Papers - NAKASE Hiroshi

Development of an oral drug delivery system targeting immune-regulating cells in experimental inflammatory bowel disease: A new therapeutic strategy

H Nakase, K Okazaki, Y Tabata, S Uose, M Ohana, K Uchida, Y Matsushima, C Kawanami, C Oshima, Y Ikada, T Chiba

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS ( AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS )  292 ( 1 ) 15 - 21  2000.01  [Refereed]

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Several studies have indicated the involvement of macrophages and dendritic cells in active inflammatory bowel disease (IBD). Manipulation of these cells is considered a very important therapeutic strategy for patients with IBD. We evaluated the effect of a new drug delivery system targeting microfold cells and macrophages with poly( DL-lactic acid) microspheres containing dexamethasone (Dx). Colitis was induced in BALB/c mice by 5% dextran sodium sulfate. Dx microspheres (n = 10) and only Dx (n = 10) were orally administered to dextran sodium sulfate-treated mice. Thereafter, serum levels and tissue distributions of Dx were investigated. To estimate the efficacy of this drug delivery system, we measured the histological score, myeloperoxidase activity and nitric oxide production, and gene expressions of tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in the colonic tissue. Serum Dx levels were not increased after oral administration of Dx microspheres. The tissue distribution of microspheres containing I-125-labeled Dx in inflamed colon was significantly higher than in other organs. The histological score, myeloperoxidase activity, and nitric oxide production of the group treated with Dx microspheres were significantly lower than of those treated with Dx alone. Gene expressions of tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma were down-regulated in mice treated with Dx microspheres. Microspheres containing glucocorticoids such as Dx, which target microfold cells and macrophages, can facilitate mucosal repair in experimental colitis and could be an ideal agent for treatment of human IBD.

PubMed J-GLOBAL

Ｍ細胞の機能と病態へのかかわり．

仲瀬裕志, 伊藤俊之, 河南智晴, 岡崎和一

G.I. Research   8   29 - 35  2000

炎症性腸疾患および腫瘍性疾患の鑑別のポイント．

仲瀬 裕志

Medical Practice   17   639 - 644  2000

特集「炎症性腸疾患の病態と治療戦略」 炎症性腸疾患におけるTh1/Th2バランスと治療

仲瀬裕志, 河南智晴, 岡崎和一

Pharma Medica   19   61 - 65  2000

Relationship between asthma and gastro-oesophageal reflux: Significance of endoscopic grade of reflux oesophagitis in adult asthmatics

H Nakase, T Itani, J Mimura, T Kawasaki, H Komori, H Tomioka, T Chiba

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ( BLACKWELL SCIENCE ASIA )  14 ( 7 ) 715 - 722  1999.07  [Refereed]

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Background: The association between asthma and gastro-oesophageal reflux disease (GERD) is well known. The aim of this study was to elucidate the causal relationship between reflux oesophagitis (RE) and asthma. Methods: Seventy-two adult asthmatics were examined regarding their GERD symptoms, and each underwent an endoscopic examination. According to the Los Angeles classification, we divided the patients into three groups: group 1 (n = 52), no mucosal break; group 2 (n = 15), RE corresponding to grades A or B; group 3 (n = 5), RE corresponding to grades C or D. The asthmatics in groups 2 and 3 received anti-reflux treatment for their GERD for 8 weeks. Their morning and evening peak expiratory flow rates (PEFR), daily variability of the PEER and daily use of an inhalation bronchodilator were compared before and after this treatment. Results: The percentage of severe asthma and postprandial exacerbation of asthma in group 3 were significantly higher than those in the other two groups. In contrast, the number of eosinophiles and the serum level of immunoglobulin E in group 3 were significantly lower than those in the other two groups. After the antireflux treatment, significant improvements of both PEER and daily use of the inhalation bronchodilator were observed only in group 3. Conclusions: The endoscopic severity of RE is associated with the characteristics of adult asthmatics and the treatment of severe RE improved the asthmatics' condition. (C) 1999 Blackwell Science Asia Pty Ltd.

DOI

Gastric ulcer formation after the Hanshin-Awaji earthquake: A case study of Helicobacter pylori infection and stress-induced gastric ulcers

Y Matsushima, N Aoyama, H Fukuda, Y Kinoshita, A Todo, S Himeno, S Fujimoto, M Kasuga, H Nakase, T Chiba

HELICOBACTER ( BLACKWELL SCIENCE INC )  4 ( 2 ) 94 - 99  1999.06  [Refereed]

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Background. Both Helicobacter pylori (H. pylori) infection and various stresses are known to induce peptic ulcer disease of the upper gastrointestinal tract. However, the pathogenetic relationship between the two factors has not yet been clarified. We conducted a case-control study to examine whether H. pylori infection played a role in the development of gastric ulcer (GU) induced by life-event stresses that were experienced after the Hanshin-Awaji earthquake. Materials and Methods. Serum samples from patients in the devastated area who developed GUs during the 2 months following the Hanshin-Awaji earthquake and those from GU patients in the same area during the corresponding period of the previous year, and from gender-, age- and institute-matched ulcer-free controls were tested for the presence of the H. pylori Ige antibody. Results. A significant association between H. pylori infection and the development of GU in uninjured patients was observed in all sets [matched odds ratio (OR) 3.23, 95% confidence interval: 1.95-5.35]. Moreover, the prevalence of H. pylori infection in patients who developed GUs after the earthquake was not different from that for GU patients in the previous year. In contrast, there was no association between H. pylori infection and the development of GU in the physically injured patients after the earthquake. Conclusions. H. pylori infection may play an important role in the development of GUs that are induced by emotional life-event stresses.

DOI

Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with ulcerative colitis

E Adachi, K Okazaki, Y Matsushima, H Seno, K Uchida, H Nakase, C Kawanami, T Nakamura, T Chiba

INTERNATIONAL JOURNAL OF PANCREATOLOGY ( HUMANA PRESS INC )  25 ( 3 ) 217 - 221  1999.06  [Refereed]

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Therapy with oral 5-aminosalicylic acid (5-ASA) for ulcerative colitis has been reported to be effective and safe. We describe a case of biochemically proven mild acute pancreatitis occurring after 9 d of oral 5-ASA therapy for ulcerative colitis. A hypersensitivity mechanism seemed to be involved in the development of pancreatitis probably owing to erratic systemic absorption of the drug. We suggest clinical and biochemical monitoring for early diagnosis of pancreatitis in patients with ulcerative colitis receiving 5-ASA administration. This is the first report of acute pancreatitis developed by oral 5-ASA therapy for the treatment of ulcerative colitis in the literature of Japan.

PubMed

Colonic ulceration caused by administration of loxoprofen sodium

H Nakase, T Itani, J Mimura, T Kawasaki, H Komori, K Hashimoto, T Chiba

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  38 ( 3 ) 249 - 251  1999.03  [Refereed]

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A 54-year-old female with chronic headache was admitted to our hospital because of hematochezia. She had routinely taken loxoprofen sodium because of severe headache, Emergent colonoscopic examination revealed ulceration of the cecum, After administration of loxoprofen sodium was discontinued and administration of sulfasalazine was initiated, her intestinal bleeding subsided, Two months after discontinuation of loxoprofen sodium, the colonoscopic examination revealed scar formation at the site of cecal ulceration. In this case, it was conceivable that the administration of loxoprofen sodium might have induced colonic ulceration.

DOI CiNii

Bronchial Asthma and Reflux Esophagitis a Clinical Study on 106 Cases with Bronchial Asthma

H. Tomioka, T. Itani, H. Nakase

Japanese Journal of Chest Diseases   58 ( 11 ) 834 - 835  1999  [Refereed]

気管支喘息と胃食道逆流症 －喘息患者に対する逆流症治療の意義．

仲瀬裕志, 千葉 勉

消化器科   28   350 - 353  1999

Power Doppler imaging of hepatic tumours: Differential diagnosis between hepatocellular carcinoma and metastatic adenocarcinoma

T Kawasaki, T Itani, H Nakase, J Mimura, H Komori, K Sugimoto

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ( BLACKWELL SCIENCE )  13 ( 11 ) 1152 - 1160  1998.11  [Refereed]

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We evaluated the usefulness of power Doppler imaging in the differential diagnosis between hepatocellular carcinoma and metastatic adenocarcinoma. Forty-seven patients with hepatocellular carcinoma and 18 patients with metastatic adenocarcinoma were evaluated using power Doppler imaging. The colour signals of hepatic rumours were graded as follows: 1, colour signals only in the marginal area; 2, small dot or dotted line colour signals within the rumours; 3, continuous solid line colour signals within the rumours. The grade 3 colour signals were classified in the following three patterns; winding line pattern, stretched line pattern and mixed pattern. The colour signals of hepatocellular carcinoma were grade 1 in seven patients, grade 2 in 11 and grade 3 in 29. The colour signals of metastatic adenocarcinoma were grade 1 in three patients and grade 3 in 15. Of the 29 hepatocellular carcinoma patients with a grade 3 signal, 26 patients had winding line patterns and three had mixed patterns. Of the 15 metastatic adenocarcinoma patients with a grade 3 signal, 12 patients had stretched line patterns and three had mixed patterns. In conclusion, power Doppler imaging is useful in the differential diagnosis between hepatocellular carcinoma and metastatic adenocarcinoma to evaluate the colour signal pattern within the tumour.

DOI

Transient protein-losing enteropathy associated with cytomegalovirus infection in a noncompromised host: A case report

H Nakase, T Itani, J Mimura, R Takeuchi, T Kawasaki, H Komori, K Hashimoto, T Chiba

AMERICAN JOURNAL OF GASTROENTEROLOGY ( ELSEVIER SCIENCE INC )  93 ( 6 ) 1005 - 1006  1998.06  [Refereed]

DOI

③消化管 大腸

仲瀬裕志, 千葉 勉

認定医・専門医のための内科学レビュー ’98 －最新主要文献と解説－     84 - 89  1998

気管支喘息患者における逆流性食道炎の評価

仲瀬 裕志

薬理と治療   26 ( 5 ) 679 - 682  1998

CiNii

Evaluation of GERD in bronchial asthmatic patients

H. Nakase

Japanese Pharmacology and Therapeutics   26 ( 5 ) 33 - 36  1998  [Refereed]

経腸栄養法における合併症と対策

仲瀬 裕志

臨床栄養   91   35 - 41  1997

Analysis of the usefulness of power Doppler imaging in diagnosing acute appendicitis

H. Uchida, T. Okuno, T. Kawasaki, F. Maenishi, S. Azuma, R. Horikawa, Y. Sakakibara, K. Noborio, H. Komori, J. Mimura, T. Itani, H. Nakase

Journal of Medical Ultrasonics   24 ( 4 ) 19 - 25  1997  [Refereed]

私の治療法 －クローン病の治療法/その1.

仲瀬 裕志

臨床科学   34   547 - 550  1997

便秘の分類と治療

仲瀬 裕志

内科診療Q＆A －     678 - 679  1997

Endoscopic variceal ligation versus endoscopic injection sclerotherapy: Comparison of hepatic and renal function

H Nakase, T Kawasaki, H Komori, N Sakatani, S Sawai, T Chiba

AMERICAN JOURNAL OF GASTROENTEROLOGY ( WILLIAMS & WILKINS )  91 ( 10 ) 2170 - 2173  1996.10  [Refereed]

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Objectives: The aim of the present study was to compare the safety of endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS) in terms of liver and kidney functions in patients with liver cirrhosis. Methods: Forty-four patients admitted to Takatsuki General Hospital between February 1991 and March 1993 with esophageal varices due to liver cirrhosis were randomly assigned to receive either EVL or EIS, Serum levels of AST, ALT, total bilirubin (T-bil), direct bilirubin (D-bil), prothrombin time (PT), hepaplastin test (HPT), antithrombin III (ATIII), creatinine (Cr), and blood urea nitrogen (BUN) were measured before and 24 h, 3 days, 7 days, and 14 days after both forms of therapy. Results: Significant elevations of serum T-bil, serum D-bil, and serum ALT and AST levels were observed in the EIS group but not in the EVL group. No significant increases of serum PT, HPT, ATIII, BUN, or Cr levels were observed after treatment in either group, Conclusion: EVL should be considered a first choice therapy for eradicating esophageal varices.