研究者詳細 - 山蔭　道明

Misc - 山蔭　道明

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Inhibition of voltage-dependent Ca2+ channels of porcine tracheal smooth muscle by the novel Ca2+ channel antagonist RWJ-22108

M Yamakage, CA Hirshman, A Namiki, TL Croxton

GENERAL PHARMACOLOGY ( PERGAMON-ELSEVIER SCIENCE LTD ) 28 ( 5 ) 689 - 694 1997年05月

1. We compared electrophysiological effects of the bronchoselective Ca2+ channel antagonist RWJ-22108 on voltage-dependent Ca2+ channels (VDCs) of porcine tracheal smooth muscle cells to the effects of nicardipine and verapamil. 2. Each of the three Ca2+ channel antagonists tested inhibited inward Ca2+ currents (I-Ca) measured by whole-cell patch clamp techniques. Inhibition was dose-dependent with similar to 50% inhibition of peak I-Ca at +20 mV obtained with 3 x 10(-6) M RWJ-22108, 3 x 10(-7) M nicardipine, or 10(-5) M verapamil. 3. Both RWJ-22108 (3 x 10(-6) M) and nicardipine (3 x 10(-7) M) shifted the voltage dependence of steady-state inactivation to more negative potentials; however, the change in the potential of half-maximal inactivation induced by RWJ-22108 (-18 mV) was significantly greater than that induced by nicardipine (-12 mV). Verapamil did not alter the voltage dependence of inactivation. 4. We conclude that inhibition of VDCs by RWJ-22108 is qualitatively similar to that by nicardipine but with a greater stabilizing effect on the inactivated channel state. (C) 1997 Elsevier Science Inc.

DOI PubMed CiNii

The relationship between respiratory patterns and work of breathing during halothane anesthesia with spontaneous ventilation

M Yamakage, S Kohro, Y Honma, M Edanaga, M Okanuma, A Namiki

ANESTHESIA AND ANALGESIA ( WILLIAMS & WILKINS ) 84 S599 - S599 1997年02月

研究発表ペーパー・要旨（国際会議）

Onset of vecuronium and pancuronium neuromuscular block with and without severe cardiac valvular disease

H Iwasaki, M Yamauchi, H Tsuchida, M Yamakage, H Ohmori, A Namiki

ANESTHESIA AND ANALGESIA ( WILLIAMS & WILKINS ) 84 S503 - S503 1997年02月

研究発表ペーパー・要旨（国際会議）

Thromboelastogram showing an undesirable effect of platelet transfusion on blood coagulability and fibrinolysis in a patient with aplastic anemia

S. Kohro, M. Yamakage, T. Takeda, A. Namiki

Journal of Anesthesia 11 ( 4 ) 303 - 306 1997年

DOI

Role of intracellular Ca2+ stores in the inhibitory effect of halothane on airway smooth muscle contraction

M Yamakage, S Kohro, A Namiki

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS ) 85 ( 3A ) A1128 - A1128 1996年09月

研究発表ペーパー・要旨（国際会議）

EFFECTS OF HALOTHANE ON INTRACELLULAR CA2+ REGULATORY SYSTEMS IN HUMAN PLATELET

S KOHRO, M YAMAKAGE, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT-RAVEN PUBL ) 83 ( 3A ) A309 - A309 1995年09月

研究発表ペーパー・要旨（国際会議）

INHIBITION OF VOLTAGE-DEPENDENT CA2+ CHANNELS IN PORCINE TRACHEAL SMOOTH-MUSCLE BY KETAMINE, PROPOFOL, AND THIOPENTAL

M YAMAKAGE, TL CROXTON, CA HIRSHMAN

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS ) 83 ( 3A ) A1203 - A1203 1995年09月

研究発表ペーパー・要旨（国際会議）

Patch clamp techniques to study effects of anesthetics on airway smooth muscle cells

YAMAKAGE Michiaki, CROXTON Thomas, HIRSHMAN Carol A

Journal of anesthesia 9 ( 1 ) 111 - 112 1995年02月

CiNii

THE EFFECTS OF EXTRACELLULAR PH ON INTRACELLULAR PH, CA2+ AND TENSION OF CANINE TRACHEAL SMOOTH-MUSCLE STRIPS

M YAMAKAGE, S KOHRO, M YAMAUCHI, A NAMIKI

LIFE SCIENCES ( PERGAMON-ELSEVIER SCIENCE LTD ) 56 ( 8 ) PL175 - PL180 1995年01月

速報，短報，研究ノート等（学術雑誌）

The effects of changes in extracellular pH (pH(o)) on intracellular Ca2+ concentration ([Ca2+](i)) or intracellular pH (pH(i)) were measured simultaneously with muscle tension in canine tracheal smooth muscle strips. [Ca2+](i) and pH(i) were measured using the fluorescent dyes fura-2 and BCECF, respectively. During high K+-induced contractions (24.2, 36.4 or 72.7 mM) at pH 7.4, pH(o) was changed to 7.8 or 7.0 with NaOH or HCl, respectively. Induced changes in pH(i) were equal to similar to 50% of the changes in pH(o). Alkalinization significantly increased [Ca2+](i) and enhanced muscle contraction at all concentrations of K+ but did not alter the relationship between muscle tension and [Ca2+](i). Acidification significantly decreased [Ca2+](i) without changing muscle tone; hence, the muscle tension - [Ca2+](i) relationship was shifted to the left. These results suggest that changes in pH(o), can alter airway smooth muscle tone by changing [Ca2+](i) and pH(i).

腹部大動脈瘤および閉塞性動脈硬化症の人工血管置換術における足底深部温の変化

山内正憲, 山蔭道明, 其田一

臨床体温 ( 「臨床体温」編集委員会 ) 14 ( 2 ) 51 - 55 1994年12月

INHIBITION BY HALOTHANE OF VOLTAGE-DEPENDENT CA2+ CURRENTS IN PORCINE TRACHEAL SMOOTH-MUSCLE CELLS

M YAMAKAGE, TL CROXTON, CA HIRSHMAN

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS ) 81 ( 3A ) A1445 - A1445 1994年09月

研究発表ペーパー・要旨（国際会議）

DIRECT INHIBITORY MECHANISMS OF HALOTHANE ON HUMAN PLATELET-AGGREGATION

S KOHRO, M YAMAKAGE, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT-RAVEN PUBL ) 81 ( 3A ) A442 - A442 1994年09月

研究発表ペーパー・要旨（国際会議）

平滑筋に対する吸入麻酔薬の直接作用機序

山蔭道明, 土田英昭, 並木昭義

麻酔 ( 克誠堂出版 ) 42 ( 11 ) p1578 - 1586 1993年11月

CiNii

EFFECTS OF ACIDOSIS AND HYPOXIA ON THE CONTRACTILITY OF CANINE TRACHEAL SMOOTH-MUSCLE - ROLE OF INTRACELLULAR CA2+ AND PH

M YAMAKAGE, T KAWAMATA, S KOHRO, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS ) 79 ( 3A ) A1208 - A1208 1993年09月

研究発表ペーパー・要旨（国際会議）

INHIBITORY EFFECTS OF HALOTHANE ON HIGH K+-INDUCED CANINE TRACHEAL SMOOTH-MUSCLE CONTRACTION AND INTRACELLULAR CA2+

M YAMAKAGE, T KAWAMATA, S KOHRO, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS ) 79 ( 3A ) A1207 - A1207 1993年09月

研究発表ペーパー・要旨（国際会議）

重度熱傷患者の術中体温低下の原因の検討

山蔭道明, 吉田泉, 川股知之, 山内正憲, 並木昭義

日臨麻会誌 ( 日本臨床麻酔学会 ) 13 ( 6 ) 548 - 554 1993年

Burn Indexが30以上の重度熱傷患者5名,計26回の手術症例において,体温低下の原因となる諸因子について検討した.麻酔導入時の体温と手術室退室時の体温との差を「体温変化(°C)」とした.体温変化と,Burn Index,麻酔時間,手術時間,出血量,輸血量,および手術時の露出体表面積との間には有意な相関関係を認めなかった.麻酔法に関しては,体温変化は笑気・酸素+ケタミン・ミダゾラム群(GO+KM群;n=16)で-0.80±0.30(平均±標準偏差)°C,笑気・酸素・イソフルレン群(GOI群;n=10)で-1.48±0.58°CでありGOI群がGO+KM群に比較して有意に低かった(P<0.01).体位に関しては,体温変化は仰臥位群(n=12)で-0.08±0.34°,腹臥位群(n=14)で-1.91±0.31°であり,腹臥位群が仰臥位群に比較して有意に低かった(P<0.005).重度熱傷患者の体温管理には,吸入麻酔薬よりもケタミンを併用した麻酔法が適切であり,さらに腹臥位手術の場合,手術開始までの時間をできるだけ短くするとともに,さらに積極的な加温方法の追加が必要である.

DOI CiNii

Mechanisms of action of volatile anesthetics on smooth muscle

M. Yamakage, H. Tsuchida, A. Namiki

Japanese Journal of Anesthesiology 42 ( 11 ) 1578 - 1586 1993年

書評論文，書評，文献紹介等

The development of intracellular Ca2+ fluorescent indicators and specific enzymatic substances as well as the application of the patch-clamp method have made it possible to clarify the mechanisms of action of volatile anesthetics on various smooth muscles. Volatile anesthetics inhibit smooth muscle contraction in part by decreasing intracellular Ca2+ concentration ([Ca2+]i) this effect is mediated by blocking calcium channels, especially the L-type voltage-operated channel, and by raising the intracellular cyclic AMP and cyclic GMP levels. Volatile anesthetic-induced suppression of smooth muscle contraction is also attributable to mechanisms independent of [Ca2+]i, which involve the depression of Ca2+ sensitization mediated by C kinase.

PubMed

三尖弁閉鎖不全を合併した拘束型心筋症の開心術麻酔経験

山内正憲, 山蔭道明, 土田英昭

臨床麻酔 ( 真興交易(株)医書出版部 ) 16 ( 7 ) 919 - 920 1992年07月

拘束型心筋症に重度のTR(三尖弁閉鎖不全)を合併した17歳男で,ミダゾラムとフェンタニールで導入し,ベクロニウムで筋弛緩を得た.肺動脈カテーテルと共にTEE(経食道内心エコー)を使用して心機能を評価し,カテコラミンの投与量などを決定した.TEEにより心房の大きさや,TRやMR(僧帽弁閉鎖不全)の程度も確認出来る為,三尖弁弁輪形成術を連続的に評価しながら補液管理を行う一方,MRの悪化に対し細心の注意を払う事が出来た

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