Misc - KUNO Atsushi

UPR In Endoplasmic Reticulum vs. UPR In Mitochondria In Diabetic Myocardium: Which Is Responsible For Deficient Regulation Of Mitochondrial Permeability Transition Pores?

Takahito Itoh, Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Tatsuya Sato, Daisuke Sunaga, Satoko Ishikawa, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  124 ( 21 )  2011.11

Research paper, summary (international conference)  

GSK-3 beta Translocates to Mitochondria by Oxidant Stress in a Kinase Activity-Dependent Manner and Contributes to Lethal ROS Production

Masaya Tanno, Takayuki Miki, Atsushi Kuno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Satoko Ishikawa, Daisuke Sunaga, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  124 ( 21 )  2011.11

Research paper, summary (international conference)  

Treatment with a Sirt1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice

Atsushi Kuno, Yusuke Hori, Tatsuya Sato, Hidemichi Kouzu, Masaya Tanno, Takayuki Miki, Yoshiyuki Horio, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  17 ( 9 ) S149 - S149  2011.09

Research paper, summary (international conference)  

肥満2型糖尿病ラットの心臓における左室収縮および活動電位の特徴(Characteristics of Left Ventricular Contractility and Action Potential in Heart of Obese Type2 Diabetes Rats)

Sato Tatsuya, Takada Akifumi, Hotta Hiroyuki, Miki Takayuki, Tanno Masaya, Kobayashi Takeshi, Maeda Sachiko, Ichise Nobutoshi, Kuno Atsushi, Kohzu Hidemichi, Itoh Takahito, Sunaga Daisuke, Ishikawa Satoko, Miura Tetsuji, Tohse Noritsugu

Circulation Journal ( (一社)日本循環器学会 )  75 ( Suppl.I ) 3 - 3  2011.03

J-GLOBAL

Resveratrol, a SIRT1 activator, inhibits muscle fibrosis in mdx mouse

Yusuke Hori, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  115   65P - 65P  2011

Research paper, summary (international conference)  

Resveratrol ameliorates cardiomyopathy in dystrophin-deficient mice

Atsushi Kuno, Yusuke Hori, Ryusuke Hosoda, Tetsuji Miura, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  115   204P - 204P  2011

Research paper, summary (international conference)  

Dysregulation of the mitochondrial permeability transition pore by increased UPRs in the ER and mitochondria underlies loss of protection in diabetic hearts.

ITOH Takahito, KOUZU Hidemichi, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, SATO Tatsuya, SUNAGA Daisuke, ISHIKAWA Satoko, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   28th  2011

J-GLOBAL

Activation of Sirt1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.

Atsushi Kuno, Masaya Tanno, Satoko Ishikawa, Yoshiyuki Horio, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  122 ( 21 )  2010.11

Research paper, summary (international conference)  

Connexin-43 Contributes to Transmission of MitoK(ATP) Channel-Derived Redox Signal to Akt-GSK-3 beta Pathway in Cardiomyocyte Protection Afforded by G-protein Coupled Receptors

Satoko Ishikawa, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Daisuke Sunaga, Tetsuji Miura

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  122 ( 21 )  2010.11

Research paper, summary (international conference)  

Apparently Slight Ventricular Dysfunction Predisposes Obese Type 2 Diabetic Rats to High Mortality After Myocardial Infarction

Hidemichi Kouzu, Akifumi Takada, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Atsushi Kuno, Takahito Itoh, Tatsuya Satoh, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  16 ( 9 ) S169 - S169  2010.09

Research paper, summary (international conference)  

Resveratrol inhibits cell death caused by oxidative stress through SIRT1 in p53-dependent and p53-independent pathway

Yu-suke Hori, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  112   57P - 57P  2010

Research paper, summary (international conference)  

Activation of SIRT1 modifies histone acetylation/methylation and attenuates cardiomyocyte hypertrophy

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  112   200P - 200P  2010

Research paper, summary (international conference)  

The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation

Atsushi Kuno, Masaya Tanno, Toshiyuku Yano, Akifumi Takada, Satoko Ishikawa, Tetsuji Miura, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  120 ( 18 ) S617 - S617  2009.11

Research paper, summary (international conference)  

ROS-mediated Dysregulation of Mitochondrial Permeability Transition Pore Underlies Increased Susceptibility of Hypertensive Hypertrophied Hearts to Ischemia/reperfusion Injury

Toshiyuki Yano, Tetsuji Miura, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Takahito Itoh, Akifumi Takada, Tatsuya Satoh, Kazuaki Shimamoto

CIRCULATION ( LIPPINCOTT WILLIAMS & WILKINS )  120 ( 18 ) S784 - S784  2009.11

Research paper, summary (international conference)  

Activation of histone/protein deacetylase SIRT1 by resveratrol induces MnSOD up-regulation via FOXO3a and improves survival of heart failure animals

A. Kuno, M. Tanno, T. Miura, Y. Horio, K. Shimamoto

EUROPEAN HEART JOURNAL ( OXFORD UNIV PRESS )  30   421 - 421  2009.09

Research paper, summary (international conference)  

【アンチエイジング医学 基礎・臨床研究の進歩】 臨床研究の進歩 老化抑制と健康寿命延長の方法論 薬剤によるアンチエイジング 老化抑制薬

久野 篤史, 堀尾 嘉幸

日本臨床 ( (株)日本臨床社 )  67 ( 7 ) 1384 - 1388  2009.07

CiNii

Adenosine A(2b) receptors unexpectedly activate cardioprotective kinases through G(i) rather than G(s)

Atsushi Kuno, Sheree Walker, Turhan Dost, Michael V. Cohen, James M. Downey

FASEB JOURNAL ( FEDERATION AMER SOC EXP BIOL )  23  2009.04

Research paper, summary (international conference)  

DPE-012 Activation of SIRT1, a Histone/Protein Deacetylase, by Resveratrol Up-regulates MnSOD and Suppresses the Progression of Heart Failure(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Miura Tetsuji, Miki Takayuki, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( Japanese Circulation Society )  73   358 - 359  2009.03

CiNii

PE-545 Distinct Roles of FOXO Subtypes in SIRT1-mediated Mn-SOD Up-regulation under Oxidative Stress(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

Kuno Atsushi, Tanno Masaya, Miura Tetsuji, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( Japanese Circulation Society )  73   537 - 537  2009.03

CiNii

Activation of SIRT1 by resveratrol prevents progression of heart failure and improves the survival in cardiomyopathic hamsters by upregulating MnSOD

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  109   112P - 112P  2009

Research paper, summary (international conference)