論文 - 大西　浩文

産・官・学が協働した学校教育における公衆衛生活動 病気の予防プロジェクト&ありがとうプロジェクト

大浦 麻絵, 大西 浩文, 小山 雅之, 長多 好恵, 助友 裕子, 長谷川 準子, 西村 剛, 岬 真一郎, 戸島 宏二, 川原 知晃, 森 満

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 )  35 ( 2 ) 177 - 181  2022年03月

　概要を見る

三密になりがちな教育現場での感染予防・感染拡大防止に貢献するとともに、新型コロナウイルス感染症に関する予防啓発・情報共有活動を2020年度から実施している。本稿では公衆衛生活動として実施している、社会を支えるすべての人々にありがとうの気持ちを伝える"ありがとうプロジェクト"、子ども達がエビデンス(科学的根拠)に基づく教育を受け、その学びの成果を社会へ発信する"病気の予防プロジェクト"において実施された保健所による教育講義についての実践報告を行う。(著者抄録)

J-GLOBAL

Serum uric acid level is associated with an increase in systolic blood pressure over time in female subjects: Linear mixed-effects model analyses.

Kazuma Mori, Masato Furuhashi, Marenao Tanaka, Yukimura Higashiura, Masayuki Koyama, Nagisa Hanawa, Hirofumi Ohnishi

Hypertension research : official journal of the Japanese Society of Hypertension   45 ( 2 ) 344 - 353  2022年02月  [国際誌]

　概要を見る

Whether hyperuricemia is a true risk factor for elevated blood pressure (BP) is controversial, and the sex-specific effects of serum uric acid (SUA) on BP during a follow-up period remain unclear. We investigated whether the association of SUA level with systolic or diastolic BP during a 10-year period differs by sex in a Japanese general population of individuals who received annual health examinations (n = 28,990). After exclusion of subjects who had no BP or SUA data at baseline, a total of 22,994 subjects (male/female: 14,603/8391, age: 47 ± 11 years) were recruited. After adjustment for age; body mass index; BP; SUA level; use of drugs for hyperuricemia and hypertension; diagnosis of diabetes mellitus, dyslipidemia, and chronic kidney disease; family history of hypertension; habits of current smoking and alcohol consumption at baseline; the duration of the observation period; and the interaction between each covariate and the duration of the observation period indicated a significant association of SUA level with change in systolic or diastolic BP over time. There was a significant interaction between sex and SUA level for the change in systolic BP (P = 0.003) but not the change in diastolic BP (P = 0.081). The SUA level at baseline (per 1 mg/dL) was significantly associated with a change in systolic BP over time in females (estimate: 0.073 mmHg/year, P = 0.003) but not in males (estimate: 0.020 mmHg/year, P = 0.160). In conclusion, a high SUA level at baseline is significantly associated with an increase in systolic BP over time in female individuals but not in male individuals.

DOI PubMed

日本人におけるFLIによるNAFLDの予測

高橋 聖子, 田中 希尚, 東浦 幸村, 塙 なぎさ, 大西 浩文, 古橋 眞人

日本内科学会雑誌 ( (一社)日本内科学会 )  111 ( Suppl. ) 198 - 198  2022年02月

J-GLOBAL

日本人におけるFLIによるNAFLDの予測

高橋 聖子, 田中 希尚, 東浦 幸村, 塙 なぎさ, 大西 浩文, 古橋 眞人

日本内科学会雑誌 ( (一社)日本内科学会 )  111 ( Suppl. ) 198 - 198  2022年02月

血清尿酸値は女性において収縮期血圧の経時的な上昇と関連する 線形混合効果モデルでの解析

森 和真, 田中 希尚, 東浦 幸村, 小山 雅之, 塙 なぎさ, 大西 浩文, 古橋 眞人

日本痛風・尿酸核酸学会総会プログラム・抄録集 ( (一社)日本痛風・尿酸核酸学会 )  55回   86 - 86  2022年01月

J-GLOBAL

ICTを用いた新型コロナウイルス感染症宿泊療養者等の健康観察システム

小山 雅之, 谷川 琢海, 福田 潤, 向原 強, 藤本 直樹, 高塚 伸太朗, 中山 龍一, 大西 浩文

Journal of Epidemiology ( (一社)日本疫学会 )  32 ( Suppl.1 ) 95 - 95  2022年01月

尿酸とCOVID-19の原因ウイルスSARS-CoV-2の宿主側受容体ACE2との関連についての検討

古橋 眞人, 田中 希尚, 東浦 幸村, 森 和真, 小山 雅之, 大西 浩文, 齋藤 重幸, 島本 和明

日本痛風・尿酸核酸学会総会プログラム・抄録集 ( (一社)日本痛風・尿酸核酸学会 )  55回   80 - 80  2022年01月

ICTを用いた新型コロナウイルス感染症宿泊療養者等の健康観察システム

小山 雅之, 谷川 琢海, 福田 潤, 向原 強, 藤本 直樹, 高塚 伸太朗, 中山 龍一, 大西 浩文

Journal of Epidemiology ( (一社)日本疫学会 )  32 ( Suppl.1 ) 95 - 95  2022年01月

J-GLOBAL

血清尿酸値は女性において収縮期血圧の経時的な上昇と関連する 線形混合効果モデルでの解析

森 和真, 田中 希尚, 東浦 幸村, 小山 雅之, 塙 なぎさ, 大西 浩文, 古橋 眞人

日本痛風・尿酸核酸学会総会プログラム・抄録集 ( (一社)日本痛風・尿酸核酸学会 )  55回   86 - 86  2022年01月

尿酸とCOVID-19の原因ウイルスSARS-CoV-2の宿主側受容体ACE2との関連についての検討

古橋 眞人, 田中 希尚, 東浦 幸村, 森 和真, 小山 雅之, 大西 浩文, 齋藤 重幸, 島本 和明

日本痛風・尿酸核酸学会総会プログラム・抄録集 ( (一社)日本痛風・尿酸核酸学会 )  55回   80 - 80  2022年01月

J-GLOBAL

Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study.

Kohichi Takada, Tomohiro Kubo, Junko Kikuchi, Makoto Yoshida, Ayako Murota, Yohei Arihara, Hajime Nakamura, Hiroyuki Nagashima, Hiroki Tanabe, Shintaro Sugita, Yumi Tanaka, Ayana Miura, Yoshihito Ohhara, Atsushi Ishiguro, Hiroshi Yokouchi, Yasuyuki Kawamoto, Yusuke Mizukami, Hirofumi Ohnishi, Ichiro Kinoshita, Akihiro Sakurai

Frontiers in oncology   12   988527 - 988527  2022年  [国際誌]

　概要を見る

Characterization of the genomic landscape of biliary tract cancer (BTC) may lead to applying genotype-matched therapy for patients with this disease. Evidence that comprehensive cancer genomic profiling (CGP) guides genotype-matched therapy to improve clinical outcomes is building. However, the significance of CGP in patients with BTC remains unclarified in clinical practice. Therefore, the purposes of this study were to assess the utility of CGP and identify associations between clinical outcomes and genomic alterations in patients with BTC. In this prospective analysis, detection rates for actionable genomic alterations and access rates for genotype-matched therapy were analyzed in 72 patients with advanced BTC who had undergone commercial CGP. Cox regression analyses assessed relationships between overall survival and genomic alterations detected with CGP. The most common genomic alterations detected were TP53 (41, 56.9%), followed by CDKN2A/B (24, 33.3%/20, 27.8%), and KRAS (20, 27.8%). Actionable genomic alterations were identified in 58.3% (42/72) of patients. Detection rates for FGFR2 fusions, IDH1 mutations, and BRAF V600E were low in this cohort. Eight (11.1%) patients received genotype-matched therapy. For patients with intrahepatic cholangiocarcinoma (ICC), CDKN2A/B loss was associated with shorter overall survival. These real-world data demonstrate that CGP can identify therapeutic options in patients with advanced BTC. CDKN2A/B loss was identified as a poor prognostic factor in patients with ICC. Thus, this study provides a rationale for considering CGP in planning therapeutic strategies for advanced BTC.

DOI PubMed

Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population.

Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura

Journal of the American Heart Association   10 ( 23 ) e021753  2021年12月  [国際誌]

　概要を見る

Background Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors. Methods and Results We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan-Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person-years of follow-up were included. The lifetime risk at the index-age of 45 years for those with optimal risk factors (total cholesterol <4.65 mmol/L, systolic blood pressure <120 mm Hg, diastolic blood pressure <80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%-11.9%] versus 19.4% [16.7%-21.4%] for men and 6.9% [1.2%-11.5%] versus 15.4% [12.6%-18.1%] for women). Conclusions The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short-term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.

DOI PubMed

High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects

Yukimura Higashiura, Masato Furuhashi, Marenao Tanaka, Satoko Takahashi, Masayuki Koyama, Hirofumi Ohnishi, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Norihito Moniwa, Kazufumi Tsuchihashi, Tetsuji Miura

Scientific Reports ( Springer Science and Business Media LLC )  11 ( 1 ) 12830 - 12830  2021年12月  [国際誌]

　概要を見る

Fatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.

DOI PubMed

Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects

Satoko Takahashi, Marenao Tanaka, Masato Furuhashi, Norihito Moniwa, Masayuki Koyama, Yukimura Higashiura, Arata Osanami, Yufu Gocho, Hirofumi Ohnishi, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Tetsuji Miura

Scientific Reports ( Springer Science and Business Media LLC )  11 ( 1 )  2021年12月

　概要を見る

A potential link between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) has been suggested. We investigated the relationship between fatty liver index (FLI), a noninvasive and simple predictor of NAFLD, and the development of CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m² or positive for urinary protein during a 10-year follow-up period in subjects who received annual health examinations (n = 28,890). After exclusion of CKD at baseline, a total of 14,163 subjects (male/female: 9077/5086) were recruited. During the 10-year period, 1458 males (16.1%) and 737 females (14.5%) had new onset of CKD. Multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard ratios (HRs) of CKD development increased with a higher FLI at baseline in both males and females after adjustment of confounders. When divided by tertiles of FLI level at baseline (T1 ~ T3), the adjusted risk of CKD development in the T3 group (HR [95% confidence interval], male/female: 1.33 [1.16–1.54]/1.33 [1.08–1.63]) was significantly higher than that in both sexes in the T1 group as the reference. The addition of FLI into traditional risk factors significantly improved the discriminatory capability for predicting CKD. In conclusion, a high level of FLI predicts the development of CKD in both sexes in a general population.

DOI

Prognostic value of 6-min walk stress echocardiography in patients with interstitial lung disease.

Kenji Yasui, Satoshi Yuda, Kiyoshi Abe, Kouichi Asanuma, Nozomi Yanagihara, Yuta Sudo, Kimiyuki Ikeda, Atsuko Muranaka, Mitsuo Otsuka, Daigo Nagahara, Hirofumi Ohnishi, Hiroki Takahashi, Tetsuji Miura, Satoshi Takahashi

Journal of echocardiography   19 ( 4 ) 232 - 242  2021年12月  [国内誌]

　概要を見る

BACKGROUND: The 6-min walk test (6MWT) provides prognostic information for patients with interstitial lung disease (ILD). Parameter determined by Doppler echocardiography after the 6MWT (6 MW stress echocardiography) is shown to be a predictor of future development of pulmonary hypertension in patients with connective tissue disease. However, the clinical utility of 6 MW stress echocardiography in predicting cardiopulmonary events in patients with ILD remains unknown. We examined whether parameters determined by 6 MW stress echocardiography independent predictors of adverse events in patients with ILD. METHODS: Echocardiographic examinations were performed in 68 consecutively enrolled patients with ILD (age, 65 ± 10 years, 65% men). A pressure gradient of tricuspid regurgitation (TRPG) and pulmonary vascular resistance (PVRecho) calculated using the following formula [PVRecho = (peak velocity of TR × 10/time-velocity integral of right ventricular outflow (RVOT-VTI)) + 0.16] were measured at baseline and at post 6MWT. Data for parameters of pulmonary functional tests and for 6MWT were collected. RESULTS: During a mean follow-up period of 22 ± 12 months, 22 patients experienced cardiopulmonary events. In univariate analysis, %VC, TRPG, PVRecho, TRPG post 6MWT, and PVRecho post 6MWT were significantly associated with cardiopulmonary events. Multivariate analysis using the Cox proportional hazards model indicated that %VC [hazard ratio (HR): 0.97, p = 0.009] and PVRecho post 6MWT (HR: 1.77, p = 0.004) were independent predictors of cardiopulmonary events in patients with ILD. CONCLUSIONS: In addition to parameters of pulmonary function tests, increased PVRecho post 6MWT is a significant predictor of cardiopulmonary events in patients with ILD. A 6 MW stress echocardiography is useful in assessing the risk of adverse events in patients with ILD.

DOI PubMed

学校と連携をした地域におけるソーシャルキャピタルの構築 ありがとうプロジェクト先行実践校のとりくみ

大浦 麻絵, 大西 浩文, 小山 雅之, 助友 裕子, 長多 好恵, 長谷川 準子, 森 満

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 )  35 ( 1特別付録 ) 26 - 26  2021年11月

J-GLOBAL

外国人患者の当院受療時ニーズに関する社会疫学的調査(第4報)

鈴村 美和, 菅原 誠, 鈴村 滋生, 森 満, 大西 浩文

日本公衆衛生学会総会抄録集 ( 日本公衆衛生学会 )  80回   489 - 489  2021年11月

J-GLOBAL

Relationship Between Plantar Callosity and Foot Deformity in Hallux Valgus Using Weightbearing Computed Tomography

Yasutaka Murahashi, Kousuke Iba, Atsushi Teramoto, Katsunori Takahashi, Yohei Okada, Tomoaki Kamiya, Hiroyuki Takashima, Kota Watanabe, Hirofumi Ohnishi, Toshihiko Yamashita

JOURNAL OF FOOT & ANKLE SURGERY ( ELSEVIER SCIENCE INC )  60 ( 6 ) 1207 - 1211  2021年11月

　概要を見る

Plantar callosities under lesser metatarsals are often accompanied by the hallux valgus, and the cause of callosity is thought to be associated with the foot deformity, such as the metatarsal length discrepancy, the abnormal metatarsal head height, cavus, flat foot, and rheumatoid conditions. However, it is unclear which variable is most involved in the cause of callosity in hallux valgus deformity. To clarify the factors associated with the callosity with hallux valgus deformity, we conducted multiple image assessments based on weightbearing radiography and computed tomography. A retrospective review was performed based on the collection of clinical records from all patients with hallux valgus treated from 2010 to 2019 in our institution. We measured the hallux valgus angle, intermetatarsal angles, calcaneal pitch angles, talo-first metatarsal angles, metatarsal length, metatarsal head height, first metatarsal pronation angles, and sesamoid position with weightbearing radiography and computed tomography. We analyzed the relation between callosity formation and imaging assessments using univariate and multivariate logistic regression models. Fifty feet were retrospectively evaluated, and multiple logistic analyses by the stepwise method revealed that the first metatarsal-lateral-sesamoid distance was the only radiographical variable associated with callosity formation among all the tested variables (p < .001). As the grade of the callosity became more severe, the lateral shift of the lateral sesamoid increased. The position of the sesamoid bone appears to have a critical role in the assessment and choice of treatment protocols and further research needs to be conducted on the relationship with the position of sesamoid bone to elucidate the mechanism of callus formation. (c) 2021 by the American College of Foot and Ankle Surgeons. All rights reserved.

DOI

学校と連携をした地域におけるソーシャルキャピタルの構築 ありがとうプロジェクト先行実践校のとりくみ

大浦 麻絵, 大西 浩文, 小山 雅之, 助友 裕子, 長多 好恵, 長谷川 準子, 森 満

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 )  35 ( 1特別付録 ) 26 - 26  2021年11月

Fatty Liver Index(FLI)は新規高血圧発症の独立した予測因子である

東浦 幸村, 古橋 眞人, 田中 希尚, 高橋 聖子, 山下 智久, 小山 雅之, 大西 浩文, 斎藤 重幸, 三浦 哲嗣, 塙 なぎさ

日本高血圧学会総会プログラム・抄録集 ( (NPO)日本高血圧学会 )  43回   217 - 217  2021年10月