Papers - MIHARA Hiroshi

A Review of Potential Role of Capsule Endoscopy in the Work-Up for Chemotherapy-Induced Diarrhea.

Takayuki Ando, Miho Sakumura, Hiroshi Mihara, Haruka Fujinami, Ichiro Yasuda

Healthcare (Basel, Switzerland)   10 ( 2 )  2022.01  [International journal]

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Chemotherapy-induced diarrhea (CID) is a common, severe side effect of chemotherapy, immunotherapy, and targeted therapy. Because patients are more prone to continuing chemotherapy if they do not suffer from CID, appropriate diagnosis and monitoring of this disease are essential. However, suitable monitoring methods are yet to be developed. To date, several studies have shown that small-bowel capsule endoscopy (SBCE) is useful in visualizing the entire small intestinal mucosa and detecting small intestinal abnormalities, including bleeding, malignant tumors, and mucosal injury, associated with the use of nonsteroidal anti-inflammatory drugs and low-dose aspirin. Currently, limited studies have evaluated the small intestinal mucosa using SBCE in patients receiving fluoropyrimidine-based chemotherapy or immune checkpoint inhibitors. These studies have reported that small intestinal mucosal injury is common in patients with severe fluoropyrimidine-induced diarrhea. SBCE might be a useful screening method for the early detection of enterocolitis induced by immune checkpoint inhibitors. SBCE may be a powerful tool for the diagnosis and monitoring of CID, and understanding its indication, contraindication, and capsule-retention risk for each patient is important for clinicians.

DOI PubMed

Intensive surveillance endoscopy for multiple gastrointestinal tumors in a patient with constitutional mismatch repair deficiency: case report

Takayuki Ando, Takahiko Nakajima, Rei Fukuda, Keiko Nomura, Yo Niida, Miho Sakumura, Iori Motoo, Hiroshi Mihara, Sohachi Nanjo, Shinya Kajiura, Haruka Fujinami, Shojo Hojo, Tsutomu Fujii, Ichiro Yasuda

BMC Gastroenterology ( Springer Science and Business Media LLC )  21 ( 1 ) 326 - 326  2021.12  [International journal]

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Constitutional mismatch repair deficiency (CMMRD) is an extremely rare autosomal recessive hereditary disease characterized by the absence of mismatch repair gene activity from birth, which results in brain tumors, colonic polyposis, gastrointestinal cancers, and lymphomas later in life. An aggressive approach, including colectomy or proctocolectomy, is recommended for the treatment of colorectal cancer. Additionally, partial colectomy with subsequent endoscopic surveillance may be an alternative strategy due to poor patient’s condition, although there is no evidence of surveillance endoscopy after partial colectomy for CMMRD. A 13-year-old male patient with a history of T-lymphoblastic lymphoma underwent total gastrointestinal endoscopy, which revealed rectal cancer, colorectal polyposis, and duodenal adenoma. Differential diagnosis included constitutional mismatch repair deficiency according to its scoring system and microsatellite instability, and subsequent germline mutation testing for mismatch repair genes confirmed the diagnosis of constitutional mismatch repair deficiency based on a homozygous mutation in mutS homolog 6 (MSH6). The patient and his family refused colectomy due to the high risk of malignancies other than colorectal cancer, which could require radical surgery. Therefore, the patient underwent low anterior resection of the rectosigmoid colon for rectal cancer and intensive surveillance endoscopy for the remaining colon polyposis. During the 3-year period after initial surgery, 130 polyps were removed and the number of polyps gradually decreased during 6-months interval surveillance endoscopies, although only one polyp was diagnosed as invasive adenocarcinoma (pT1). Our experience of short surveillance endoscopy illustrates that this strategy might be one of options according to patient’s condition.

DOI PubMed

瘻孔近傍のボーリング生検で診断し得た疣状食道癌(verrucous carcinoma)の一例

田畑 和久, 元尾 伊織, 作村 美穂, 三原 弘, 安藤 孝将, 荻野 万里, 寺本 彰, 南條 宗八, 藤浪 斗, 梶浦 新也, 安田 一朗

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  37 ( 2 ) 154 - 154  2021.12

「ESD手技の工夫・こだわり」 けん引クリップを用いた胃ESDの工夫

高橋 冴子, 藤浪 斗, 作村 美穂, 寺本 彰, 元尾 伊織, 南條 宗八, 三原 弘, 梶浦 新也, 安藤 孝将, 安田 一朗

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  37 ( 2 ) 161 - 161  2021.12

当院で施行した内視鏡的異物除去術の臨床的検討

荻野 万里, 藤浪 斗, 寺本 彰, 高橋 冴子, 南條 宗八, 田畑 和久, 作村 美穂, 元尾 伊織, 三原 弘, 安藤 孝将, 梶浦 新也, 安田 一朗

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  37 ( 2 ) 153 - 153  2021.12

【胆道狭窄の診断と治療】各論(治療) 術後良性胆管空腸吻合部狭窄に対する内視鏡治療

井上 祐真, 安田 一朗, 松野 潤, 花岡 辰行, 中村 佳史, 林 伸彦, 元尾 伊織, 南條 宗八, 三原 弘, 梶浦 新也, 安藤 孝将, 藤浪 斗, 田尻 和人

肝胆膵 ( (株)アークメディア )  83 ( 5 ) 797 - 805  2021.11

Bilateral Serous Retinal Detachment Associated with a Mitogen-activated Protein KinaseKinase Inhibitor in a Patient with BRAF-mutant Colorectal Cancer.

Miho Sakumura, Takayuki Ando, Tomoko Ueda-Consolvo, Iori Motoo, Hiroshi Mihara, Shinya Kajiura, Akira Teramoto, Sohachi Nanjo, Haruka Fujinami, Ichiro Yasuda

Internal medicine (Tokyo, Japan)   61 ( 11 ) 1707 - 1712  2021.10  [Domestic journal]

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We herein report a 73-year-old woman with BRAF V600E-mutated colon cancer treated with encorafenib plus cetuximab with binimetinib as standard salvage therapy for patients with advanced colorectal cancer. She developed bilateral serous retinal detachment the next day, and the regimen was discontinued, resulting in complete resolution by the third day. Doublet therapy without binimetinib was initiated along with a weekly ophthalmologic examination for 10 weeks without recurrence of retinal detachment. Thus, binimetinib was presumed to have been the cause of the retinal detachment. This clinical course suggests the need for close monitoring of patients for vision impairment and close collaboration with ophthalmologists.

DOI PubMed

Google Cloud Platform機械学習で構築したAIモデルでの食道炎分類精度の検討

三原 弘, 倉石 俊, 小川 健二, 清水 沙也香, 平木 将矢, 南條 宗八, 安藤 孝将, 梶浦 新也, 藤浪 斗, 安田 一朗

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  63 ( Suppl.2 ) 2014 - 2014  2021.10

MEK阻害薬により両側性漿液性網膜剥離を生じたBRAF V600E変異陽性進行大腸癌の一例

伊藤 顕太郎, 作村 美穂, 安藤 孝将, 元尾 伊織, 寺本 彰, 三原 弘, 南條 宗八, 藤浪 斗, 梶浦 新也, 安田 一朗

日本消化器病学会北陸支部例会プログラム・抄録集 ( 日本消化器病学会-北陸支部 )  132回   41 - 41  2021.10

ニボルマブ療法を受けた進行食道癌患者における免疫関連有害事象の特徴と治療成績に及ぼす影響

作村 美穂, 安藤 孝将, 中田 直克, 元尾 伊織, 梶浦 新也, 渕野 真代, 南條 宗八, 三原 弘, 藤浪 斗, 小川 浩平, 塚田 健一郎, 中島 孝治, 細川 歩, 安田 一朗

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  118 ( 臨増大会 ) A738 - A738  2021.10

DICを合併する進行胃癌に対する一次治療としてのFOLFOX療法の有効性と安全性

高橋 直希, 安藤 孝将, 元尾 伊織, 作村 美穂, 梶浦 新也, 中島 孝治, 細川 歩, 植田 亮, 鈴木 庸弘, 渕野 真代, 三原 弘, 南條 宗八, 藤浪 斗, 安田 一朗

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  118 ( 臨増大会 ) A719 - A719  2021.10

潰瘍性大腸炎における血清ロイシンリッチα2グリコプロテイン測定の有用性の検討

南條 宗八, 渕野 真代, 高橋 冴子, 三原 弘, 渡辺 かすみ, 高橋 直希, 花岡 辰行, 植田 優子, 作村 美穂, 高橋 孝輔, 荒木 康宏, 元尾 伊織, 梶浦 新也, 安藤 孝将, 藤浪 斗, 田尻 和人, 安田 一朗

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  118 ( 臨増大会 ) A762 - A762  2021.10

高度な食道狭窄を呈したバレット食道の一例

渡邊 かすみ, 南條 宗八, 渕野 真代, 藤浪 斗, 高橋 直希, 高橋 冴子, 植田 優子, 作村 美穂, 元尾 伊織, 三原 弘, 梶浦 新也, 安藤 孝将, 安田 一朗

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  37 ( 1 ) 49 - 49  2021.07

HIV感染に合併したHPV関連肛門管癌の一例

鍵谷 聡一郎, 元尾 伊織, 安藤 孝将, 三原 弘, 作村 美穂, 南條 宗八, 藤浪 斗, 梶浦 新也, 安田 一朗

日本消化器病学会北陸支部例会プログラム・抄録集 ( 日本消化器病学会-北陸支部 )  131回   39 - 39  2021.06

【緊急内視鏡の今】胆膵領域の緊急内視鏡 急性胆嚢炎

安田 一朗, 花岡 辰行, 高橋 孝輔, 荒木 康宏, 元尾 伊織, 南條 宗八, 三原 弘, 梶浦 新也, 安藤 孝将, 藤浪 斗, 田尻 和人, 土井 晋平

消化器内視鏡 ( (株)東京医学社 )  33 ( 4 ) 762 - 768  2021.04

【緊急内視鏡の今】胆膵領域の緊急内視鏡 急性胆嚢炎

安田 一朗, 花岡 辰行, 高橋 孝輔, 荒木 康宏, 元尾 伊織, 南條 宗八, 三原 弘, 梶浦 新也, 安藤 孝将, 藤浪 斗, 田尻 和人, 土井 晋平

消化器内視鏡 ( (株)東京医学社 )  33 ( 4 ) 762 - 768  2021.04

Endoscopic Ultrasound-guided Fine Needle Aspiration for the Diagnosis of Duodenal Stenosis Due to Urothelial Carcinoma.

Iori Motoo, Takayuki Ando, Hiroshi Mihara, Shinichi Tanaka, Sohachi Nanjo, Shinya Kajiura, Haruka Fujinami, Kosuke Takahashi, Ichiro Yasuda

Internal medicine (Tokyo, Japan)   60 ( 5 ) 719 - 724  2021.03  [Domestic journal]

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Upper tract urothelial carcinoma (UTUC) initially presents with hematuria and hydronephrosis. We report a case of UTUC presenting with initial findings of duodenal stenosis before the appearance of hydronephrosis. A 59-year-old man presented with upper abdominal symptoms on his initial visit. Esophagogastroduodenoscopy (EGD) revealed circumferential stenosis at the descending part of the duodenum. However, the underlying cause of duodenal stenosis was unknown as repeated histopathological examinations of endoscopic biopsy specimens showed no specific findings. We then performed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of the thickened duodenal wall, and successfully diagnosed duodenal metastasis of UTUC. EUS-FNA is an effective diagnostic method in cases in which the cause of duodenal stenosis is unknown.

DOI PubMed

【胆道ドレナージを極める】経乳頭的アプローチ 悪性遠位胆管狭窄に対する経乳頭的ドレナージ

安田 一朗, 花岡 辰行, 高橋 孝輔, 荒木 康宏, 元尾 伊織, 南條 宗八, 三原 弘, 梶浦 新也, 安藤 孝将, 藤浪 斗, 田尻 和人

消化器内視鏡 ( (株)東京医学社 )  33 ( 3 ) 488 - 495  2021.03

合併するアレルギー性疾患に対して抗IgE抗体オマリズマブを併用した好酸球性胃腸炎4例の検討

渡辺 かすみ, 渕野 真代, 三原 弘, 作村 美穂, 元尾 伊織, 南條 宗八, 安藤 孝将, 梶浦 新也, 藤浪 斗, 安田 一朗

日本消化管学会雑誌 ( (一社)日本消化管学会 )  5 ( Suppl. ) 309 - 309  2021.01

機能性消化管疾患の病態と治療 機能性消化管疾患のUp-to-date-病態から治療法まで- 肥満細胞トリプターゼは十二指腸(小腸)上皮のTRPV4機能を増強させることで上皮の透過性亢進を誘発しうる

三原 弘, 渕野 真代, 南條 宗八, 藤浪 斗, 安藤 孝将, 梶浦 新也, 安田 一朗

日本消化管学会雑誌 ( (一社)日本消化管学会 )  5 ( Suppl. ) 154 - 154  2021.01