Misc - MURASE Kazuyuki

Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology )  104 ( 9 ) 1365 - 1370  2007

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Amyotrophic lateral sclerosis (ALS) is a degenerative disease involving both upper and lower motor neurons and the pathogenesis of this disorder is still unknown. To date, few reports have suggested that motor neuron diseases may have a paraneoplastic origin. However, it is still under discussion whether ALS occurring in cancer patients is paraneoplastic. A 60-year-old man with rectal cancer (Stage IV) having multiple lung, liver and para-aortic lymph node metastases underwent anterior resection of the rectum as palliative surgery. He was referred to our hospital for adjuvant chemotherapy. Lung and lymph node metastases decreased after 2 courses of chemotherapy using CPT-11 and 5-FU/LV but liver metastases were enlarged, following up increase in CEA. Thereafter, he suffered from muscle weakness in hands, arms, and legs and results of neurophysiologic studies were compatible with primary lateral sclerosis (ALS). For second line chemotherapy, he was treated with low-dose CDDP/5-FU over 6 courses. As a result, the size the of metastatic lesions markedly reduced and CEA was decreased to the normal level. Although significant tumor reduction was observed, his neurological symptoms rapidly progressed. He died of aspiration pneumonia 8 months after onset of the disease. Autopsy revealed that his neuropathological findings were compatible with ALS, and it was thought to be the primary cause of death in the because of absence of cancer progression. In this case the neurological syndrome was not affected by cancer therapy. Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain.

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Treatment of hepatic fibrosis in rat treated with dimethylnitrosamine by siRNA/HSP47 encapsulated in vitamin A conjugated liposome

Yasushi Sato, Junji Kato, Kazuyuki Murase, Masayoshi Kobune, Tsutomu Sato, Rishu Takimoto, Takuya Matsunaga, Tetsuji Takayama, Yoshiro Niitsu

JOURNAL OF GENE MEDICINE ( JOHN WILEY & SONS LTD )  8 ( 12 ) 1455 - 1455  2006.12

Research paper, summary (international conference)  

Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  47 ( 11 ) 1457 - 1462  2006.11

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A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

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Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  47 ( 7 ) 645 - 649  2006.07

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Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  47 ( 7 ) 645 - 649  2006

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A 54-year-old male presented at a previous hospital with abdominal pain, where the patient was diagnosed as having abdominal and retroperitoneal lymphadenopathies by CT scan, then, he was referred to our hospital for further examination. Upper gastrointestinal endoscopy showed a tumor formation in the second portion of the duodenum, and there were medium sized atypical lymphocytes in biopsy specimens of the tumor. Since the atypical lymphocytes in the biopsy specimens were positive for CD3, CD8, CD56 and CD103 by immunostain, and had a rearrangement of the T-cell receptor γ-chain, the patient was diagnosed as having enteropathy-type T-cell lymphoma (ETL). Although ETL usually occurs as a complication of celiac disease, malabsorption and anti-gliadin antibodies, which are normally present in celiac disease, were not observed in this patient.

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Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  46 ( 5 ) 363 - 367  2005.05

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A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

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Phenotypic transdifferentiation of human mesenchymal stem cells into human hepatocytes directly injected to the rat liver without evidence of fusion.

Y Sato, H Araki, J Kato, K Murase, K Miyanishi, T Sato, T Takayama, Y Niitsu

GASTROENTEROLOGY ( W B SAUNDERS CO )  128 ( 4 ) A702 - A702  2005.04

Research paper, summary (international conference)  

11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

村瀬 和幸, 松永 卓也, 栗林 景晶, 井山 諭, 菊池 尚平, 藤見 章仁, 新津 洋司郎, 古川 勝久

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 )  24 ( 1 ) 121 - 121  2005.02

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Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  45 ( 9 ) 1028 - 1032  2004.09

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当科で経験した非血縁者間ミニ移植を施行した4症例(一般演題)(日本アフェレシス学会第23回北海道地方会抄録)

藤見 章仁, 松永 卓也, 村瀬 和幸, 竹内 直子, 高平 尚季, 二階堂 ともみ, 瀧本 理修, 新津 洋司郎

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 )  23 ( 2 ) 202 - 202  2004.05

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Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)

MURASE Kazuyuki, MATSUNAGA Takuya, TAKIMOTO Rishu, TAKAHIRA Naoki, FUJIMI Akihito, TAKEUCHI Naoko, TERUI Takeshi, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  45 ( 5 ) 383 - 386  2004.05

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A 31-year-old pregnant woman was referred to our hospital due to anemia and thrombocytopenia, and was diagnosed as having myelodysplastic syndrome (refractory anemia) with autoimmune thrombocytopenia. Administration of high dose methylprednisolone and γ-globulin did not raise her platelet count, and she subsequently delivered a healthy baby after the transfusion of a large amount of platelets. Although the anemia spontaneously improved after delivery, the platelet count remained unchanged. Prednisolone was thus administered a second time, which did finally increase the platelet count. This is the first reported case of a pregnant woman with myelodysplastic syndrome in whom corticosteroid administration was effective for thrombocytopenia.

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Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  45 ( 9 ) 1028 - 1032  2004

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A seventy-six year old female patient with chronic myelogenous leukemia (CML), (chronic phase), was treated with imatinib and obtained a major cytogenetic response after 6 months of treatment. However, resistance to imatinib appeared 9 months later due to an ABL gene point mutation, and the patient's platelet count and BCR/ABL positive rate had remarkably increased. We discontinued imatinib and used IFNα or hydroxyurea, resulting in the disappearance of the ABL gene mutation clone. After that, we obtained a secondary hematologic response with the administration of imatinib.

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A case of catheter tip dislocation to the duodenal bulb for hepatic arterial infusion chemotherapy

TAKANASHI Kunihiro, TAKAYANAGI Norihiro, NISHIHORI Yoshiki, FUJII Shigeyuki, HORIMOTO Masayoshi, ONODERA Yoshimitsu, MURASE Kazuyuki, KOGAWA Takahiro, NAGAOKA Yasuhiro, NIITSU Yoshiro

日本消化器病學會雜誌 = The Japanese journal of gastro-enterology   100 ( 5 ) 578 - 582  2003.05

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A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

Acta Hepatologica Japonica ( Japan Society of Hepatology )  44 ( 12 ) 649 - 655  2003

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A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate

DOI Tadashi, HOMMA Hisato, MEZAWA Shinichi, KIDA Masaya, KUKITSU Takehiro, MIYANISHI Kouji, MURASE Kazuyuki, TAKADA Kouichi, IYAMA Satoshi, NIITSU Youshirou

Nippon Shokakibyo Gakkai Zasshi ( The Japanese Society of Gastroenterology )  98 ( 11 ) 1304 - 1308  2001.11

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症例はアルコール性慢性膵炎を指摘されている66歳の男性．慢性膵炎の急性増悪の経過中に形成された膵仮性嚢胞の破綻による膵性腹水を発症した．経皮的腹腔ドレナージ，絶食，メシル酸ナファモスタットの経静脈投与などの保存的治療を行ったが内膵液痩が持続し，膵炎の遷延も認められたことからメシル酸ナファモスタットの持続動注療法を施行したところ膵性腹水は消失した．メシル酸ナファモスタット持続動注による膵炎の鎮静化によって内膵液痩の修復が促進されたものと考えられた．

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