論文 - 久原　真

Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis

Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Rika Yamauchi, Masaki Saitoh, Shin Hisahara, Hiroaki Yoshikawa, Masakatsu Motomura, Jun Kawamata, Shun Shimohama

CLINICAL NEUROPHYSIOLOGY ( ELSEVIER IRELAND LTD )  123 ( 9 ) 1886 - 1890  2012年09月  [査読有り]

　概要を見る

Objectives: Tacrolimus (FK506) is a macrolide T-cell immunomodulator used to treat myasthenia gravis (MG). Besides immunosuppression, tacrolimus has been reported to have the potential to increase muscle strength by enhancing ryanodine receptor (RyR) function. However, few attempts have been made to demonstrate the early effect of tacrolimus as an RyR enhancer in clinical investigation. Methods: In 20 MG patients, masseteric compound muscle action potential (CMAP) and mandibular movement-related potentials (MRPs) were recorded simultaneously after stimulating the trigeminal motor nerve with a needle electrode. The excitation-contraction (E-C) coupling time (ECCT) was calculated by the latency difference between CMAP and MRP. Bite force was measured using a pressure-sensitive sheet. Serial assessments of % decrement in masseteric repetitive nerve stimulation (RNS), ECCT and bite force were performed before and within 4 weeks of tacrolimus (3 mg day (1)) treatment. The median (mean, range) interval of assessment was 2 (2.4, 1-4) weeks. We also measured serum antibodies against RyR, acetylcholine receptor and muscle-specific receptor tyrosine kinase. Results: Bite force increased after tacrolimus treatment accompanying clinical improvement assessed by Myasthenia Gravis Foundation of America classification, but the bite force difference did not reach statistical significance. Wilcoxon matched-pairs signed-ranks test detected a significant ECCT shortening in 12 patients assessed after 1-2 weeks of tacrolimus treatment as well as in eight patients assessed after 3-4 weeks. In contrast, masseteric CMAP and % decrement showed no significant changes after shortterm tacrolimus treatment. Significance: This early effect of tacrolimus may imply a pharmacological enhancement of RyR function to improve E-C coupling in MG. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

DOI PubMed

Relationship between dysphagia and depressive states in patients with Parkinson's disease

Meng Han, Hirofumi Ohnishi, Michio Nonaka, Rika Yamauchi, Takayoshi Hozuki, Takashi Hayashi, Masaki Saitoh, Shin Hisahara, Tomihiro Imai, Shun Shimohama, Mitsuru Mori

Parkinson's Disease: Diagnosis, Treatment and Prognosis     201 - 208  2012年07月

　概要を見る

Aspiration pneumonia related to dysphagia is known to be the leading cause of death in patients with Parkinson's disease (PD). We investigated the relationship between depressive states and dysphagia in patients with PD. A hundred and twenty-seven PD patients gave their informed consent and were enrolled in this study. We used the Beck Depression Inventory II (BDI-II) questionnaire to determine the participants' depressive states, and also used a questionnaire to assess participants' state of dysphagia. Participants were divided into four groups according to their BDI-II score. We compared the PD patients with Swallowing Disturbances Questionnaire (SDQ) scores of more than or equal to 11 with the SDQ scores of less than 11 regarding depressive categories. A logistic regression analysis was conducted to calculate odds ratios (ORs) and their 95% confidence intervals (95%CI) adjusting for age, sex, disease duration, wearing-off phenomenon and severity of movement disorder. OR (95%CI) of depressive categories,in which the trivial class was set as a reference group, were 3.28 (0.93-11.55), 13.44 (3.10-58.16), 30.35 (5.65-162.97) in the mild class, the moderate class and the severe class, respectively. This study suggests that there may be a strong relationship between depressive states and dysphagia in patients with PD. © 2012 Nova Science Publishers, Inc. All rights reserved.

Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis

Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Hiroaki Yoshikawa, Rika Yamauchi, Masaki Saitoh, Shin Hisahara, Masakatsu Motomura, Jun Kawamata, Shun Shimohama

CLINICAL NEUROPHYSIOLOGY ( ELSEVIER IRELAND LTD )  123 ( 6 ) 1242 - 1247  2012年06月  [査読有り]

　概要を見る

Objective: The aim of this study was to elucidate the relationship between the impairment of excitation-contraction (E-C) coupling and anti-ryanodine receptor (RyR) antibody in patients with myasthenia gravis (MG). Methods: Masseteric compound muscle action potential (CMAP) and mandibular movement-related potentials (MRPs) were recorded simultaneously after stimulating the trigeminal motor nerve with a needle electrode. The E-C coupling time (ECCT) was calculated as the latency difference between CMAP and MRP. For each patient, we selected a representative data set when there was no abnormal decrement in response to repetitive nerve stimulation. The 26 data sets were divided into an anti-RyR-positive group (n = 12) and an anti-RyR-negative group (n = 14). Results: Masseteric ECCT was significantly longer (p = 0.017) in anti-RyR-positive group (median, mean, range; 3.6, 3.8, 3.0-5.9 ms) than in anti-RyR-negative group (3.1, 3.1, 2.7-4.0) although there were no significant differences in masseteric CMAP amplitude and % decrement between the two groups. The bite force was significantly lower in anti-RyR-positive group than in normal controls. Conclusions: Presence of anti-RyR antibodies is associated with significantly prolonged masseteric ECCT compared to absence of the antibodies in MG. Significance: Anti-RyR antibody contributes to E-C coupling impairment in the masseter muscle in patients with MG. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

DOI PubMed

咬筋のend-plateは生理的刺激頻度では伝達ブロックが起きにくい

今井 富裕, 津田 笑子, 山内 理香, 保月 隆良, 齊藤 正樹, 久原 真, 川又 純, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 12 ) 1461 - 1461  2011年12月

筋萎縮性側索硬化症における鼻腔吸気圧測定『開放法』と『閉鎖法』

山内 理香, 山本 大輔, 松村 晃寛, 津田 笑子, 保月 隆良, 林 貴士, 齊藤 正樹, 久原 真, 川又 純, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 12 ) 1365 - 1365  2011年12月

赤血球画分を用いた酸化DJ-1定量の検討

松村 晃寛, 久原 真, 齊藤 正樹, 川又 純, 今井 富裕, 下濱 俊, 斎藤 芳郎, 野口 範子, 二木 鋭雄

臨床神経学 ( (一社)日本神経学会 )  51 ( 12 ) 1266 - 1266  2011年12月

Relationship between dysphagia and depressive states in patients with Parkinson's disease

Meng Han, Hirofumi Ohnishi, Michio Nonaka, Rika Yamauchi, Takayoshi Hozuki, Takashi Hayashi, Masaki Saitoh, Shin Hisahara, Tomihiro Imai, Shun Shimohama, Mitsuru Mori

PARKINSONISM & RELATED DISORDERS ( ELSEVIER SCI LTD )  17 ( 6 ) 437 - 439  2011年07月  [査読有り]

　概要を見る

Aspiration pneumonia related to dysphagia is known to be the leading cause of death in patients with Parkinson's disease (PD). We investigated the relationship between depressive states and dysphagia in patients with PD. A hundred and twenty-seven PD patients gave their informed consent and were enrolled in this study. We used the Beck Depression Inventory (BDI) questionnaire to determine the participants' depressive states, and also used a questionnaire to assess participants' state of dysphagia. Participants were divided into four groups according to their BDI score. We compared the PD patients with Swallowing Disturbances Questionnaire (SDQ) scores of more than or equal to 11 with the SDQ scores of less than 11 regarding depressive categories. A logistic regression analysis was conducted to calculate odds ratios (ORs) and their 95% confidence intervals (95%CI) adjusting for age, sex, disease duration, wearing-off phenomenon and severity of movement disorder. OR (95%CI) of depressive categories, in which the trivial class was set as a reference group, were 3.28 (0.93-11.55), 13.44(3.10-58.16), 30.35 (5.65-162.97) in the mild class, the moderate class and the severe class, respectively. This study suggests that there may be a strong relationship between depressive states and dysphagia in patients with PD. (C) 2011 Elsevier Ltd. All rights reserved.

DOI PubMed

Painful legs and moving toesの1例

津田 笑子, 林 貴士, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 3 ) 225 - 225  2011年03月

FAP ATTR Val30Metの1弧発例

山本 大輔, 津田 笑子, 今井 富裕, 林 貴士, 齊藤 正樹, 久原 真, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 3 ) 226 - 226  2011年03月

ステロイドパルスが有効であった特発性全身性無汗症の1例

保月 隆良, 松村 晃寛, 山本 大輔, 津田 玲子, 津田 笑子, 山内 理香, 林 貴士, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 3 ) 224 - 224  2011年03月

Bartter症候群を基盤に低K性ミオパチーの一例

津田 玲子, 山内 理香, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 3 ) 226 - 226  2011年03月

脳有鉤嚢虫症の1例

保月 隆良, 山本 大輔, 松村 晃寛, 津田 玲子, 津田 笑子, 山内 理香, 林 貴士, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  51 ( 3 ) 226 - 226  2011年03月

Toxin-Induced and Genetic Animal Models of Parkinson's Disease

Shin Hisahara, Shun Shimohama

PARKINSONS DISEASE ( HINDAWI PUBLISHING CORPORATION )  2011   951709  2011年  [査読有り]

　概要を見る

Parkinson's disease (PD) is a common progressive neurodegenerative disorder. The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not fully understood. Epidemiologically, environmental neurotoxins such as pesticides are promising candidates for causative factors of PD. Oxidative stress and mitochondrial dysfunction induced by these toxins could contribute to the progression of PD. While most cases of PD are sporadic, specific mutations in genes that cause familial forms of PD have led to provide new insights into its pathogenesis. This paper focuses on animal models of both toxin-induced and genetically determined PD that have provided significant insight for understanding this disease. We also discuss the validity, benefits, and limitations of representative models.

DOI PubMed

筋萎縮性側索硬化症(ALS)における呼吸不全の進展様式と頸髄病理所見の対応

山内 理香, 山本 大輔, 松下 隆司, 豊島 貴信, 松村 晃寛, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊, 野中 道夫, 荻野 次郎, 外岡 暁子, 中西 勝也

臨床神経学 ( (一社)日本神経学会 )  50 ( 12 ) 1126 - 1126  2010年12月

Resveratrolによる神経系細胞における酸化ストレス耐性の検討

久原 真, 齊藤 正樹, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  50 ( 12 ) 1240 - 1240  2010年12月

Subclinicalなneuropathyを合併した原因不明の脊髄炎の1例

山本 大輔, 津田 笑子, 矢澤 省吾, 今井 富裕, 林 貴士, 齊藤 正樹, 久原 真, 下濱 俊

臨床神経生理学 ( (一社)日本臨床神経生理学会 )  38 ( 5 ) 331 - 331  2010年10月

【意識障害 緊急を要する病状・病態の初期診療と意識障害への初期対応】神経内科でみる意識障害

齊藤 正樹, 松村 晃寛, 津田 笑子, 久原 真

月刊レジデント ( (株)医学出版 )  3 ( 9 ) 92 - 98  2010年09月

左正中神経単麻痺を呈したライム病の一例

山本 大輔, 松村 晃寛, 林 貴士, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊

臨床神経学 ( (一社)日本神経学会 )  50 ( 8 ) 603 - 603  2010年08月

ステロイドパルス療法(IVMP)と高圧酸素療法(HBO)が奏効した間歇型一酸化炭素中毒の一例

矢島 秀教, 豊島 貴信, 津田 笑子, 齊藤 正樹, 久原 真, 今井 富裕, 下濱 俊, 文屋 尚文, 蕨 玲子, 浅井 康文

臨床神経学 ( (一社)日本神経学会 )  50 ( 8 ) 602 - 602  2010年08月

抗NMDA受容体抗体が関連したと考えられる脳炎の一例

津田 笑子, 矢島 秀教, 豊島 貴信, 保月 隆良, 久原 真, 齊藤 正樹, 今井 富裕, 下濱 俊, 高橋 幸利

臨床神経学 ( (一社)日本神経学会 )  50 ( 8 ) 603 - 603  2010年08月