研究者詳細 - 久原　真

論文 - 久原　真

分割表示 150 件中 121 - 140 件目／全件表示 >>

脊髄MRIで異常所見を認めた脳脊髄液減少症の一例

佐藤さゆり, 山本大輔, 津田笑子, 齊藤正樹, 久原真, 今井富裕, 下濱俊

臨床神経学 ( (一社)日本神経学会 ) 50 ( 8 ) 600 - 600 2010年08月

Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis

Emiko Tsuda, Tomihiro Imai, Takayoshi Hozuki, Rika Yamauchi, Masaki Saitoh, Shin Hisahara, Hiroaki Yoshikawa, Masakatsu Motomura, Shun Shimohama

CLINICAL NEUROPHYSIOLOGY ( ELSEVIER IRELAND LTD ) 121 ( 7 ) 1051 - 1058 2010年07月 [査読有り]

Objective: The aim of this study was to elucidate the relationship between the impairment of excitation-contraction (E-C) coupling of masseter and the bite force in patients with myasthenia gravis (MG). Methods: In 20 patients with MG, masseteric compound muscle action potential (CMAP) and mandibular movement-related potentials (MRP) were recorded simultaneously after stimulating the trigeminal motor nerve with a needle electrode. The E-C coupling time (ECCT) was calculated by the latency difference between CMAP and MRP. Bite force was measured using a pressure-sensitive sheet. Serial assessments of % decrement in masseteric repetitive nerve stimulation (RNS), ECCT, and bite force were performed before and after corticosteroid therapy alone or in various combinations with FK506, cyclosporin A, intravenous immunoglobulin and immunoabsorption. Results: Percent amplitude decrement in RNS and ECCT decreased significantly accompanying an increase in bite force after treatment. Simple regression analysis demonstrated a linear correlation among % decrement, ECCT and bite force. However, ECCT shortening accompanying bite force recovery without reduction in % decrement was observed in 4 patients. Conclusions: Masseteric E-C coupling is impaired in some MG patients, and functional recovery of E-C coupling contributes at least in part to the increase in bite force after treatment. Significance: Impaired E-C coupling contributes to muscle weakness in patients with MG. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

DOI PubMed

パーキンソン病患者の抑うつ症状と嚥下障害との関連

韓萌, 大西浩文, 野中道夫, 山内理香, 保月隆良, 林貴士, 齊藤正樹, 久原真, 今井富裕, 下濱俊, 森満

総合リハビリテーション ( (株)医学書院 ) 38 ( 7 ) 677 - 683 2010年07月

パーキンソン病(PD)患者における抑うつと嚥下障害の関連について検討した.札幌医科大学附属病院神経内科に通院するPD患者連続78名を解析対象とし,BDI-IIベック抑うつ質問票と嚥下障害質問票から患者の自記式で得た回答を既定の評価基準に従って点数化した.H&Y重症度分類と抑うつカテゴリーが重症になるほど嚥下障害の頻度が増加した.また,嚥下障害の有無を従属変数とした多重ロジスティック回帰分析では,抑うつカテゴリーが中等症,重症となるほど嚥下障害に対するオッズ比が有意に増大しており,嚥下障害予防の観点からはPD患者の抑うつ状態にも留意することが重要である.(著者抄録)

ステロイドパルス療法直後の骨代謝マーカーの推移

保月隆良, 今井富裕, 津田笑子, 松村晃寛, 山本大輔, 山内理香, 林貴士, 齊藤正樹, 久原真, 下濱俊

神経治療学 ( (一社)日本神経治療学会 ) 27 ( 3 ) 413 - 413 2010年05月

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.

Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y

The Journal of biological chemistry 285 ( 11 ) 8375 - 8382 2010年03月 [査読有り]

DOI PubMed

大量免疫グロブリン療法を施行したMPO-ANCA陽性肥厚性硬膜炎の1例

保月隆良, 松村晃寛, 山本大輔, 林貴士, 齊藤正樹, 久原真, 今井富裕, 下濱俊

臨床神経学 ( (一社)日本神経学会 ) 50 ( 2 ) 129 - 129 2010年02月

3,4-diaminopyridine治療を開始した非担癌性Lambert-Eaton症候群の1例

松村晃寛, 松下隆司, 保月隆良, 齊藤正樹, 久原真, 今井富裕, 下濱俊

臨床神経学 ( (一社)日本神経学会 ) 50 ( 2 ) 127 - 127 2010年02月

Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K-2 in Corticosteroid-Treated Patients: A Pilot Study

Takayoshi Hozuki, Tomihiro Imai, Emiko Tsuda, Akihiro Matsumura, Daisuke Yamamoto, Takanobu Toyoshima, Syuuichiro Suzuki, Rika Yamauchi, Takashi Hayashi, Shin Hisahara, Shun Shimohama

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE ) 49 ( 5 ) 371 - 376 2010年 [査読有り]

Objective The aim of this study was to investigate the responses of serum osteocalcin (OC), undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K-2 supplementation on bone metabolic markers in corticosteroid-treated patients. Methods Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned randomly to 2 groups (A: risedronate monotherapy, n=8; B: combined risedronate and vitamin K-2 therapy, n=8) and treated for 1 year. Another 6 patients who received intravenous steroid pulse therapy were assigned to group C for investigation of the effects of corticosteroids on OC and ucOC 1 month after pulse therapy. Results Serial measurements revealed that significant decreases of OC, ucOC and NTx persisted with a similar time course profile during 1 year of treatment in groups A and B, and between-group analysis failed to demonstrate any additional effects of vitamin K-2 on risedronate therapy. Intravenous steroid pulse therapy induced a transient depression of OC and ucOC within 1 week in group C. Conclusion These results indicate that serum concentrations of OC and ucOC become consistently low during corticosteroid administration despite risedronate therapy with or without vitamin K-2 supplementation, and the serum ucOC level may not be a reliable indicator of vitamin K status under corticosteroid administration.

DOI PubMed

多発脳神経障害を呈する頭蓋底感染症の診断的治療について当施設における12年間の経験から

松村晃寛, 津田玲子, 山本大輔, 豊島貴信, 松下隆司, 鈴木秀一郎, 津田笑子, 山内理香, 保月隆良, 林貴士, 齊藤正樹, 久原真, 今井富裕, 下濱俊

NEUROINFECTION ( 日本神経感染症学会 ) 14 ( 2 ) 147 - 147 2009年10月

Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX

Naotoshi Iwahara, Shin Hisahara, Takashi Hayashi, Yoshiyuki Horio

Biochemical and Biophysical Research Communications 386 ( 4 ) 671 - 675 2009年09月

An orphan nuclear receptor TLX is a transcriptional repressor that promotes the proliferation and self-renewal of neural precursor cells (NPCs). SIRT1, an NAD+-dependent protein deacetylase, is highly expressed in the NPCs and participates in neurogenesis. Here, we found that TLX colocalized with SIRT1 and knockdown of TLX by small interfering RNAs decreased SIRT1 levels in NPCs. TLX increased the SIRT1 expression by binding to the newly identified TLX-activating element in the SIRT1 gene promoter in HEK293 cells. Thus, TLX is an inducer of SIRT1 and may contribute to neurogenesis both as a transactivator and as a repressor. © 2009 Elsevier Inc. All rights reserved.

DOI PubMed

神経・筋疾患における嚥下障害の当科治療経験例

山本大輔, 津田笑子, 今井富裕, 鈴木秀一郎, 小田美月, 保月隆良, 久原真, 野中道夫, 山口浩司, 金泉悦子, 下濱俊

静脈経腸栄養 ( (株)ジェフコーポレーション ) 24 ( 3 ) 849 - 849 2009年05月

原因不明のまま治療開始した頭蓋底病変の予後多発脳神経障害を呈した感染症を中心に

松村晃寛, 山本大輔, 豊島貴信, 鈴木秀一郎, 津田笑子, 山内理香, 保月隆良, 林貴士, 久原真, 今井富裕, 下濱俊

神経治療学 ( (一社)日本神経治療学会 ) 26 ( 3 ) 389 - 389 2009年05月

無菌性髄膜炎、胸腰髄病変を呈した再発性多発軟骨炎の1例

松村晃寛, 小田美月, 久原真, 野中道夫, 今井富裕, 下濱俊, 荻野次郎, 土田哲人

臨床神経学 ( (一社)日本神経学会 ) 49 ( 5 ) 313 - 313 2009年05月

頸部放射線治療の7年後に一側性の副神経麻痺・腕神経叢障害を発症した遅発性放射線障害の1例

松村晃寛, 保月隆良, 久原真, 野中道夫, 今井富裕, 下濱俊

臨床神経学 ( (一社)日本神経学会 ) 49 ( 1 ) 67 - 67 2009年01月

パーキンソン病患者のADLとQOLに対する抑うつの影響

韓萌, 大西浩文, 森満, 林貴士, 久原真, 野中道夫, 今井富裕, 下濱俊

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 ) 22 ( 1特別付録 ) 65 - 65 2008年11月

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y

Proceedings of the National Academy of Sciences of the United States of America ( 40 ) 105 15599 - 15604 2008年10月 [査読有り]

DOI PubMed

家族歴の判然としない遅発成人型DRPLAの1例

松村晃寛, 小田美月, 久原真, 野中道夫, 今井富裕, 下濱俊

臨床神経学 ( (一社)日本神経学会 ) 48 ( 8 ) 589 - 589 2008年08月

Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia.

Tsuda E, Imai T, Matsumura A, Hisahara S, Nonaka M, Shiraishi H, Motomura M, Shimohama S

Internal medicine (Tokyo, Japan) ( 5 ) 47 ( 5 ) 445 - 447 2008年 [査読有り] [国内誌]

A 41-year-old man with progressive limb weakness manifested fluctuating muscle weakness as seen in myasthenia gravis (MG). Laboratory investigations revealed hyperthyroidism without the complication of MG. Electrophysiological studies demonstrated abnormal features of neuromuscular transmissions resembling those of the Lambert-Eaton myasthenic syndrome rather than those of MG. A CT scan showed a mediastinal mass that suggested thymic hyperplasia which often complicates MG or hyperthyroidism. Medical treatment of hyperthyroidism resulted in resolution of MG-like symptoms and regression of thymic hyperplasia on CT concomitant with normalization of thyroid function. This case highlights the fact that careful investigations are needed to differentiate MG-like symptoms from genuine MG in cases of hyperthyroidism with thymic lesions.

DOI PubMed

両視床の異常信号を伴う認知症を呈した硬膜動静脈瘻の1例

松村晃寛, 小田美月, 保月隆良, 野中道夫, 久原真, 今井富裕, 下濱俊, 原口浩一, 野中雅, 秋葉英成

臨床神経学 ( (一社)日本神経学会 ) 47 ( 6 ) 371 - 371 2007年06月

上矢状静脈洞の著明な拡張と血栓を伴った全身性エリテマトーデスの1例

小泉武, 大久保由希子, 静川裕彦, 久原真, 野中道夫, 今井富裕, 千葉進, 松本博之, 大坂美鈴, 宝金清博

臨床神経学 ( (一社)日本神経学会 ) 45 ( 1 ) 61 - 61 2005年01月

　前のページ - 次のページ　

<久原 真>

論文 - 久原 真

<久原　真>

論文 - 久原　真