Details of a Researcher - TAKAHASHI Satoshi

Papers - TAKAHASHI Satoshi

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Current controversial issues in the decontamination process for urological endoscopes.

Hitoshi Yanaihara, Ryoichi Hamasuna, Satoshi Takahashi, Shingo Yamamoto, Soichi Arakawa, Satoru Ishikawa, Tetsuro Matsumoto

International journal of urology : official journal of the Japanese Urological Association 19 ( 1 ) 5 - 6 2012.01 [International journal]

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Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial.

Ryoichi Hamasuna, Satoshi Takahashi, Hiroshi Kiyota, Mitsuru Yasuda, Hiroshi Hayami, Soichi Arakawa, Kazunori Tomono, Tetsuro Matsumoto

Sexually transmitted infections 87 ( 5 ) 389 - 90 2011.08 [International journal]

OBJECTIVES: Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis. METHODS: The study was an open clinical trial evaluating the effectiveness of gatifloxacin with 200 mg doses twice a day for 7 days against male NGU. RESULTS: Between March and September 2008, 169 male patients were enrolled, and microbiological and clinical cure rates could be evaluated in 86 patients detected with C trachomatis or M genitalium and in 135 with NGU, respectively. Microbiological cure rates of gatifloxacin against C trachomatis and M genitalium were 100% and 83%, respectively, and the total clinical cure rate was 99%. CONCLUSION: Analysis of in-vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M genitalium infection.

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A case with fistula formation between a perinephric retroperitoneal abscess and the duodenum: successful outcome after conservative management.

Masahiro Matsuki, Satoshi Takahashi, Shin-Ichi Hisasue, Takashi Muranaka, Akio Takayanagi, Takeshi Maehana, Teruhisa Uehara, Naoya Masumori, Taiji Tsukamoto

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 17 ( 4 ) 541 - 3 2011.08 [International journal]

A 67-year-old woman diagnosed with pyonephrosis and perinephric abscess because of an impacted urinary stone in the pelvicoureteric junction was admitted to the hospital with a high-grade fever. Although construction of a right nephrostomy for drainage of the abscess improved her general condition, she had a fever again 2 weeks after the initial treatment. Computed tomography revealed a persistent perinephric retroperitoneal abscess and a second drainage procedure was performed. Then, imaging examination revealed fistula formation between the cavity of the perinephric retroperitoneal abscess and the duodenum. The patient received conservative management including percutaneous drainage, discontinuation of oral intake, and antimicrobial chemotherapy. Three days after the second drainage and discontinuation of oral intake, imaging examination revealed complete closure of the fistula. Fistula formation between a perinephric abscess and the duodenum is very rare but a favorable outcome was obtained by our conservative management.

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Japanese guideline for clinical research of antimicrobial agents on urogenital infections: the first edition.

Mitsuru Yasuda, Satoshi Takahashi, Hiroshi Kiyota, Kiyohito Ishikawa, Akira Takahashi, Shingo Yamamoto, Soichi Arakawa, Koichi Monden, Tetsuro Muratani, Ryoichi Hamasuna, Hiroshi Hayami, Tetsuro Matsumoto

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 17 ( 4 ) 579 - 94 2011.08 [International journal]

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Guideline for the prevention of health care-associated infection in urological practice in Japan.

Ryoichi Hamasuna, Satoshi Takahashi, Shingo Yamamoto, Soichi Arakawa, Hitoshi Yanaihara, Satoru Ishikawa, Tetsuro Matsumoto

International journal of urology : official journal of the Japanese Urological Association 18 ( 7 ) 495 - 502 2011.07 [International journal]

For developing the Japanese guideline for the prevention of health care-associated infection in urological practice, we surveyed the literature including standard precautions, environmental considerations in both the inpatient and outpatient settings, the management of urinary catheters, endoscopy techniques, and the disinfection and sterilization of instruments used in endoscopies and related procedures. The concept of this guideline is to show the minimum precautions that urologists and other medical professionals should observe when they work in the urological field. Standard precautions based on hand hygiene and the use of personal protective equipment should be observed in both the inpatient and outpatient settings. In the inpatient setting, the management of the toilet is important. Collecting urine should be restricted only when it is necessary to determine a patient's urinary output. The management for urinary catheter and infection are created based on the "European and Asian guidelines on management and prevention of catheter-associated urinary tract infections". In addition, we propose that nephrostomy should be carried out after maximum barrier precautions have been taken. Urinary catheters are replaced in the event of an occlusion or if there are signs that an occlusion might occur, but the same catheter cannot be left in place for more than 2 months. Regarding the handling of urine containing Mycobacterium tuberculosis, airborne infection countermeasures are unnecessary, except for the laboratory personnel. For the procedures using urological endoscopes, aseptic techniques are recommended. Endoscopes and related devices should be used by sterilization or high-level disinfection, but formaldehyde gas cannot be used.

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Clinical efficacy of levofloxacin 500 mg once daily for 7 days for patients with non-gonococcal urethritis

Satoshi Takahashi, Kohji Ichihara, Jiro Hashimoto, Yuichiro Kurimura, Akihiko Iwasawa, Kenji Hayashi, Kenichi Sunaoshi, Koichi Takeda, Nobukazu Suzuki, Takashi Satoh, Taiji Tsukamoto

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER TOKYO ) 17 ( 3 ) 392 - 396 2011.06 [Refereed]

To confirm the efficacy of the treatment regimen with oral levofloxacin (LVFX) 500 mg once daily for 7 days for patients with non-gonococcal urethritis (NGU), we evaluated the microbiological and clinical outcomes of the regimen in those patients. We finally evaluated 53 patients with symptomatic NGU and 5 patients with asymptomatic NGU. As a result of microbiological examinations, 19 of the symptomatic patients were diagnosed as having non-gonococcal chlamydial urethritis (NGCU); 13 had non-gonococcal non-chlamydial urethritis (NGNCU), and 21 had urethritis without any microbial detection. Five of the asymptomatic patients were diagnosed as having NGCU. Microbiological cure was achieved in 91% of the 32 patients with symptomatic NGU and in 80% of the 5 patients with asymptomatic NGCU. Clinical cure was obtained in 92% of the 53 patients with symptomatic NGU. The microbiological eradication rate for Chlamydia trachomatis was 92% in 24 patients. As for other organisms, the microbiological eradication rate for Mycoplasma genitalium was 60% in 5 patients and that for Ureaplasma urealyticum was 100% in 10. The microbiological and clinical efficacy of oral LVFX 500 mg once daily for 7 days for the patients with NGU was the same for the azithromycin (AZM) 1,000 mg single dose that we previously reported. The eradication rates of C. trachomatis and U. urealyticum in the treatment regimen with LVFX 500 mg were high enough in the clinical setting; however, for M. genitalium, the rate was relatively inferior to that with AZM.

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Management for males whose female partners are diagnosed with genital chlamydial infection

Satoshi Takahashi, Yuichiro Kurimura, Jiro Hashimoto, Kenichi Sunaoshi, Koichi Takeda, Nobukazu Suzuki, Ryoji Furuya, Keisuke Taguchi, Takashi Satoh, Akihiko Iwasawa, Kenji Hayashi, Takaoki Hirose, Taiji Tsukamoto

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER TOKYO ) 17 ( 1 ) 76 - 79 2011.02 [Refereed]

The purpose of this study was to investigate the infection rate of asymptomatic men whose female sexual partners were diagnosed as having genital chlamydial infection and discuss the management for them. The subjects were asymptomatic men whose female sexual partners were diagnosed with genital chlamydial infection at other obstetric and gynecological clinics. Microscopic findings of urinary sediment and the results of a nucleic acid amplification test of the first-voided urine specimen were retrospectively examined in those men who visited our clinics. A total of 267 men were included and analyzed. The infection rate for urinary Chlamydia trachomatis in asymptomatic men was 36.3% (97 of 267). In the analysis of urinary sediment, 35 of the 267 (13.1%) had pyuria and 82.9% (29 of 35) in the men with pyuria were positive for urinary C. trachomatis in. Even in men without pyuria, the urinary C. trachomatis-positive rate was 29.3% (68 of 232). When such men have pyuria in the clinic, prompt treatment is the appropriate approach. If the men are without pyuria, testing for urinary C. trachomatis should be performed. Prompt treatment before doing any clinical evaluation can be an option in couples with trouble.

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Peritoneal dissemination of prostate cancer due to laparoscopic radical prostatectomy: A case report

Yoshiki Hiyama, Hiroshi Kitamura, Satoshi Takahashi, Naoya Masumori, Tetsuya Shindo, Mitsuhiro Tsujiwaki, Tomoko Mitsuhashi, Tadashi Hasegawa, Taiji Tsukamoto

Journal of Medical Case Reports 5 355 2011 [Refereed]

Introduction. Peritoneal dissemination with no further metastases of prostate cancer is very rare, with only three cases reported in the available literature. We report the first case of iatrogenic peritoneal dissemination due to laparoscopic radical prostatectomy. Case Presentation. A 59-year-old Japanese man underwent laparoscopic radical prostatectomy for clinical T2bN0M0 prostate cancer, and the pathological diagnosis was pT3aN0 Gleason 3+4 adenocarcinoma with a negative surgical margin. Salvage radiation therapy was performed since his serum prostate-specific antigen remained at a measurable value. After the radiation, he underwent castration, followed by combined androgen blockade with estramustine phosphate and dexamethasone as each treatment was effective for only a few months to a year. Nine years after the laparoscopic radical prostatectomy, computed tomography revealed a peritoneal tumor, although no other organ metastasis had been identified until then. He died six months after the appearance of peritoneal metastasis. An autopsy demonstrated peritoneal dissemination of the prostate cancer without any other metastasis. Conclusion: Physicians should take into account metastasis to unexpected sites. Furthermore, we suggest that meticulous care be taken not to disseminate cancer cells to the peritoneum during laparoscopic radical prostatectomy. © 2011 Hiyama et al licensee BioMed Central Ltd.

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PP-352 鼠径・陰嚢部手術における手術部位感染症(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

上原央久, 高橋聡, 栗村雄一郎, 橋本次朗, 桧山佳樹, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 102 ( 2 ) 462 - 462 2011

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PP-349 泌尿器科準清潔手術において術前に除菌すべき尿細菌培養所見についての検討(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

橋本次朗, 高橋聡, 栗村雄一郎, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 102 ( 2 ) 462 - 462 2011

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Editorial comment to Prevalence of human papillomavirus infection in the urinary tract of men with urethritis.

Satoshi Takahashi

International journal of urology : official journal of the Japanese Urological Association 17 ( 6 ) 568 - 9 2010.06 [International journal]

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Decrease in incidence of surgical site infections in contemporary series of patients with radical cystectomy

Yuuki Kyoda, Satoshi Takahashi, Koh Takeyama, Naoya Masumori, Taiji Tsukamoto

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER TOKYO ) 16 ( 2 ) 118 - 122 2010.04 [Refereed]

We previously reported that the incidence of surgical site infection (SSI) after radical cystectomy was 33% between January 1996 and December 2003 at Sapporo Medical University Hospital. Base on that result, we modified perioperative management for surgical wounds after January 2004. The modifications included the method of suturing and standardization of the period for removal of closed drains and surgical dressings. This study compared the incidence of SSI between the former and latter periods, and assessed risk factors for SSI. The study consisted of 109 patients between January 1996 and December 2003 (Group A), and 104 patients between January 2004 and December 2007 (Group B), who underwent radical cystectomy and urinary diversion or reconstruction. The incidence of SSI was reduced from 32.1% in Group A to 18.2% in Group B (p = 0.027). Methicillin-resistant Staphylococcus aureus (MRSA) was isolated from SSI wounds in 40.0% of patients in Group A and 42.1% of those in Group B. Preoperative MRSA bacteriuria was the only risk factor for SSI in both groups. The incidences of SSI in patients who had such bacteriuria were 45.4% in Group A and 50.0% in Group B. Modification of perioperative management for the surgical wound was partly responsible for the reduction of the incidence of SSI. In conclusion, MRSA is still the main isolated pathogen of SSI after radical cystectomy and this clinical problem remains a challenge to urologists. Effective countermeasures are needed for MRSA bacteriuria involved in the development of SSI.

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Efficacy of treatment with carbapenems and third-generation cephalosporins for patients with febrile complicated pyelonephritis

Satoshi Takahashi, Yuichiro Kurimura, Koh Takeyama, Kohei Hashimoto, Shintaro Miyamoto, Kohji Ichihara, Manabu Igarashi, Jiro Hashimoto, Ryoji Furuya, Hiroshi Hotta, Kohsuke Uchida, Noriomi Miyao, Masahiro Yanase, Yoshio Takagi, Hitoshi Tachiki, Keisuke Taguchi, Taiji Tsukamoto

JOURNAL OF INFECTION AND CHEMOTHERAPY ( SPRINGER TOKYO ) 15 ( 6 ) 390 - 395 2009.12 [Refereed]

The purpose of this study was to clarify the clinical relevance of carbapenem and third-generation cephalosporin treatment for febrile complicated pyelonephritis, which often leads to urosepsis. Parenteral antimicrobial treatment with a carbapenem or third-generation cephalosporin was administered to febrile patients and the treatment was switched to oral antimicrobial agents after they became afebrile. In principle, the duration of the course of antimicrobial chemotherapy was limited to a total of 14 days. Clinically, the success rates were 97.3% in the carbapenem group and 96.0% in the third-generation cephalosporin group. For microbiological efficacy, the success rates were 89.2% in the carbapenem group and 92.0% in the third-generation cephalosporin group. There were no serious adverse events in the course of the study. The treatment regimen with a carbapenem or a third-generation cephalosporin was highly effective for patients with febrile complicated pyelonephritis and was well tolerated. Either of these regimens could become one of the standard treatments for patients with febrile complicated pyelonephritis.

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腹腔鏡下腎・腎尿管手術において開放移行となった症例の臨床的特徴

西田幸代, 舛森直哉, 高橋聡, 伊藤直樹, 塚本泰司

Japanese Journal of Endourology and ESWL ( (一社)日本泌尿器内視鏡学会 ) 22 ( 3 ) 223 - 223 2009.11

Is urethritis accompanied by seminal vesiculitis?

Ryoji Furuya, Satoshi Takahashi, Seiji Furuya, Nobuhito Saitoh, Hiroshi Ogura, Yuichiro Kurimura, Taiji Tsukamoto

International journal of urology : official journal of the Japanese Urological Association 16 ( 7 ) 628 - 31 2009.07 [International journal]

OBJECTIVE: To determine whether urethritis is accompanied by seminal vesiculitis using transrectal ultrasound (TRUS) imaging. METHODS: Fifty-six male patients (mean age 31.6 8.7 years) with urethritis were included in the study. As a control group,we also considered 34 healthy volunteers (mean age 21.3 1.8 years). The two groups were evaluated by the nucleic acid amplification test and imaging studies using TRUS. RESULTS: The nucleic acid amplification test could identify 15 patients (26.8%) with gonococcal urethritis (five had accompanying chlamydial urethritis), 32 (57.1%) with chlamydial urethritis, and nine (16.1%) with nongonococcal and nonchlamydial urethritis. The mean anteroposterior diameter of the bilateral seminal vesicles was significantly longer in the urethritis group than in the controls (12.9 3.3 mm vs 11.0 2.0 mm, P = 0.004). The incidence of dilatation or cystic changes of seminal vesicles was significantly higher in the urethritis group than in the controls (dilatation: 30% vs 9%, P = 0.019; cystic change: 39% vs 12%, P = 0.007). There was no significant difference in the incidence of dilatation or cystic changes of seminal vesicles between gonococcal urethritis and chlamydial urethritis. CONCLUSIONS: Patients with urethritis are likely to have accompanying seminal vesiculitis. This suggests a close interrelationship among urethritis, seminal vesiculitis and epididymitis.

DOI PubMed

Genetic profiles of fluoroquinolone-resistant Escherichia coli isolates obtained from patients with cystitis: phylogeny, virulence factors, PAIusp subtypes, and mutation patterns.

Akira Takahashi, Tetsuro Muratani, Mitsuru Yasuda, Satoshi Takahashi, Koichi Monden, Kiyohito Ishikawa, Hiroshi Kiyota, Soichi Arakawa, Tetsuro Matsumoto, Hiroki Shima, Hisao Kurazono, Shingo Yamamoto

Journal of clinical microbiology 47 ( 3 ) 791 - 5 2009.03 [International journal]

The low virulence of quinolone- and fluoroquinolone-resistant Escherichia coli strains is known, although the reasons for this remain unclear. We surveyed the mutation patterns of quinolone resistance determining regions (QRDRs), phylogenetic distribution, prevalence of 18 urovirulence genes, and PAIusp subtypes in 89 fluoroquinolone-resistant E. coli (FQREC) isolates obtained from patients with cystitis and compared them with those of their fluoroquinolone-susceptible counterparts (FQSEC). Phylogenetic group B2 was significantly less prevalent in FQREC than in FQSEC (49% versus 78%; P=0.0138), but it still dominated, followed by phylogroup D (35%), in FQREC. When the prevalences of virulence factor (VF) genes were compared between FQREC and FQSEC, sfa/foc, cnf1, hly, kpsMT, ompT, ibeA, usp, and iroN showed significantly lower prevalences in FQREC than in FQSEC (1.1% versus 24% [P<0.0001], 0% versus 29% [P<0.0001], 7.9% versus 33% [P<0.0001], 74% versus 90% [P=0.01], 71% versus 87% [P=0.017], 5.6% versus 37% [P<0.0001], 54% versus 82% [P<0.0001], and 7.9% versus 32% [P=0.0001], respectively), whereas aer, iha, and ETTT showed significantly higher prevalences in FQREC (85% versus 36% [P<0.0001], 66% versus 29% [P<0.0001], and 53% versus 16% [P<0.0001], respectively). Furthermore, a similar difference in prevalences of uropathogenic VF genes was seen between FQREC and FQSEC in phylogroup B2. This indicated that the low virulence in FQREC was intimately correlated with a lesser distribution of VFs in phylogroup B2, which dominated in FQREC and FQSEC. It was interesting that the mutation pattern of Ser83Leu and Asp87Asn encoded in gyrA and Ser80Ile and Glu84Val encoded in parC was frequently found in FQREC isolates that belonged to phylogroup B2 and that most of these isolates showed PAIusp subtype 2a. PAIusp subtypes 1a, 1b, and 2b, which were frequently seen in FQSEC, were rarely found in FQREC. These results suggested that the acquisition of fluoroquinolone resistance, e.g., mutations in QRDRs, might be a specific event in limited strains, such as those that possess PAIusp subtype 2a in phylogroup B2.

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OP-421 BCG膀胱内注入療法の副作用についての検討(膀胱腫瘍/薬物療法1,一般演題口演,第97回日本泌尿器科学会総会)

栗村雄一郎, 高橋聡, 進藤哲也, 橋本次朗, 田口圭介, 島正樹, 五十嵐学, 高橋敦, 高木良雄, 井上隆太, 国島康晴, 舛森直哉, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 100 ( 2 ) 294 - 294 2009

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Pharyngeal Neisseria gonorrhoeae detection in oral-throat wash specimens of male patients with urethritis.

Satoshi Takahashi, Yuichiro Kurimura, Jiro Hashimoto, Koh Takeyama, Mikio Koroku, Hitoshi Tanda, Masahiro Nishimura, Taiji Tsukamoto

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 14 ( 6 ) 442 - 4 2008.12 [International journal]

Detection of Neisseria gonorrhoeae and Chlamydia trachomatis in the pharynx has been highlighted in the prevention of the unexpected spread of sexually transmitted diseases. We tried to clarify the detection rate of Neisseria gonorrhoeae in the pharynx and the clinical relevance of oral-throat wash specimens to detect the organism in heterosexual men with gonococcal and nongonococcal urethritis. In our cohort of 79 male patients with urethritis, oral throat wash specimens were collected after they had gargled with normal saline for approximately 30 to 60 s. Positive pharyngeal N. gonorrhoeae was defined as a positive result on the strand displacement amplification test for the specimen from the oral-throat wash. N. gonorrhoeae was detected in the oral-throat wash specimens of 13 (31.7%) of the 41 male patients with gonococcal urethritis. Oral-throat wash with a nucleic acid amplification test can detect pharyngeal N. gonorrhoeae easily and efficiently.

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Septic pulmonary embolism caused by Candida albicans after treatment for urinary multidrug-resistant Pseudomonas aeruginosa.

Satoshi Takahashi, Teruhisa Uehara, Masaki Shima, Shogo Takasugi, Kohei Hashimoto, Naoki Itoh

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 14 ( 6 ) 436 - 8 2008.12 [International journal]

After treatment with antimicrobial chemotherapy for the elimination of urinary multidrug-resistant Pseudomonas aeruginosa (MDRP), a 48-year-old man with recurrence of bladder cancer complained of acute onset of dyspnea, and computed tomography revealed multiple nodular lesions in the lung. Candida albicans was isolated from both urinary and blood samples. He was diagnosed as having a septic pulmonary embolism caused by C. albicans. Fungal septic pulmonary embolism is a rare condition; however, we must be cautious about superinfection as a consequence of strong antimicrobial chemotherapy, and understand that the treatment for urinary MDRP is likely to be difficult.

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Clinical efficacy of azithromycin for male nongonococcal urethritis.

Satoshi Takahashi, Masanori Matsukawa, Yuichiro Kurimura, Koh Takeyama, Yasuharu Kunishima, Akihiko Iwasawa, Mikio Koroku, Hitoshi Tanda, Nobukazu Suzuki, Yoshio Takagi, Takaoki Hirose, Masahiro Nishimura, Taiji Tsukamoto

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 14 ( 6 ) 409 - 12 2008.12 [International journal]

The aim of this study was to confirm the clinical efficacy of a single-dose azithromycin (AZM) regimen (1000 mg) for patients with nongonococcal urethritis in real-life practice. The study finally evaluated 55 patients, 42 who were symptomatic and 13 who were asymptomatic, after excluding 40 who visited clinics only once. Sixteen of the symptomatic patients were diagnosed as having nongonococcal chlamydial urethritis, 7 as having nongonococcal nonchlamydial urethritis, and 19 as having urethritis without any microbial detection. Chlamydia trachomatis was detected in 11 asymptomatic patients, Mycoplasma genitalium in 1, and Ureaplasma urealyticum in 1. Of the patients who were microbiologically evaluated before and after single-dose AZM, microbiological cure was achieved in 87% (20/23) of those with symptomatic nongonococcal urethritis and in 100% (13/13) of those with asymptomatic nongonococcal urethritis. The clinical cure rate was 86% for the 42 symptomatic patients with detectable and undetectable pathogens. There were adverse events in 5 (9%) patients but they were commonly mild and self-limited. In conclusion, the single-dose AZM regimen was well tolerated and eradicated the estimated and potential pathogens of nongonococcal urethritis.

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Papers - TAKAHASHI Satoshi