Details of a Researcher - SENGOKU Yasuhito

Papers - SENGOKU Yasuhito

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健常者の情報処理の特性を評価するための新しい二重課題法の開発

KITAJIMA HISAE, OYANAGI TOSHIO, SENGOKU YASUHITO, NAKAJIMA SONOMI, MITANI MASANOBU, TACHI NOBUTADA

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) ( 7 ) 105 - 109 2004.03

日常生活で複数の課題を同時並列的に処理する能力は重要であり、この能力を測定する方法として二重課題法という研究手法が用いられることが多い。しかし、リハビリテーション分野では治療に結びつけるという視点からの臨床的な評価方法は十分検討されていない。本研究では、二重課題に対する応答を一つの運動反応に限定した二重課題を開発し、健常者42名による実験を行い、二重課題として成立しているかを検討した。課題は単一課題である視覚弁別課題と聴覚弁別課題、また同じ視聴覚刺激を用いて弁別を行う二重課題とした。30名で単一課題と比較して二重課題の反応時間が遅延していた。また反応時間の遅延率も先行研究と類似していた。この結果から運動反応を限定した本課題でも同時並列的な処理能力を従来の二重課題法と同様に測定できることが示唆された。During activities of daily living, the ability to process many activities simultaneously is important for us. A methodology which is termed as the dual task paradigm is often used to investigate this ability. However, this paradigm is not reported for assessment from the viewpoint of connecting treatment for patients in the field of rehabilitation. Through this research we shall try to develop a new method of dual task assessment, whereas the response to the dual task is limited to not two but only one. We tested our approach with forty-two normal subjects and examined whether the new method is achieved as dual task paradigm or not. We implemented two single tasks (visual discrimination task and auditory discrimination task) and one dual task that demanded simultaneous discrimination of visual and auditory stimuli. As compared with reaction time of single tasks, the one for dual task increased for thirty of the subjects. In addition, the rate of delayed reaction time is similar to the one to previous studies. For the results our tasks will can measure the ability to process concurrent and parallel information during dual task performance.

DOI CiNii J-GLOBAL

札幌医科大学附属病院リハビリテーション部における小児理学療法の現状

KOZUKA NAOKI, TANIGUCHI SHIHO, SAWADA ATSUSHI, KANNO ATSUYA, TACHI NOBUTADA, SENGOKU YASUHITO, ISHIKAWA AKIRA, YOKOGUSHI KAZUTOSHI

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) ( 7 ) 111 - 114 2004.03

平成15年4月より、札幌医科大学医学部附属病院リハビリテーション部において、発達障害を中心とした小児のリハビリテーション治療を開始した。開始から平成16年3月時点までに、治療に関わった症例は21症例である。これらの症例に関して、そのプロフィールと実施した治療内容を中心に紹介し、加えて著変を示した1症例の報告をする中で、リハビリテーション部における小児リハビリテーションの現状と今後の展望を紹介することを本稿の目的とした。In this paper we present a current situation of pediatric physical therapy in the Division of Rehabilitation, Sapporo Medical University. In addition, we present the results of a survey of 21 case studies and 1 detail case report. Age, sex, diagnosis, purpose of hospitalization, content of physical therapy and so on were assessed for developmentally disordered children under therapeutic intervention during a twelve-month period between April, 2003 and March, 2004.

DOI CiNii J-GLOBAL

健常学齢児の平衡機能に関する研究

TAKIZAWA SATOSHI, SENGOKU YASUHITO, NAKAJIMA SONOMI, TACHI NOBUTADA

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) ( 7 ) 85 - 90 2004.03

健常の小学校の児童を低学年群（7歳と8歳）、中学年群（9歳と10歳）、高学年群（11歳と12歳）に分けて、平衡機能を比較検討した。対象となったのは、札幌市立Ｍ小学校に在籍する学級担任が体育科目で優れた児童と評価した、低学年群（38名）、中学年群（36名）、高学年群（38名）、計112名であった。重心動揺検査の結果、加齢に伴い、開眼・閉眼両条件で動揺面積や軌跡長が漸次減少するものの、統計的な有意差は認められなかった。しかし、開眼・閉眼条件間では全ての学年群で有意さが認められ、また、加齢に伴い測定値のばらつきも少なくなり、更に、動揺面積に比べると軌跡長の成熟が早い傾向が認められた。本研究結果からは、学齢期における重心動揺は、幼児期のような著しい減少傾向はないが、成人がとる値に向けて個人差が減少しながら接近していくという特徴が考えられた。また、重心動揺検査で測定される平衡機能の成熟過程が、被験者の発育や前庭感覚、固有感覚、視覚機能の成熟を適切に反映している可能性が示唆された。The equilibrium function of normal primary school students divided into three groups-lower grade (age 7 and 8, total 38), middle grade (age 9 and 10, total 36), and higher grade (age 11 and 12, total 38)- was studied using stabilometry. The (total 112) students were evaluated by the teachers as rating high in athletic ability. The results showed that a difference in the length and area of movements of the center of gravity between eyes open testing and eye closed testing was significantly large. However there were no differences noted in tests. The interesting features of these results were that, firstly, the score of the eyes closed testing was larger than that of the eye open testing; secondly, the older the students, the more the score gradually decreased in both tests; and thirdly, the maturity of the testees (those with high athletic ability) was more outstanding than that of other study reports. The first and second resulting features were similar to the other study reports. The third resulting feature suggests that students' growth and athletic ability might affect this.

DOI CiNii J-GLOBAL

半側空間無視患者に対する机上検査結果とADL場面での無視症状との関連

SASAKI TSUTOMU, SENGOKU YASUHITO, OYANAGI TOSHIO, TACHI NOBUTADA, NAKAJIMA SONOMI, SUGAMA KOSUKE

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) ( 7 ) 79 - 84 2004.03

半側空間無視（以下、USN）患者に用いる机上検査で測定される能力がどのように日常生活活動（以下、ADL）に反映されているのかを検討するために、USN患者20名を対象として、机上検査結果とADL場面でのUSN症状との関連性を分析した。結果、現在臨床で用いられている机上検査と特異的な関連性を示す具体的臨床症状は少なく、既存の方法で施行した机上検査、ADL評価では症状の発現に関連する能力の細分化は困難であると考えられた。この様な結果が得られた主要な原因としては、机上検査、ADL遂行に複数の能力が内包されていることが考えられた。USN発現に関与している能力の細分化をより明確にするための新しい評価手続きの開発が示唆された。To investigate how abilities measured by desk tasks, such as line bisection, line cancellation, affect on the performance of neglect patients in the ctivities of daily livings (ADL), we analyzed the correlation between the results of desk tasks and the performance in ADL of twenty neglect patients. Present study showed that no specific correlation between them appeared. We concluded that it would most provably hard to fractionate the abilities that caused neglect phenomenon by means of the traditional evaluation methods. These would be mainly due to that so many abilities involved in both desk tasks and ADL performance. It would be suggested that we need to develop a new evaluation procedure to fractionate the abilities that cause neglect phenomenon.

DOI CiNii J-GLOBAL

Database and Collaboration System for Sharing Multimedia Medical Information

OYANAGI TOSHIO, MITANI MASANOBU, SENGOKU YASUHITO, NAKAJIMA SONOMI, MIYAZAKI MASAKO

医療情報学 ( Japan Association for Medical Informatics ) 23 ( 6 ) 473 - 481 2004.02

We have been developing a tele-health system to share medical and health information among medical facilities and institutions by utilizing multi-media information technologies. We completed a development of collaboration tool, termed MediaCollaborator, which enables sharing motion images as well as still images among two or more people over a TCP/IP network. This paper presents some issues of MediaCollaborator first and then explains our approach to them. We developed a method to overcome the issues and implemented it as two software components: (1) a database to manage files of motion and still images and other documents; (2) a server system to integrate the database and MediaCollaborator. We show how the components work with MediaCollaborator in detail. We are certain that our system is less expensive, portable, flexible to integrate other software and technologies, and easy to use.

DOI CiNii J-GLOBAL

保育場面における1障害児の相互交渉について--関わり相手の違いによる相互交渉の比較

柳谷聡子, 中島そのみ, 仙石泰仁

北海道作業療法 ( 北海道作業療法士会 ) 21 ( 2 ) 87 - 94 2004

CiNii

[Non-radioactive PCR southern method for analysis of CTG repeat in myotonic dystrophy].

Naoki Kozuka, Nobutada Tachi, Kazuhiro Ohya, Eiji Uchida, Shin Kikuchi, Yasuhito Sengoku

No to hattatsu = Brain and development 35 ( 5 ) 380 - 7 2003.09 [Domestic journal]

Myotonic dystrophy (MyD) is a hereditary neuromuscular disorder of an autosomal dominant trait. MyD is caused by an expansion of unstable CTG trinucleotide repeat in the 3' untranslated region of mRNA coding myotonin protein kinase (MT-PK). We analyzed CTG repeat expansion in 10 patients with congenital MyD and their relatives using the non-radioactive PCR Southern method. The region containing the CTG repeat was amplified by PCR using specific primers. The PCR products were electrophoresed on a 1% agarose gel and transferred to a nylon membrane. The CTG repeat expansion was shown using a fluorescein-labelled (CTG) 10 probe. To estimate the number of CTG repeats, we compared the smears obtained on Southern blotting with a picture of PCR products and a DNA size marker (100 bp). We compared our results of radioactive Southern blotting for genomic DNA digested by Eco RI or Bgl I and for PCR products. In congenital MyD patients, heterogeneous smears (3.89-10.22 kb:about 1252-3362 CTG repeat) were observed, whereas in the adult type MyD had heterogeneous smears (0.92-1.82 kb:about 262-562 CTG repeat). In asymptomatic MyD patients, there were heterogeneous smears (0.35-1.16 kb:about 72-342 CTG repeat). These results demonstrated anticipation. We conclude that the non-radioactive PCR Southern method is useful and convenient for the DNA diagnosis of MyD.

PubMed

つまみ動作を用いた視覚刺激-運動協応課題による運動制御の測定

須鎌康介, 仙石泰仁, 中島そのみ, 金谷匡紘, 佐々木努, 北島久恵

北海道作業療法 ( (公社)北海道作業療法士会 ) 20 ( Suppl. ) 80 - 80 2003.09 [Refereed]

[Non-radioactive PCR southern method for analysis of CTG repeat in myotonic dystrophy].

Naoki Kozuka, Nobutada Tachi, Kazuhiro Ohya, Eiji Uchida, Shin Kikuchi, Yasuhito Sengoku

No to hattatsu = Brain and development 35 ( 5 ) 380 - 7 2003.09 [Domestic journal]

PubMed

つまみ動作を用いた視覚-運動反応課題における反応時間について

金谷匡紘, 仙石泰仁, 中島そのみ, 須鎌康介, 佐々木努, 杉原俊一

北海道作業療法 ( (公社)北海道作業療法士会 ) 20 ( Suppl. ) 79 - 79 2003.09 [Refereed]

Molecular genetic analysis of X-linked recessive myotubular myopathy

Uchida Eiji, Tachi Nobutada, Kozuka Naoki, Kikuchi Shin, Sengoku Yasuhito, Takeda Hidekatsu

Bulletin of School of Health Sciences, Sapporo Medical University ( 札幌医科大学 ) 6 ( 6 ) 49 - 58 2003.03

The purposes of this study are to establish the effective and efficient screening protocol identifying the gene mutation, and to clarify the relationship between genotype and phenotype of Xlinked myotubular myopathy (XLMTM) using the molecular genetic method. Five male patients in five families with XLMTM based on clinical features and muscle biopsy were analyzed according to the screening protocol. Three types of abnormal band were identified by SSCP and HD analysis using genomic DNA from patients. In the direct sequence analysis, two frameshift mutations in exon 4 and 10 and one nonsense mutation in exon 3 were found. Frameshift mutation in exon 10 was a novel mutation. RT-PCR method was performed to the other patients who showed no abnormal bands by SSCP and HD. In the direct sequence analysis, one missense mutation was found in exon 9. This mutation was a novel mutation. The relationship between phenotype and genotype was not clarified. The screening protocol employed in this study detected the three mutations in genomic DNA and the one mutation in cDNA. The patient whom the mutation was not found was supposed to have the mutation in non-coding region of MTM1 gene. Present protocol is considered to be suitable to detect the mutations in XLMTM. 本研究は遺伝性筋疾患であるX-linked myotubular myopathy（XLMTM）における遺伝子解析において、遺伝子変異を検出する効果的かつ効率的なスクリーニング方法を規定すること、および本疾患の表現型と遺伝子型の関連を明らかにすることを目的とした。対象は臨床症状および筋生検によって重症のXLMTMと診断された５家系５名の男児とし、スクリーニングプロトコルにしたがって解析を行った。その結果、ゲノムDNAを用いたSSCPおよびHD解析において５名の患者のうち、３名について泳動変異を検出した。これらの直接塩基配列決定の結果、２名のフレームシフト変異（エクソン４および10）と１名のナンセンス変異（エクソン３）が確認された。エクソン10におけるフレームシフト変異はこれまで報告例のない新しい変異であった。ゲノムDNAを用いたスクリーニングで泳動変異が観察されなかった２名の患者に対してはRT?PCR法を用いたcDNAの直接塩基配列決定を行った。その結果、１名のミスセンス変異（エクソン９）を同定し、これまで報告例のない新しい変異であることを確認した。残り１名については変異が確認できなかった。表現型と遺伝子型の関係については、すべての患者が重症例であったこと、症例数が少なかったことから明らかにできなかった。本研究ではゲノムDNAで３名、cDNAで１名の遺伝子変異を確認したが、変異を確認できなかった患者は非翻訳領域に変異が存在する可能性が考えられた。これらの結果から、本研究で実施したスクリーニングプロトコルはXLMTMにおける遺伝子変異検出に対し十分適切であることが考えられる。

DOI CiNii

父親由来小児筋強直性ジストロフィー症に関する研究

KIKUCHI SHIN, KOZUKA NAOKI, UCHIDA EIJI, SENGOKU YASUHITO, HORIMOTO YOSHITAKA, OYA KAZUHIRO, TAKEDA HIDEKATSU, TACHI NOBUTADA

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) ( 6 ) 43 - 48 2003.03

筋強直性ジストロトロフィー症（DM）は成人発症筋ジストロフィーの中で最も多い疾患であり、19q13.3に存在するCTGリピートが異常増大することによって発症する。DMが全身多臓器疾患であり、様々な臨床症状がみられる。最も重篤なタイプは先天型DM（CDM）である。CDMは患者である母親から遺伝することがほとんどである。しかし、父親由来CDMの報告もみられ、臨床症状とCTGリピートの増大に父親由来または母親由来の影響についても報告されている。そこで、我々は父親由来CDMの５家系と母親由来CDMの２家系を対象に臨床症状とCTGリピート数の比較を行なった。CTGリピート数の決定にはnon RI-PCRサザンブロット法を用い、臨床症状については13項目について調査した。親の相違によりCTGリピートと臨床症状に違いはみられなかった。また、父親由来CDMは母親由来CDMと比較して、CTGリピートが小さく、臨床症状も軽度であった。保因者が母親であった場合、子宮内あるいは他の母親由来の因子がDMの子に影響しているものと思われる。Myotonic Dystrophy (DM), the most common muscular atrophy in adult, is caused by abnormal expansion CTG repeats in 19q13.3. DM is a multisystemic disorder with a high phenotypic variability. The most severe type of DM is Congenital DM (CDM). CDM is transmitted from the affected mother. However, some cases of paternally transmitted CDM have been reported. The intergenerational increase in severity is influenced by the sex. Here, we compared five paternal CDM families with two maternal DM families in terms of the clinical symptoms and the size of CTG repeat expansion. The detection of the number of CTG repeats was performed by non RI-PCR Southern blot hybridization. The clinical features of 13 items were discussed. There was no difference in CTG repeat length and clinical features between the fathers and mothers. Paternal CDM resulted in shorter CTG repeat length and lighter severity of the clinical symptoms in the affected offspring than maternal CDM. When the carrier was the mother, intrauterine or other maternal factors might have been involved in the transmission of the DM.

DOI CiNii J-GLOBAL

黒龍江省小児脳性麻痺防治療育中心(黒龍江省脳性麻痺療育センター)における肢体不自由児療育の現状

KOZUKA NAOKI, TACHI NOBUTADA, SENGOKU YASUHITO, CHEN XIUJIE, ZHANG LIHUA, LI HAIHUA, HUO XIU ZHI, JIANG ZHI MEI, LI XIAO JIE, LI LIN, AOYAMA HIROSHI, INUI KIMIHARU

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) 6 ( 6 ) 87 - 91 2003.03

平成14年７月21日から８月４日までの15日間、北海道保健福祉部と中華人民共和国黒龍江省衛生庁との療育技術および理学療法・作業療法に関する人材養成事業の一環として、黒龍江省佳木斯市の佳木斯大学康復医学院で教鞭を執り、時同じく黒龍江省小児脳性麻痺防治療育中心（黒龍江省脳性麻痺療育センター）にて現地の肢体不自由児およびその家族に対する療育指導に携わる貴重な機会を得た。その際、実際に治療および指導を実施した16症例の診断名、在胎週数、出生体重、発達障害を引き起こしたと考えられる危険因子、運動発達レベル、現在実施中の運動療法、発生している下肢変形について調査した。これらの結果を含め、現在の黒龍江省脳性麻痺療育センターが抱えている問題、あるいは当センターの現状に代表される中華人民共和国の肢体不自由児療育の現状を報告することを本稿の目的とした。In this paper we present specific measures that will insure better rehabilitation in the Treatment and Rehabilitation Center for Child Cerebral Palsy in Heilongjiang Province, People's Republic of China. In addition, we present the results of a survey of 16 case studies(14 were children with cerebral palsy and 2 were children with mental retardation). Gestational age, birth weight, prenatal risk factors and so on were assessed for developmentally disordered children under therapeutic intervention in this center during a fifteen-day period between July 21, and August 4, 2002.

DOI CiNii J-GLOBAL

視覚刺激に対応した目と手の協応課題による不器用さの分析―視覚刺激に対応した目と手の協応課題による不器用さの分析に向けて―

SUGAMA KOSUKE, SENGOKU YASUHITO, NAKAJIMA SONOMI, SASAKI TSUTOMU, TANAKA TOSHIAKI

札幌医科大学保健医療学部紀要 ( 札幌医科大学 ) 6 ( 6 ) 59 - 67 2003.03

学習障害児や注意欠陥多動性障害児などの軽度発達障害児はそれぞれの主症状とともに、巧緻動作の未熟さなど不器用さが主訴としてあげられることが多く、姿勢調節や目と手の協応性の問題などの影響が指摘されている。今回、視覚刺激に誘導された運動制御を測定する機器の開発を行った。測定課題は水平方向へ移動する光点に合わせて左右のつまみ力を調整するものであり光点の動きとの時間的なずれと力の調節の相違を分析した。その結果、運動開始のタイミングは片手に比べ両手で行ったときに向上することが明らかになり、つまみ力の調整でも片手での試行に比べ両手での試行がより光点の動きに合わせることが可能であることが明らかになった。今回の視覚刺激?運動協応課題の結果が目と手の協応性を評価する机上検査に影響を与える可能性が示唆された。さらに、固有受容覚や触覚からの情報と視覚的情報の関与の度合いがタイミングや力の調節能に影響を与える可能性が示唆された。Awkward motor activities in children having mild developmental disorders may be related to a variety of factors. We developed an instrument for assessing disturbances of eye-hand coordination which may lead to awkward motor activities. The instrument consisted of a visual stimulation program where the subject tracks a light spot on a monitor with the use of a pinch-meter. The subject had to adjust their pinch forces in order to track the light spot as a visual target. Three experimental procedures were carried out using the right hand, the left hand, and finally both hands in all right-handed subjects. These experimental procedures analyzed two variables, one being the time lag between the moving target and the time of change in the pinch-force. The results showed that the time lag was reduced in the case of the right hand, the left hand, and then using both hands. Results showed that coordination of pinch-force with both hands were superior to the one hand alone. Some subjects who received a low score in the traditional motor accuracy test also had a rather large time lag. Our results suggested that the functional difference of eye-hand coordination between the right and the left hands might be influenced by visio-motor central ability. Furthermore, our results seem to indicate that the information of proprioceptional and tactile sensation may be improved in the areas of timing and the processing of visual stimulation.

DOI CiNii J-GLOBAL

An occupational therapy for a patient who showed disturbance of executive function after right putaminal hemorrhage.

MIYAMAE CHIHIRO, HARADA TAKUYA, SENGOKU YASUHITO

作業療法 ( 日本作業療法士協会 ) 22 ( 1 ) 53 - 61 2003.02

DOI CiNii J-GLOBAL

Non-radioactive PCR southern method for analysis of CTG repeat in myotonic dystrophy

Naoki Kozuka, Nobutada Tachi, Kazuhiro Ohya, Eiji Uchida, Shin Kikuchi, Yasuhito Sengoku

No To Hattatsu 35 ( 5 ) 380 - 387 2003

Myotonic dystrophy (MyD) is a hereditary neuromuscular disorder of an autosomal dominant trait. MyD is caused by an expansion of unstable CTG trinucleotide repeat in the 3′ untranslated region of mRNA coding myotonin protein kinase (MT-PK). We analyzed CTG repeat expansion in 10 patients with congenital MyD and their relatives using the non-radioactive PCR Southern method. The region containing the CTG repeat was amplified by PCR using specific primers. The PCR products were electrophoresed on a 1% agarose gel and transferred to a nylon membrane. The CTG repeat expansion was shown using a fluorescein-labelled (CTG) 10 probe. To estimate the number of CTG repeats, we compared the smears obtained on Southern blotting with a picture of PCR products and a DNA size marker (100 bp). We compared our results of radioactive Southern blotting for genomic DNA digested by Eco RI or Bgl I and for PCR products. In congenital MyD patients, heterogeneous smears (3.89-10.22kb: about 1252-3362 CTG repeat) were observed, whereas in the adult type MyD had heterogeneous smears (0.92-1.82kb: about 262-562 CTG repeat). In asymptomatic MyD patients, there were heterogeneous smears (0.35-1.16kb: about 72-342 CTG repeat). These results demonstrated anticipation. We conclude that the non-radioactive PCR Southern method is useful and convenient for the DNA diagnosis of MyD.

DOI PubMed CiNii J-GLOBAL

黒龍江省小児脳性麻痺防治療育中心（黒龍江省脳性麻痺療育センター）における肢体不自由児療育の現状

小塚直樹, 舘延忠, 仙石泰仁, Chen, X. Zhang, L. Li, H. Huo Xiu, Z. Jiang Zhi, M. Li Xiao, J. Li, L, 青山宏, 乾公美

札幌医科大学保健医療学部紀要 6 49 - 58 2003 [Refereed]

神経疾患クロナゼパムの中止によって多動の消失したLennox症候群の1例

TACHI NOBUTADA, INOUE TOMOKO, SENGOKU YASUHITO

小児科臨床 ( 日本小児医事出版社 ) 55 ( 8 ) 1597 - 1601 2002.08

CiNii J-GLOBAL

クロナゼパムの中止によって多動の消失したLennox症候群の1例 (主題神経疾患)

舘延忠, 井上知子, 仙石泰仁

小児科臨床 ( 日本小児医事出版社 ) 55 ( 8 ) 1597 - 1601 2002.08

CiNii

Preliminary study of developmental characteristics of the relation between prehension and manipulation of drawing device during precision drawing tasks.

NAKAJIMA SONOMI, SENGOKU YASUHITO, NAKAMURA MARIKO

作業療法 ( 日本作業療法士協会 ) 21 ( 2 ) 109 - 117 2002.04

DOI CiNii J-GLOBAL

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