術の工夫本当に妊孕能温存に寄与しているのか

杉尾明香, 明石祐史, 玉手雅人, 森下美幸, 馬場剛, 遠藤俊明, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 60 ( 1 ) 67 - 67 2016年03月

難易度の高い子宮筋腫に対する腹腔鏡手術頸部筋腫・巨大筋腫・広間膜内発育に対する戦略的手術の分析

西澤庸子, 明石祐史, 玉手雅人, 杉尾明香, 森下美幸, 馬場剛, 遠藤俊明, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 60 ( 1 ) 66 - 66 2016年03月

Three cases of unexplained recurrent pregnancy loss with different results for chromosome analysis of chorionic villi

Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Miyuki Morishita, Masahito Mizuuchi, Shinichi Ishioka, Tamotsu Kiya, Tsuyoshi Saito

JOURNAL OF REPRODUCTIVE IMMUNOLOGY ( ELSEVIER IRELAND LTD ) 112 129 - 129 2015年11月

研究発表ペーパー・要旨（国際会議）

DOI

腹腔鏡下子宮全摘出術におけるReduced port surgey(RPS)の導入 RPS適応拡大へ向けて

杉尾明香, 明石祐史, 玉手雅人, 森下美幸, 馬場剛, 遠藤俊明, 齋藤豪

産婦人科手術 ( (株)メジカルビュー社 ) ( 26 ) 173 - 173 2015年06月

手術手技研究会のサマリー子宮卵巣全摘出術のパラダイムシフトと性別適合手術としての全腹腔鏡下子宮全摘出術

明石祐史, 玉手雅人, 足立英文, 杉尾明香, 森下美幸, 馬場剛, 遠藤俊明, 斎藤豪, 舛森直哉

GID(性同一性障害)学会雑誌 ( GID(性同一性障害)学会 ) 7 ( 1 ) 105 - 108 2014年12月

性別適合手術としての全腹腔鏡下子宮全摘出術の検討低侵襲化の光と影

安田紗緒里, 明石祐史, 玉手雅人, 杉尾明香, 森下美幸, 馬場剛, 遠藤俊明, 齋藤豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 ) 62回 49 - 49 2014年09月

子宮鏡観察モデルの作成方法

森下美幸, 玉手雅人, 杉尾明香, 明石祐史, 馬場剛, 遠藤俊明, 斉藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 30 ( Suppl.I ) 262 - 262 2014年08月

腹腔鏡下卵巣子宮内膜症性嚢胞核出術に対する希釈バソプレッシン注入法の効果と妊孕能への影響

杉尾明香, 明石祐史, 玉手雅人, 森下美幸, 馬場剛, 遠藤俊明, 齋藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 30 ( Suppl.I ) 158 - 158 2014年08月

FDAの勧告を鑑みていまあらためて考える子宮の回収法婦人科腹腔鏡手術におけるBagging法によるモルセレーションの可能性

明石祐史, 玉手雅人, 杉尾明香, 森下美幸, 馬場剛, 遠藤俊明, 斎藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 30 ( Suppl.I ) 201 - 201 2014年08月

子宮内膜症合併不妊患者の腹腔内評価が治療方針に与える影響について

森下美幸, 玉手雅人, 杉尾明香, 明石祐史, 馬場剛, 遠藤俊明, 斉藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 30 ( Suppl.I ) 162 - 162 2014年08月

ヘテロ型先天性プロテインC欠損症合併妊娠に対し抗凝固療法を用いて周産期管理を行った一例

真里谷奨, 遠藤俊明, 杉尾明香, 森下美幸, 明石祐史, 馬場剛, 山中郁仁, 石岡伸一, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 56 ( 1 ) 38 - 42 2012年03月

35歳(初妊初産婦)。祖母、父、叔母、姉にヘテロ型プロテインC欠損症を認め、本人31歳時に6年間の不妊で某医を受診し、子宮鏡下ポリープ切除術、開腹下癒着剥離術を受け、1ヵ月後に左下肢と肺に血栓形成を認め、ヘテロ型プロテインC欠損症の診断でワルファリン内服を行っていた。妊娠を希望しワルファリンを自己中止し、膝裏に疼痛と浮腫を認め、前医で妊娠と下腿に血栓を認め当院へ搬送・入院した。妊娠9週2日で胎児発育に問題なく、母体に総腸骨静脈分岐部から下腿に広汎な血栓を認め、妊娠継続希望でヘパリンナトリウムを開始し、自覚症状消失でヘパリンカルシウム自己皮下注、アスピリン内服の外来とした。妊娠40週1日に陣痛発来で入院し、経腟分娩で3060gの男児を出産した(Apgar score 8/9)。分娩後出血の止血後にヘパリンナトリウムを開始し、産褥3日よりワルファリンを併用した。以後順調に経過し、血栓の発生は認めず産後13日目に退院した。

First case of vaginal radical trachelectomy in a pregnant Japanese woman

IWAMI Nanako, ISHIOKA Shin-ichi, ENDO Toshiaki, BABA Tsuyoshi, NAGASAWA Kunihiko, TAKAHASHI Madoka, SUGIO Asuka, TAKADA Sakura, MARIYA Tasuku, MIZUNUMA Masahiro, SAITO Tsuyoshi

International journal of clinical oncology 16 ( 6 ) 737 - 740 2011年12月 [ 国内誌 ]

A diagnosis of cervical cancer during pregnancy poses difficult management and ethical problems. Survival of the patient is the foremost concern, but fetal viability and well-being must also be addressed. Radical trachelectomy (RT) has recently begun to be performed as a possible treatment modality for early stage invasive uterine cervical cancer in pregnant patients who would like to continue their pregnancy. A 32-year-old Japanese woman visited a local hospital for prenatal care, and was diagnosed with a FIGO I B1 adenocarcinoma of the uterine cervix. She had a strong desire to avoid pregnancy termination, so she was admitted to our hospital for fertility-preserving surgery. After extensive counseling, vaginal radical trachelectomy with abdominal pelvic lymphadenectomy was performed in the 16th gestational week. The excised uterine cervix and lymph nodes were pathologically negative for cancer. To maintain her pregnancy, daily vaginal disinfection with povidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal suppository were continued until the delivery. At 34 weeks' gestation, an emergency cesarean section was performed because of sudden premature rupture of the membranes. A baby girl was born weighing 2112 g, with Apgar score of 8/9. The mother remains without evidence of recurrence at the time of this report. This is the first case of successful pregnancy and delivery in Japan after vaginal RT.

DOI PubMed CiNii

ISHIOKA Shin-ichi, ENDO Toshiaki, HAYASHI Takuhiro, BABA Tsuyoshi, UMEMURA Kota, SAITO Tsuyoshi

International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology 12 ( 5 ) 350 - 355 2007年10月 [ 国内誌 ]

BACKGROUND: Pregnancy-related complications after vaginal radical trachelectomy (RT) for early-stage invasive uterine cervical cancer were studied in comparison with those occurring after laser conization. The strategy to reduce vaginal RT-related complications during pregnancy is also discussed. METHODS: Pregnancy courses after vaginal RT in two patients and those after laser conization in five patients, whose operations were performed during the same period, were studied with respect to symptoms, cervical length, and infectious signs. RESULTS: The cervix shortened progressively both in patients with laser conization and in those with RT. However, throughout the pregnancy, the remaining cervix after the operation was longer in patients who had undergone conization than in those who had undergone vaginal RT. After laser conization, two of the five patients suffered from preterm rupture of the membrane (PROM) at 36 weeks of gestation, and both patients who had undergone vaginal RT had premature PROM (pPROM), at 32 and 24 weeks of gestation, respectively. CONCLUSION: Prevention of preterm labor and the following occurrence of pPROM is a significant task to be resolved in order to improve pregnancy outcome after vaginal RT for early-stage invasive uterine cervical cancer. Daily vaginal disinfection with povidone iodine and the administration of a ulinastatin vaginal suppository, bed rest, and the use of ritodrine would be the best approach, and a more conservative approach for stage Ia2 also might be taken into consideration.

PubMed CiNii

多嚢胞性卵巣症候群とインスリン抵抗性関連遺伝子の多型

馬場剛, 遠藤俊明, 本間寛之, 北島義盛, 松浦基樹, 南妃奈, 西川聡, 石岡伸一, 林卓宏, 金谷美加, 真名瀬賢吾, 佐田文宏, 岸玲子, 山田秀人, 水上尚典, 神谷博文, 森若治, 齋藤豪

日本内分泌学会雑誌 ( (一社)日本内分泌学会 ) 82 ( 4 ) 864 - 864 2007年03月

多嚢胞性卵巣症候群とインスリン抵抗性関連遺伝子の多型

馬場剛, 遠藤俊明, 本間寛之, 北島義盛, 林卓宏, 金谷美加, 真名瀬賢吾, 佐田文宏, 山田秀人, 水上尚典, 神谷博文, 斎藤豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 ) 59 ( 2 ) 569 - 569 2007年02月

Delayed postpartum hemorrhage due to cesarean scar dehiscence

Tsuyoshi Baba, Miyuki Morishita, Masami Nagata, Yasushi Yamakawa, Masahiro Mizunuma

Archives of Gynecology and Obstetrics 272 ( 1 ) 82 - 83 2005年06月 [ 国際誌 ]

DOI PubMed

Epidermal growth factor increased the expression of alpha 2 beta 1-integrin and modulated integrin-mediated signaling in human cervical adenocarcinoma cells

Yamanaka, I, M Koizumi, T Baba, S Yamashita, T Suzuki, R Kudo

EXPERIMENTAL CELL RESEARCH ( ACADEMIC PRESS INC ELSEVIER SCIENCE ) 286 ( 2 ) 165 - 174 2003年06月 [ 国際誌 ]

Epidermal growth factor (EGF) receptor (EGFR) is involved in various basic biochemical pathways and is thus thought to play an important role in cell migration. We examined the effect of EGF on motility, migration, and morphology of a human adenocarcinoma cell line CAC-1. EGF treatment increased the motility of cervical adenocarcinoma cells and promoted migration of the cells on fibronectin and type IV collagen. EGF induced morphological changes with lamellipodia during EGFR-mediated motility. The results of an immunoprecipitation study showed that EGF up-regulated the expression of alpha2beta1-integrin in a dose-dependent manner. EGF-induced cell migration was blocked by alpha2beta1-integrin antibody. Our results also showed that EGF treatment stimulated the level of tyrosine dephosphorylation of FAK, which is required for EGF-induced changes in motility, migration, and cell morphology. A tyrosine kinase inhibitor (ZD1839) blocked EGF-induced changes in cervical adenocarcinoma cells. The results suggest that EGF promotes cell motility and migration and increases the expression of alpha2beta1-integrin, possibly by decreasing FAK phosphorylation. (C) 2003 Elsevier Science (USA). All rights reserved.

DOI PubMed CiNii

Imaging studies in patients with malignant melanoma in the female genital tract

M Takehara, T Saito, H Mizumoto, T Baba, R Tanaka, T Fujimoto, K Adachi, R Kudo

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER ( BLACKWELL PUBLISHING INC ) 12 ( 5 ) 506 - 509 2002年09月

The purpose of this study was to review magnetic resonance imaging (MRI) and pathologic features of primary malignant melanoma (melanoma) in the female genital tract. We retrospectively evaluated MRI in six women with melanoma of the genital tract. The signal intensity of the tumor on T1-weighted images (WI) was compared with the amount of melanin granules in hematoxylin-eosin stained sections of resected specimen. On T1WI, four melanomas showed a high signal intensity, one intermediate, and one low. The four melanomas with a high signal intensity on T1W1 were rich in melanin granules, while the one intermediate tumor had few granules. The other one was amelanotic. We believe that a high signal on T1WI is characteristic of primary melanotic melanoma of the female genital tract. Our findings suggest that it is strongly influenced by the presence of melanin granules.

DOI

Specific detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction of a beta-casein-like protein, preferentially expressed in malignant neoplasms

T Baba, M Koizumi, T Suzuki, Yamanaka, I, S Yamashita, R Kudo

ANTICANCER RESEARCH ( INT INST ANTICANCER RESEARCH ) 21 ( 4A ) 2547 - 2551 2001年07月

Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta -casein. We evaluated if BCLP mRNA detection in the blood is useful in gynecologic malignancies. We examined 30 patients with uterine cancer, nine cultured cancer cell lines and 26 healthy women volunteers. From these study populations and samples, total RNA was obtained. Reverse transcriptase-PCR (RT-PCR) of BCLP was performed on each sample. Eighteen (60.0%) patients and 4 (15.4%) volunteers were positive for BCLP mRNA. The RTPCR reached sensitivity and specificity of 60.0% and 84.6%, respectively. Of eight patients having diagnosed recurrence, 7 (87.5%) were positive for BCLP mRNA. In patients with recurrence, sensitivity and specificity were 87.5% and 50%, respectively. The expression of mRNA showed a correlation with recurrence, but no correlation with metastasis or histological type. BCLP was specifically expressed in cancer cells and might be an aid in clinical diagnosis.

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