論文 - 松浦　基樹

サードアームを有効活用した後方アプローチによるロボット支援下子宮全摘術

松浦 基樹, 西村 庸子, 玉手 雅人, 磯山 響子, 秋元 太志, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 152 - 152  2022年06月

帝王切開瘢痕部妊娠に対する一期的修復術の工夫

齋藤 晋平, 玉手 雅人, 西村 庸子, 磯山 響子, 幅田 周太郎, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 129 - 129  2022年06月

失敗から学ぶ 手術におけるわれわれの取組みやコツ 開腹、腟式 帝王切開瘢痕部妊娠に対する 一期的修復術の工夫

齋藤 晋平, 玉手 雅人, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 13 - 17  2022年06月

Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy.

Masanori Someya, Yuki Fukushima, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoh Kozuka, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata

Japanese journal of radiology   40 ( 5 ) 458 - 465  2022年05月  [国内誌]

　概要を見る

Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In this review, we will describe the mechanism of tumor immunity and how chemoradiotherapy may overcome and improve the efficacy of tumor immunity. We will also discuss the usefulness of proteins involved with tumor immunity as a predictive marker of radiotherapy response, and present an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy to demonstrate the promising combination therapy that has been currently emerging.

DOI PubMed

がん・生殖手術の未来図 当院における子宮頸がんに対するがん生殖技術の足取りと未来図

玉手 雅人, 松浦 基樹, 足立 岳貴, 有元 千紘, 西村 庸子, 黒川 晶子, 秋元 太志, 齋藤 豪

日本外科系連合学会誌 ( 日本外科系連合学会 )  47 ( 3 ) 404 - 404  2022年05月

当院における妊孕性温存手術後の癒着因子の抽出とアウトカム

和田 渚, 玉手 雅人, 木島 紗弓, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 344  2022年02月

子宮頸部原発胎児型横紋筋肉腫の一例

小谷松 紗弓, 玉手 雅人, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 297  2022年02月

子宮頸部原発胎児型横紋筋肉腫の一例

小谷松 紗弓, 玉手 雅人, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 297  2022年02月

当院における妊孕性温存手術後の癒着因子の抽出とアウトカム

和田 渚, 玉手 雅人, 木島 紗弓, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 344  2022年02月

Comparative Evaluation of Preoperative Imaging and Postoperative Histopathology in 108 Patients Who Underwent Laparoscopic- or Robot-Assisted Surgery for Endometrial Cancer.

Noriko Terada, Motoki Matsuura, Shoko Kurokawa, Mizue Teramoto, Masamitsu Hanakenaka, Tsuyoshi Saito

Gynecology and minimally invasive therapy   11 ( 4 ) 203 - 208  2022年  [国際誌]

　概要を見る

OBJECTIVES: The aim of this study was to compare preoperative imaging evaluation results and postoperative histopathology examinations of patients who underwent laparoscopic- or robot-assisted surgery for suspected Stage IA endometrial carcinoma. MATERIALS AND METHODS: There were 298 patients diagnosed with endometrial cancer at our institution between April 2014 and March 2019. Preoperative imaging evaluation based on magnetic resonance imaging (MRI) and computed tomography (CT) revealed 180 patients suspected of having Stage IA disease. Of these, 72 underwent open surgery, 12 underwent robot-assisted surgery, and 96 underwent laparoscopic surgery. In this study, preoperative imaging evaluation results and postoperative histopathology examinations of 108 patients who underwent laparoscopic- or robot-assisted surgery were retrospectively compared. RESULTS: Of the 108 patients, who underwent laparoscopic- or robot-assisted surgery for suspected Stage IA disease, 98 had Stage IA, two had Stage IB, and four had Stages II and III disease. The sensitivity of imaging evaluations based on preoperative MRI and CT was 90.7%. CONCLUSION: Utilizing preoperative MRI and CT imaging resulted in a high rate of successful diagnosis of Stage IA endometrial carcinoma.

DOI PubMed

Case of superficial myofibroblastoma protruding from the posterior fornix treated using laparoscopic surgery

Satoshi Shikanai, Motoki Matsuura, Hiroaki Soyama, Nagisa Wada, Mina Umemoto, Ichiro Miura, Tsuyoshi Saito

JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY ( Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy )  38 ( 2 ) 230 - 234  2022年

DOI

後腟円蓋より発生する腟腫瘍に対し腹腔鏡下手術を行い、表在性筋線維芽細胞腫と判明した1例

鹿内 智史, 松浦 基樹, 曽山 浩明, 和田 渚, 梅本 美菜, 三浦 一郎, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  38 ( 2 ) 230 - 234  2022年

　概要を見る

症例は43歳(0妊0産)で、過多月経と外陰部腫瘤を主訴とした。腫瘍は腟鏡診では後腟円蓋より外向性に発育し表面平滑で、各種画像、子宮頸部擦過診所見より、良性の腟壁由来の間葉系腫瘍、多発子宮筋腫を疑った。腹腔鏡下子宮全摘出術および腟腫瘍摘出術を行い、病理組織学的所見より表在性筋線維芽細胞腫と診断した。

The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma.

Hiroshi Shimada, Takayuki Kohno, Takumi Konno, Tadahi Okada, Kimihito Saito, Yuma Shindo, Shin Kikuchi, Mitsuhiro Tsujiwaki, Marie Ogawa, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

Cancers   13 ( 24 )  2021年12月  [国際誌]

　概要を見る

Tight junction proteins play roles beyond permeability barriers functions and control cell proliferation and differentiation. The relation between tight junctions and the signal transduction pathways affects cell growth, invasion and migration. Abnormality of tight junction proteins closely contributes to epithelial mesenchymal transition (EMT) and malignancy of various cancers. Angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) forms tricellular contacts that has a barrier function. Downregulation of angulin-1/LSR correlates with the malignancy in various cancers, including endometrioid-endometrial carcinoma (EEC). These alterations have been shown to link to not only multiple signaling pathways such as Hippo/YAP, HDAC, AMPK, but also cell metabolism in ECC cell line Sawano. Moreover, loss of angulin-1/LSR upregulates claudin-1, and loss of apoptosis stimulating p53 protein 2 (ASPP2) downregulates angulin-1/LSR. Angulin-1/LSR and ASPP2 concentrate at both midbody and centrosome in cytokinesis. In EEC tissues, angulin-1/LSR and ASPP2 are reduced and claudin-2 is overexpressed during malignancy, while in the tissues of endometriosis changes in localization of angulin-1/LSR and claudin-2 are seen. This review highlights how downregulation of angulin-1/LSR promotes development of endometriosis and EEC and discusses about the roles of angulin-1/LSR and its related proteins, including claudins and ASPP2.

DOI PubMed

Radical Vaginal Trachelectomy.

Tsuyoshi Saito, Motoki Matsuura, Masato Tamate, Masahiro Iwasaki, Tasuku Mariya

Surgery journal (New York, N.Y.)   7 ( Suppl 2 ) S103-S107  2021年12月  [国際誌]

　概要を見る

Recently, radical vaginal hysterectomy (RVH) has developed into laparoscopically assisted radical vaginal hysterectomy (LARVH), which is associated with the laparoscopical procedure, and it is applied as radical vaginal trachelectomy and semi-radical vaginal hysterectomy. LARVH is indicated for patients with stage IB1 and IIA1 cervical carcinoma, especially those with a tumor size of less than 2 cm, because the cardinal ligaments cannot be resected widely. Although RVH that is associated with laparoscopic pelvic lymphadenectomy is the most used surgical procedure, radical trachelectomy may be performed either abdominally or vaginally (laparoscopic or robotic). One report found that the pregnancy rate was higher in patients who underwent minimally invasive or radical vaginal trachelectomy than in those who underwent radical abdominal trachelectomy.

DOI PubMed

子宮頸がんに対する鏡視下広汎子宮全摘術の現状と課題-LACC studyから2年- 鏡視下広汎子宮全摘術の一隅を照らすCST教育

玉手 雅人, 松浦 基樹, 西村 庸子, 常松 梨紗, 幅田 周太朗, 金尾 祐之, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  26 ( 7 ) WS9 - 7  2021年12月

低侵襲手術時代における子宮体癌に対するリンパ節摘出の意義と方法 早期子宮体癌に対するリンパ節郭清の意義と術式の選択

松浦 基樹, 玉手 雅人, 長尾 沙智子, 西村 庸子, 秋元 太志, 幅田 周太朗, 寺田 倫子, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  26 ( 7 ) WS10 - 2  2021年12月

妊娠女性の頸部細胞診 妊娠中施行radical trachelectomy症例における妊娠中細胞診の変化

石岡 伸一, 新開 翔太, 真里谷 奨, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.2 ) 458 - 458  2021年10月

骨髄間葉系間質細胞は子宮内膜症の病態に関与しているか?

幅田 周太朗, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.2 ) 563 - 563  2021年10月

子宮頸癌根治照射症例におけるCD8の浸潤形式と予後との関連

染谷 正則, 土屋 高旭, 福島 悠希, 長谷川 智一, 北川 未央, 後町 俊夫, 岩崎 雅宏, 松浦 基樹, 齋藤 豪, 坂田 耕一

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  59回   O37 - 7  2021年10月

Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy.

Masanori Someya, Takaaki Tsuchiya, Yuki Fukushima, Tomokazu Hasegawa, Masakazu Hori, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Yoshihisa Matsumoto, Koh-Ichi Sakata

Medical molecular morphology   54 ( 3 ) 245 - 252  2021年09月  [国内誌]

　概要を見る

To supplement clinical decision-making in the management of cervical cancer, various prognostic factors, including tumor immune microenvironments, were examined in patients with cervical cancer treated with definitive chemoradiotherapy. We retrospectively analyzed the expression of CD8, FoxP3, HLA-1, PD-L1, and XRCC4 in 100 cases of cervical cancer. The observed tumor immune microenvironments were also classified into three types: inflamed, excluded, and cold type. Less FoxP3+ T cells and cold-type tumor were found to be poor prognostic factors in addition to non-SCC, large pre-treatment tumor volume, and three or less cycles of concurrent chemotherapy based on multivariate analysis. Cold-type tumors had significantly worse prognoses than the other two types, whereas inflamed- and excluded-type tumors showed similar 5-year disease-specific survival (P < 0.001; 0% vs. 60.3% vs. 72.3%). Radiotherapy could overcome the inhibitory immune microenvironment that occurs in excluded type. Individualized combination therapy adapted to pre-treatment tumor immunity may be necessary to improve radiotherapy outcomes in cervical cancer.

DOI PubMed