Misc - TAKAHASHI Satoshi

尿路性器感染症 (創立百周年記念号) -- (わが国における泌尿器科学100年の歴史)

塚本 泰司, 高橋 聡

日本泌尿器科学会雑誌 ( 日本泌尿器科学会 )  103   106 - 111  2012.09

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性器伝染性軟属腫 (特集 ストップ ザ 性感染症) -- (診断・治療)

高橋 聡, 塚本 泰司

臨牀と研究 ( 大道学館出版部 )  89 ( 7 ) 904 - 906  2012.07

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尿路病原性大腸菌感染に対するサーファクタント蛋白質の防御的役割

西谷 千明, 栗村 雄一郎, 有木 茂, 高橋 素子, 齋藤 充史, 長谷川 喜弘, 橋本 次朗, 高橋 聡, 相馬 仁, 塚本 泰司, 黒木 由夫

日本生化学会大会プログラム・講演要旨集 ( (公社)日本生化学会 )  84回   4T16a - 5  2011.09

J-GLOBAL

A ROLE FOR PREOPERATIVE SYSTEMIC CHEMOTHERAPY IN NODE-POSITIVE UPPER TRACT UROTHELIAL CARCINOMA TREATED WITH RADICAL NEPHROURETERECTOMY: A RETROSPECTIVE EXPERIENCE

Hiroshi Kitamura, Toshiaki Tanaka, Manabu Igarashi, Naotaka Nishiyama, Fumimasa Fukuta, Tetsuya Shindo, Shin-Ichi Hisasue, Satoshi Takahashi, Naoya Masumori, Taiji Tsukamoto

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  185 ( 4 ) E271 - E272  2011.04

Research paper, summary (international conference)  

SURFACTANT PROTEINS A AND D INHIBIT UROPATHOGENIC ESCHERICHIA COLI BINDING TO UROTHELIAL CELLS

Yuichiro Kurimura, Teruhisa Uehara, Kohji Ichihara, Jiro Hashimoto, Satoshi Takahashi, Shigeru Ariki, Chiaki Nishitani, Motoko Takahashi, Yoshio Kuroki, Taiji Tsukamoto

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  185 ( 4 ) E546 - E546  2011.04

Research paper, summary (international conference)  

APP-078 尿路におけるサーファクタント蛋白質(SP-A、SP-D)の感染防御 : 尿路病原性大腸菌の尿路上皮への接着阻害(総会賞応募ポスター,第99回日本泌尿器科学会総会)

栗村 雄一郎, 西谷 千明, 橋本 次朗, 高橋 聡, 有木 茂, 高橋 素子, 黒木 由夫, 塚本 泰司

日本泌尿器科學會雜誌 ( 社団法人日本泌尿器科学会 )  102 ( 2 ) 331 - 331  2011.03

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Clinical relevance of single administration of prophylactic antimicrobial agents against febrile events after removal of ureteral stents for patients with urinary diversion or reconstruction

HASHIMOTO Jiro, TAKAHASHI Satoshi, KURIMURA Yuichiro, TAKEYAMA Koh, KUNISHIMA Yasuharu, TSUKAMOTO Taiji

Int J Urol   17 ( 2 ) 163 - 166  2010.02

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Clinical features of patients with brain metastasis from testicular germ cell tumor

松田 洋平, 田中 俊明, 佐藤 俊介, 北村 寛, 高橋 聡, 舛森 直哉, 塚本 泰司

Acta urologica Japonica ( 泌尿器科紀要刊行会 )  56 ( 2 ) 99 - 102  2010.02

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We retrospectively reviewed 190 patients with germ cell tumors of testis or extragonadal origin who were treated in our hospital between 1980 and 2007. Five (2.6%) of them had brain metastasis. We studied the clinical features and treatment outcome of these patients. Median age was 30 years old (23-48). The clinical stage was III in all the patients, except one with stage I disease. Two patients had brain metastasis at the initial presentation. All patients underwent multiple regimens of chemotherapy. As local therapies for brain metastases, surgical resection was done in 4 and gamma knife was in 1. Whole brain irradiation was added to surgery in 2 patients. All patients died of the disease within one year after brain metastasis development, except 1 patient who was free of disease 47 months after the presentation. The long survivor had solitary brain metastasis at the initial presentation and received 4 regimens of chemotherapy, 2 surgical resections of brain metastases and whole brain irradiation. Finally, chemotherapy consisting of irinotecan and nedaplatin resulted in normalization of the tumor markers and complete remission was proved by the subsequent surgical resection. Although most patients with brain metastasis have a poor clinical outcome, aggressive local treatment and employment of novel anticancerous agents may contribute to improve clinical course of selected patients with germ cell tumors and brain metastasis.

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Adenomatoid Tumor of the Testis with Testicular Pain : A Case Report

島 正樹, 高橋 聡, 前田 俊浩, 舛森 直哉, 伊藤 直樹, 塚本 泰司

泌尿器科紀要 ( 泌尿器科紀要刊行会 )  55 ( 5 ) 285 - 286  2009.05

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A 30-year-old man who complained of sudden right scrotal pain visited our clinic. Physical examination revealed a palpable mass with tenderness on his right testis. An emergent operation was performed for acute scrotum. The intraoperative findings showed a small, white, elastic solid, a smooth surface tumor that originated from the tunica albuginea of the right testis. It seemed to be benign macroscopically and partial orchiectomy was performed. Soon after surgery, the pain disappeared. Pathohistological examination revealed an adenomatoid tumor of the testis which originated from the rete testis. Adenomatoid tumor of the testis is a rare benign tumor. In general, it can be diagnosed by observation of an incidental, pain-free and small palpable mass of the testis. Therefore, we should be aware that an adenomatoid tumor of the testis can be one of the differential diagnoses of acute scrotum.

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IS CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME ACCOMPANIED WITH SEMINAL VESICULITIS?

R. Furuya, S. Takahashi, S. Furuya, N. Saitoh, H. Ogura, Y. Kurimura, T. Tsukamoto

EUROPEAN UROLOGY SUPPLEMENTS ( ELSEVIER SCIENCE BV )  8 ( 4 ) 259 - 259  2009.03

Research paper, summary (international conference)  

Surgical site infection in patients with radical cystectomy

Satoshi Takahashi, Yuki Kyoda, Naoki Itoh, Taiji Tsukamoto

WOUND REPAIR AND REGENERATION ( WILEY-BLACKWELL PUBLISHING, INC )  17 ( 1 ) A6 - A6  2009.01

Research paper, summary (international conference)  

Condyloma acuminatum

高橋 聡, 塚本 泰司

Japanese journal of clinical medicine ( 日本臨床社 )  67 ( 1 ) 153 - 156  2009.01

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Clinical course linkage among different priapism subtypes : Dilemma in the management strategies

HISASUE Shin-ichi, KOBAYASHI Ko, KATO Ryuichi, HASHIMOTO Kohei, YAMASHITA Shinichi, TAKAHASHI Satoshi, MASUMORI Naoya, TSUKAMOTO Taiji

International journal of urology   15 ( 11 ) 1006 - 1010  2008.11

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Gatifloxacin treatment for chronic prostatitis : a prospective multicenter clinical trial

KUNISHIMA Yasuharu, TAKEYAMA Koh, TAKAHASHI Satoshi, MATSUKAWA Masanori, KOROKU Mikio, TANDA Hitoshi, TANAKA Toshiaki, HIROSE Takaoki, IWASAWA Akihiko, NISHIMURA Masahiro, TAKEDA Kou-ichi, SUZUKI Nobukazu, HORITA Hiroki, YOKOO Akifumi, TSUKAMOTO Taiji

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   14 ( 2 ) 137 - 140  2008.04

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Current survey of urinary tuberculosis in Hokkaido, Japan

TAKAHASHI Satoshi, TAKEYAMA Koh, KUNISHIMA Yasuharu, HASHIMOTO Kohei, MIYAMOTO Shintaro, ICHIHARA Kohji, TAKAGI Yoshio, TANAKA Toshiaki, HIROSE Takaoki, SUNAOSHI Ken-ichi, TAKEI Fumiyasu, MIYAO Noriomi, KURIMURA Yuichiro, TAKAGI Seiji, TSUKAMOTO Taiji

J Infect Chemother   13 ( 2 ) 105 - 108  2007.04

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Intravesical instillation of resiniferatoxin for the patients with interstitial cystitis

高橋 聡, 柳瀬 雅裕, 井上 隆太, 市原 浩司, 舛森 直哉, 塚本 泰司, 井川 靖彦, 西沢 理

Acta urologica Japonica ( 泌尿器科紀要刊行会 )  52 ( 12 ) 911 - 913  2006.12

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間質性膀胱炎に対し水圧療法を施行し、その後、症状が再燃した3症例(初診時66歳、59歳、70歳、全例女性)にレジニフェラトキシン膀胱内注入療法を行い、その有効性を検討した。その結果、1)全例、水圧療法時の診断としてNational Institute of Diabetes,Digestive and Kidney Diseasesのクライテリアに合致しており、比較的症状の重い症例であった可能性がみられた。2)1～2回の注入で、特に膀胱部痛に対しは著明に効果があり、1例は5年間、2例は3年間の有効期間で現在に至っている。効果が持続した理由は明らかでない。3)経過観察中、排尿困難等の排尿症状、血液学的異常は認められなかった。しかし一方、排尿量に関しては1回排尿量はやや改善したが、著明な改善は得られなかった。4)膀胱部痛に対しては非常に有効であり、膀胱部痛が主症状である症例を選択できれば、レジニフェラトキシンは間質性膀胱炎に対する治療の1つとして考慮されてよいと考えられた。Although hydrodistention of the bladder is accepted as the initial treatment for patients with interstitial cystitis (IC), second-line treatment for worsening symptoms is not concretely established. Resiniferatoxin (RTX) desensitizes bladder afferent c-fibers and its intravesical instillation is effective for patients with detrusor overactivity. We studied the clinical relevance of intravesical treatment with RTX for patients with IC. The treatment was performed for 3 patients with incomplete improvement after hydrodistention. All 3 patients were free of bladder pain posttreatment and had slight improvement of the maximum voided volume. Though RTX treatment requires general anesthesia against severe bladder pain it is effective for selected patients with interstitial cystitis and can be potentially used as one of the treatment options.

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Analysis of clinical manifestations of male patients with urethritis

TAKAHASHI Satoshi, TAKEYAMA Koh, KUNISHIMA Yasuharu, TAKEDA Kohichi, SUZUKI Nobukazu, NISHIMURA Masahiro, FURUYA Ryoji, TSUKAMOTO Taiji

J. Infect. Chemother.   12 ( 5 ) 283 - 286  2006.10

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Detection of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum DNAs in urine from asymptomatic healthy young Japanese men

TAKAHASHI Satoshi, TAKEYAMA Koh, MIYAMOTO Shintaro, ICHIHARA Kohji, MAEDA Toshihiro, KUNISHIMA Yasuharu, MATSUKAWA Masanori, TSUKAMOTO Taiji

J Infect Chemother.   12 ( 5 ) 269 - 271  2006.10

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Malignant fibrous histiocytoma of the retroperitoneum: review of clinical course and histopathology

市原 浩司, 高橋 聡, 高橋 敦, 舛森 直哉, 伊藤 直樹, 長谷川 匡, 高木 良雄, 田口 圭介, 塚本 泰司

Acta urologica Japonica ( 泌尿器科紀要刊行会 )  52 ( 10 ) 761 - 764  2006.10

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1985年～2005年に診断した悪性線維性組織球腫(MFH;Malignant fibrous histiocytoma)7例(男5例女2例、平均年齢58歳)について検討した。主訴の腹部背部痛は全例の6割で認められ、2例に発熱倦怠感等全身症状を伴った。腫瘍発生部位は後腹膜腔以外に精索周囲組織もあり、腫瘍長径平均11.5cmで、臨床経過は観察期間が中央値5ヵ月、6例で治療目的に腫瘍摘出術を実施した。摘出術実施6例中、術後局所再発は5例、再発までの期間は平均1.5ヵ月であり、手術以外の治療を放射線治療を4例で実施し、うち2例で再発、転移巣の治療を行った。化学治療は1例に実施し、mesna、adriamycin、ifosfamide、dacarbazine(MAID)を用いたが、開始後局所再発で死亡した。死亡した5例の生存期間は平均3.5ヵ月で、現在も生存中の2例中1例が左精索原発のMFHであった。また、1例は右腎被膜由来のMFHで再発を繰り返していたが、その都度完全摘除が可能であった。The definition of malignant fibrous histiocytoma (MFH) was modified and simplified in the new WHO-Soft Tissue and Bone Tumor Classification published in 2002. We reviewed the clinical courses of 7 patients with MFH of the retroperitoneum treated in our hospital from 1985 to 2005 and reexamined their pathological diagnoses according to the new classification. All pathological specimens were reviewed again by an expert pathologist (TH) and were confirmed as MFH. Median follow-up was 5 months (0.5 to 44 months). Five patients were diagnosed as having the pleomorphic type, and 2, the inflammatory type. The tumor was located in the retroperitoneal space in 6 patients and around the left spermatic cord in 1. Radical surgery was the primary treatment for 6 patients. The disease recurred locally in 5 patients and distant metastasis developed in 3. The lung and liver were the principal locations of distant metastases. The 2-year disease-specific survival rate was 30% and 2 patients have been alive for more than 3 years. Our experience and those of others reported in the literature suggested that the factors for long-term survival in MFH are pleomorphic-type histology, superficial location, small tumor size and intensive wide excision, although most patients with MFH might have a poor prognosis. Because the tumor size of MFH tended to be large, especially that in the retroperitoneal cavity, wide excision with sufficient tumor-free margin is hard to guarantee.

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Hydrodistention of the bladder in patients with interstitial cystitis: clinical efficacy and its association with immunohistochemical findings for bladder tissues

井上 隆太, 高橋 聡, 砂押 研一, 市原 浩司, 舛森 直哉, 塚本 泰司

Acta urologica Japonica ( 泌尿器科紀要刊行会 )  52 ( 10 ) 765 - 768  2006.10

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対象は1996年5月～2005年5月に泌尿器科を受診し、間質性膀胱炎を疑った男4例女23例の27例(平均54.3歳)。間質性膀胱炎の診断は自覚症状と過去の治療歴(抗コリン薬や消炎鎮痛剤による治療で改善なし)に基づいた。尿細胞診にて異型細胞を認めないことを確認し、選択基準である膀胱鏡で点状出血、ハンナー潰瘍、膀胱痛、尿意切迫感を認める点は全例に当てはまった。22例に水圧療法前の膀胱内圧測定が可能で、初発尿意時の膀胱容量は75.2±46.3ml、最大膀胱容量は208.4±121.0mlで、注入中強い膀胱部痛を認め排尿筋活動は認められなかった。potassium sensibility test(PST)は13例に実施し11例が陽性であった。麻酔下膀胱鏡所見はハンナー潰瘍3例、点状出血26例、粘膜亀裂を10例に認めた。水圧療法の合併症で水圧療法中の膀胱破裂と急性腎盂炎が各1例にあり、膀胱破裂は小切開でのドレナージと7日間の尿道カテーテル留置、急性腎盂炎には輸液と抗菌薬投与で軽快した。We retrospectively analyzed the clinical relevance of hydrodistention under anesthesia for patients having urgency and/or lower abdominal pain who were clinically diagnosed as having interstitial cystitis (IC) from May 1996 to May 2005. Their symptoms were refractory to anticholinergic or antiinflammatory agents. Hydrodistention was performed under general or spinal anesthesia with direct vision by cystoscopy and irrigation fluid was instilled into the bladder at a pressure of 80 cmH2O. Cystoscopic findings revealed glomerulation in 26 patients (96%), cracking in 10 (37%) and Hunner's ulcer in 3. Twenty-four patients (89%) obtained improvement of the objective symptoms after treatment. However, symptoms soon deteriorated in 16 patients, and the average duration of efficacy was only 4.7 months (SD; +/-3.7). There were two episodes of complication in this treatment. Bladder rupture occurred during hydrodistention, but was successfully managed with simple percutaneous perivesical drainage. One patient with acute pyelonephritis was treated with an antimicrobial agent without any additional treatment. Although bladder specimens were examined by immunohistochemistry, tryptase and c-kit were not linked with the mast cell count, severity of symptoms or treatment efficacy. Hydrodistention of the bladder may be recommended as the first treatment choice for patients with IC because it provides relatively high efficacy. However, the short duration of the efficacy requires a second-line treatment option for better management of patients with IC.

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