Papers - TAKAHASHI Satoshi

[Management of specific patients in view of hospital infection management. 3. Patients with indwelling urinary catheters].

Taiji Tsukamoto, Satoshi Takahashi, Yuichiro Kurimura

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   97 ( 11 ) 2737 - 42  2008.11  [Domestic journal]

PubMed

[Case of urinary mycobacterium fortuitum in a patient with urinary tract tuberculosis posttreatment].

Takeshi Maehana, Satoshi Takahashi, Megumi Hirobe, Keisuke Taguchi

Hinyokika kiyo. Acta urologica Japonica   54 ( 11 ) 741 - 3  2008.11  [Domestic journal]

　View Summary

A 70-year-old male who complained of urinary frequency and a feeling of incomplete emptying was admitted to our hospital. Imaging findings showed dilation of the left renal pelvis and ureter. He was diagnosed as having urinary tuberculosis because a positive urinary Mycobacterium tuberculosis result was obtained by polymerase chain reaction (PCR). He was treated with a combination of the antituberculosis agents isoniazid, rifampicin, pyrazinamide and ethambutol for six months. The symptoms and pyuria disappeared and M. tuberculosis was negative by PCR; however, Mycobacterium fortuitum was isolated by culture. Due to asymptomatic urinary tract infection by the multidrug resistant M. fortuitum, he was followed up with observation. Currently, he remains unchanged with regard to symptoms and imaging examination. M. fortuitum is a nontubercular mycobacterium, and clinical relevance between urinary tract infection and M. fortuitum has rarely emerged. However, we should be aware that nontubercular mycobacteria such as M. fortuitum can infect the urinary tract, especially in immunocompromised patients.

PubMed

Fate of seminal vesicles and prostate after medical castration: How long is the optimal duration of neoadjuvant treatment for prostate cancer before radiation?

Ryoji Furuya, Shin-ichi Hisasue, Seiji Furuya, Nobuhito Saitoh, Hiroshi Ogura, Satoshi Takahashi, Taiji Tsukamoto

UROLOGY ( ELSEVIER SCIENCE INC )  72 ( 2 ) 417 - 421  2008.08  [Refereed]

　View Summary

OBJECTIVES To clarify the morphological alteration of prostate and seminal vesicles (SV) quantitatively after testosterone ablation, we investigated the prostate volume (PV) and the SV volume (SVV) using transrectal ultrasonography. METHODS Between July 2002 and October 2004, we prospectively investigated 29 prostate cancer patients. The medical castration group included 21 patients (42 SV and 21 prostate; Median Gleason sum, 74 years) who were diagnosed as having T1b to T3aN0M0 prostate cancer and underwent androgen ablation with a lutenizing hormone (LH-RH) analogue and chlormadinone acetate. As normal controls, 8 patients (16 SV and 8 prostate; median age, 68.5 years) with T1aN0M0 prostate cancer without any other additional treatment were enrolled in this study. We measured both PV and SVV in these groups with transrectal ultrasonography. RESULTS Both PV and SVV significantly decreased in the medical castration group (PV: 28.4 +/- 9.3 mL to 17.0 +/- 5.3 mL, SVV: 3.5 +/- 1.8 mL to 1.9 +/- 1.0 mL; median, 6 months), whereas those in the control group were maintained (PV: 16.6 +/- 5.7 mL to 16.5 +/- 5.3 mL, SVV: 2.5 +/- 1.0 mL to 2.6 +/- 1.6 mL; median, 12 months). In longitudinal assessment, mean PSA, PV, and SVV were significantly reduced gradually up to 12 months after medical castration. CONCLUSIONS Not only PV but also SVV was significantly reduced after medical castration. Moreover, size reduction continued up to 12 months in SV, with especially marked reduction seen through the first 6 months. These results demonstrated that optimum duration for androgen ablation before radiotherapy is at least 6 months, and up to 12 months for the maximum effect.

DOI

[Case of male accessory urethra with orifice in the scrotal skin].

Tetsuya Shindo, Satoshi Takahashi, Yuuki Kyoda, Shintaro Miyamoto, Kohei Hashimoto, Naoya Masumori, Taiji Tsukamoto

Hinyokika kiyo. Acta urologica Japonica   54 ( 7 ) 505 - 7  2008.07  [Domestic journal]

　View Summary

A 67-year-old male had an innate fistular orifice at the scrotal skin. In spite of occasional pus discharge from the orifice, no treatment had been performed for the fistula because it improved spontaneously. Due to increasing pus discharge, the fistula was resected at a dermatology clinic, but a persistent fistula tract was confirmed postoperatively by MRI. The fistula adjoined the bulbar urethra and was considered an accessory urethra. We performed resection of the fistula to resolve the frequent pus discharge and pain due to infection of the fistula. The isolated fistula did not communicate with the urethra and the proximal edge ended blindly. Pathological examination showed that the proximal end consisted of transitional epithelium and the distal end consisted of stratified squamous epithelium which meant an accessory urethra. Accessory urethra is not a rare condition, but cases like this one with an orifice that opened at the scrotal skin are extremely rare. As the treatment for the fistula, complete resection should be indicated.

PubMed

Glomerulation observed during transurethral resection of the prostate for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia is a common finding but no predictor of clinical outcome

Ryoji Furuya, Naoya Masumori, Sej Furuya, Toshiro Oda, Satoshi Takahashi, Masaya Takeuchi

UROLOGY ( ELSEVIER SCIENCE INC )  70 ( 5 ) 922 - 926  2007.11  [Refereed]

　View Summary

OBJECTIVES Although glomerulation in the bladder mucosa when the bladder is overdistended is a finding suggestive of interstitial cystitis (10, it is sometimes observed at transurethral resection of the prostate (TURP) for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). We prospectively investigated the incidence and clinical implications of glomerulation found at TURP. METHODS From December 2003 to October 2005, 197 patients aged 50 years or older who were considered to be appropriate candidates to undergo TURP for LUTS/BPH were investigated in this study. just before beginning resection under spinal anesthesia, the bladder was filled to a water pressure of 80 cm and the capacity was measured. After evacuation of the fluid, careful inspection was conducted for glomerulation during refilling. Before TURP, and 3 and 12 months after TURP, the International Prostate Symptom Score and O'Leary-Sant IC Symptom and Problem Index were determined, and uroflowmetry and measurement of residual urine volume were performed. RESULTS Glomerutation was observed in 40 of the 197 patients (20.3%). There was no difference in bladder capacity between the glomerulation and nonglomerulation groups, although the glomerulation group was younger with lighter resected weight and a higher baseline IC problem index than the nonglomerulation group. There were no differences in other parameters before, 3, and 12 months after TURP between the 2 groups. CONCLUSIONS Although glomerulation at TURP is a common finding, the clinical implications related to IC are unknown. Glomerulation itself may not be a predictor of the clinical outcome of TURP. Glomerulation observed during transurethral resection of the prostate for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia is a common finding but no predictor of clinical outcome. UROLOGY 70: 922-926, 2007. (c) 2007 Elsevier Inc.

DOI

Comparison of 1-day, 2-day, and 3-day administration of antimicrobial prophylaxis in radical prostatectomy.

Koh Takeyama, Satoshi Takahashi, Toshihiro Maeda, Masatoshi Mutoh, Yasuharu Kunishima, Masanori Matsukawa, Yoshio Takagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   13 ( 5 ) 320 - 3  2007.10  [International journal]

　View Summary

An adequate protocol for antimicrobial prophylaxis (AMP) in radical prostatectomy has not been established. We retrospectively compared the incidence and severity of infectious complications after radical prostatectomy with three different protocols for AMP. The study cohort consisted of 67 patients with prostate cancer who underwent radical prostatectomy at Hakodate Goryoukaku Hospital between January 2003 and December 2005. As a prophylactic antimicrobial agent, one of the cephalosporins or penicillins was administered intravenously to all patients. The analyzed protocols were for: (1) a 3-day group: administration of AMP until the second postoperative day (POD 2), (2) a 2-day group: administration of AMP until POD 1, and (3) a 1-day group: administration of AMP only on the operative day. The incidence and severity of infectious complications were retrospectively investigated. Three patients in the 3-day group (9.4%), 2 patients in the 2-day group (12.5%), and 2 patients in the 1-day group (10.5%) developed some infectious complications. The incidence of infectious complications was not significantly different among the three groups. No patients developed severe infectious complications such as sepsis. We conclude that single-day AMP is sufficient in patients with radical prostatectomy.

PubMed

Change in Environment of Medical Equipment after Introduction of the Electronic Chart System : Results of Bacterial Survey of Computer Mice

MASUMORI Naoya, KUNISHIMA Yasuharu, TAKAHASHI Satoshi, ITOH Shiori, ITOH Naoki, TSUKAMOTO Taiji, MATSUKAWA Masanori

Japanese Journal of Infection Prevention and Control ( Japanese Society of Environmental Infections )  22 ( 2 ) 113 - 117  2007.06

　View Summary

Computers were first installed in the medical environment with the introduction of the electronic chart system. Bacterial contamination of computer mice frequently used by many members of the medical staff was investigated with a microbacteriologic survey by the smear method on February 1, 2006 for 16 computer mice located in the urological ward. The computer mice attached to the 9 desktop-type computers were different to those of the 7 laptop computers. The laptop computers were transported to the patients' bedsides when needed for the dispensing and infusion of drugs. Specimens were collected from 3 locations on the mice, the left click button, the body, and the scroll button. Bacteria were detected on all mice. More bacteria were isolated from the scroll button than from the click button or the body. Two patients with MRSA had been treated during the survey, but no outbreak was found. MRSA was detected on the scroll button of the mouse of one laptop computer. This strain was identical to the MRSAstrain obtained from a patient with surgical site infection. No Pseudomonas aeruginosa was detected. Although random, undirected microbiologic sampling is not necessary, the computer mousemay act as a reservoir for colonizing bacteria.

DOI CiNii

The 6-fluoro-8-methoxy quinolone, gatifloxacin, down-regulates interleukin-8 production in prostate cell line PC-3

Koh Takeyama, Hiroaki Mitsuzawa, Chiaki Nishitani, Takeyuki Shimizu, Hitomi Sano, Yasuharu Kunishima, Satoshi Takahashi, Hiroshi Hotta, Masanori Matsukawa, Ken-ichiro Shibata, Taiji Tsukamoto, Yoshio Kuroki

Antimicrob. Agents Chemother.   51   162 - 168  2007

DOI

Time courses of bacterial density in urine during antibacterial chemotherapy and influential factors in patients having positive bacteriuria with a complicated urinary tract

Masanori Matsukawa, Yasuharu Kunishima, Satoshi Takahashi, Kou Takeyama, Taiji Tsukamoto

Journal of Infection and Chemotherapy ( Springer Japan )  13 ( 2 ) 99 - 104  2007  [Refereed]

　View Summary

A series of consecutive urine cultures was performed to determine the time points of elimination of bacteria from urine and the factors influencing these time points in patients receiving antimicrobial chemotherapy for positive bacteriuria. Between 1988 and 2000, 110 patients who had positive bacteriuria and received a 5-day regimen of parenteral antibacterials were included in this study. Quantitative urine cultures were performed every 24h throughout the therapy. Bacteria were identified minimum inhibitory concentrations of antibacterial agents for causative bacteria were determined, and the bacteria were categorized as susceptible or nonsusceptible. The complexity of the urinary tract was graded as high or low. A multivariate Cox proportional hazards model was utilized to identify the factors that determined the time course of bacterial density in urine. Two penicillins, seven cephalosporins, five carbapenems and one fluoroquinolone were administered to 110 patients. The overall bacteriurial elimination rate at the end of treatment was 73% (80/110), and the most frequent day of elimination was day 1 (54% 43/80), followed by day 2 (20% 16/80). The significant factors for persistence of bacteriuria after chemotherapy were the presence of an indwelling catheter, a nonsusceptible pathogen, and high complexity of the urinary tract risk ratios were: 2.398 (P = 0.0009), 2.227 (P = 0.0020), and 2.113 (P = 0.0455), respectively, which also influenced the day of elimination. In conclusion, the efficacy of treatment and the time point of bacteriurial elimination were determined by the presence of a urinary catheter, drug susceptibility, and urinary complexity in patients with positive bacteriuria undergoing antibacterial chemotherapy. © 2007 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

DOI PubMed

APP-081 尿路変向・再建術後症例における尿管ステント抜去時の発熱に関する検討(第95回日本泌尿器科学会総会)

橋本 次朗, 高橋 聡, 竹山 康, 国島 康晴, 舛森 直哉, 伊藤 直樹, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  98 ( 2 ) 281 - 281  2007

DOI CiNii

PP-558 泌尿器科領域の術後感染予防抗菌薬投与における薬物動態的検討(第95回日本泌尿器科学会総会)

高橋 聡, 国島 康晴, 竹山 康, 市原 浩司, 高柳 明夫, 竹内 基, 橋本 浩平, 福多 史昌, 小林 皇, 舛森 直哉, 伊藤 直樹, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  98 ( 2 ) 536 - 536  2007

DOI CiNii

Modified and bilateral retroperitoneal lymph node dissection for testicular cancer: Peri- and postoperative complications and therapeutic outcome

Toshiaki Tanaka, Hiroshi Kitamura, Yasuharu Kunishima, Satoshi Takahashi, Atsushi Takahashi, Naoya Masumori, Naoki Itoh, Taiji Tsukamoto

JAPANESE JOURNAL OF CLINICAL ONCOLOGY ( OXFORD UNIV PRESS )  36 ( 6 ) 381 - 386  2006.06  [Refereed]

　View Summary

Objective: To characterize surgical invasiveness and morbidity and to verify therapeutic efficacy, we reviewed perioperative and postoperative courses and therapeutic outcomes of patients who underwent retroperitoneal lymph node dissection (RPLND) for testicular germ cell cancers. Methods: The study included 31 patients who underwent retroperitoneal lymph node dissection. A modified template was used if retroperitoneal metastasis was limited to the areas below the level of the renal hilus and above the level of the inferior mesenteric artery (IMA). Perioperative and postoperative courses and complications were reviewed as well as therapeutic outcomes. Results: Overall, 27 perioperative and postoperative complications were observed in 15 patients (48.4%). Superficial surgical site infection and paralytic ileus were seen most frequently. All of them were resolved without special additional treatments; however, patients who underwent retrocrural dissection had a tendency to have severe symptomatic complications such as chylothorax, phrenic nerve palsy and orthostatic hypotension. Antegrade ejaculation was preserved in 94.1% of patients with modified template dissection, whereas no patients with additional dissection below the level of the IMA had the function preserved. One patient (3.2%) developed a postoperative recurrent disease in the retroperitoneum, which was outside the dissection field, as well as in the mediastinum. Conclusions: Although RLND had high morbidity, most peri- and postoperative complications were manageable conservatively. Modified template dissection enabled patients to preserve antegrade ejaculation without compromising its therapeutic efficacy, if the disease extension allowed us to use the template.

DOI

Chlamydial seminal vesiculitis without symptomatic urethritis and epididymitis

R Furuya, S Takahashi, S Furuya, K Takeyama, N Masumori, T Tsukamoto

INTERNATIONAL JOURNAL OF UROLOGY ( BLACKWELL PUBLISHING )  13 ( 4 ) 466 - 467  2006.04  [Refereed]

　View Summary

We previously reported that seminal vesiculitis was associated with acute epididymitis, and that Chlamydia trachomatis was the major causative pathogen for infection of the seminal vesicle, suggesting that seminal vesiculitis was a discrete disease entity. In this paper, we report two patients with bacteriologically and cytologically proven seminal vesiculitis who had asymptomatic urethritis but not epididymitis. The clinical courses of these patients suggest that chlamydial seminal vesiculitis may be a cause of asymptomatic infection of the urethra or subsequent development of acute epididymitis.

[Male genital herpes].

Satoshi Takahashi, Takaoki Hirose

Nihon rinsho. Japanese journal of clinical medicine   64 Suppl 3   77 - 80  2006.03  [Domestic journal]

PubMed

S13-4 The efficacy of antimicrobial agents for chronic prostatitis and prospects for the future(Symposium 13「Diagnosis and Treatment of Chronic Prostatitis」)

Takahashi Satoshi, Kunishima Yasuharu, Takeyama Koh, Tsukamoto Taiji

The Japanese Journal of Urology ( THE JAPANESE UROLOGICAL ASSOCIATION )  97 ( 2 ) 173 - 173  2006

DOI CiNii

MP-126 慢性前立腺炎に対する抗菌薬(GFLX)投与の有用性に関する検討(一般演題ポスター,第94回日本泌尿器科学会総会)

国島 康晴, 高橋 聡, 塚本 泰司, 丹田 均, 小六 幹夫, 廣瀬 崇興, 岩澤 晶彦, 西村 昌宏, 横尾 彰文, 松川 雅則, 鈴木 伸和, 竹田 孝一, 堀田 浩貴

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  97 ( 2 ) 398 - 398  2006

DOI CiNii

OP-209 男子尿道炎に対するアジスロマイシンの臨床効果に関する多施設共同研究(一般演題口演,第94回日本泌尿器科学会総会)

松川 雅則, 国島 康晴, 高橋 聡, 塚本 泰司, 岩澤 晶彦, 丹田 均, 小六 幹夫, 鈴木 伸和, 高木 良雄, 廣瀬 崇興, 西村 昌宏

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  97 ( 2 ) 333 - 333  2006

DOI CiNii

[Application of real-time polymerase chain reaction for the detection of prostatic bacteria in patients with chronic prostatitis/chronic pelvic pain syndrome].

Satoshi Takahashi

The Japanese journal of antibiotics   58 ( 2 ) 187 - 92  2005.04  [Domestic journal]

PubMed

OP2-035 抗菌薬による前立腺癌細胞株のサイトカイン産生抑制(一般演題(口演))

竹山 康, 国島 康晴, 高橋 聡, 西山 直隆, 堀田 裕, 松川 雅則, 塚本 泰司, 黒木 由夫

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  95 ( 2 ) 359 - 359  2004

DOI CiNii

PP3-191 経直腸的前立腺針生検における抗菌薬予防投与に関するprospective study(一般演題(ポスター))

国島 康晴, 竹山 康, 高橋 聡, 松川 雅則, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  95 ( 2 ) 521 - 521  2004

DOI CiNii