論文 - 大西　浩文

一般住民におけるFatty Liver Index(FLI)と高血圧発症との関連

東浦 幸村, 古橋 眞人, 田中 希尚, 大西 浩文, 三浦 哲嗣

日本動脈硬化学会総会プログラム・抄録集 ( (一社)日本動脈硬化学会 )  53回   186 - 186  2021年10月

Fatty Liver Index(FLI)は新規高血圧発症の独立した予測因子である

東浦 幸村, 古橋 眞人, 田中 希尚, 高橋 聖子, 山下 智久, 小山 雅之, 大西 浩文, 斎藤 重幸, 三浦 哲嗣, 塙 なぎさ

日本高血圧学会総会プログラム・抄録集 ( (NPO)日本高血圧学会 )  43回   217 - 217  2021年10月

J-GLOBAL

一般住民におけるFatty Liver Index(FLI)と高血圧発症との関連

東浦 幸村, 古橋 眞人, 田中 希尚, 大西 浩文, 三浦 哲嗣

日本動脈硬化学会総会プログラム・抄録集 ( (一社)日本動脈硬化学会 )  53回   186 - 186  2021年10月

J-GLOBAL

Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population

Masato Furuhashi, Akiko Sakai, Marenao Tanaka, Yukimura Higashiura, Kazuma Mori, Masayuki Koyama, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto

Hypertension ( Ovid Technologies (Wolters Kluwer Health) )  78 ( 4 ) 1138 - 1149  2021年08月  [国際誌]

　概要を見る

Severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 invades the host through ACE (angiotensin-converting enzyme) 2 as the host cellular receptor for a viral spike protein. ACE2 converts angiotensin II to angiotensin-(1–7) and cleaved ACE2 is detectable in urine and plasma. However, regulation of U-ACE2 (urinary ACE2) and P-ACE2 (plasma ACE2) and their alterations by renin-angiotensin-aldosterone system inhibitors remain unclear. We simultaneously investigated U-ACE2 and P-ACE2 in 605 Japanese participants (male/female: 280/325, mean age: 65±15 years) in the Tanno-Sobetsu cohort study in 2017. Males had significantly lower U-ACE2 and higher P-ACE2 than did females. There was no significant correlation between U-ACE2 and P-ACE2. P-ACE2 was significantly lower in subjects treated with renin-angiotensin-aldosterone system inhibitors than in those not treated with renin-angiotensin-aldosterone system inhibitors, but there was no significant difference in U-ACE2 between the groups. Multivariable regression analyses showed that female sex, high levels of systolic blood pressure, hemoglobin A1c, and urinary albumin-to-creatinine ratio, and low uric acid level were independent predictors of high U-ACE2 level and that high levels of γ-glutamyl transpeptidase, estimated glomerular filtration rate, and uric acid were independent predictors of high P-ACE2 level. In conclusion, U-ACE2 and P-ACE2 are distinctly regulated and the use of renin-angiotensin-aldosterone system inhibitors is not an independent predictor of their levels in a Japanese general population. U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level.

DOI PubMed

Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis.

Chihiro Nagase, Masaya Tanno, Hidemichi Kouzu, Takayuki Miki, Junichi Nishida, Naoto Murakami, Nobuaki Kokubu, Nobutaka Nagano, Ryo Nishikawa, Nobuhiro Yoshioka, Tohru Hasegawa, Hiroyuki Kita, Akihito Tsuchida, Hirofumi Ohnishi, Tetsuji Miura

Scientific reports   11 ( 1 ) 15578 - 15578  2021年08月  [国際誌]

　概要を見る

Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS ≥ 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS ≥ 10, AUC-GLP-1 < median, age and hypertension were selected as explanatory variables, though fasting GLP-1 level was not selected. The findings suggest that reduction in GLP-1 secretory capacity is a novel independent risk factor of coronary stenosis.

DOI PubMed

Independent Association of Fatty Liver Index With Left Ventricular Diastolic Dysfunction in Subjects Without Medication

Masato Furuhashi, Atsuko Muranaka, Satoshi Yuda, Marenao Tanaka, Masayuki Koyama, Mina Kawamukai-Nishida, Satoko Takahashi, Yukimura Higashiura, Daisuke Miyamori, Ryo Nishikawa, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura

The American Journal of Cardiology ( Elsevier BV )  158   139 - 146  2021年08月  [国際誌]

　概要を見る

Nonalcoholic fatty liver disease has been reported to be potentially linked to cardiovascular disease. Fatty liver index (FLI) is a noninvasive and simple predictor of nonalcoholic fatty liver disease. However, little is known about the relationship between FLI and cardiac function, especially in a general population. We investigated the relationships of FLI with echocardiographic parameters in 185 subjects (men/women: 79/106) of the Tanno-Sobetsu Study, a population-based cohort, who were not being treated with any medication and who underwent echocardiography. FLI was negatively correlated with high-density lipoprotein cholesterol and peak myocardial velocity during early diastole (e'; r = -0.342, p <0.001), an index of left ventricular (LV) diastolic function, and ratio of peak mitral velocities during early and late diastole (E/A) and was positively correlated with age, systolic and diastolic blood pressures, creatinine, uric acid, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein, ratio of mitral to myocardial early diastolic peak velocity (E/e'), left atrial volume index and LV mass index. No significant correlation was found between FLI and LV ejection fraction. Stepwise multivariable regression analysis showed that FLI was independently and negatively associated with e' after adjustment of age, gender, high-density lipoprotein cholesterol, homeostasis model assessment of insulin resistance, and high-sensitivity C-reactive protein. Conversely, e' was independently and negatively associated with FLI after adjustment of age, gender, systolic blood pressure, and LV ejection fraction. In conclusion, elevated FLI is independently associated with LV diastolic dysfunction in a general population without medication. FLI would be a novel marker of LV diastolic dysfunction as an early sign of myocardial injury.

DOI PubMed

Elevated Fatty Liver Index Is Independently Associated With New Onset of Hypertension During a 10‐Year Period in Both Male and Female Subjects

Yukimura Higashiura, Masato Furuhashi, Marenao Tanaka, Satoko Takahashi, Kazuma Mori, Daisuke Miyamori, Masayuki Koyama, Hirofumi Ohnishi, Norihito Moniwa, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Tetsuji Miura

Journal of the American Heart Association ( Ovid Technologies (Wolters Kluwer Health) )  10 ( 14 ) e021430  2021年07月  [国際誌]

　概要を見る

Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. Because of a sex difference in FLI level, we hypothesized that FLI is associated with development of hypertension to a greater extent in men or women.

We investigated the relationship between FLI and development of hypertension during a 10‐year period in a general population of subjects who received annual health examinations (n=28 990). After exclusion (44.9%) of subjects with missing data and those with hypertension at baseline, a total of 15 965 subjects (men/women: 9466/6499) were included. FLI level was significantly higher in men than in women. During the 10‐year period, 2304 men (24.3%) and 745 women (11.5%) had new onset of hypertension. Multivariable Cox proportional hazard models with a restricted cubic spline showed that the hazard ratios (HRs) for development of hypertension after adjustment of age, systolic blood pressure, estimated glomerular filtration rate, habits of smoking and alcohol drinking, family history of hypertension, and diagnosis of diabetes mellitus and dyslipidemia increased gradually with increase in FLI in men and increased rapidly and then slowly with increase in FLI in women. There was a significant interaction between FLI and sex for the risk of hypertension in all of the subjects ( P =0.049). The addition of FLI to traditional risk factors significantly improved the discriminatory capability.

A high level of FLI predicts the development of hypertension in both men and women, although distribution patterns of HRs were different between sexes.

DOI PubMed

Seasonal variation of serum 25-hydroxyvitamin D level in hemodialysis patients in the northernmost island of Japan

Yufu Gocho, Marenao Tanaka, Hirohito Sugawara, Masato Furuhashi, Norihito Moniwa, Tomohisa Yamashita, Hideki Takizawa, Hiroya Mukai, Kouhei Ohno, Takuto Maeda, Arata Osanami, Hirofumi Ohnishi, Hiroaki Komatsu, Kazuma Mori, Tetsuji Miura

Clinical and Experimental Nephrology ( Springer Science and Business Media LLC )  25 ( 12 ) 1360 - 1366  2021年07月  [国内誌]

　概要を見る

BACKGROUND: Serum vitamin D level shows a seasonal variation, being lower in winter than in summer in healthy subjects. The aim of this study was to determine whether there is presence of such a seasonal variation in hemodialysis patients. METHODS: A total of 102 patients on hemodialysis were enrolled in February 2017 (winter) for analyses of serum levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and treatments for chronic kidney disease-mineral and bone disorder (CKD-MBD). The examinations were repeated in August 2017 (summer). After exclusion of patients with malignancy, loss of follow-up and missing data, 78 patients contributed to the analyses. RESULTS: Serum level of 25(OH)D, but not that of 1,25(OH)2D, was significantly lower in winter (14.0 ng/mL) than in summer (15.5 ng/mL), though there was no significant difference in regimen for CKD-MBD treatment including vitamin D receptor activators (VDRAs) between the two seasons. Serum intact parathyroid hormone level tended to be higher and alkaline phosphatase was significantly higher in winter than in summer. Linear mixed-effects model analysis showed that level of 25(OH)D, but not that of 1,25(OH)2D, was significantly associated with season (winter and summer) after adjustment of age, sex, dialysis vintage, albumin level and use of drugs for CKD-MBD. CONCLUSION: Serum 25(OH)D has a seasonal variation, being lower in winter than in summer, independent of CKD-MBD treatment including treatment with VDRAs in Japanese hemodialysis patients. The impact of the seasonal variation on risk of vitamin D deficiency and its effect on prognosis remain to be investigated.

DOI PubMed

Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication.

Masato Furuhashi, Yukimura Higashiura, Masayuki Koyama, Marenao Tanaka, Takayo Murase, Takashi Nakamura, Seigo Akari, Akiko Sakai, Kazuma Mori, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura

Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 9 ) 1213 - 1220  2021年06月  [国際誌]

　概要を見る

Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR activity has been shown to be a novel metabolic biomarker related to obesity, liver dysfunction, hyperuricemia, dyslipidemia, and insulin resistance. However, the association between plasma XOR activity and hypertension has not been fully elucidated. We investigated the association of hypertension with plasma XOR activity in 271 nondiabetic subjects (male/female: 119/152) who had not taken any medications in the Tanno-Sobetsu Study, a population-based cohort. Males had higher plasma XOR activity than females. Plasma XOR activity was positively correlated with mean arterial pressure (r = 0.128, P = 0.036). When the subjects were divided by the presence and absence of hypertension into an HT group (male/female: 34/40) and a non-HT group (male/female: 85/112), plasma XOR activity in the HT group was significantly higher than that in the non-HT group (median: 39 vs. 28 pmol/h/mL, P = 0.028). There was no significant difference in uric acid levels between the two groups. Multivariable logistic regression analysis showed that plasma XOR activity (odds ratio: 1.091 [95% confidence interval: 1.023-1.177] per 10 pmol/h/mL, P = 0.007) was an independent determinant of the risk for hypertension after adjustment for age, sex, current smoking and alcohol consumption, estimated glomerular filtration rate, brain natriuretic peptide, and insulin resistance index. The interaction of sex with plasma XOR activity was not significant for the risk of hypertension. In conclusion, plasma XOR activity is independently associated with hypertension in nondiabetic individuals who are not taking any medications.

DOI PubMed

CKD発症予測におけるfatty liver indexの意義

高橋 聖子, 田中 希尚, 古橋 眞人, 長南 新太, 宮森 大輔, 後町 結, 塙 なぎさ, 茂庭 仁人, 大西 浩文, 三浦 哲嗣

日本腎臓学会誌 ( (一社)日本腎臓学会 )  63 ( 4 ) 453 - 453  2021年06月

CKD発症予測におけるfatty liver indexの意義

高橋 聖子, 田中 希尚, 古橋 眞人, 長南 新太, 宮森 大輔, 後町 結, 塙 なぎさ, 茂庭 仁人, 大西 浩文, 三浦 哲嗣

日本腎臓学会誌 ( (一社)日本腎臓学会 )  63 ( 4 ) 453 - 453  2021年06月

Does renin‐angiotensin system inhibition have impacts on muscle mass and bone mineral density in heart failure patients?

Satoshi Katano, Toshiyuki Yano, Masaki Shimizu, Katsuhiko Ohori, Hidemichi Kouzu, Masayuki Koyama, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Hiroyuki Takashima, Masaki Katayose, Hirofumi Ohnishi, Tetsuji Miura

ESC Heart Failure ( Wiley )   2021年05月

DOI

【健康教育・ヘルスプロモーションとCOVID-19】小学生における感染症予防に関する情報発信活動 小学校教科「総合的な学習の時間」を活用した取り組み

大浦 麻絵, 大西 浩文, 小山 雅之, 長多 好恵, 長谷川 準子, 助友 裕子, 森 満

日本健康教育学会誌 ( (一社)日本健康教育学会 )  29 ( 2 ) 215 - 222  2021年05月

J-GLOBAL

北海道のST上昇型急性心筋梗塞における総虚血時間と再灌流療法選択の実態

親谷 佳佑, 小山 雅之, 大西 浩文, 三浦 哲嗣

日本循環器病予防学会誌 ( (一社)日本循環器病予防学会 )  56 ( 2 ) 173 - 173  2021年05月

J-GLOBAL

【健康教育・ヘルスプロモーションとCOVID-19】小学生における感染症予防に関する情報発信活動 小学校教科「総合的な学習の時間」を活用した取り組み

大浦 麻絵, 大西 浩文, 小山 雅之, 長多 好恵, 長谷川 準子, 助友 裕子, 森 満

日本健康教育学会誌 ( (一社)日本健康教育学会 )  29 ( 2 ) 215 - 222  2021年05月

　概要を見る

目的:「病気の予防プロジェクト」は児童が感染症予防について主体的に学び,全校や市民に向けて情報発信することを目的として行われた.活動内容:小学校と医学系研究者とが協働をした20時間を超える学習プログラム「病気の予防プロジェクト」を2019年から小学校教育の中で始動した.2019年度はインフルエンザ感染症予防,2020年度は新型コロナウイルス感染症予防について学習し,予防についての情報発信を行った.札幌市立N小学校6年生の総合的な学習の時間の中で実施され,2019年度は75人,2020年度は82人の全児童が受講した.活動評価・今後の課題:児童が主体性や活動範囲をより伸ばすことができたことが評価される.児童においては取り組みの温度差が課題として挙げられる.また,科学的検証視点を入れていくことや,児童からの健康情報の伝達の他に,保護者側からのアドバイスなど家庭で取り組む学びの支援などを構築していくことも課題となる.(著者抄録)

北海道のST上昇型急性心筋梗塞における総虚血時間と再灌流療法選択の実態

親谷 佳佑, 小山 雅之, 大西 浩文, 三浦 哲嗣

日本循環器病予防学会誌 ( (一社)日本循環器病予防学会 )  56 ( 2 ) 173 - 173  2021年05月

「地域で子ども達を守ろう!新型コロナウイルス撃退大作戦」始動までの道のり

大浦 麻絵, 大西 浩文, 小山 雅之, 長多 好恵, 長谷川 準子, 助友 裕子, 森 満

北海道の公衆衛生 ( 北海道公衆衛生協会 )  ( 47 ) 65 - 66  2021年03月

Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study

Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Masahiro Yoshida, Ayumi Tatekoshi, Akihito Endo, Taichiro Ishige, Yuh Shiwa, Soushi Ibata, Akari Goto, Kana Nagashima, Hiroto Horiguchi, Chisa Fujita, Hiroshi Ikeda, Kohichi Takada, Takayuki Nobuoka, Yusuke Kamihara, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-ichi Yokota, Masayoshi Kobune

Nutrition ( Elsevier BV )  83   111093 - 111093  2021年03月

DOI

冠動脈狭窄症における危険因子の管理と病変分布との関連 BOREAS-CAGレジストリデータのクロスセクション分析(Relationship between Risk Factor Management and Lesion Distribution in Coronary Artery Stenosis: A Cross-sectional Analysis of BOREAS-CAG Registry Data)

高橋 遼, 國分 宣明, 小山 雅之, 岸上 直広, 中田 潤, 西川 諒, 村上 直人, 永野 伸卓, 丹野 雅也, 大西 浩文, 橋本 暁佳, 土橋 和文, 三浦 哲嗣

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   OJ06 - 3  2021年03月

冠動脈狭窄症における危険因子管理と病変分布との関連:BOREAS-CAGレジストリデータの横断的分析

高橋遼, 國分宣明, 小山雅之, 岸上直広, 中田潤, 西川諒, 村上直人, 永野伸卓, 丹野雅也, 大西浩文, 橋本暁佳, 土橋和文, 三浦哲嗣

日本循環器学会学術集会(Web) ( (一社)日本循環器学会 )  85回   OJ06 - 3  2021年03月

J-GLOBAL