Details of a Researcher - NAKASE Hiroshi

Papers - NAKASE Hiroshi

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An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.

Tsukasa Yamakawa, Keisuke Ishigami, Sae Ohwada, Tomoe Kazama, Daisuke Hirayama, Shinji Yoshii, Hiro-O Yamano, Hiroshi Nakase

Clinical journal of gastroenterology 16 ( 2 ) 187 - 192 2023.04 [Domestic journal]

A 77-year-old patient with ulcerative colitis (UC) was transferred to our department because of worsening bloody diarrhea and abdominal pain, which was consistent with a UC flare. Two days after admission, she complained of cough and high fever. The polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was positive, and a computed tomography showed pneumonia in the left lobe, consistent with coronavirus disease 2019 (COVID-19) pneumonia. However, frequent bloody diarrhea and abdominal pain due to the UC flare persisted; therefore, an additional immunosuppressive agent needed to be considered. We initiated infliximab biosimilar (IFX-BS), and her abdominal symptoms improved. However, they deteriorated after the second IFX-BS infusion. After confirming that the patient was negative for SARS-CoV-2 by PCR, we administered a combination of azathioprine and IFX-BS. The combination treatment improved her intestinal symptoms without worsening COVID-19 pneumonia. She has remained in remission for over a year since her discharge.

DOI PubMed

IgG4関連疾患:内視鏡の役割(胆膵/全体) IgG4関連消化管病変の臨床的特徴

川上裕次郎, 柾木喜晴, 仲瀬裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 ) 65 ( Suppl.1 ) 742 - 742 2023.04

膵疾患に対するEUS診断の現状膵臓癌に対するがんゲノムプロファイリング検査(CGP)のための適正な検体採取方法の検討

室田文子, 柾木喜晴, 仲瀬裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 ) 65 ( Suppl.1 ) 790 - 790 2023.04

側方進展をきたした十二指腸乳頭部腫瘍に対する一括切除を目指したEP with hybrid ESD

川上裕次郎, 柾木喜晴, 仲瀬裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 ) 65 ( Suppl.1 ) 856 - 856 2023.04

Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn's Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn's Disease (iCREST-CD).

Takayuki Yamamoto, Hiroshi Nakase, Kenji Watanabe, Shinichiro Shinzaki, Noritaka Takatsu, Toshimitsu Fujii, Ryuichi Okamoto, Katsuyoshi Matsuoka, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Hisashi Shiga, Shigeki Bamba, Yohei Mikami, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Atsuo Maemoto, Yoko Murata, Shinichi Yoshigoe, Shinya Nagasaka, Tsutomu Yajima, Tadakazu Hisamatsu

Journal of Crohn's & colitis 17 ( 8 ) 1193 - 1206 2023.03 [International journal]

BACKGROUND AND AIMS: Perianal lesion is a refractory phenotype of Crohn's disease (CD) with significantly diminished quality of life. We evaluated the clinical characteristics of perianal lesions in newly diagnosed CD patients and the impact of perianal lesions on the quality of life in Japanese patients with CD. METHODS: Patients newly diagnosed with CD after June 2016 were included between December 2018 and June 2020 from the Inception Cohort Registry Study of Patients with CD (iCREST-CD). RESULTS: Perianal lesions were present in 324 (48.2%) of 672 patients with newly diagnosed CD. 71.9% (233/324) were male. The prevalence of perianal lesions was higher in patients aged <40 years versus ≥40 years, and it decreased with age. Perianal fistula (59.9%) and abscess (30.6%) were the most common perianal lesions. In multivariate analyses, male sex, age <40 years, and ileocolonic disease location were significantly associated with a high prevalence of perianal lesions, whereas stricturing behaviour and alcohol intake were associated with low prevalence. Fatigue was more frequent (33.3% vs 21.6%) and, work productivity and activity impairment-work time missed (36.3% vs 29.5%) and activity impairment (51.9% vs 41.1%) were numerically higher in patients with than those without perianal lesions. CONCLUSIONS: At the time of CD diagnosis, approximately half of the patients had perianal lesions; perianal abscesses and perianal fistulas were the most common. Young age, male sex, disease location, and behaviour are significantly associated with the presence of perianal lesions. The presence of perianal lesion was associated with fatigue and impairment of daily activities.

DOI PubMed

膵空腸吻合部ロストステントの膵管内完全迷入に対し、EUS-PDルートを用いて除去に成功した1例

中村隼人, 柾木喜晴, 我妻康平, 川上裕次郎, 石上敬介, 室田文子, 木村康利, 仲瀬裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 ) 132回・126回 40 - 40 2023.03

免疫チェックポイント阻害薬関連腸炎における粘膜サイトカインの検討

大和田紗恵, 三宅高和, 横山佳浩, 風間友江, 吉井新二, 山野泰穂, 仲瀬裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 ) 120 ( 臨増総会 ) A373 - A373 2023.03

当科の核酸アナログ治療20年の検討

阿久津典之, 佐々木茂, 沼田泰尚, 平野雄大, 我妻康平, 石上敬介, 川上裕次郎, 柾木喜晴, 室田文子, 仲瀬裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 ) 120 ( 臨増総会 ) A420 - A420 2023.03

当科における原発性硬化性胆管炎(PSC)症例の検討

沼田泰尚, 阿久津典之, 世戸凌太, 中村隼人, 浪岡万由子, 廣部洋輔, 三浦克与志, 平野雄大, 我妻康平, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 佐々木茂, 仲瀬裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 ) 120 ( 臨増総会 ) A399 - A399 2023.03

がん遺伝子パネルを契機に生殖細胞系列のBRCA2変異陽性と診断され,白金製剤使用後にPARP阻害剤が導入可能となった1例

世戸凌太, 室田文子, 我妻康平, 川上裕次郎, 沼田泰尚, 石上敬介, 柾木喜晴, 阿久津典之, 笠原薫, 佐々木茂, 仲瀬裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 ) 132回・126回 72 - 72 2023.03

橈骨動脈アプローチによるTACEにより治療しえたHCCの1例

沼田泰尚, 中村隼人, 廣部洋輔, 平野雄大, 我妻康平, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 佐々木茂, 仲瀬裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 ) 132回・126回 46 - 46 2023.03

メトトレキサートによる肝線維症が原因と考えられた食道静脈瘤の1例

中村隼人, 沼田泰尚, 平野雄大, 我妻康平, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 佐々木茂, 仲瀬裕志

新規デバイスデリバリーシステムを用いた経乳頭的胆嚢生検にて診断したIgG4関連胆嚢炎の1例

亀山尚弘, 川上裕次郎, 世戸凌太, 廣部洋輔, 柾木喜晴, 室田文子, 阿久津典之, 木村康利, 仲瀬裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 ) 132回・126回 39 - 39 2023.03

当科における切除可能肝門部領域胆管癌の治療成績

川上裕次郎, 柾木喜晴, 我妻康平, 沼田泰尚, 石上敬介, 室田文子, 阿久津典之, 木村康利, 仲瀬裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 ) 120 ( 臨増総会 ) A329 - A329 2023.03

EUS-FNAにて診断したIgG4関連動脈周囲炎の1例

廣部洋輔, 川上裕次郎, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 仲瀬裕志

永石歓和, 仲瀬裕志

消化器病学サイエンス ( (株)先端医学社 ) 7 ( 1 ) 33 - 38 2023.03

間葉系幹細胞(mesenchymal stem cells:MSC)は,多彩な生理活性物質を産生・分泌して免疫制御能や組織修復・再生能を発揮する体性幹細胞である.炎症組織では,MSCが局所の炎症性サイトカインによる刺激を受けて活性化する.MSCは,スフェロイドを形成することで免疫制御能や血管新生能,抗アポトーシス効果などの細胞機能が向上する.MSCは,消化器領域の慢性炎症性疾患における新しい治療選択肢として実用化が模索されている.(著者抄録)

肝疾患と便中カルプロテクチンの関連の検討

沼田泰尚, 平野雄大, 我妻康平, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 佐々木茂, 仲瀬裕志

日本内科学会雑誌 ( (一社)日本内科学会 ) 112 ( 臨増 ) 144 - 144 2023.02

山野泰穂, 吉井新二, 久保俊之, 山川司, 三宅高和, 風間友江, 柴田泰洋, 三橋慧, 須藤豪太, 赤保内正和, 瀧澤歩, 山本英一郎, 仲瀬裕志

胃と腸 ( (株)医学書院 ) 58 ( 2 ) 135 - 145 2023.02

＜文献概要＞近年,大腸鋸歯状病変,特にSSLは第3の大腸癌への発育進展ルート"serrated neoplastic pathway"として注目されており,癌あるいは癌を疑う所見を伴うSSLに対して的確に内視鏡診断することが重要である.当科にて経験したSSL関連病変115病変の検討で,癌併存SSL病変,SSLD病変とそれ以外の病変群とで拡大内視鏡所見を比較検討した.その結果,癌併存SSL病変では複数のpit patternから構成されており,開II型を背景に軽度から高度異型を示すVI型を必ず伴っていたのに対して,SSLDでは鋸IV型,IIIL型が混在しており,明確なVI型の判断はなされていなかった.なお,大腸鋸歯状病変に対する内視鏡診断では拡大内視鏡診断の考え方,病理組織標本の取り扱いや病理組織学的診断基準などの要因による影響を受けるため注意を要する.

慢性肝疾患患者における骨密度とundercarboxylated osteocalcinの関連

我妻康平, 石上敬介, 阿久津典之, 平野雄大, 川上裕次郎, 沼田泰尚, 柾木喜晴, 室田文子, 佐々木茂, 仲瀬裕志

日本内科学会雑誌 ( (一社)日本内科学会 ) 112 ( 臨増 ) 170 - 170 2023.02

Anxiety and behavioral changes in Japanese patients with inflammatory bowel disease due to COVID-19 pandemic: a national survey.

Hiroshi Nakase, Kohei Wagatsuma, Masanori Nojima, Takayuki Matsumoto, Minoru Matsuura, Hideki Iijima, Katsuyoshi Matsuoka, Naoki Ohmiya, Shunji Ishihara, Fumihito Hirai, Ken Takeuchi, Satoshi Tamura, Fukunori Kinjo, Nobuhiro Ueno, Makoto Naganuma, Kenji Watanabe, Rintaro Moroi, Nobuaki Nishimata, Satoshi Motoya, Koichi Kurahara, Sakuma Takahashi, Atsuo Maemoto, Hirotake Sakuraba, Masayuki Saruta, Keiichi Tominaga, Takashi Hisabe, Hiroki Tanaka, Shuji Terai, Sakiko Hiraoka, Hironobu Takedomi, Kazuyuki Narimatsu, Katsuya Endo, Masanao Nakamura, Tadakazu Hisamatsu

Journal of gastroenterology 58 ( 3 ) 1 - 12 2023.01 [Domestic journal]

BACKGROUND: Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst the COVID-19 pandemic, we investigated the impact of the pandemic on the anxiety and behavioral changes in Japanese patients with IBD. METHODS: We analyzed 3032 questionnaires from patients with IBD, aged 16 years or older visiting 30 hospitals and 1 clinic between March 2020 and June 2021. The primary outcome was the score of the anxiety experienced by patients with IBD during the pandemic. RESULTS: Participants reported a median age of 44 years; 43.3% of the patients were women. Moreover, 60.6% and 39.4% were diagnosed with ulcerative colitis and Crohn's disease, respectively, with a median disease duration of 10 years. Participants indicated an average of disease-related anxiety score of 5.1 ± 2.5 on a ten-point scale, with a tendency to increase, 1 month after the number of infected persons per population increased. The top three causes for anxiety were the risk of contracting COVID-19 during hospital visits, SARS-CoV-2 infection due to IBD, and infection by IBD medication. Factors associated with anxiety were gender (women), being a homemaker, hospital visit timings, mode of transportation (train), use of immunosuppressive drugs, and nutritional therapy. Most patients continued attending their scheduled hospital visits, taking their medications, experienced the need for a family doctor, and sought guidance and information regarding COVID-19 from primary doctors, television, and Internet news. CONCLUSIONS: Patients with IBD experienced moderate disease-related anxiety due to the pandemic and should be proactively informed about infectious diseases to relieve their anxiety.

DOI PubMed

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Papers - NAKASE Hiroshi