Papers - NAKASE Hiroshi

Intestinal cancer in patients with Crohn's disease: A systematic review and meta‐analysis

Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Tomohiro Minagawa, Yuki Horio, Ryuichi Kuwahara, Shiro Nakamura, Kenji Watanabe, Masayuki Saruta, Toshimitsu Fujii, Taku Kobayashi, Ken Sugimoto, Fumihito Hirai, Motohiro Esaki, Sakiko Hiraoka, Katsuyoshi Matsuoka, Shinichiro Shinzaki, Minoru Matsuura, Nagamu Inoue, Hiroshi Nakase, Mamoru Watanabe

Journal of Gastroenterology and Hepatology ( Wiley )   2020.09

DOI

COVID-19パンデミック状況下における炎症性腸疾患の管理に関する専門家の意見JAPAN IBD COVID-19 TASKFORCE 厚生労働科学研究費補助金(難治性疾患政策研究事業)難治性炎症性腸管障害に関する調査研究班

仲瀬 裕志, 松本 主之, 松浦 稔, 飯島 英樹, 松岡 克善, 大宮 直木, 石原 俊治, 平井 郁仁, 我妻 康平, 横山 佳浩, 久松 理一

日本消化管学会雑誌 ( (一社)日本消化管学会 )  4 ( 1 ) 15 - 24  2020.09

　View Summary

Coronavirus disease 2019(COVID-19)にともなう消化器症状ならびにCOVID-19パンデミック状況下での、炎症性腸疾患(IBD)患者に対しての、日常診療上の重要なポイントを解説する。現時点では、(1)IBD患者のCOVID-19リスクは、一般の方と比べて高くない、(2)原則としてIBD疾患活動性の制御が優先される、(3)寛解状態のIBD患者において、免疫調節薬や生物学的製剤治療を中止する必要はない、(4)ステロイド投与中患者、高齢IBD患者(60歳以上)では、COVID-19による入院、ICU管理、人工呼吸器使用率が高いといえる。(著者抄録)

Author's reply: acute serologic autoimmune hepatitis in the post-partum period.

Noriyuki Akutsu, Keisuke Ishigami, Hiroshi Nakase

Clinical journal of gastroenterology   13 ( 4 ) 634 - 634  2020.08  [Refereed]  [Domestic journal]

DOI PubMed

横行結腸に発生したcytological dysplasiaを伴う分類困難な鋸歯状病変の1例

秋田 浩太朗, 山野 泰穂, 柴田 泰洋, 久保 俊之, 吉井 新二, 横山 佳浩, 風間 友江, 三橋 慧, 能正 勝彦, 山下 健太郎, 須藤 豪太, 山本 英一郎, 鈴木 拓, 寺井 琴美, 辻脇 光洋, 長谷川 匡, 永塚 真, 菅井 有, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1265 - 1265  2020.08

SSA/P由来が示唆された横行結腸SM癌の一例

久保 俊之, 山野 泰穂, 中村 友哉, 柴田 泰洋, 山川 司, 風間 友江, 赤保内 正和, 吉井 新二, 山下 健太郎, 須藤 豪太, 山本 英一郎, 鈴木 拓, 永塚 真, 菅井 有, 杉田 真太朗, 長谷川 匡, 遠藤 高夫, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1327 - 1327  2020.08

Superficially serrated adenoma(SuSA)の発がんが観察された微小大腸癌の1例

柴田 泰洋, 山野 泰穂, 久保 俊之, 吉井 新二, 山下 健太郎, 須藤 豪太, 山本 英一郎, 鈴木 拓, 寺井 琴美, 長谷川 匡, 永塚 真, 菅井 有, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1265 - 1265  2020.08

Arteriovenous malformation in pancreas mimicking hypervascular tumor.

Keisuke Ishigami, Tomoya Sakuma, Masato Saito, Yujiro Kawakami, Yoshiharu Masaki, Ayako Murota, Masayo Motoya, Yasutoshi Kimura, Hiroshi Nakase

JGH open : an open access journal of gastroenterology and hepatology   4 ( 4 ) 773 - 774  2020.08  [International journal]

　View Summary

Arteriovenous malformation (AVM) is defined as a disease that causes blood flow abnormality due to anastomoses of the arteries and veins. AVM can occur in any gastrointestinal tract, but pancreatic AVM (P-AVM) is very rare. Previous reports demonstrated that contrast-enhanced CT (CECT) typically showed abnormal vascular network in pancreas. We present a 58-year old man with a history of acute pancreatitis. He was referred to our hospital for examination of pancreatic mass. CECT showed a round-shaped hypervascular lesion with a diameter of 8 mm in the head of the pancreas. Selective angiography showed vascular network and early visualization of superior mesenteric vein. We finally diagnosed this case as P-AVM. He underwent duodenum preserving pancreatic head resection. Histological findings confirmed the preoperative diagnosis of P-AVM.

DOI PubMed

術後再建腸管に対するショートタイプダブルバルーン内視鏡を用いたERCP関連手技の治療成績

川上 裕次郎, 柾木 喜晴, 平野 雄大, 我妻 康平, 石上 敬介, 伊東 文子, 阿久津 典之, 本谷 雅代, 佐々木 茂, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1307 - 1307  2020.08

悪性胆道狭窄における術前胆道ドレナージ不全についての検討

平野 雄大, 柾木 喜晴, 我妻 康平, 川上 裕次郎, 石上 敬介, 室田 文子, 本谷 雅代, 木村 康利, 仲瀬 裕志

胆道 ( (一社)日本胆道学会 )  34 ( 3 ) 490 - 490  2020.08

Non traumatic tubeを用いた大腸内視鏡観察法の工夫

吉井 新二, 山野 泰穂, 仲瀬 裕志, 柴田 泰洋, 久保 俊之, 山下 健太郎, 能正 勝彦

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1279 - 1279  2020.08

Motion capture技術を用いた大腸内視鏡挿入手技の客観的評価の試み

山野 泰穂, 久保 俊之, 仲瀬 裕志, 白田 智洋, 我妻 康平, 風間 友江, 上野 あかり, 中村 友哉, 大和田 紗英, 柴田 泰洋, 山川 司, 赤保内 正和, 仲地 耕平, 吉井 新二, 山下 健太郎

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  62 ( Suppl.1 ) 1230 - 1230  2020.08

胆道癌の術前進展度診断における、胆道鏡の有用性に関する検討

柾木 喜晴, 平野 雄大, 我妻 康平, 川上 裕次郎, 石上 敬介, 室田 文子, 本谷 雅代, 木村 康利, 仲瀬 裕志

胆道 ( (一社)日本胆道学会 )  34 ( 3 ) 500 - 500  2020.08

Interactive Web-based Graphs of Coronavirus Disease 2019 Cases and Deaths per Population by Country.

Masashi Idogawa, Shoichiro Tange, Hiroshi Nakase, Takashi Tokino

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America   71 ( 15 ) 902 - 903  2020.07  [Refereed]  [International journal]

DOI PubMed

Long-Term Follow-Up of Targeted Biopsy Yield (LOFTY Study) in Ulcerative Colitis Surveillance Colonoscopy.

Keisuke Hata, Soichiro Ishihara, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Reiko Kunisaki, Hiroshi Nakase, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Masaru Shinozaki, Noriyuki Ogata, Kentaro Moriichi, Fumihito Hirai, Kenichi Sugihara, Tadakazu Hisamatsu, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi

Journal of clinical medicine   9 ( 7 )  2020.07  [Refereed]  [International journal]

　View Summary

We previously performed a randomized controlled trial (RCT) comparing targeted and random biopsy in neoplasia detection in patients with ulcerative colitis (UC), which showed the short-term effectiveness of targeted biopsy with one-time colonoscopy. In this retrospective cohort study, we investigated the long-term effectiveness of targeted biopsy in tertiary care hospitals, using the follow-up data from patients with UC for ≥ 8 years who had enrolled in the initial RCT. The primary outcome was death from colorectal cancer (CRC). Secondary outcomes were advanced neoplasia (CRC or high-grade dysplasia) and colectomy due to neoplasia after the RCT. We compared these outcomes between target and random groups. Data on 195 of the 221 patients (88.2%) enrolled in the previous RCT were collected from 28 institutions between 2008 and 2019. No patients died of CRC in either group, with a median 8.8-year follow-up demonstrating a robustness for targeted biopsy in terms of CRC death prevention. Advanced neoplasia was detected in four and three patients in the target and random groups, respectively. Colectomy was required due to neoplasia in three patients in each group. The chance of developing CRC in patients with a negative colonoscopy was low, and the targeted biopsy appeared effective in this population. Conversely, patients found with low-grade dysplasia at initial RCT have 10-fold higher risk of progression to high-grade dysplasia and/or CRC. Ten extracolonic malignancies were observed during the follow-up, resulting in four deaths. Panchromoendoscopy was used only in 4.6% and targeted biopsy was only performed in 59.1% of colonoscopies. We recommend targeted biopsy rather than > 33 random biopsies in real-world settings under adequate observation by specialists.

DOI PubMed

The shining DIAMOND for evidence-based treatment strategies for Crohn's disease.

Hiroshi Nakase, Takayuki Matsumoto, Kenji Watanabe, Tadakazu Hisamatsu

Journal of gastroenterology    2020.07  [Refereed]  [Domestic journal]

　View Summary

Anti-tumor necrosis factor (TNF)-α antibodies are effective therapeutic agents to treat inflammatory bowel disease (IBD). In the biologic era, the development of immunogenicity has been a critical issue for secondary loss of response. The superiority of anti-TNF therapy in combination with immunomodulators (IMs) is well-established for infliximab (IFX) but less evident for adalimumab (ADA). To clarify the contribution of thiopurines to ADA-treated patients with Crohn's disease (CD), the deep remission of immunomodulator and adalimumab combination therapy for Crohn's disease (DIAMOND) studies provided the first randomized comparison of efficacy between ADA monotherapy and ADA with thiopurine. The results of the DIAMOND and DIAMOND2 studies revealed the appropriate ADA therapeutic strategy for immunosuppressant-naïve patients with active CD based on therapeutic drug monitoring, endoscopic findings and clinical issues regarding the use of thiopurines.

DOI PubMed

Gastrointestinal: Abdominal aortic aneurysm caused symptoms mimicking superior mesenteric artery syndrome.

G Sudo, H Takagi, S Nakahara, A Goto, Y Hinoda, H Nakase

Journal of gastroenterology and hepatology    2020.07  [International journal]

DOI PubMed

Comparison of dissection speed during colorectal ESD between the novel Multiloop (M-loop) traction method and ESD methods without traction.

Yuichiro Suzuki, Tokuma Tanuma, Masanori Nojima, Gota Sudo, Yuki Murakami, Tatsuya Ishii, Masakazu Akahonai, Yosuke Kobayashi, Hidetaka Hamamoto, Hironori Aoki, Taku Harada, Akio Katanuma, Hiroshi Nakase

Endoscopy international open   8 ( 7 ) E840-E847  2020.07  [Refereed]  [International journal]

　View Summary

Background and study aims  We previously reported on a novel traction method called Multiloop (M-loop) for faster colorectal endoscopic submucosal dissection (ESD). In this study, we retrospectively compared the difference in submucosal dissection time (SDT), and submucosal dissection speed (SDS) between groups of patients who were treated using traction with the M-loop method, and with non-traction methods of colorectal ESD. Patients and methods  We reviewed and timed duration of colorectal ESD by the non-traction method from videos recorded between June 2016 and December 2017. From January 2018 onward, we used the M-loop method during all colorectal ESDs and timed it until August 2018. Outcomes of colorectal ESD with the M-loop method and non-traction methods were compared. The study involved two experts and eight non-experts and was carried out at a tertiary endoscopic center in Japan. Results  The study included 50 patients who treated with the M-loop method and 115 patients treated with the non-traction method. Submucosal dissection time (SDT) was not significantly different (M-loop group, 42.1  ±  4.2 min, non-traction ESD group, 51.9 ± 3.3 min) ( P  = 0.098), but submucosal dissection speed (SDS) was significantly greater (M-loop group, 28.0 ± 2.9 mm 2  /min, non-traction ESD group, 19.9 ± 2.0 mm 2 /min) ( P  = 0.0014) in the M-loop method group. Multivariate analysis showed that the M-loop method increased SDS by odds ratio of 1.46 ( P  = 0.001) when compared to the non-traction ESD method. A significant difference was also observed for SDT and SDS when the two methods were compared after propensity score matching ( P  = 0.001). No differences in unfavorable outcomes were observed. Conclusions  The M-loop method improved SDS compared to non-traction methods of ESD. The method is an effective tool to assist colorectal ESD.

DOI PubMed

Lynch症候群に合併した多発微小大腸癌の1例

柴田 泰洋, 山野 泰穂, 久保 俊之, 吉井 新二, 山下 健太郎, 須藤 豪太, 山本 英一郎, 鈴木 拓, 寺井 琴美, 長谷川 匡, 永塚 真, 菅井 有, 仲瀬 裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  117 ( 臨増総会 ) A319 - A319  2020.07

Lynch症候群に合併した多発微小大腸癌の1例

柴田 泰洋, 山野 泰穂, 久保 俊之, 吉井 新二, 山下 健太郎, 須藤 豪太, 山本 英一郎, 鈴木 拓, 寺井 琴美, 長谷川 匡, 永塚 真, 菅井 有, 仲瀬 裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  117 ( 臨増総会 ) A319 - A319  2020.07

新規大腸がん間質関連遺伝子の同定とがん微小環境における機能の解明

須藤 豪太, 山本 英一郎, 三橋 慧, 久保 俊之, 山野 泰穂, 鈴木 拓, 仲瀬 裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  117 ( 臨増総会 ) A318 - A318  2020.07