Papers - TAKAHASHI Satoshi

[Application of real-time polymerase chain reaction technology to detect prostatic bacteria in patients with chronic prostatitis/chronic pelvic pain syndrome].

Satoshi Takahashi

The Japanese journal of antibiotics   56 ( 4 ) 338 - 9  2003.08  [Domestic journal]

PubMed

[Comparative studies on activities on antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2000). III. Secular changes in susceptibility].

Yoshiaki Kumamoto, Taiji Tsukamoto, Takaoki Hirose, Masanori Matsukawa, Satoshi Takahashi, Yasuharu Kunishima, Makoto Fujime, Kazuhiko Fujita, Masahiko Ogihara, Kei Ishibashi, Jun Igari, Shiro Shigeta, Toyoko Oguri, Keizo Yamaguchi, Tetsuya Matsumoto, Fusako Kashitani, Hiroshi Yoshida, Yuuji Imafuku, Masaru Murai, Hiroshi Ooe, Mineko Nishikawa, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Toshitsugu Oka, Masaya Kitamura, Yuuji Takano, Yasuhiro Matsuoka, Seiji Matsuda, Shinichi Sato, Toshinari Furuhama, Hiromi Kumon, Koichi Monden, Shigeru Kohno, Yoshitsugu Miyazaki, Kazunori Tomono, Siho Aoki, Chikako Mochida, Yoichi Hirakata

The Japanese journal of antibiotics   55 ( 5 ) 568 - 655  2002.10  [Refereed]  [Domestic journal]

　View Summary

The bacteria (Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa) isolated from patients diagnosed as having urinary tract infections (UTIs) in 10 institutions in Japan were supplied between August 2000 and July 2001. Then, the susceptibilities of these bacteria to various antimicrobial agents were examined, and the results were compared with those obtained between 1992 and 1999. Comparison was made by classifying strains isolated from patients into those in uncomplicated UTIs and those in complicated UTIs (including with or without indwelling catheter). E. faecalis showed good susceptibility to ampicillin (ABPC) and imipenem (IPM), and the MIC90s were 2 micrograms/ml. Also, E. faecalis showed good susceptibility to vancomycin (VCM). However, the MIC90, which was 2 micrograms/ml between 1992 and 1999, rose to 4 micrograms/ml in patients with complicated UTIs because the strains inhibited at 4 micrograms/ml increased more than before. The low susceptibility of S. aureus to arbekacin (ABK) in complicated UTIs, as shown in 1998 and 1999, recovered in 2000, and no strains inhibited at > or = 4 micrograms/ml were detected. E. coli showed good susceptibility to CTM (MIC90: 0.25-0.5 microgram/ml) and CZOP (MIC90: < or = 0.125 microgram/ml) and was not resistant to those. E. coli also showed good susceptibility to the other drugs except to penicillins. Decreases in susceptibility of E. coli to quinolones, ciprofloxacin (CPFX), and sparfloxacin (SPFX) were observed in the patients with complicated UTIs. The susceptibility of Klebsiella spp. to all drugs did not significantly change in 2000 and was generally good except to penicillins. Although the susceptibility of P. aeruginosa to carbapenems was notable, the MIC90 went up from 4 micrograms/ml to 16 micrograms/ml in complicated UTIs compared with those observed in the previous year.

PubMed

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2000). I. Susceptibility distribution].

Yoshiaki Kumamoto, Taiji Tsukamoto, Makoto Fujime, Kazuhiko Fujita, Takaoki Hirose, Masanori Matsukawa, Satoshi Takahashi, Yasuharu Kunishima, Jun Igari, Masahiko Ogihara, Kei Ishibashi, Toyoko Oguri, Shiro Shigeta, Keizo Yamaguchi, Tetsuya Matsumoto, Fusako Kashitani, Hiroshi Yoshida, Yuuji Imafuku, Masaru Murai, Hiroshi Ooe, Mineko Nishikawa, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Toshitsugu Oka, Masaya Kitamura, Yuuji Takano, Yasuhiro Matsuoka, Seiji Matsuda, Shinichi Sato, Toshinari Furuhama, Hiromi Kumon, Koichi Monden, Siho Aoki, Chikako Mochida, Yoichi Hirakata, Shigeru Kohno, Yoshitsugu Miyazaki, Kazunori Tomono

The Japanese journal of antibiotics   55 ( 4 ) 370 - 98  2002.08  [Refereed]  [Domestic journal]

　View Summary

The bacterial strains isolated from patients diagnosed as having urinary tract infections (UTIs) in 10 institutions in Japan were supplied between the period of August 2000 and July 2001. Then, the susceptibilities of them to many kinds of antimicrobial agents were investigated. The number of them were 511 strains. The breakdown of these strains was Gram-positive bacteria as 29.0% and Gram-negative bacteria as 71.0%. Susceptibilities of these bacteria to antimicrobial agents were as follows; vancomycin (VCM), ampicillin (ABPC) and imipenem (IPM) showed strong activities against Enterococcus faecalis. No increase in low-susceptible strains of E. faecalis observed against these antimicrobial agents. VCM showed a strong activity against MRSA preventing growth of all strains with 1 microgram/ml. In addition, the activity of arbekacin (ABK) was strong with the MIC90 of 2 micrograms/ml against MRSA and prevented growth of all strains with 4 micrograms/ml. ABK showed a strong activity against Staphylococcus epidermidis preventing growth of all strains with 0.5 microgram/ml. ABPC, cefotiam (CTM) and cefozopran (CZOP) also showed a relatively strong activity against S. epidermidis (MIC90: 4 to 8 micrograms/ml). Against Escherichia coli, carbapenems showed high activities: meropenem (MEPM) prevented growth of all strains within 0.125 microgram/ml; IPM prevented growth of all strains with 0.25 microgram/ml. CZOP and CTM also showed strong activities against E. coli: MIC90 of CZOP was within 0.125 microgram/ml; MIC80 and MIC90 of CTM were 0.25 and 0.5 microgram/ml, respectively. Quinolone resistant E. coli was detected at frequency of 14.0%, which was significantly higher than that in the last year. Almost all drugs showed strong activities against Klebsiella pneumoniae and Proteus mirabilis, and MEPM prevented growth of all strains within 0.125 microgram/ml. Against Pseudomonas aeruginosa, almost drugs were not so active. The MIC90 of carbapenems and gentamicin (GM) were 16 micrograms/ml and those of all other drugs were more than 32 micrograms/ml. Against Serratia marcescens, the MIC90 of IPM and GM were the lowest value being 2 micrograms/ml, and that of MEPM was 4 micrograms/ml.

PubMed

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2000). II. Background of patients].

Yoshiaki Kumamoto, Taiji Tsukamoto, Makoto Fujime, Kazuhiko Fujita, Takaoki Hirose, Masanori Matsukawa, Satoshi Takahashi, Yasuharu Kunishima, Jun Igari, Masahiko Ogihara, Kei Ishibashi, Toyoko Oguri, Shiro Shigeta, Keizo Yamaguchi, Tetsuya Matsumoto, Fusako Kashitani, Hiroshi Yoshida, Yuuji Imafuku, Masaru Murai, Hiroshi Ooe, Mineko Nishikawa, Kiyoaki Watanabe, Yoshio Kobayashi, Hiroshi Uchida, Toshitsugu Oka, Masaya Kitamura, Yuuji Takano, Yasuhiro Matsuoka, Seiji Matsuda, Shinichi Sato, Toshinari Furuhama, Hiromi Kumon, Koichi Monden, Siho Aoki, Chikako Mochida, Yoichi Hirakata, Shigeru Kohno, Yoshitsugu Miyazaki, Kazunori Tomono

The Japanese journal of antibiotics   55 ( 4 ) 399 - 411  2002.08  [Refereed]  [Domestic journal]

　View Summary

Five-hundred eighty eight bacterial strains isolated from 435 patients diagnosed as having urinary tract infections (UTIs) in 10 institutions in Japan were supplied between August 2000 and July 2001. Then, the clinical background of patients were investigated such as sex, age, and type of infections, infections and kind of bacteria, frequency of bacteria isolation by age and infections, bacteria and infections by timing of antibiotics administration, and bacteria and infections by surgical procedures. About the relationship between age and sex of patients and type of infections, the number of male patients aged less than 50 years was few, and complicated UTIs without indwelling catheter was the most frequent. In females, the number of patients aged less than 20 years was few. The majority of female patients aged 40 years and over had complicated UTIs while uncomplicated UTIs was most frequent in the patients being twenties. As for type of infections and kind of bacteria, Escherichia coli decreased when the infections became complicated, and pseudomonas aeruginosa increased when the infection became complicated. Enterococcus faecalis was isolated more frequently in complicated UTIs than in uncomplicated UTIs. Considering this result by age of patients, isolated frequency of E. coli was gradually decreased with aging in patients aged 20 years and over with uncomplicated UTIs or complicated UTIs without indwelling catheter. The isolated frequencies of Klebsiella spp., P. aeruginosa, and E. faecalis were high in the patients with complicated UTIs without indwelling catheter. In the patients aged 70 years and over with complicated UTIs with indwelling catheter, P. aeruginosa and E. faecalis were frequently isolated. As for type of causative organisms in UTIs before and after the administration of antibiotics, the isolation of bacteria was remarkably decreased after administration in the patients with uncomplicated UTIs and complicated UTIs without indwelling catheter. E. coli decreased after administration of antibiotics, and P. aeruginosa increased after administration in the patients with all types of infections. As for type of causative organisms in UTIs and surgical procedures, E. coli was frequently isolated in the patients without surgery in all types of infections, while P. aeruginosa was frequently isolated in the patients who underwent surgery. In uncomplicated UTIs, Proteus spp. and E. faecalis were frequently isolated in the patients with surgery. In complicated UTIs without indwelling catheter, Klebsiella spp. was frequently isolated in the patients without surgery and E. faecalis was frequently isolated in the patients with surgery. In complicated UTIs with indwelling catheter, most of organisms except P. aeruginosa and S. aureus were frequently isolated in the patients without surgery.

PubMed

NIH慢性前立腺炎symptom index(NIH-CPSI)の有用性に関する検討

国島 康晴, 松川 稚則, 西山 直隆, 竹山 康, 清水 俊明, 高橋 聡, 堀田 裕, 廣瀬 崇興, 古屋 聖兒, 小椋 啓, 高塚 慶次, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  92 ( 2 ) 397 - 397  2001

DOI CiNii

泌尿器科手術侵襲とSIRS

西山 直隆, 国島 康晴, 松川 雅則, 竹山 康, 本間 一也, 清水 俊明, 高橋 聡, 堀田 裕, 横尾 彰文, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  91 ( 3 ) 246 - 246  2000

DOI CiNii

透析施行者の前立腺癌に対する内分泌(Total Androgen Blockade)療法時の薬物血中濃度に関する検討

高橋 聡, 加藤 隆一, 久末 伸一, 高木 誠次, 伊藤 直樹, 塚本 泰司

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  91 ( 3 ) 419 - 419  2000

DOI CiNii

Expression of intercellular adhesion molecule-1 in mice with Pseudomonas-induced pyelonephritis

A Yokoo, T Hirose, M Matsukawa, H Hotta, Y Kunishima, S Takahashi

JOURNAL OF UROLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  160 ( 2 ) 592 - 596  1998.08  [Refereed]

　View Summary

Purpose: To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in the renal inflammatory process, we studied the time-course fluctuation of ICAM-1 expression on inflammatory lesions in mice with experimentally induced bacterial pyelonephritis and the effect of in vivo administration of an anti-ICAM-1 monoclonal antibody (mAb) on leukocytic migration. Materials and Methods: Ascending pyelonephritis was induced by transurethral instillation of Pseudomonas aeruginosa, and the expression of ICAM-1 in the pyelonephritic lesions was studied by immunohistochemical methods. Results: The expression of ICAM-1 on the pyelonephritic lesions closely paralleled the degree of infiltration of neutrophils and macrophages until 3 days after infection. At 7 days after infection, though the degree of infiltration of these cells was quite high, expression of ICAM-1 was reduced. Treatment with the anti-ICAM-1 mAb in mice with bacterial pyelonephritis resulted in suppression of influx of neutrophils and macrophages in the infected sites until 3 days after infection. However, at 7 days after infection inhibition of the influx of these cells was not seen. Conclusions: These results suggest that ICAM-1 expression is transient and plays a key role in the influx of neutrophils and macrophages associated with the early-phase response, and that in the late phase ICAM-1 independent adhesion molecules may be more predominant.