Misc - MURASE Kazuyuki

Case report: Two cases of myelodysplastic syndrome associated with proderma gangrenosum

村瀬 和幸, 佐藤 勉, 瀧本 理修

内科 ( 南江堂 )  108 ( 3 ) 558 - 560  2011.09

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A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 8 ) 1405 - 1412  2011.08

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A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions.

DOI PubMed CiNii

Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer

Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 2 ) 231 - 237  2011.02

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A 75-year-old man received chemoradiotherapy (CRT) for stage IVa esophageal cancer and complete response (CR) was obtained. However, he was referred to our department for recurrence in an area of esophagus not included in the previously irradiated field. Left pleural effusion increased after admission. Tuberculous pleuritis was eventually diagnosed by thoracoscopic pleural biopsy. It is necessary to accurately diagnose the cause of pleural effusion after CRT, because treatment strategies greatly depend on it. It is also necessary to consider the possible onset of tuberculous pleuritis, in particular, in patients with a history of tuberculosis infection.

DOI PubMed CiNii

抗体薬 ゲムツズマブ オゾガマイシン (分子標的治療薬--最新の選び方・使い方) -- (がん分子標的治療薬の使い方)

佐藤 勉, 村瀬 和幸, 加藤 淳二

がん治療レクチャー ( 総合医学社 )  2 ( 2 ) 272 - 274  2011

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Treatment of liver cirrhosis with vitamin A-coupled liposomes carrying siRNA against heat shock protein 47

佐藤 康史, 村瀬 和幸, 新津 洋司郎

最新医学 ( 最新医学社 )  65 ( 12 ) 2593 - 2598  2010.12

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Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells.

Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  116 ( 21 ) 1317 - 1317  2010.11

Research paper, summary (international conference)  

Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH )  70  2010.04

Research paper, summary (international conference)  

Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH )  70  2010.04

Research paper, summary (international conference)  

DOI

Evaluation of the Efficacy of Liposomal Amphotericin B

IYAMA Satoshi, MURASE Kazuyuki, SATO Tsutomu, KIKUCHI Shohei, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Risyu, KATO Junji

Kansenshogaku Zasshi ( The Japanese Association for Infectious Diseases )  84 ( 2 ) 182 - 186  2010.03

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A retrospective study was performed to evaluate the efficacy and safety of liposomal amphotericin B (L-AMB) in a total of 32 cases who were among patients hospitalized at the Fourth Department of Internal Medicine, Sapooro Medical University from December 2006 to April 2008. Primary diagnoses were hematologic diseases in 87.5％of subjects. The most common hematologic diseases included acute myelogenous leukemia in 50％of the subjects, followed by malignant lymphoma in 12.5％of the subjects. The mean administration period was 14.2±12.9 days, and the mean cumulative dose was 1,786±2,181 mg. L-AMB improved 21 of 29 cases (72.4％) with some fungal infections or fever-associated neutropenia. Adverse events occurred in 9 cases to a slight degree, in 7 cases to a moderate degree, and in no case to a severe degree. Hypokalemia and hypercreatininemia were seen in 7 cases (21.9％) and 4 cases (12.5％), respectively, but these adverse reactions were so mild that the treatment did not need to be discontinued. Any adverse reactions for which treatment administration was discontinued were confirmed to have disappeared at the end of the study. These results support the efficacy and safety of L-AMB in accordance with previous foreign reports. It was noteworthy that early use of L-AMB prior to established diagnosis sometimes better therapeutic outcomes. It was also suggested that L-AMB could be safely administered while controlling electrolyte balance, such as serum potassium concentration, with sufficient fluid replacement, including physiological saline infusion. There are limitations in the use of the conventional form of amphotericin B because of its renal toxicity and other reasons. However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection.

DOI CiNii

Treatment of liver fibrosis with vitamin A coupled liposomes carrying HSP47siRNA

Naoko Birukawa, Kazuyuki Murase, Yasushi Sato, Akemi Kosaka, Akihiro Yoneda, Hiroki Nishita, Naoko Kitamura, Yasunobu Tanaka, Hirokazu Takahashi, Keiko Kajiwara, Junji Kato, Yoshiro Niitsu

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  112   27P - 27P  2010

Research paper, summary (international conference)  

Cyclopamine Induced Apoptosis in Primary CD34+Acute Leukemic Cells.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Yasushi Sato, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 1450 - 1450  2009.11

Research paper, summary (international conference)  

CD34+Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 584 - 584  2009.11

Research paper, summary (international conference)  

ACTIVATED HEPATIC STELLATE CELLS, BUT NOT QUIESCENT HEPATIC STELLATE CELLS SUSTAIN THEIR SURVIVAL BY PI3K/AKT/NFKB SIGNAL FROM COLLAGEN SECRETED BY THEMSELVES

Naoko K. Birukawa, Kazuyuki Murase, Yasushi Sato, Hiroki Nishita, Akihiro Yoneda, Akemi Kosaka, Naoko Kitamura, Junji Kato, Yoshiro Niitsu

HEPATOLOGY ( JOHN WILEY & SONS INC )  50 ( 4 ) 835A - 835A  2009.10

Research paper, summary (international conference)  

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+Leukemic Cells

Masayoshi Kobune, Kazuyuki Murase, Satoshi Lyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 570 - 570  2008.11

Research paper, summary (international conference)  

Wnt3 Signaling Augments integrin beta 1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 599 - 600  2008.11

Research paper, summary (international conference)  

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Writ Signaling.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 810 - 810  2008.11

Research paper, summary (international conference)  

北海道における中枢神経原発悪性リンパ腫の現状

畠山 直樹, 鈴木 信寛, 政氏 伸夫, 橋野 聡, 藤本 勝也, 村瀬 和幸, 奈良崎 亘, 照井 健, 黒田 裕行, 小林 一, 泉山 康, 木田 雅也, 進藤 基博, 佐藤 一也, 黒澤 光俊, 鈴木 佐知子, 笠井 正晴, 福原 敬

臨床血液 ( (一社)日本血液学会-東京事務局 )  49 ( 9 ) 972 - 972  2008.09

Treatment of idiopathic myelofibrosis employing siRNA for heat shock protein 47 (siRNA/HSP47) encapsulated in liposomes

Junichi Watanabe, Takuya Matsunaga, Kazuyuki Murase, Yasushi Sato, Taiko Nagaya, Hirotoshi Ishiwatari, Sho Takahashi, Koichi Takada, Masayoshi Kobune, Kazuya Shimoda, Mine Harada, Yoshiro Niitsu

BLOOD ( AMER SOC HEMATOLOGY )  110 ( 11 ) 235B - 235B  2007.11

Research paper, summary (international conference)  

Factor XI deficiency caused by a mutation of Gly400Val

SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology   48 ( 2 ) 148 - 150  2007.02

DOI CiNii

Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  48 ( 1 ) 56 - 60  2007.01

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A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin α4β7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin α4β7.

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