Papers - NAKASE Hiroshi

胆道閉塞患者におけるEUS-HGSのための至適ステント選択(Optimal stent selection for endoscopic ultrasound-guided hepaticogastrostomy in patients with biliary obstruction)

柾木 喜晴, 大沼 法永, 中村 友哉, 川上 裕次郎, 室田 文子, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  66 ( Suppl.1 ) 958 - 958  2024.04

自己免疫性膵炎診療における消化管精査の意義

川上 裕次郎, 柾木 喜晴, 仲瀬 裕志

Gastroenterological Endoscopy ( (一社)日本消化器内視鏡学会 )  66 ( Suppl.1 ) 1017 - 1017  2024.04

Genomic analysis of an aggressive hepatic leiomyosarcoma case following treatment for hepatocellular carcinoma.

Yuto Numata, Noriyuki Akutsu, Masashi Idogawa, Kohei Wagatsuma, Yasunao Numata, Keisuike Ishigami, Tomoya Nakamura, Takehiro Hirano, Yujiro Kawakami, Yoshiharu Masaki, Ayako Murota, Shigeru Sasaki, Hiroshi Nakase

Hepatology research : the official journal of the Japan Society of Hepatology    2024.03  [International journal]

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A 70-year-old man undergoing treatment for immunoglobulin G4-related disease developed a liver mass on computed tomography during routine imaging examination. The tumor was located in the hepatic S1/4 region, was 38 mm in size, and showed arterial enhancement on dynamic contrast-enhanced computed tomography. We performed a liver biopsy and diagnosed moderately differentiated hepatocellular carcinoma. The patient underwent proton beam therapy. The tumor remained unchanged but enlarged after 4 years. The patient was diagnosed with hepatocellular carcinoma recurrence and received hepatic arterial chemoembolization. However, 1 year later, the patient developed jaundice, and the liver tumor grew in size. Unfortunately, the patient passed away. Autopsy revealed that the tumor consisted of spindle-shaped cells exhibiting nuclear atypia and a fission pattern and tested positive for α-smooth muscle actin and vimentin. No hepatocellular carcinoma components were observed, and the patient was pathologically diagnosed with hepatic leiomyosarcoma. Next-generation sequencing revealed somatic mutations in CACNA2D4, CTNNB1, DOCK5, IPO8, MTMR1, PABPC5, SEMA6D, and ZFP36L1. Based on the genetic mutation, sarcomatoid hepatocarcinoma was the most likely pathogenesis in this case. This mutation is indicative of the transition from sarcomatoid hepatocarcinoma to hepatic leiomyosarcoma.

DOI PubMed

Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas.

Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-O Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki

BMC gastroenterology   24 ( 1 ) 91 - 91  2024.03  [International journal]

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BACKGROUND: Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions. METHODS: SMOC1 expression was analyzed immunohistochemically in a series of colorectal tumors (n = 199) and adjacent normal colonic tissues (n = 112). RESULTS: SMOC1 was abundantly expressed in normal colon and SSLs while it was significantly downregulated in TSAs, advanced adenomas and cancers. Mean immunohistochemistry scores were as follows: normal colon, 24.2; hyperplastic polyp (HP), 18.9; SSL, 23.8; SSL with dysplasia (SSLD)/SSL with early invasive cancer (EIC), 15.8; TSA, 5.4; TSA with high grade dysplasia (HGD)/EIC, 4.7; non-advanced adenoma, 21.4; advanced adenoma, 11.9; EIC, 10.9. Higher levels SMOC1 expression correlated positively with proximal colon locations and flat tumoral morphology, reflecting its abundant expression in SSLs. Among TSAs that contained both flat and protruding components, levels of SMOC1 expression were significantly lower in the protruding components. CONCLUSION: Our results suggest that reduced expression of SMOC1 is associated with progression of TSAs and conventional adenomas and that SMOC1 expression may be a biomarker for diagnosis of serrated lesions and risk prediction in colorectal tumors.

DOI PubMed

膵癌との鑑別を要したIgG4関連動脈周囲炎の1例

大沼 法永, 柾木 喜晴, 中村 友哉, 平野 雄大, 川上 裕次郎, 石上 敬介, 室田 文子, 仲瀬 裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  134回・128回   59 - 59  2024.03

最新技術を用いた消化器診療 膵病変へのEUS-FNBにおけるTrident針とFranseen針の比較検討

中村 友哉, 川上 裕次郎, 柾木 喜晴, 室田 文子, 仲瀬 裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  134回・128回   36 - 36  2024.03

肝細胞癌に対しデュルバルマブ+トレメリムマブ併用療法中irAE膵炎を発症しEUS-FNAで診断しえた1例

山本 智香, 室田 文子, 平野 雄大, 我妻 康平, 川上 裕次郎, 沼田 泰尚, 石上 敬介, 柾木 喜晴, 阿久津 典之, 長谷川 匡, 仲瀬 裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  134回・128回   45 - 45  2024.03

IgGサブクラス欠損症を背景とした血清IgG4陰性自己免疫性膵炎の1例

中村 友哉, 川上 裕次郎, 平野 雄大, 我妻 康平, 沼田 泰尚, 石上 敬介, 柾木 喜晴, 室田 文子, 阿久津 典之, 佐々木 茂, 杉田 真太朗, 仲瀬 裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  134回・128回   59 - 59  2024.03

凍結胚移植後に繰り返し生じた高度な急性薬剤性肝障害の1例

常盤 孝介, 我妻 康平, 阿久津 典之, 山本 智香, 大沼 法永, 中村 友哉, 平野 雄大, 川上 裕次郎, 沼田 泰尚, 石上 敬介, 柾木 喜晴, 室田 文子, 佐々木 茂, 仲瀬 裕志

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  134回・128回   68 - 68  2024.03

IgG4-hepatopathyの臨床病理学的特徴

川上 裕次郎, 柾木 喜晴, 中村 友哉, 平野 雄大, 我妻 康平, 沼田 泰尚, 石上 敬介, 室田 文子, 阿久津 典之, 仲瀬 裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  121 ( 臨増総会 ) A351 - A351  2024.03

潰瘍性大腸炎におけるトファシチニブの長期治療成績とその位置付け

伊藤 貴博, 前本 篤男, 横山 佳浩, 桂田 武彦, 安藤 勝祥, 藤谷 幹浩, 蘆田 知史, 那須野 正尚, 田中 浩紀, 仲瀬 裕志

日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  121 ( 臨増総会 ) A318 - A318  2024.03

The frequency and pathogenicity of BRCA1 and BRCA2 variants in the general Japanese population.

Masashi Idogawa, Tasuku Mariya, Yumi Tanaka, Tsuyoshi Saito, Hiroshi Nakase, Takashi Tokino, Akihiro Sakurai

Journal of human genetics    2024.02  [International journal]

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Hereditary breast and ovarian cancer syndrome (HBOC) resulting from pathogenic variants of BRCA1 or BRCA2 is the most common and well-documented hereditary tumor. Although founder variants have been identified in population-based surveys in various countries, the types of variants are not uniform across races and regions. Recently, the Tohoku Medical Megabank Organization (ToMMo) released whole-genome sequence data including approximately 54,000 individuals from the general population of the Tohoku area in Japan. We analyzed these data and comprehensively identified the prevalence of BRCA1/2 pathogenic and truncating variants. We believe that an accurate understanding of the unique distribution and characteristics of pathogenic BRCA1/2 variants in Japan through this analysis will enable better surveillance and intervention for HBOC patients, not only in Japan but also worldwide.

DOI PubMed

Long Noncoding RNA RP11-278A23.1, a Potential Modulator of p53 Tumor Suppression, Contributes to Colorectal Cancer Progression.

Masayo Kamikokura, Shoichiro Tange, Hiroshi Nakase, Takashi Tokino, Masashi Idogawa

Cancers   16 ( 5 )  2024.02  [International journal]

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Recently, many studies revealed that long noncoding RNAs (lncRNAs) play important roles in cancers. To identify lncRNAs contributing to colorectal cancers, we screened lncRNAs through expression and survival analyses in datasets from The Cancer Genome Atlas (TCGA). The screen revealed that RP11-278A23.1 expression is significantly increased in colorectal cancer tissues compared with normal tissues and that high RP11-278A23.1 expression correlates with poor prognosis. The knockdown of RP11-278A23.1 inhibited the growth of and promoted apoptosis in colorectal cancer cells. Next, to comprehensively examine differentially expressed genes after RP11-278A23.1 knockdown, RNA sequencing was performed in HCT116 cells. The expression of p21, a p53 target gene, was significantly upregulated, and the expression of several p53 target proapoptotic genes was also altered. RP11-278A23.1 knockdown increased p53 expression at the translational level but not at the transcriptional level. Interestingly, RP11-278A23.1 knockdown also altered the expression of these proapoptotic genes in DLD1 cells with mutated p53 and in p53-knockout HCT116 cells. These results suggest that RP11-278A23.1 modifies the expression of these apoptosis-related genes in p53-dependent and p53-independent manners. In summary, lncRNA RP11-278A23.1 contributes to colorectal cancer progression by promoting cell growth and inhibiting apoptosis, suggesting that this lncRNA may be a useful therapeutic target.

DOI PubMed

IgG4関連疾患における消化管生検の検討

川上 裕次郎, 平野 雄大, 石上 敬介, 我妻 康平, 柾木 喜晴, 室田 文子, 仲瀬 裕志

日本内科学会雑誌 ( (一社)日本内科学会 )  113 ( 臨増 ) 142 - 142  2024.02

消化器癌における化学療法と癌関連心不全についての検討

室田 文子, 川上 裕次郎, 柾木 喜晴, 石上 敬介, 阿久津 典之, 吉井 新二, 山野 泰穂, 佐々木 茂, 仲瀬 裕志

日本内科学会雑誌 ( (一社)日本内科学会 )  113 ( 臨増 ) 143 - 143  2024.02

内視鏡的切除により診断できた皮膚様食道扁平上皮癌

足立 靖, 菊地 剛史, 後藤 啓, 吉田 幸成, 石井 良文, 高橋 宏明, 佐々木 泰史, 仲瀬 裕志, 遠藤 高夫

日本消化管学会雑誌 ( (一社)日本消化管学会 )  8 ( Suppl. ) 360 - 360  2024.01

Maintenance steroid therapy is associated with decreased risk of malignancy and better prognosis of patients with autoimmune pancreatitis: A multicenter cohort study in Japan

Tetsuya Takikawa, Kazuhiro Kikuta, Takanori Sano, Tsukasa Ikeura, Nao Fujimori, Takeji Umemura, Itaru Naitoh, Hiroshi Nakase, Hiroyuki Isayama, Atsushi Kanno, Ken Kamata, Yuzo Kodama, Dai Inoue, Akio Ido, Toshiharu Ueki, Hiroshi Seno, Hiroaki Yasuda, Eisuke Iwasaki, Takayoshi Nishino, Kensuke Kubota, Toshihiko Arizumi, Atsushi Tanaka, Kazushige Uchida, Ryotaro Matsumoto, Shin Hamada, Seiji Nakamura, Kazuichi Okazaki, Yoshifumi Takeyama, Atsushi Masamune, Shinji Nakayama, Akira Nakamura, Yoshiharu Masaki, Mako Ushio, Tomohiro Watanabe, Masahiro Tsujimae, Shiro Tanoue, Toru Maruo, Masahiro Shiokawa, Satoki Yamane, Atsuto Kayashima

Pancreatology ( Elsevier BV )   2024.01

DOI

von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis

Noriyuki Okubo, Shingo Sugawara, Tohru Fujiwara, Ko Sakatsume, Tsuyoshi Doman, Mihoko Yamashita, Kota Goto, Masaki Tateishi, Misako Suzuki, Ryutaro Shirakawa, Yuka Eura, Koichi Kokame, Masaki Hayakawa, Masanori Matsumoto, Yasunori Kawate, Mizuki Miura, Hiroshi Takiguchi, Yoshimitsu Soga, Shinichi Shirai, Kenji Ando, Yoshio Arai, Takaharu Nakayoshi, Yoshihiro Fukumoto, Hiroyuki Takahama, Satoshi Yasuda, Toshihiro Tamura, Shin Watanabe, Takeshi Kimura, Nobuhiro Yaoita, Hiroaki Shimokawa, Yoshikatsu Saiki, Koichi Kaikita, Kenichi Tsujita, Shinji Yoshii, Hiroshi Nakase, Shin-ichi Fujimaki, Hisanori Horiuchi

Research and Practice in Thrombosis and Haemostasis ( Elsevier BV )  8 ( 1 ) 102284 - 102284  2024.01

DOI

Gut microbiota and metabolites in patients with COVID-19 are altered by the type of SARS-CoV-2 variant.

Yoshihiro Yokoyama, Tomoko Ichiki, Tsukasa Yamakawa, Yoshihisa Tsuji, Koji Kuronuma, Satoshi Takahashi, Eichi Narimatsu, Akio Katanuma, Hiroshi Nakase

Frontiers in microbiology   15   1358530 - 1358530  2024  [International journal]

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INTRODUCTION: Patients with COVID-19 have dysbiosis of the intestinal microbiota with altered metabolites in the stool. However, it remains unclear whether the differences among SARS-CoV-2 variants lead to differences in intestinal microbiota and metabolites. Thus, we compared the microbiome and metabolome changes for each SARS-CoV-2 variant in patients with COVID-19. MATERIALS AND METHODS: We conducted a multicenter observational study of patients with COVID-19 and performed fecal microbiome, metabolome, and calprotectin analyses and compared the results among the different SARS-CoV-2 variants. RESULTS: Twenty-one patients with COVID-19 were enrolled and stratified according to the SARS-CoV-2 strain: six with the Alpha, 10 with the Delta, and five with the Omicron variant. Fecal microbiome analysis showed that α-diversity was reduced in the order of the Omicron, Delta, and Alpha variants (p = 0.07). Linear discriminant analysis revealed differences in the abundance of short-chain fatty acid-producing gut microbiota for each SARS-CoV-2 variant. Fecal metabolome analysis showed that the Omicron and Delta variants had markedly reduced propionic and lactic acid levels compared to the Alpha strain (p < 0.05). CONCLUSION: The intestinal microbiota of patients with COVID-19 varies depending on the SARS-CoV-2 variant. Dysbiosis of the intestinal microbiota due to differences in SARS-CoV-2 variants causes a decrease in intestinal short-chain fatty acids.

DOI PubMed

Transcolonic endoscopic ultrasound-guided fine-needle biopsy to diagnose a pancreatic tail adenocarcinoma in a patient with surgically altered anatomy.

Yujiro Kawakami, Yoshiharu Masaki, Masahiro Taniguchi, Keisuke Ishigami, Ayako Murota, Masayo Motoya, Hiroshi Nakase

Endoscopy   55 ( S 01 ) E334-E335  2023.12  [International journal]

DOI PubMed