論文 - 松浦　基樹

腹腔鏡下子宮体癌手術における工夫

石堂 茉泉, 松浦 基樹, 斉藤 公仁, 鹿内 智史, 西村 庸子, 玉手 雅人, 秋元 太志, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 斎藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  66回   0106 - 0106  2018年09月

次世代術者のキャリアとビジョン〜悪性腫瘍手術を見据えて〜 守破離 現状直視と未来のビジョン

玉手 雅人, 松浦 基樹, 明石 祐史, 寒河江 悟, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  34 ( Suppl.I ) 144 - 144  2018年08月

Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women.

Satomi Aoyama-Kikawa, Hiromasa Fujita, Sharon J B Hanley, Mitsunori Kasamo, Kokichi Kikuchi, Toshihiko Torigoe, Yoshihiro Matsuno, Akiko Tamakoshi, Takayuki Sasaki, Motoki Matsuura, Yasuhito Kato, Peixin Dong, Hidemichi Watari, Tsuyoshi Saito, Kazuo Sengoku, Noriaki Sakuragi

Cancer science   109 ( 6 ) 2003 - 2012  2018年06月  [査読有り]  [国際誌]

　概要を見る

Although cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3-year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and HPV testing were carried out. Women with abnormal cytology or HPV16/18 positivity underwent colposcopy. Those with 12 other high-risk (hr) HPV types underwent repeat cytology after 6 months. Primary study endpoints were detection of high-grade cervical disease defined as CIN2/CIN3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hrHPV, HPV 16, and HPV 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. HPV16/18 were detected in all (8/8) invasive cervical cancers and in all (2/2) adenocarcinomas in situ. Both cytological abnormalities and hrHPV positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an HPV-based screening program. Results should help policy-makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on HPV genotype.

DOI PubMed

術前の良悪性の診断が困難だった卵巣腫瘍症例の検討

鈴木 利理, 玉手 雅人, 長尾 沙智子, 田渕 雄大, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 29 ) 171 - 171  2018年06月

遺伝性乳癌卵巣癌症候群(HBOC)における子宮頸部・内膜細胞診の検討

寺本 瑞絵, 柏木 葉月, 秋元 太志, 玉手 雅人, 寺田 倫子, 鈴木 美和, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  57 ( Suppl.1 ) 220 - 220  2018年04月

子宮内膜細胞診の有用性 子宮内膜液状化細胞診検体による遺伝子解析研究

松浦 基樹, 玉手 雅人, 郷久 晴朗, 寺本 瑞絵, 幸保 莉香, 畠山 晴良, 山口 貴世志, 杉田 真太朗, 池上 恒雄, 岩崎 雅宏, 長谷川 匡, 古川 洋一, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  57 ( Suppl.1 ) 123 - 123  2018年04月

LOSS OF ASPP2 PROMOTES CELL INVASION AND MIGRATION VIA YAP IN HUMAN ENDOMETRIAL CANCER

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

DEVICES IN LAPAROSCOPIC SURGERY FOR ENDOMETRIAL CANCER

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

Recurring Ovarian Primary Glioblastoma with Effective Carboplatin plus Etoposide Therapy

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

当科での広間膜内筋腫に対する核出術における手術戦略

田渕 雄大, 玉手 雅人, 長尾 沙智子, 杉尾 明香, 明石 祐史, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF036 - 05  2017年12月

子宮全摘術における腟管切開と縫合

玉手 雅人, 松浦 基樹, 長尾 沙智子, 杉尾 明香, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) EP056 - 01  2017年12月

変性筋腫核出術の工夫

岡田 匡氷, 玉手 雅人, 田渕 雄大, 長尾 沙智子, 杉尾 明香, 明石 祐史, 松浦 基樹, 斎藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF036 - 06  2017年12月

診療、教育、研究の充実にはオフの活動が不可欠!

齋藤 豪, 松浦 基樹, 玉手 雅人, 岩崎 雅宏, 郷久 晴朗, 寺田 倫子

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) 3 - 1  2017年12月

膜を意識して行う腹腔鏡下En bloc骨盤リンパ節郭清

松浦 基樹, 玉手 雅人, 斎藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF113 - 02  2017年12月

子宮体癌における予後因子と子宮頸部細胞診所見の関連性の検討

田中 綾一, 鈴木 孝浩, 玉手 雅人, 寺田 倫子, 松浦 基樹, 鈴木 美和, 高橋 円, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  56 ( Suppl.2 ) 726 - 726  2017年10月

Comparison of secondary cytoreductive surgery plus chemotherapy with chemotherapy alone for recurrent epithelial ovarian, tubal, or peritoneal carcinoma A propensity score-matched analysis of 112 consecutive patients

Akimasa Takahashi, Kazuyoshi Kato, Motoki Matsuura, Takahiro Katsuda, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Eiji Kondo, Kohei Omatsu, Kuniko Utsugi, Nobuhiro Takeshima

MEDICINE ( LIPPINCOTT WILLIAMS & WILKINS )  96 ( 37 ) e8006  2017年09月  [査読有り]

　概要を見る

To compare secondary cytoreductive surgery (SCS) plus chemotherapy with chemotherapy alone in Japanese patients with recurrent epithelial ovarian, tubal, or peritoneal cancer (ROC).From our institutional database, we identified 112 patients who underwent therapy for ROC between 2005 and 2013. Of the 112 patients, 77 received salvage chemotherapy alone (CT group) and 35 received SCS plus chemotherapy (SCS group). To reduce the impact of treatment selection bias on treatment outcomes, propensity score-matching analysis was used.In the entire cohort, prognostic features were poorer in the CT group than in the SCS group. The platinum-free interval was significantly lower (15.35 months vs 30.77 months), cancer antigen 125 (CA125) level was significantly higher (247.38IU/mL vs 83.17 IU/mL), and number of solitary recurrence sites was significantly lower in the CT group than in the SCS group. The matched cohort consisted of 29 CT and 29 SCS patients with a median follow-up period of 24 and 58 months, respectively. In the matched cohort, progression-free survival (PFS) was longer in the SCS group than in the CT group (P=.02); however, overall survival did not differ (P=.23).SCS might be associated with improved PFS in ROC patients. SCS is beneficial in appropriately selected ROC patients.

DOI PubMed

Clinicopathological Features of Early and Late Recurrence of Endometrial Carcinoma After Surgical Resection

Akimasa Takahashi, Motoki Matsuura, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Eiji Kondo, Kohei Omatsu, Kazuyoshi Kato, Kuniko Utsugi, Nobuhiro Takeshima

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER ( BMJ PUBLISHING GROUP )  27 ( 5 ) 967 - 972  2017年06月  [査読有り]

　概要を見る

Objectives: The incidence of endometrial carcinoma has been increasing annually in developed nations; it is currently the secondmost common gynecological malignancy. Although the majority of patients are diagnosed at an early stage, 15% to 20% reportedly recur; consequently, patients are usually followed clinically for 3 years after the initial curative surgery. We therefore aimed to determine the incidence and clinicopathological features of early and late recurrences of endometrial carcinoma after surgical resection.Materials and Methods: This retrospective study was performed using the clinical records of 2233 patients who underwent surgical resection for endometrial carcinoma between January 1970 and December 2009 at a single cancer center. Tumor recurrenceswere classified as early (<5 years) and late (>5 years) after initial surgery. Clinicopathological variables and tumor recurrence patterns were compared between the early and late recurrence groups. Survival analysis was performed using the Kaplan-Meier method.Results: Among 2233 study patients, 255 (11.4%) experienced endometrial carcinoma recurrence; of these, early and late recurrences occurred in 232 (91.0%) and 23 (9.0%) patients, respectively. Late recurrencewas associated with invasion of less than half of themyometrium at diagnosis and the presence of histopathological features of endometrioid adenocarcinoma with low- or intermediate-grade histological subtype and absence of lymphovascular invasion. After recurrence, there was no significant difference in overall survival between the early and late recurrence groups (P - 0.437). Furthermore, surgical treatment was associated with a significantly improved prognosis in the late recurrence group (P = 0.044).Conclusions: The findings of this study indicated that patients who initially underwent successful treatment for low-grade and early-stage endometrial carcinoma should be followed clinically for more than 5 years. In cases of late recurrence, surgical management may improve prognosis.

DOI PubMed

Rap1GAP inhibits tumor progression in endometrial cancer

Masato Tamate, Ryoichi Tanaka, Hiroyuki Osogami, Motoki Matsuura, Seiro Satohisa, Masahiro Iwasaki, Tsuyoshi Saito

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( ACADEMIC PRESS INC ELSEVIER SCIENCE )  485 ( 2 ) 476 - 483  2017年04月  [査読有り]

　概要を見る

Objective: Endometrioid adenocarcinoma (EAC) is a common endometrial cancer with recent dramatic increases in incidence. Previous findings indicate that Rap1GAP acts as a tumor suppressor inhibiting Ras superfamily protein Rapl in multiple aggressive carcinomas; however, Rap1GAP expression in EAC has not been investigated. In this study, the tumor suppressing activity of Rap1GAP in EAC was explored. Methods: EAC cell lines were used to examine Rapl GAP levels by real-time RT-PCR and western blotting and the effects of Rap1GAP on cancer cell invasion and migration. Rap1GAP expression was analyzed by immunohistochemical staining for Rapi GAP, E-cadherin in surgically resected tumors of 114 EAC patients scored according to EAC differentiation grade. Prognostic variables such as age, stage, grade, tumor size, and immunostaining for Rap1GAP, E-cadherin were evaluated using Cox regression multivariate analysis. Results: Low Rap1GAP expression was detected in poorly differentiated EAC cells. Rap1GAP deficiency significantly accelerated while Rapl deficiency decreased cancer cell migration and invasion. Patients with higher Rap1GAP, E-cadherin, and especially combined RaplGAP/E-cadherin levels had better overall survival than EAC patients with no or weak expression. In addition, Rapi GAP expression was an independent prognostic factor in EAC. Conclusions: Inhibition of Rap1GAP expression increases EAC cell migration and invasion through upregulation of Rapi. Low expression of Rap1GAP correlates with poor EAC differentiation. Our findings suggest that Rap1GAP is an important tumor suppressor with high prognostic value in EAC.(C) 2017 Elsevier Inc. All rights reserved.

DOI PubMed

A CASE OF PORT SITE METASTASIS AFTER LAPAROSCOPIC SURGERY FOR OVARIAN CARCINOSARCOMA

Motoki Matsuura

International Journal of Gynecological Cancer    2017年

IMPORTANCE OF UTERINE CERVICAL CERCLAGE TO MAINTAIN A SUCCESSFUL PREGNANCY FOR PATIENTS WHO UNDERGO VAGINAL RADICAL TRACHELECTOMY

Motoki Matsuura

International Journal of Gynecological Cancer    2017年