Misc - SUZUKI Hiromu

胃癌におけるp16/CDKN2遺伝子プロモーター領域のメチル化

鈴木 拓, 伊東 文生, 豊田 実, 菊池 剛史, 垣内 英樹, 日野田 裕治, 今井 浩三

生物物理化学 = Journal of Electrophoresis   42   25 - 25  1998.09

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[Hereditary macrothrombocytopenia]

Kaoru KASAHARA, Tohru TAKAHASHI, Fumie HAMAMOTO, Toshiaki HAYASHI, Masaaki ADACHI, Hirosuke OKUDA, Shuji SATOH, Yuji HINODA, Kohzoh IMAI

Rinsho Ketsueki ( The Japanese Society of Hematology )  39 ( 4 ) 308 - 313  1998

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A 19 year-old male was referred to our department because of macrothrombocytopenia. His platelet count was 73,000/μl and giant platelets were observed in the peripheral blood smear specimen. Though he had been suffering from severe atopic dermatitis for four years, he seemed to be healthy without bleeding tendency. When he underwent a shunt operation for tetralogy of Fallot without any complication at nine-years old, thrombocytopenia was allegedly pointed out for the first time. Bone marrow aspiration revealed no abnormal findings with no chromosomal aberration. Normal platelet aggregation responses against adenosine diphosphate, epinephrine, collagen, and ristocetin were observed. The platelet adhesiveness (modified Salzman method) was slightly elevated. Unlike other reported syndromes associated with macrothrombocytopenia, his leukocytes had no inclusion bodies. His mother also had macrothrombocytopenia thus, this disorder was suspected to be hereditary.

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A case of anaplastic carcinoma of the pancreas with high serum IL-6 level

SUZUKI Hiromu, ENDO Takao, YAWATA Atsushi, AZUMA Naoki, ITO Fumio, IMAI Kohzoh

膵臓 = The Journal of Japan Pancreas Society   12 ( 1 ) 59 - 64  1997.02

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[Rapidly progressed chronic myelomonocytic leukemia associated with severe skin infiltration]

Hiromu SUZUKI, Tohru TAKAHASHI, Toshiaki HAYASHI, Hajime KANAMOTO, Fumie HAMAMOTO, Masaaki ADACHI, Yuji HINODA, Kohzoh IMAI

Rinsho Ketsueki ( The Japanese Society of Hematology )  38 ( 9 ) 752 - 756  1997

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A 79-year-old man developed nodular skin eruption in his trunk in March 1995. He was diagnosed as CTCL and hospitalized to the department of dermatology and low dose VP-16 therapy was started. 6 months later, he was referred to our department because of severe melena. On admission, marked monocytosis was observed both in the bone marrow (43.6%) and peripheral blood (monocyte>1,000/μl). Skin biopsy showed infiltration of large mononuclear cells in the dermis and subcutaneous tissue. Thus a diagnosis of CMML with skin infiltration was made. Skin eruption developed over his entire skin and peripheral monocytes increased over 5,000/μl. Chemotherapy was started and skin infiltration was slightly improved, but the disease developed into acute phase and he died 3 months after admission.

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