研究者詳細 - 大西　浩文

論文 - 大西　浩文

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Machine learning-based analyses of contributing factors for the development of hypertension: a comparative study.

Marenao Tanaka, Yukinori Akiyama, Kazuma Mori, Itaru Hosaka, Keisuke Endo, Toshifumi Ogawa, Tatsuya Sato, Toru Suzuki, Toshiyuki Yano, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi

Clinical and experimental hypertension (New York, N.Y. : 1993) 47 ( 1 ) 2449613 - 2449613 2025年12月 [国際誌]

OBJECTIVES: Sufficient attention has not been given to machine learning (ML) models using longitudinal data for investigating important predictors of new onset of hypertension. We investigated the predictive ability of several ML models for the development of hypertension. METHODS: A total of 15 965 Japanese participants (men/women: 9,466/6,499, mean age: 45 years) who received annual health examinations were randomly divided into a training group (70%, n = 11,175) and a test group (30%, n = 4,790). The predictive abilities of 58 candidates including fatty liver index (FLI), which is calculated by using body mass index, waist circumference and levels of γ-glutamyl transferase and triglycerides, were investigated by statistics analogous to the area under the curve (AUC) in receiver operating characteristic curve analyses using ML models including logistic regression, random forest, naïve Bayes, extreme gradient boosting and artificial neural network. RESULTS: During a 10-year period (mean period: 6.1 years), 2,132 subjects (19.1%) in the training group and 917 subjects (19.1%) in the test group had new onset of hypertension. Among the 58 parameters, systolic blood pressure, age and FLI were identified as important candidates by random forest feature selection with 10-fold cross-validation. The AUCs of ML models were 0.765-0.825, and discriminatory capacity was significantly improved in the artificial neural network model compared to that in the logistic regression model. CONCLUSIONS: The development of hypertension can be simply and accurately predicted by each ML model using systolic blood pressure, age and FLI as selected features. By building multiple ML models, more practical prediction might be possible.

DOI PubMed

Biomechanical effects of fascial hydrorelease: a cadaveric study

Kousuke Shiwaku, Hidenori Otsubo, Daisuke Suzuki, Calmero Pirri, Taiki Kodesyo, Tomoaki Kamiya, Keigo Taniguchi, Hirofumi Ohnishi, Atsushi Teramoto, Carla Stecco

BMC Musculoskeletal Disorders ( Springer Science and Business Media LLC ) 26 ( 1 ) 2025年03月

DOI

Utility of a Wearable Tracker to Assess Sleep Quality in Nurses and Their Spouses: A Prospective Cohort Study

Tomohiro Ishinuki, Erika Goda, Hiroomi Tatsumi, Goro Kutomi, Toshio Ohyanagi, Hirofumi Ohnishi, Yoshiki Masuda, Thomas T. Hui, Toru Mizuguchi

SAGE Open Nursing ( SAGE Publications ) 11 2025年01月

Introduction Sleep disturbances among nurses engaged in night duty and their spouses need to be improved to ensure their ability to provide care and perform daily tasks. Therefore, an objective investigation is needed to establish a sleep improvement strategy. Objective To investigate the utility of a sleep tracker to assess sleep quality in nurses and spouses. Method Nurses ( n = 30) and spouses ( n = 30) wore a sleep tracker for 14 days to investigate sleep scores. Sleep quality and number of steps were evaluated by Fitbit. They responded to the Richards-Campbell Sleep Questionnaire and Pittsburgh Sleep Quality Index. A multiple regression analysis was performed to identify the factors affecting sleep quality. Results Factors affecting sleep scores in nurses were hypnotic medication, night duty, and steps, while those in spouses were mental instability, hypnotic medication, alcohol, night duty, and steps. Factors affecting the Richards-Campbell Sleep Questionnaire in nurses were household chores, night duty, and steps, while those in spouses were hypnotic medication and steps. Conclusion The sleep quality of nurses was affected by household chores, hypnotic medication, night duty, and steps. Besides the factors of nurses, spouses were affected by mental instability and alcohol. Night duty affected negativity in both nurses and spouses. Steps exerted positive effects in both the sleep tracker and the Richards-Campbell Sleep Questionnaire. The sleep tracker may be useful for identifying factors that improve sleep quality.

DOI

The serum γ-Glutamyltransferase Level is Associated with the Development of Hypertension in Alcohol Infrequent Drinkers but not in Frequent Drinkers

Kazuma Mori, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi

Internal Medicine ( Japanese Society of Internal Medicine ) 2025年

DOI

Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan.

Naomi Maeda, Masayuki Koyama, Shintaro Takatsuka, Keisuke Oyatani, Nobuaki Himuro, Tasuku Mariya, Yoshika Kuno, Shiro Hinotsu, Tsuyoshi Saito, Hirofumi Ohnishi

PloS one 20 ( 2 ) e0319177 2025年 [国際誌]

BACKGROUND: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. OBJECTIVE: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. METHODS: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. RESULTS: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25-29 years, at 5.58% (95% confidence interval [CI]: 5.43-5.73), and increased with age, peaking at 10.58% (95% CI: 10.10-11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97-7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² = 0.87, p < 0.01). CONCLUSION: This study reveals that the risk of developing HDP is associated with both older childbearing and younger pregnancies and follows a J-curve, suggesting that factors other than maternal aging also contribute to the increased incidence of HDP and that further research on risk factors for HDP, which is on the rise worldwide, is urgently needed.

DOI PubMed

High Intraocular Pressure Is Independently Associated With New-Onset Systemic Hypertension Over a 10-Year Period

Araya Umetsu, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo, Kazuma Mori, Hirofumi Ohnishi, Megumi Watanabe, Hiroshi Ohguro, Nagisa Hanawa, Masato Furuhashi

Circulation Journal ( Japanese Circulation Society ) 2024年07月

DOI

Prediction of the future number of fall-related emergency medical services calls in older individuals.

Shuji Uemura, Ryuichi Nakayama, Masayuki Koyama, Yukiko Taguchi, Naofumi Bunya, Keigo Sawamoto, Hirofumi Ohnishi, Eichi Narimatsu

International journal of emergency medicine 17 ( 1 ) 72 - 72 2024年06月 [国際誌]

BACKGROUND: Falls among older individuals contribute significantly to the rise in ambulance transport use. To recognize the importance of future countermeasures, we estimated the projected number and percentage of fall-related emergency medical service (EMS) calls. METHODS: We examined the sex, age group, and location of falls among patients aged ≥ 65 years who contacted emergency services in Sapporo City from 2013 to 2021. Annual fall-related calls per population subgroup were calculated, and trends were analyzed. Four models were used to estimate the future number of fall-related calls from the 2025-2060 projected population: (1) based on the 2022 data, estimates from the 2013-2022 data using (2) Poisson progression, (3) neural network, (4) estimates from the 2013-2019 data using neural network. The number of all EMS calls was also determined using the same method to obtain the ratio of all EMS calls. RESULTS: During 2013-2022, 70,262 fall-related calls were made for those aged ≥ 65 years. The rate was higher indoors among females and outdoor among males in most age groups and generally increased with age. After adjusting for age, the rate increased by year. Future estimates of the number of fall calls are approximately double the number in 2022 in 2040 and three times in 2060, with falls accounting for approximately 11% and 13% of all EMS calls in 2040 and 2060, respectively. CONCLUSION: The number of fall-related EMS calls among older people is expected to increase in the future, and the percentage of EMS calls will also increase; therefore, countermeasures are urgently needed.

DOI PubMed

慢性腎臓病と代謝異常関連脂肪肝疾患(MAFLD)との合併は虚血性心疾患の発症リスクを増加させる

宮森大輔, 田中希尚, 佐藤達也, 遠藤圭佑, 森和真, 塙なぎさ, 大西浩文, 古橋眞人

日本腎臓学会誌 ( (一社)日本腎臓学会 ) 66 ( 4 ) 652 - 652 2024年06月

慢性腎臓病と代謝異常関連脂肪肝疾患(MAFLD)との合併は虚血性心疾患の発症リスクを増加させる

宮森大輔, 田中希尚, 佐藤達也, 遠藤圭佑, 森和真, 塙なぎさ, 大西浩文, 古橋眞人

日本腎臓学会誌 ( (一社)日本腎臓学会 ) 66 ( 4 ) 652 - 652 2024年06月

Cross-cultural adaptation, validity and reliability of the Japanese version of ABILHAND-kids for children with cerebral palsy using Rasch measurement model.

Sayaka Katori, Nobuaki Himuro, Yukihiro Kitai, Ryo Tanabe, Hirofumi Ohnishi

Disability and rehabilitation 1 - 9 2024年04月 [国際誌]

PURPOSE: The aim of this study was to develop the Japanese version of the ABILHAND-Kids and to examine its psychometric properties for Japanese children with cerebral palsy (CP). METHODS: The experimental version of 75 items was developed using forward-backward translation method. Parents of 137 children with CP answered it. Their responses were analyzed to successive items, and psychometric properties of the final version were investigated through the Rasch measurement model. RESULTS: The Japanese version of the ABILHAND-Kids contained 22 items. It showed valid item-patient targeting, no significant floor and ceiling effects, and no differential item functioning for demographic and clinical subgroups. All items contributed to the definition of one-dimensional measure. For internal consistency, the person separation index was 0.94. For test-retest reliability, the intraclass correlation coefficients were 0.96 (95% CI: 0.92-0.98). The minimal detectable difference was calculated with a logit score of 0.79 and a total raw score of 4.50. The logit score showed a strong correlation with the Manual Ability Classification System level (ρ= -0.70) and the Gross Motor Function Classification System level (ρ= -0.62). CONCLUSIONS: The Japanese version of the ABILHAND-Kids was found to be valid and reliable. It appears to be a good tool for assessing manual abilities in daily activities in children with CP.

DOI PubMed

Sampsonの式あるいは人工知能を用いて推定したsmall dense LDLコレステロール値の精度の検証

大久保武志, 遠藤圭佑, 田中希尚, 佐藤達也, 小林亮, 田中真輝人, 秋山幸功, 保坂到, 中田圭, 小山雅之, 大西浩文, 高橋聡, 古橋眞人

糖尿病 ( (一社)日本糖尿病学会 ) 67 ( Suppl.1 ) S - 251 2024年04月

Sampsonの式あるいは人工知能を用いて推定したsmall dense LDLコレステロール値の精度の検証

大久保武志, 遠藤圭佑, 田中希尚, 佐藤達也, 小林亮, 田中真輝人, 秋山幸功, 保坂到, 中田圭, 小山雅之, 大西浩文, 高橋聡, 古橋眞人

糖尿病 ( (一社)日本糖尿病学会 ) 67 ( Suppl.1 ) S - 251 2024年04月

Sampson方程式による小型低密度リポ蛋白質コレステロールは虚血性心疾患発症の優れた予測因子である

印鑰雅史, 佐藤達也, 佐藤達也, 田中希尚, 田中希尚, 遠藤圭佑, 保坂到, 三上拓真, 大西浩文, 塙なぎさ, 古橋眞人

日本循環器学会学術集会(Web) ( (一社)日本循環器学会 ) 88回 OJ03 - 2 2024年03月

J-GLOBAL

Sampsonの式で算出したsmall dense LDLコレステロールは虚血性心疾患発症の有力な予測因子である(Calculated Small Dense Low-density Lipoprotein Cholesterol by Sampson Equation is a Predominant Predictor for the Development of Ischemic Heart Disease)

印鑰雅史, 佐藤達也, 田中希尚, 遠藤圭佑, 保坂到, 三上拓真, 大西浩文, 塙なぎさ, 古橋眞人

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 ) 88回 OJ03 - 2 2024年03月

児童の手洗いを科学するアクションリサーチ ATPを用いた可視化の検討

大浦麻絵, 中田圭, 内藤由紀子, 大岩大祐, 小山雅之, 長多好恵, 助友裕子, 大西浩文

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 ) 37 ( 2 ) 65 - 69 2024年03月

目的:小学校教育において実践している手洗い健康教育プログラムに新たにATP(アデノシン三リン酸)検査を導入した.科学的な指標を用い,児童の手の汚れを可視化させた.汚れの可視化を導入した手洗い教育プログラムの有効性に関する資料とすることを目的とした.方法:北海道札幌市公立小学校の放課後教室でpilot studyを実施した.16人の児童に対し,IDで連結した無記名自記式アンケート調査と手洗い前後のATP検査を実施した.結果:全体における手洗い後のATP値は(中央値(四分位範囲)=4968.5(3589.0,7481.8)であり手洗い前(67738.0(56702.5,85732.5))と比べて減少していた(p<0.05).3～5年生に限定しても,手洗い後のATP値(4739.0[3249.0,7481.8])は手洗い前(67738.0[58527.3,85732.5])に比べて減少していた(p<0.05).1,2年生においては,差は認められなかった(p=0.07).活動評価:発達がより一律となる高学年の方がより深い理解や応用的な考え方が出来ることで,手洗いが上手であった可能性が考えられた.ATP検査は客観的指標として手洗い力などとして教育効果を測る新たな視点として有効であることが示唆された.(著者抄録)

J-GLOBAL

子ども達から子ども達へ伝えるピア健康教育の実践病気の予防プロジェクト2022

大浦麻絵, 大西浩文, 中田真由, 小山雅之, 中田圭, 長多好恵, 長谷川準子, 助友裕子, 森満

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 ) 37 ( 2 ) 137 - 141 2024年03月

本稿では札幌市内小中学校を中心として取り組んでいる「病気の予防プロジェクト」より2022年度に実施した札幌市立小学校2校での活動を紹介する.病気の予防プロジェクトは,子ども達が主体的にエビデンス(科学的根拠)に基づいた知識を学び,学びを深化させ,他者に情報発信するActive Learningプログラムである.N小学校では6年生は他校の生徒や札幌市民へ,F小学校では3年生が1,2年生を中心に全校へ向け情報発信を行った."コロナ禍において,自分達にも何かできることはないだろうか?"子ども達の素直な気持ちを活かした健康教育活動とするため,学校と学校を取り巻く地域資源の一つである大学の研究班とが連携して実施した.本活動は健康教育が目指すセルフエスティームを基盤としており,活動状況から子ども達の社会性,自己肯定感を自然な形で育むことが出来る可能性が考えられた.(著者抄録)

J-GLOBAL

脳性麻痺児における介助のしやすさに関連する因子の特定システマティックレビュー

井上孝仁, 和泉裕斗, 樋室伸顕, 西部寿人, 井上和広, 藤坂広幸, 大西浩文

小児理学療法学 ( (一社)日本小児理学療法学会 ) 2 ( Suppl.1 ) 122 - 122 2024年03月

J-GLOBAL

The Contributions of Knee Extension Strength and Hand Grip Strength to Factors Relevant to Physical Frailty: The Tanno-Sobetsu Study.

Toshiaki Seko, Hiroshi Akasaka, Masayuki Koyama, Nobuaki Himuro, Shigeyuki Saitoh, Shunichi Ogawa, Sayo Miura, Mitsuru Mori, Hirofumi Ohnishi

Geriatrics (Basel, Switzerland) 9 ( 1 ) 2024年01月 [国際誌]

Sarcopenia is the core factor of frailty. This study specifically focused on lower limb muscle strength and examined muscle indices that indicate the risk of frailty or pre-frailty in older adults. The study included 327 community-dwelling individuals aged ≥65 years (43.7% male) who participated in the cohort. Frailty was defined based on five symptoms: weight loss, low activity level, exhaustion, weakness and slowness. Participants were classified into frail (three or more applicable), pre-frail (one to two applicable) and non-frail groups. Muscle strength (knee extension strength, toe grip strength and hand grip strength) were assessed, and appendicular muscle mass was assessed via a bioelectrical impedance analysis. The adjusted odds ratio (OR) of muscle indices for with frailty (frail group vs. pre-frail group) or pre-frailty (pre-frail group vs. non-frail group) were calculated. The prevalence of frail and pre-frail was 7% and 40%, respectively. Adjusted for age, sex, albumin and medical history, knee extension strength was significantly associated with frailty (odds ratio 0.95, 95% CI 0.92-0.98), while hand grip strength was associated with pre-frailty (odds ratio 0.92, 95% CI 0.88-0.97) but not with other muscle indices. This study is significant for identifying knee extension strength as a factor relevant to frailty in older adults considered pre-frailty, emphasizing the importance of this specific muscle measure in predicting and managing frailty.

DOI PubMed

Science behind children's handwashing: action study of 9- to 10-years-old elementary school students in Japan.

Asae Oura, Yukiko Naito, Hiroko Yako-Suketomo, Kei Nakata, Masayuki Koyama, Hirofumi Ohnishi

Frontiers in public health 12 1425646 - 1425646 2024年 [国際誌]

BACKGROUND: Hand washing instructions for children have been implemented in school education to establish good lifestyle habits. However, repeated hand washing through education from early childhood was common for both teachers and children. If this continues, children might assume they already know how to wash their hands, stop taking handwashing instructions seriously, and become increasingly lax about washing their hands. PURPOSE: This study aimed to develop a new handwashing education method for children. METHODS: We applied the adenosine triphosphate (ATP) test to health education on hand washing in elementary schools. This study was conducted as part of a class for elementary school students in October 2023, in Hokkaido, Japan. The subjects were 157 third-grade (9-10 years old) elementary school students. After excluding absent pupils, 147 were included in the analysis. RESULTS: Both pre- and post-education, ATP values after handwashing were lower than those before handwashing. Following the education, children's handwashing behavior improved, with an increase in the number of point washed and appropriate timing of handwashing. CONCLUSION: The new handwashing education program utilizing the ATP-test succeeded in promoting handwashing behavior among many children. Visualizing handwashing using ATP values was effective in motivating children.

DOI PubMed

Validation of Estimated Small Dense Low-Density Lipoprotein Cholesterol Concentration in a Japanese General Population.

Keisuke Endo, Ryo Kobayashi, Makito Tanaka, Marenao Tanaka, Yukinori Akiyama, Tatsuya Sato, Itaru Hosaka, Kei Nakata, Masayuki Koyama, Hirofumi Ohnishi, Satoshi Takahashi, Masato Furuhashi

Journal of atherosclerosis and thrombosis 2023年12月 [国内誌]

AIM: A high level of directly measured small dense low-density lipoprotein cholesterol (sdLDL-C) is a strong risk factor for atherosclerotic cardiovascular disease. A method for estimating sdLDL-C by using Sampson's equation that includes levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C and triglycerides (TG) has recently been proposed. We investigated the validation and exploration of estimated sdLDL-C level. METHODS: The associations between measured and estimated sdLDL-C levels were investigated in 605 Japanese subjects (men/women: 280/325; mean age: 65±15 years) who received annual health check-ups in the Tanno Sobetsu Study, a population-based cohort. RESULTS: Estimated sdLDL-C level was highly correlated with measured sdLDL-C level in all subjects (R2 =0.701), nondiabetic subjects without any medication (n=254, R 2=0.686) and subjects with diabetes mellitus (n=128, R2=0.721). Multivariable regression analysis showed that levels of non-HDL-C, TG and γ-glutamyl transpeptidase (γGTP) were independent predictors of measured sdLDL-C level. In a stratification of the LDL window, all of the subjects with a combination of high non-HDL-C (≥ 170 mg/dL) and high TG (≥ 150 mg/dL) had high levels of measured and estimated sdLDL-C (≥ 35 mg/dL). Furthermore, machine learning-based estimation of sdLDL-C level by artificial intelligence software, Prediction One, was substantially improved by using components of Sampson's equation (R2=0.803) and by using those components with the addition of γGTP and deletion of TC (R2=0.929). CONCLUSIONS: sdLDL-C level estimated by Sampson's equation can be used instead of measured sdLDL-C level in general practice. By building multiple machine learning models of artificial intelligence, a more accurate and practical estimation of sdLDL-C level might be possible.

DOI PubMed

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