研究者詳細 - 松浦　基樹

論文 - 松浦　基樹

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hinotoriを用いた婦人科ロボット支援手術

長尾沙智子, 松浦基樹, 黒川晶子, 玉手雅人, 秋元太志, 諸井明仁, 齋藤豪

産婦人科手術 ( (株)メジカルビュー社 ) ( 35 ) 150 - 150 2024年06月

vNOTESを導入する際の諸問題 vNOTES,船頭多くして船海に出るために

玉手雅人, 松浦基樹, 長尾沙智子, 黒川晶子, 諸井明仁, 秋元太志, 幅田周太朗, 齋藤豪

産婦人科手術 ( (株)メジカルビュー社 ) ( 35 ) 137 - 137 2024年06月

Early outcomes of three new robotic surgical systems in patients undergoing hysterectomy.

Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Updates in surgery 2024年05月 [国際誌]

New robot models, such as hinotori™, da Vinci SP™, and Hugo™, have been introduced in Japan. This study examined the surgical outcomes of these models in patients from the initial stages of their introduction to the present day.We retrospectively reviewed 36 patients with endometrial cancer or benign gynecologic disease, who underwent robotic hysterectomy using da Vinci SP™, hinotori™, or Hugo™ between March 2023 and March 2024.Robotic hysterectomy was performed using hinotori™ in 10 patients, da Vinci SP™ in 16 patients, and Hugo™ in 10 patients. No significant differences were observed in the characteristics of the patients subjected to surgery using these models. The total operative time was 123.0 min (93-144 min) for hinotori™, 95.0 min (79-165 min) for da Vinci SP™, and 98.5 min (74-177 min) for Hugo™. The total operative time of hinotori™ was significantly longer than that of the other two models (p = 0.031). No differences were observed among the robot systems with respect to complications during or after surgery and the intensity of postoperative pain.Differences in the surgical time were noted depending on the model used. It has been proven that surgeons who are already proficient in performing robotic surgery with da Vinci Xi™ can safely perform surgeries with the new models.

DOI PubMed

Surgical Outcomes of da Vinci Xi™ and da Vinci SP™ for Early-Stage Endometrial Cancer in Patients Undergoing Hysterectomy.

Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Journal of clinical medicine 13 ( 10 ) 2024年05月 [国際誌]

Objectives: This study aimed to evaluate and compare the feasibility and outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da Vinci SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, and assess the postoperative recurrence rate and overall survival of patients. Methods: A retrospective review of 84 patients who underwent robotic hysterectomy for endometrial cancer (stage 1A) was conducted. Surgical procedures, patient characteristics, intraoperative measures, and postoperative outcomes were statistically analyzed. A single gynecologist performed all surgeries. Results: Patient characteristics, average age, and body mass index showed no significant differences between the two models. The total operative time was significantly shorter with da Vinci SP™. Recurrence was identified in only one patient operated on with da Vinci Xi™. All patients were alive during analysis, with a median overall survival of 38 and 9 months for da Vinci Xi™ and da Vinci SP™, respectively. Conclusions: Robotic hysterectomy without lymph node dissection appears to be a safe and effective approach for patients with early-stage endometrial cancer. The da Vinci SP offers the advantage of shorter operative times than the da Vinci Xi™. These findings support the consideration of robotic surgery as a viable option for selected patients.

DOI PubMed

Prediction of Mismatch Repair Status in Endometrial Cancer from Histological Slide Images Using Various Deep Learning-Based Algorithms.

Mina Umemoto, Tasuku Mariya, Yuta Nambu, Mai Nagata, Toshihiro Horimai, Shintaro Sugita, Takayuki Kanaseki, Yuka Takenaka, Shota Shinkai, Motoki Matsuura, Masahiro Iwasaki, Yoshihiko Hirohashi, Tadashi Hasegawa, Toshihiko Torigoe, Yuichi Fujino, Tsuyoshi Saito

Cancers 16 ( 10 ) 2024年05月 [国際誌]

The application of deep learning algorithms to predict the molecular profiles of various cancers from digital images of hematoxylin and eosin (H&E)-stained slides has been reported in recent years, mainly for gastric and colon cancers. In this study, we investigated the potential use of H&E-stained endometrial cancer slide images to predict the associated mismatch repair (MMR) status. H&E-stained slide images were collected from 127 cases of the primary lesion of endometrial cancer. After digitization using a Nanozoomer virtual slide scanner (Hamamatsu Photonics), we segmented the scanned images into 5397 tiles of 512 × 512 pixels. The MMR proteins (PMS2, MSH6) were immunohistochemically stained, classified into MMR proficient/deficient, and annotated for each case and tile. We trained several neural networks, including convolutional and attention-based networks, using tiles annotated with the MMR status. Among the tested networks, ResNet50 exhibited the highest area under the receiver operating characteristic curve (AUROC) of 0.91 for predicting the MMR status. The constructed prediction algorithm may be applicable to other molecular profiles and useful for pre-screening before implementing other, more costly genetic profiling tests.

DOI PubMed

我々はこうしている～子宮頸癌手術におけるMISの工夫我々が行う子宮頸癌に対する腹腔鏡下広汎子宮全摘術の工夫

松浦基樹, 長尾沙智子, 黒川晶子, 玉手雅人, 秋元太志, 幅田周太朗, 齋藤豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 ) 42 ( 2 ) 114 - 117 2024年04月

子宮移植までのマイルストーン

玉手雅人, 馬場剛, 和田渚, 古来愛香, 幅田周太朗, 小川万梨絵, 松浦基樹, 齋藤豪

日本生殖医学会雑誌 ( (一社)日本生殖医学会 ) 69 ( 1-2 ) 122 - 122 2024年04月

自己採取および尿採取法による腟内HPV検査の患者の受け入れに関する検討

齋藤豪, 松浦基樹, 寺田倫子, 玉手雅人, 高田優子, 西村庸子, 山下真祐子, 諸井明仁

日本女性医学学会雑誌 ( (一社)日本女性医学学会 ) 31 ( 3 ) 404 - 409 2024年04月

子宮頸がん検診の受診率向上は喫緊の課題である.自己採取または尿採取腟内HPV検査は複数の介入研究で受診率向上に有効と報告されている.医師採取HPV検査と同等の感度があれば,受診率向上が課題であるわが国において有効な手段となりうる.われわれはこれまで自己採取・尿採取HPV検査の有効性について比較検討研究を行い報告してきたが,本研究ではよりよい自己採取法を目指し,検体採取対象者に対し検査の受け入れに関するアンケート調査を行った.年齢は20～50歳とし,CIN2以上の患者を100名以上含む計300名を対象に研究を行った.アンケート300人中281人が回答し,子宮頸がんについては「知っている」,あるいは,「なんとなく知っている」と答えた人が93.1%,頸がんが検診でがんになる前の段階で見つけることを「知っている」と答えた人は87.9%,頸がんの原因がHPVと言うウイルスの感染であることを「知っている」と答えた人の割合は93.3%といずれも高い割合であった.採取前に38.6%が不安ありと答えたが,すべての患者が採取を完遂し患者にとって受け入れられているものと考えた.頸がんに対する認知度は高いものの検診率の増加に結びついていないことが今後の課題であり,自己採取HPV検査も解決策の一つと考えられた.(著者抄録)

The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line.

Takumi Konno, Takayuki Kohno, Shin Kikuchi, Arisa Kura, Kimihito Saito, Tadahi Okada, Hiroshi Shimada, Yuya Yamazaki, Tomoki Sugiyama, Motoki Matsuura, Yuki Ohsaki, Tsuyoshi Saito, Takashi Kojima

Tissue barriers 2304443 - 2304443 2024年01月 [国際誌]

It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhibitors on the epithelial permeability barrier, cell migration and mitochondrial metabolism in 2D and 2.5D cultures of human endometrioid endometrial carcinoma Sawano cells. We also investigated the changes of bicellular and tricellular tight junction molecules and ciliogenesis induced by these inhibitors. The growth factors TGF-β and EGF affected the epithelial permeability barrier, cell migration and expression of bicellular and tricellular tight junction molecules in 2D and 2.5D cultures of Sawano cells. EW-7197 (a TGF-β receptor inhibitor), AG1478 (an EGFR inhibitor) and SP600125 (a JNK inhibitor) affected the epithelial permeability barrier, cell migration and mitochondrial metabolism and prevented the changes induced by TGF-β and EGF in 2D and 2.5D cultures. EW-7197 and AG1478 induced ciliogenesis in 2.5D cultures. In conclusion, TGF-β and EGF promoted the malignancy of endometrial cancer via interplay among the epithelial permeability barrier, cell migration and mitochondrial metabolism. EW-7197 and AG1478 may be useful as novel therapeutic treatments options for endometrial cancer.

DOI PubMed

Step-by-step demonstration of “sciatic-nerve-preserved beyond-LEER” in a Thiel-embalmed cadaver: a novel salvage surgery for recurrent gynecologic malignancies

Hiroyuki Kanao, Masato Tamate, Motoki Matsuura, Sachiko Nagao, Miseon Nakazawa, Shutaro Habata, Tsuyoshi Saito

Journal of Gynecologic Oncology 2024年

DOI

A Rare Case of Small Intestinal Cancer With Uterine Metastasis After Surgery for Ovarian Metastasis, Diagnosed Using Immunostaining.

Sachiko Nagao, Motoki Matsuura, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Case reports in oncological medicine 2024 8551816 - 8551816 2024年 [国際誌]

Uterine metastases from extragenital sites are rare. We present a case of a woman who had undergone surgery for small intestinal cancer and subsequently developed metastases in her left ovary and uterus. A nulliparous woman in her 50s underwent laparoscopic partial small bowel resection with lymph node dissection for small intestinal cancer. Five months later, computed tomography (CT) revealed a left ovarian tumor and ascites. She underwent bilateral adnexectomy and adjuvant chemotherapy, and the ovarian tumor was diagnosed as a small intestinal cancer metastasis. Two years after the small intestinal cancer surgery, a positron emission tomography (PET)-CT scan revealed a uterine accumulation. Cervical cytology was negative for intraepithelial lesion or malignancy. Endometrial histology showed an adenocarcinoma of the uterus. The patient underwent total abdominal hysterectomy followed by adjuvant chemotherapy. Histopathology and immunohistochemistry of the uterine tumor revealed that it was a metastasis of small intestinal cancer (Cytokeratin 7 [CK7] [-], Cytokeratin 20 [CK20] [+], Special AT-Rich Sequence-Binding Protein 2 [SATB2] [+], Paired Box Gene 2 [PAX2] [-], and estrogen receptor [ER] [-]). In patients with cancer, histopathology and immunohistochemistry are important for distinguishing between primary and metastatic tumors and for guiding the choice of treatment.

DOI PubMed

Niraparib in Japanese patients with platinum-sensitive recurrent ovarian cancer: final results of a multicenter phase 2 study

Hiroaki Itamochi, Nobuhiro Takeshima, Junzo Hamanishi, Kosei Hasegawa, Motoki Matsuura, Kiyonori Miura, Shoji Nagao, Hidekatsu Nakai, Naotake Tanaka, Hideki Tokunaga, Shin Nishio, Hidemichi Watari, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Ai Kato, Ajit Suri, Toshiaki Yasuoka, Kazuhiro Takehara

Journal of Gynecologic Oncology 2024年

DOI

Diagnosis and Methods of Repair for a Uteroperitoneal Fistula (UPF) Formed After Gynecological Surgeries.

Nagisa Wada, Masato Tamate, Motoki Matsuura, Tsuyoshi Saito

Cureus 15 ( 12 ) e51064 2023年12月 [国際誌]

A uteroperitoneal fistula (UPF) is a rare disorder that can lead to infertility and has never been reported. UPFs can cause infertility and perinatal complications. A 34-year-old woman (gravida 0) with a history of three gynecological surgeries using a uterine manipulator was diagnosed with a UPF using hysteroscopy and hysterosalpingography. She underwent laparoscopic uterine repair as an infertility treatment. The uterine perforation may have been caused by uterine manipulator insertion or suture failure in the myometrium during her previous laparoscopic myomectomy and cystectomy procedures. The UPF disappeared after the current surgical treatment. The complications of UPFs include infection, infertility, ectopic pregnancy, and uterine rupture. We expected that the presence of a fistula would increase the risk of impaired fertilization, implantation failure, and ectopic pregnancy. This case report contributes valuable insights into the diagnosis of UPFs and their laparoscopic repair.

DOI PubMed

内視鏡手術支援ロボット最新事情-開発者と使用者から見た理想と現実、問題点- da Vinci SPが切り拓く婦人科ロボット手術の近未来

松浦基樹, 長尾沙智子, 黒川晶子, 玉手雅人, 秋元太志, 齋藤豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 ) 28 ( 7 ) 981 - 981 2023年12月

分娩後の子宮全摘術時に発見され腹膜癌との鑑別が困難であった異所性脱落膜の1例

有元千紘, 長尾沙智子, 堀清貴, 山崎智子, 玉手雅人, 高田さくら, 松浦基樹, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 67 ( 1 ) 11 - 15 2023年12月

異所性脱落膜は,妊娠中の間葉系未分化細胞の化生もしくは子宮内膜症組織などにプロゲステロンが作用することにより生じる。悪性所見と類似した肉眼的所見を呈することがあるため,鑑別や治療方針の決定に難渋することがある。今回我々は,分娩後の子宮全摘術時に偶然発見され,腹膜癌との鑑別が困難であった異所性脱落膜の一例を経験したため,文献的考察とともに報告する。症例は,39歳,2妊1産,妊娠初期に子宮体部後壁に内膜を圧排する粘膜下筋腫を認めていた。妊娠40週0日に陣痛誘発目的に入院し翌日経腟分娩となったが,胎盤娩出後より出血の増加を認めた。経腹超音波検査にて子宮頸部に6cm大の筋腫を認め,筋腫分娩が疑われた。子宮収縮薬投与や子宮用止血バルーン挿入を行ったが止血は得られず,分娩6時間後に子宮全摘術を決定した。術中にダグラス窩,子宮,直腸からS状結腸漿膜面に散在する集簇性小結節を認め,肉眼的には腹膜播種に類似しており腹膜癌などの悪性腫瘍を否定できなかった。子宮全摘術と小結節の一部生検を行い,手術終了とした。病理組織学的検査では異所性脱落膜の診断であり,悪性所見を認めなかった。術後経過問題なく,1週間後に退院となった。異所性脱落膜は悪性腫瘍と類似した所見を呈する場合があるが,確立された鑑別方法はなく,現時点では病理組織学的診断が不可欠である。本邦での報告は稀ではあるが,妊娠中ないし産褥期の女性において悪性腫瘍との鑑別が必要な病態の1つとして異所性脱落膜があることを認識しておくことが重要であると考える。(著者抄録)

子宮内異物・腟閉鎖症例に対して腹腔鏡下子宮全摘術を施行した一例

黒川晶子, 玉手雅人, 西村庸子, 秋元太志, 松浦基樹, 齋藤豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 ) 28 ( 7 ) 3044 - 3044 2023年12月

腟に発症したPEComaの1例

小谷松紗弓, 松浦基樹, 西村庸子, 秋元太志, 磯山響子, 玉手雅人, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 67 ( 1 ) 89 - 89 2023年12月

分娩後の子宮全摘出術時に発見され,腹膜癌との鑑別が困難であった異所性脱落膜の1例

有元千紘, 長尾沙智子, 山崎智子, 玉手雅人, 高田さくら, 松浦基樹, 齋藤豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 ) 67 ( 1 ) 85 - 86 2023年12月

婦人科良性疾患に対するロボット支援手術の在り方良性婦人科ロボット手術の進むべき道筋

松浦基樹, 長尾沙智子, 黒川晶子, 玉手雅人, 秋元太志, 齋藤豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 ) 28 ( 7 ) 811 - 811 2023年12月