研究者詳細 - 大西　浩文

論文 - 大西　浩文

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Clinical impact of rehabilitation and <scp>ICU</scp> diary on critically ill patients: A systematic review and meta‐analysis

Tomohiro Ishinuki, Ling Zhang, Keisuke Harada, Hiroomi Tatsumi, Nobuaki Kokubu, Yoshika Kuno, Kanon Kumasaka, Rina Koike, Toshio Ohyanagi, Hirofumi Ohnishi, Eichi Narimatsu, Yoshiki Masuda, Toru Mizuguchi

Nursing in Critical Care ( Wiley ) 28 554 - 565 2023年01月 [査読有り] [国際誌]

DOI

Preserved Lower Limb Muscle Mass Prevents Insulin Resistance Development in Nondiabetic Older Adults.

Toshiaki Seko, Hiroshi Akasaka, Masayuki Koyama, Nobuaki Himuro, Shigeyuki Saitoh, Tetsuji Miura, Mitsuru Mori, Hirofumi Ohnishi

Journal of the American Medical Directors Association 24 ( 3 ) 376 - 381 2022年12月 [国際誌]

OBJECTIVE: To investigate roles of sarcopenia indexes in prediction of development of insulin resistance in nondiabetic older adults. DESIGN: A 2-year follow-up cohort. SETTING AND PARTICIPANTS: The Tanno-Sobetsu study, a prospective observational cohort, included 194 community-dwelling nondiabetic older adults during 2017-2019. METHODS: Lower limb, upper limb, appendicular, and trunk muscle masses by a bioelectrical impedance analysis, grip strength, knee extension torque, and walking speed were measured in study participants aged ≥65 years (79 men and 115 women) at baseline. Muscle mass and strength were divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). Insulin resistance was assessed by homeostasis model (HOMA-IR) at baseline, and the study participants whose HOMA-IR was less than 1.73 at baseline were followed for a maximum of 2 years. The study endpoint was development of insulin resistance defined as HOMA-IR ≥1.73. The adjusted hazard ratio (HR) of each sarcopenia component for development of insulin resistance was calculated. RESULTS: Lower limb muscle mass (HR 0.88, 95% CI 0.79-0.98) and appendicular muscle mass (HR 0.89, 95% CI 0.81-0.99), but not other sarcopenia components, were associated with the development of insulin resistance, independently of sex and age, HOMA-IR, and waist circumference at baseline. CONCLUSIONS AND IMPLICATIONS: The loss of lower limb muscle mass is a significant risk factor for development of insulin resistance independently of obesity in nondiabetic older adults. The lower limb muscle mass may be a novel target of interventions for the prevention of diabetes in older adults.

DOI PubMed

オンラインPRO情報システムによる周術期における乳がん患者の不安に関連する要因の検証

石貫智裕, 水口徹, 九冨五郎, 島宏彰, 和田朝香, 里見蕗乃, 空閑陽子, 宇野智子, 久野芳佳, 浅石和昭, 下川原出, 増岡秀次, 三神俊彦, 大村東生, 本間敏男, 大西浩文, 大柳俊夫

北海道外科雑誌 ( 北海道外科学会 ) 67 ( 2 ) 161 - 161 2022年12月

J-GLOBAL

尿酸とCOVID-19の原因ウイルスSARS-CoV-2の宿主側受容体ACE2との関連についての検討

古橋眞人, 田中希尚, 東浦幸村, 森和真, 小山雅之, 大西浩文, 齋藤重幸, 島本和明

痛風と尿酸・核酸 ( (一社)日本痛風・尿酸核酸学会 ) 46 ( 2 ) 160 - 160 2022年12月

血清尿酸値は女性において収縮期血圧の経時的な上昇と関連する線形混合効果モデルでの解析

森和真, 田中希尚, 東浦幸村, 小山雅之, 塙なぎさ, 大西浩文, 古橋眞人

痛風と尿酸・核酸 ( (一社)日本痛風・尿酸核酸学会 ) 46 ( 2 ) 166 - 166 2022年12月

A Biomechanical Comparison of 2 Over-the-Top Anterior Cruciate Ligament Reconstruction Techniques: A Cadaveric Study Using a Robotic Simulator.

Kousuke Shiwaku, Tomoyuki Suzuki, Konsei Shino, Satoshi Yamakawa, Hidenori Otsubo, Shinichiro Okimura, Daisuke Suzuki, Shogo Nabeki, Atsushi Teramoto, Hirofumi Ohnishi, Hiromichi Fujie, Toshihiko Yamashita

Orthopaedic journal of sports medicine 10 ( 12 ) 23259671221139876 - 23259671221139876 2022年12月 [国際誌]

BACKGROUND: For skeletally immature patients, over-the-top (OTT) anterior cruciate ligament (ACL) reconstruction (ACLR) is preferred. However, increased anterior laxity at deep knee flexion angles remains concerning. We modified the procedure to proximally shift the graft fixation site on the femur to prevent graft loosening at higher knee flexion angles and named it the supra-OTT procedure. PURPOSE: To compare anterior laxity and in situ forces of the ACL graft between conventional OTT and supra-OTT ACLR in a cadaveric model. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 11 fresh-frozen cadaveric knee specimens underwent 4 robotic testing conditions: ACL intact, ACL resected, conventional OTT, and supra-OTT. For each condition, a 100-N load was applied at 0°, 15°, 30°, 60°, and 90° of knee flexion to simulate the Lachman test or anterior drawer test. In addition, a combined load of 5-N·m internal tibial torque and 10-N·m valgus torque was applied at 15° and 30° of knee flexion as a simulated pivot-shift test. Anterior tibial translation and in situ graft forces were recorded. The only difference between conventional OTT and supra-OTT ACLR was the graft fixation site on the femur. For conventional OTT ACLR, graft fixation was performed just on the proximal and lateral ends of the posterior condyle. For supra-OTT ACLR, the fixation point was around the proximal insertion of the lateral head of the gastrocnemius and the lateral edge of the posterior cortex, approximately 2 cm proximal to the conventional OTT position. RESULTS: On the simulated anterior drawer test at 60° and 90° of knee flexion, anterior tibial translation after supra-OTT ACLR was significantly smaller than after conventional OTT ACLR (P < .01). However, no significant differences were noted at other flexion angles or on the simulated pivot-shift test between the conventional OTT and supra-OTT procedures. Some overconstraint and higher graft forces were noted with both techniques, but the supra-OTT technique caused even more overconstraint at higher flexion angles. CONCLUSION: Supra-OTT ACLR showed better biomechanical performance to control anterior laxity than conventional OTT ACLR at higher knee flexion angles. CLINICAL RELEVANCE: The supra-OTT procedure may improve anterior stability at deep knee flexion angles.

DOI PubMed

Walking Speed Is Better Than Hand Grip Strength as an Indicator of Early Decline in Physical Function with Age in Japanese Women Over 65: A Longitudinal Analysis of the Tanno-Sobetsu Study Using Linear Mixed-Effects Models.

Shunichi Ogawa, Nobuaki Himuro, Masayuki Koyama, Toshiaki Seko, Mitsuru Mori, Hirofumi Ohnishi

International journal of environmental research and public health 19 ( 23 ) 2022年11月 [国際誌]

The decline in physical function with age is a major contributor to the need for long-term care. Age-related changes in hand grip strength, knee extension, and walking speed have been reported in cross-sectional studies, but longitudinal data are needed. This longitudinal study measured changes in these three measures among community-dwelling adults aged 65-89 years who participated in general health examinations between 2017 and 2019. Analyses were stratified by sex. Linear mixed-effects models adjusted for confounding factors were used to examine the interaction of different patterns of change with age of the three measures. A total of 284 participants were included in the analysis. The interaction term of age × walking speed, with age × handgrip strength as the reference, was statistically significant in women and showed different patterns in walking speed and hand grip strength. In men, none of the age × physical function interaction terms were significant in any model. For early recognition of the onset of physical function decline in older adults, any of the three measures may be used in men, but walking speed may be more suitable than hand grip strength in women. These findings may be useful in devising sex-specific screening strategies.

DOI PubMed

Correction: Toe grip strength declines earlier than hand grip strength and knee extension strength in community‑dwelling older men: a cross sectional study.

Sayo Miura, Toshiaki Seko, Nobuaki Himuro, Masayuki Koyama, Shigeyuki Saitoh, Hirofumi Ohnishi

Journal of foot and ankle research 15 ( 1 ) 81 - 81 2022年11月 [国際誌]

DOI PubMed

The Role of the Medial Meniscus in Anterior Knee Stability.

Kousuke Shiwaku, Tomoaki Kamiya, Daisuke Suzuki, Satoshi Yamakawa, Hidenori Otsubo, Tomoyuki Suzuki, Katsunori Takahashi, Yohei Okada, Atsushi Teramoto, Hirofumi Ohnishi, Hiromichi Fujie, Toshihiko Yamashita

Orthopaedic journal of sports medicine 10 ( 11 ) 23259671221132845 - 23259671221132845 2022年11月 [国際誌]

Background: Few studies have compared the force distribution between the anterolateral, posterolateral, and medial structures of the knee. Purpose: To investigate the important structures in an intact knee contributing to force distribution in response to anterior tibial load. Study Design: Controlled laboratory study. Methods: Nine fresh-frozen cadaveric knee specimens underwent robotic testing. First, 100 N of anterior tibial load was applied to the intact knee at 0°, 15°, 30°, 60°, and 90° of knee flexion. The anterior cruciate ligament (ACL), anterolateral capsule, lateral collateral ligament, popliteal tendon, posterior root of the lateral meniscus, superficial medial collateral ligament, posterior root of the medial meniscus (MM), and posterior cruciate ligament were then completely transected in sequential order. After each transection, the authors reproduced the intact knee motion when a 100-N anterior tibial load was applied. By applying the principle of superposition, the resultant force of each structure was determined based on the 6 degrees of freedom force/torque data of each state. Results: At every measured knee flexion angle, the resultant force of the ACL was the largest of the tested structures. At knee flexion angles of 60° and 90°, the resultant force of the MM was larger than that of all other structures with the exception of the ACL. Conclusion: The MM was identified as playing an important role in response to anterior tibial load at 60° and 90° of flexion. Clinical Relevance: In clinical settings, the ACL of patients with a poorly functioning MM, such as tear of the MM posterior root, should be monitored considering the large resultant force in response to an anterior tibial load.

DOI PubMed

新型コロナウイルス感染症の自宅療養者に対する健康観察アプリケーションのユーザビリティ

中山龍一, 小山雅之, 高塚伸太朗, 向原強, 谷川琢海, 藤本直樹, 福田潤, 小澤秀弘, 大西浩文, 上村修二

医療情報学連合大会論文集 ( (一社)日本医療情報学会 ) 42回 539 - 541 2022年11月

新型コロナウイルス感染症の自宅療養者に対する健康観察アプリケーションのユーザビリティ

中山龍一, 小山雅之, 高塚伸太朗, 向原強, 谷川琢海, 藤本直樹, 福田潤, 小澤秀弘, 大西浩文, 上村修二

医療情報学連合大会論文集 ( (一社)日本医療情報学会 ) 42回 539 - 541 2022年11月

官学連携により産まれたCOVID-19健康観察システム「こびまるライト」

小山雅之, 谷川琢海, 高塚伸太朗, 中山龍一, 向原強, 藤本直樹, 福田潤, 齋藤彩乃, 石川珠美, 小澤秀弘, 大西浩文

医療情報学連合大会論文集 ( (一社)日本医療情報学会 ) 42回 545 - 546 2022年11月

官学連携により産まれたCOVID-19健康観察システム「こびまるライト」

小山雅之, 谷川琢海, 高塚伸太朗, 中山龍一, 向原強, 藤本直樹, 福田潤, 齋藤彩乃, 石川珠美, 小澤秀弘, 大西浩文

医療情報学連合大会論文集 ( (一社)日本医療情報学会 ) 42回 545 - 546 2022年11月

Toe Grip strength declines earlier than hand grip strength and knee extension strength in community-dwelling older men: a cross sectional study.

Sayo Miura, Toshiaki Seko, Nobuaki Himuro, Masayuki Koyama, Shigeyuki Saitoh, Hirofumi Ohnishi

Journal of foot and ankle research 15 ( 1 ) 79 - 79 2022年10月 [国際誌]

BACKGROUND: The aim of this study is to examine the age-related changes in the toe grip strength and its differences from hand grip strength and knee extension strength using cross-sectional data. METHODS: Of participants aged 65 years over who underwent health checkups for lifestyle-related diseases in 2018, 307 men and women met the criteria. Toe grip strength, hand grip strength, and knee extension strength were also measured as optional tests. The participants were divided into five groups categorized by every 5 years of age (Group 65-85). The data were analyzed with multiple comparisons using the linear mixed multilevel model to examine the following categories: association between age and muscle strength, differences in the pattern of change, and gender, using the 65-69 years group as a reference. RESULTS: In men, there were interaction effects between the factors of age and muscle, but in women there were not. Toe grip strength was significantly lower in Group 70, 75, 80, and 85 in men, lower in Group 85 than in 65 in women. Hand grip strength was significantly lower in Group 85 than in 65 in both men and women. There was no significant difference in knee extension strength among the age groups for both men and women. CONCLUSIONS: The decline in toe grip strength may occur earlier and in a different pattern from hand grip strength and knee extension strength in men.

DOI PubMed

Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs.

Hirotaka Nishikiori, Koji Kuronuma, Kenichi Hirota, Naoya Yama, Tomohiro Suzuki, Maki Onodera, Koichi Onodera, Kimiyuki Ikeda, Yuki Mori, Yuichiro Asai, Yuzo Takagi, Seiwa Honda, Hirofumi Ohnishi, Masamitsu Hatakenaka, Hiroki Takahashi, Hirofumi Chiba

The European respiratory journal 61 ( 2 ) 2022年10月 [国際誌]

BACKGROUND: Antifibrotic therapies are available to treat chronic fibrosing interstitial lung diseases (CF-ILDs), including idiopathic pulmonary fibrosis. Early use of these treatments is recommended to slow deterioration of respiratory function and to prevent acute exacerbation. However, identifying patients in the early stages of CF-ILD using chest radiographs (CRs) is challenging. In this study, we developed and tested a deep learning algorithm to detect CF-ILD using CR images. METHOD: From the image archive of Sapporo Medical University Hospital, 653 CRs from 263 patients with CF-ILDs and 506 from 506 patients without CF-ILD were identified; 921 were used for deep learning and 238 were used for algorithm testing. The algorithm was designed to output a numerical score ranging from 0 to 1, representing the probability of CF-ILD. Using the testing dataset, the algorithm's capability to identify CF-ILD was compared with that of doctors. A second dataset, in which CF-ILD was confirmed using computed tomography images, was used to further evaluate the algorithm's performance. RESULTS: The area under the curve of the receiver operating characteristic curve, which indicates the algorithm's detection capability, was 0.979. Using a score cutoff of 0.267, the sensitivity and specificity of detection were 0.896 and 1.000, respectively. These data showed that the algorithm's performance was non-inferior to that of doctors, including pulmonologists and radiologists; performance was verified using the second dataset. CONCLUSIONS: We developed a deep learning algorithm to detect CF-ILDs using CR images. The algorithm's detection capability was non-inferior to that of doctors.

DOI PubMed

オンラインPRO情報システムによる乳がん患者の精神状態と生活の質変化に関する研究

石貫智裕, 九冨五郎, 沖田憲司, 島宏彰, 和田朝香, 青木武士, 吉田寛, 渡邉学, 横尾英樹, 問山裕二, 大西浩文, 大柳俊夫, 水口徹

日本癌治療学会学術集会(Web) ( (一社)日本癌治療学会 ) 60回 P63 - 5 2022年10月

J-GLOBAL

オンラインPRO情報システムによる乳がん患者の精神状態と生活の質変化に関する研究

石貫智裕, 九冨五郎, 沖田憲司, 島宏彰, 和田朝香, 青木武士, 吉田寛, 渡邉学, 横尾英樹, 問山裕二, 大西浩文, 大柳俊夫, 水口徹

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 60回 P63 - 5 2022年10月

児童生徒が主体的に取り組む感染症予防対策の実践活動ありがとうプロジェクトの進捗報告(第2報)

大浦麻絵, 大西浩文, 小山雅之, 長多好恵, 長谷川準子, 助友裕子, 森満

北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 ) 36 ( 1特別付録 ) 55 - 55 2022年10月

J-GLOBAL