Misc - TAKAHASHI Satoshi

Bactericidal effect of levofloxacin on strains with equal susceptibility in an in vitro urinary bladder model

S Takahashi, M Sano, M Nishimura, M Matsukawa, M Mikami, T Hirose, T Tsukamoto

CHEMOTHERAPY ( KARGER )  44 ( 5 ) 337 - 342  1998.09

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The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed, Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simulated to its clinically achievable urinary levels at the recommended dosage (100 mg 3 times daily), An isolate of P. aeruginosa for which the MIC of LVFX was 16 mu g/ml was completely eradicated after 10 h of exposure to LVFX, On the other hand, 40 h of exposure to LVFX were required for complete eradication of an isolate of E. faecalis with equal susceptibility, although the bacterial count was rapidly reduced to 10(2) CFU/ml in the early phase of the exposure, It was concluded that LVFX exerts a more potent bactericidal effect on P. aeruginosa than on E, faecalis despite a similar susceptibility of these organisms to LVFX.

DOI PubMed CiNii

Follow up of urology patients discharged with urinary methicillin-resistant Staphylococcus aureus

S Takahashi, T Hirose, K Takeyama, T Satoh, T Tsukamoto

JOURNAL OF HOSPITAL INFECTION ( W B SAUNDERS CO LTD )  37 ( 3 ) 249 - 251  1997.11

Rapid communication, short report, research note, etc. (scientific journal)  

A CLINICAL STUDY ON COMBINATION THERAPY OF ANTIMICROBIAL AGENTS FOR COMPLICATED URINARY TRACT INFECTION -With Special Reference to Combination with Clarithromycin-

SANO Masato, TAKAHASHI Satoshi, NISHIMURA Masahiro, HIROSE Takaoki, KUMAMOTO Yoshiaki, TSUKAMOTO Taiji, KOBAYASHI Yorimichi

The Japanese Journal of Urology ( The Japanese Urological Association )  88 ( 6 ) 596 - 604  1997

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(Purpose) To confirm the clinical efficacy of the combined therapy to complicated urinary tract infection (UTI), we conducted a comparative clinical study of the combined therapy with ciprofloxacin (CPFX) and clarithromycin (CAM) acting an biofilm elimination or CPFX alone in patients with complicated UTI.
(Patients and Methods) The study was carried out in patients with complicated UTI having WBCs with 5/hpf or more in urinary sediment and bacteriuria at least 10⁴CFU/ml. The combined therapy was CPFX and CAM, each 600mg/day, for 14 days, and the single therapy group CPFX, 600mg/day, for 14 days. On Day 7 and 14, the eradication rate and efficacy rate (according to the criteria of the Japanese UTI committee) were determined. In the patients with indwelling catheter, the surface of the catheter tip was observed under a scanning electron microscope (SEM) on Day 14.
(Results) In both cases with and without catheters, clinical efficacy was higher in the combined therapy group than in the single therapy group. In paricular, the efficacy rates at 14 Day were significantly higher in the former group. Furthermore, we investigated the theraupetic effect in the below MIC breakpoint of CPFX in complicated UTI. The combined therapy group showed a higher clinical efficacy in both cases with and without indwelling catheter than the single therapy group, although there was not statistically significant. Biofilm on the surface of the catheter tip was eliminated in 75% of the combined therapy group. However, none of the biofilm was eliminated in the single therapy group.
(Conclusion) From the above results, we surmise that the combined use of CPFX and CAM will show some degree of efficacy in eliminating both the causative organism and its biofilm in the complicated UTI.

DOI CiNii

前立腺癌の臨床的検討 : 第317回北海道地方会

笹村 啓人, 堀田 裕, 舛森 直哉, 塚本 泰司, 熊本 悦明, 高木 良雄, 高木 誠次, 丸田 浩, 西中 一幸, 田中 吉則, 田中 紀明, 林 謙治, 門野 雅夫, 田口 圭介, 横尾 彰文, 高塚 慶次, 高橋 聡, 梅原 次男, 三宅 正文, 尾田 寿朗, 青木 正治, 佐藤 隆志, 岩沢 晶彦, 国島 康晴

日本泌尿器科學會雜誌 ( 社団法人日本泌尿器科学会 )  85 ( 9 ) 1410 - 1410  1994.09

CiNii

LEYDIG-CELL TUMOR - A CASE-REPORT WITH REFERENCE TO ITS ENDOCRINOLOGIC FEATURES

N MASUMORI, Y KUMAMOTO, N ITOH, T TSUKAMOTO, N MIYAO, M KOROKU, T HIROSE, S TAKAHASHI

EUROPEAN UROLOGY ( KARGER )  24 ( 2 ) 302 - 304  1993

Article, review, commentary, editorial, etc. (scientific journal)  

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We reported an adult case of Leydig cell tumor, which demonstrated an increase of serum estradiol (E2) and suppression of serum testosterone (T) before orchiectomy. The direct inhibitory action of the elevated E2 on the enzymes involved in steroidogenesis and the negative feedback action on luteinizing hormone (LH) secretion of the E2 possibly caused the suppression of serum T. A human chorionic gonadotropin test before the operation revealed the elevation of T and E2, although the response was poor compared with that in normal subjects. However, the postoperative test showed no elevation of these hormones. This result may indicate that the Leydig cell tumor preserves a response to LH stimulation.