Papers - MIHARA Hiroshi

高齢者の転移性・再発大腸癌患者におけるBevacizumab併用化学療法の有効性と安全性の検討

西野 貴晶, 梶浦 新也, 作村 美穂, 高木 宏明, 吉田 啓紀, 南條 宗八, 三原 弘, 安藤 孝将, 藤浪 斗, 杉山 敏郎

日本老年医学会雑誌 ( (一社)日本老年医学会 )  55 ( 4 ) 707 - 707  2018.10

実診療におけるナルデメジンの処方状況と効果について

二日市 有花, 梶浦 新也, 橋本 伊佐也, 猪又 峰彦, 島 友子, 堀川 英世, 藤浪 斗, 安藤 孝将, 三原 弘, 南條 宗八, 吉田 啓紀, 高木 宏明, 高嶋 祐介, 西野 貴明, 島田 清太郎, 作村 美穂, 高木 昭佳, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  115 ( 臨増大会 ) A790 - A790  2018.10

クローン病におけるインフリキシマブ・バイオシミラーの有効性、安全性の検討

高嶋 祐介, 南條 宗八, 三原 弘, 二日市 有花, 島田 清太郎, 作村 美穂, 西野 貴晶, 小林 才人, 明石 桃子, 高木 宏明, 吉田 啓紀, 安藤 孝将, 梶浦 新也, 藤浪 斗, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  115 ( 臨増大会 ) A767 - A767  2018.10

BBP不応切除不能大腸癌におけるFOLFIRI plus ramucirumab or afribercept療法の有効性

吉田 啓紀, 安藤 孝将, 島田 清太郎, 作村 美穂, 高嶋 祐介, 南條 宗八, 三原 弘, 梶浦 新也, 藤浪 斗, 小林 由夏, 安田 一朗, 杉山 敏郎

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  56回   P19 - 1  2018.10

Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum.

Mami Tokunaga, Sohachi Nanjo, Hiroki Yoshita, Haruka Fujinami, Tohru Watanabe, Yoko Ishii, Saito Kobayashi, Momoko Akashi, Hiroaki Takagi, Hiroshi Mihara, Shinya Kajiura, Takayuki Ando, Isaya Hashimoto, Shozo Hojo, Tomoyuki Okumura, Toshiro Sugiyama

Internal medicine (Tokyo, Japan)   57 ( 12 ) 1719 - 1723  2018.06  [Refereed]  [Domestic journal]

　View Summary

A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.

DOI PubMed

当科におけるクローン病に対するブデソニドの使用経験

長田 巧平, 三原 弘, 高木 宏明, 吉田 啓紀, 南條 宗八, 梶浦 新也, 安藤 孝将, 藤浪 斗, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  115 ( 臨増総会 ) A333 - A333  2018.03

Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.

Mihara H, Uchida K, Koizumi S, Moriyama Y

PloS one   13 ( 10 ) e0206276  2018  [Refereed]  [International journal]

　View Summary

Adenosine triphosphate (ATP) modulates mechanosensitive vagal afferent nerves in the gastrointestinal tract. ATP is stored in secretory vesicles via the ATP transporter VNUT. Recently, the bisphosphate clodronate was reported to inhibit VNUT and was suggested to be a safe potent therapeutic option for chronic pain. Transient receptor potential vanilloid 4 (TRPV4) is activated by mechanical stimuli and some epoxyeicosatrienoic acids and becomes sensitized under inflammatory conditions. We have previously reported that TRPV4 and VNUT are expressed in mouse esophageal keratinocytes and that TRPV4 activation induces ATP release in gastric epithelial cells. Here we show the expression of TRPV4 and VNUT in normal human gastrointestinal cell derived cell lines (GES-1 and CCD 841) and in tissues from normal and VNUT-KO mice. TRPV4 agonists (GSK101 or 8,9-EET) induced an increase in cytosolic Ca2+ and/or current responses in mouse primary colonic epithelial cells and CCD 841 cells, but not in cells isolated from TRPV4-KO mice. TRPV4 agonists (GSK101 or 5.6-EET) also induced ATP release in GES-1 and CCD 841 cells, which could be blocked by the VNUT inhibitor, clodronate. Thus, VNUT inhibition with clodronate could represent a novel therapeutic option for visceral pain.

DOI PubMed

Neuroendocrine carcinoma of the stomach: A response to combination chemotherapy consisting of ramucirumab plus paclitaxel

Yuki Matsubara, Takayuki Ando, Ayumu Hosokawa, Hiroshi Mihara, Hiroaki Takagi, Naokatsu Nakata, Hiroki Yoshita, Sohachi Nanjo, Shinya Kajiura, Haruka Fujinami, Toshiro Sugiyama

Internal Medicine ( Japanese Society of Internal Medicine )  57 ( 5 ) 671 - 675  2018  [Refereed]  [Domestic journal]

　View Summary

Extrapulmonary neuroendocrine carcinoma (NEC) is a rare disease, and there is no standard chemotherapy. A 73-year-old man was diagnosed with advanced gastric NEC. He received chemotherapy of irinotecan plus cisplatin, and amrubicin monotherapy. After failure of second-line chemotherapy, he received ramucirumab plus paclitaxel this treatment was chosen because vascular endothelial growth factor 2 was strongly expressed in the tumor endothelial cells. After two cycles, his NEC had markedly reduced in size, and he continued with this treatment for over eight months. In this case, the combination of an anti-angiogenic inhibitor and a cytotoxic agent was highly effective for gastric NEC.

DOI PubMed

EUS-FNAによる診断後、集学的治療により良好な経過を得ている悪性腹膜中皮腫の一例

横田 朋学, 安藤 孝将, 細川 歩, 三原 弘, 橋本 伊佐也, 北条 荘三, 吉田 啓紀, 南條 宗八, 梶浦 新也, 藤浪 斗, 杉山 敏郎

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  33 ( 2 ) 147 - 147  2017.11

若年者の切除不能進行・再発胃癌に対する化学療法の治療成績

高木 宏明, 安藤 孝将, 細川 歩, 吉田 啓紀, 南條 宗八, 三原 弘, 梶浦 新也, 藤浪 斗, 杉山 敏郎

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  55回   P85 - 6  2017.10

Phase I/II Study of S-1 Plus Cisplatin Alternating With S-1 Plus Docetaxel in Patients With Advanced Gastric Cancer.

Hosokawa A, Ando T, Ogawa K, Ueda A, Yoshita H, Mihara H, Fujinami H, Kajiura S, Yabushita K, Horikawa N, Kobayashi Y, Yoshioka A, Origasa H, Sugiyama T

American journal of clinical oncology ( Ovid Technologies (Wolters Kluwer Health) )  41 ( 10 ) 977 - 981  2017.09  [Refereed]

DOI PubMed

当科におけるクローン病消化管癌合併例の検討

渕野 真代, 三原 弘, 南條 宗八, 藤浪 斗, 明石 桃子, 高木 宏明, 吉田 啓紀, 梶浦 新也, 安藤 孝将, 細川 歩, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  114 ( 臨増大会 ) A791 - A791  2017.09

Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium

Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama

HELICOBACTER ( WILEY )  22 ( 2 )  2017.04  [Refereed]

　View Summary

BackgroundHelicobacter pylori (HP) infection induces methylation silencing of specific genes in gastric epithelium. Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release. As CpG islands in TRPV4 are methylated in HP-infected gastric epithelium, we evaluated HP infection-dependent changes in TRPV4 expression in gastric epithelium. Materials and MethodsHuman gastric biopsy samples, a human gastric cancer cell line (AGS), and a normal gastric epithelial cell line (GES-1) were used to detect TRPV4 mRNA and protein expression by RT-PCR and Western blotting, respectively. Ca2+ imaging was used to evaluate TRPV4 ion channel activity. TRPV4 methylation status was assessed by methylation-specific PCR (MSP). ATP release was measured by a luciferin-luciferase assay. ResultsTRPV4 mRNA and protein were detected in human gastric biopsy samples and in GES-1 cells. MSP and demethylation assays showed TRPV4 methylation silencing in AGS cells. HP coculture directly induced methylation silencing of TRPV4 in GES-1 cells. In human samples, HP infection was associated with TRPV4 methylation silencing that recovered after HP eradication in a time-dependent manner. ConclusionHP infection-dependent DNA methylation suppressed TRPV4 expression in human gastric epithelia, suggesting that TRPV4 methylation may be involved in HP-associated dyspepsia.

DOI PubMed

膵内分泌細胞腫瘍に対する超音波内視鏡下穿刺吸引法の安全性と有用性の検討

高木 宏明, 梶浦 新也, 細川 歩, 中田 直克, 吉田 啓紀, 南條 宗八, 河合 健吾, 三原 弘, 安藤 孝将, 田尻 和人, 藤浪 斗, 峯村 正実, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  114 ( 臨増総会 ) A347 - A347  2017.03

クローン病における免疫調節薬中止後の再燃リスク因子の検討

明石 桃子, 南條 宗八, 三原 弘, 松原 裕樹, 渕野 真代, 北林 誠, 高木 宏明, 中田 直克, 吉田 啓紀, 安藤 孝将, 藤浪 斗, 梶浦 新也, 細川 歩, 杉山 敏郎

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  114 ( 臨増総会 ) A335 - A335  2017.03

超音波内視鏡下穿刺吸引法で診断された膵神経内分泌腫瘍の5例

高木 宏明, 梶浦 新也, 細川 歩, 中田 直克, 吉田 啓紀, 南條 宗八, 河合 健吾, 三原 弘, 安藤 孝将, 田尻 和人, 藤浪 斗, 峯村 正実, 杉山 敏郎

ENDOSCOPIC FORUM for digestive disease ( (株)癌と化学療法社 )  32 ( 2 ) 157 - 157  2016.11

胃 腹膜播種 腹水を有する進行胃癌に対するサルベージ治療としてのIrinotecan療法の有効性

安藤 孝将, 細川 歩, 植田 亮, 北林 誠, 高木 宏明, 吉田 啓紀, 中田 直克, 南條 宗八, 三原 弘, 藤浪 斗, 梶浦 新也, 小川 浩平, 杉山 敏郎

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  54回   WS56 - 3  2016.10

Cisplatin投与困難な進行胃癌症例に対するS-1+Oxaliplatin療法の治療成績

島田 清太郎, 安藤 孝将, 細川 歩, 高木 宏明, 高取 俊介, 中田 直克, 吉田 啓紀, 三原 弘, 梶浦 新也, 三浦 慶昭, 藤浪 斗, 杉山 敏郎

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  54回   P32 - 6  2016.10

TAS102療法中に発症した血球貪食症候群の1例

二日市 有花, 梶浦 新也, 細川 歩, 元尾 伊織, 中田 直克, 吉田 啓紀, 在田 幸太郎, 和田 暁法, 南條 宗八, 三原 弘, 安藤 孝将, 藤浪 斗, 村上 純, 杉山 敏郎

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  54回   P74 - 3  2016.10

A case of advanced gastric cancer with severe jaundice from multiple liver metastases that was significantly improved after capecitabine plus oxaliplatin treatment

Hiroaki Takagi, Takayuki Ando, Ayumu Hosokawa, Takaaki Nishino, Hiroshi Mihara, Hiroki Yoshita, Naokatsu Nakada, Sohachi Nanjo, Yoshiaki Miura, Shinya Kajiura, Haruka Fujinami, Toshiro Sugiyama

Japanese Journal of Cancer and Chemotherapy ( Japanese Journal of Cancer and Chemotherapy Publishers Inc. )  43 ( 9 ) 1117 - 1119  2016.09  [Refereed]

　View Summary

A 74-year-old man with advanced gastric cancer was admitted to our hospital. His liver function was impaired (total bilirubin 1.6 mg/dL) with multiple liver metastases. He was treated with chemotherapy of S-1 plus cisplatin but it was discontinued due to severe diarrhea (CTCAE Grade 3) on day 6 and his liver dysfunction progressed (total bilirubin 10.3 mg/dL). After his diarrhea improved, he was treated with capecitabine plus oxaliplatin (capecitabine 3,600 mg/day on day 1-14, oxaliplatin 130 mg/m2 on day 1, q3 weeks). His severe jaundice and general condition improved without severe non-hematological toxicity, and he was ultimately discharged. He achieved a partial response (RECIST vl.1) after capecitabine plus oxaliplatin treatment, and this therapy has been continued for 15 months. This case suggests that capecitabine plus oxaliplatin may be beneficial even in advanced gastric cancer patients with impaired liver function from multiple liver metastases.

PubMed