論文 - 松浦　基樹

婦人科内視鏡技術認定医が不在である当院でのTLHの取り組み

西森 貢隆, 嶋田 浩志, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 91 - 91  2023年12月

Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases

Motoki Matsuura, Kiyoko Takane, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Seira Hatakeyama, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Masahiro Iwasaki, Shintaro Sugita, Tadashi Hasegawa, Yasunori Ota, Tsuyoshi Saito, Yoichi Furukawa

BJC Reports ( Springer Science and Business Media LLC )  1 ( 1 )  2023年11月

　概要を見る

Abstract Background Endometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful treatment. We previously showed that cytological examination combined with genetic analysis using liquid-based cytology (LBC) samples improved the diagnostic sensitivity of EC. Methods Among 218 individuals who underwent endometrial screening by LBC, 208 samples were analysed by cancer-panel sequencing. Excluding 13 samples with low sequence coverage, we further analysed 195 samples. Results Among the 195 women analysed, 39 and 15 were eventually shown to suffer from malignant endometrial and non-endometrial neoplasms, respectively. Driver mutation(s) were found in nine of the 15 cytology-negative patients with endometrial malignancy, corroborating that combination of cytological and genetic analyses should increase the sensitivity of the diagnosis of malignant endometrial neoplasms. Importantly, driver alterations were found in 32 of 125 women without malignant or premalignant diseases, which raises caution for the interpretation of genetic alterations detected in the endometrial samples. Comparison between the driver mutations in the 32 subjects and those in the 29 endometrial malignancies unveiled that the number of mutations and mutations in PTEN, CTNNB1, and TP53 may be applied for the assessment and prediction of development of EC. Conclusions The genetic analysis combined with liquid-based cytology is useful to improve the diagnostic sensitivity of endometrial neoplasms. However, caution must be taken when cancer-associated mutation(s) are detected in the genetic analysis. Further investigation may clarify the risk of malignant endometrial neoplasms in women with driver mutation(s).

DOI

【婦人科悪性腫瘍手術-トラブルシューティングとその予防法-】単純外陰切除術

齋藤 豪, 松浦 基樹, 玉手 雅人, 真里谷 奨

産婦人科の実際 ( 金原出版(株) )  72 ( 12 ) 1397 - 1401  2023年11月

Study on the prevalence and subtypes of human papillomavirus infection among women in the Xuhui District, Shanghai City, China.

Han Liu, Chao Zeng, Mingming Jiang, Yue Dai, Minyi Xu, Fangfang Zhou, Yaling Wang, Alessandra Pulliero, Tomasz Sobierajski, Whitney Nesser, Motoki Matsuura, Lei Wang, Jiaying Wu, Muyuan Ji

Translational cancer research   12 ( 10 ) 2923 - 2931  2023年10月  [国際誌]

　概要を見る

BACKGROUND: Human papillomavirus (HPV) can cause various gynecological diseases, create a long-term inflammatory immune microenvironment, and induce the occurrence of cervical tumors. However, the prevalence of HPV is species-specific in different eras or in different countries and regions. This paper aimed to investigate the characteristics of HPV infection in the Xuhui District, Shanghai City, China. METHODS: We collected HPV data from 6,760 female testers, focusing on the younger population for data analysis. We focused more on the HPV subtypes to which young women were susceptible, performed t-Distributed Stochastic Neighbor Embedding (TSNE) analysis to screen for characteristic subtypes, and compared the prevalent subtypes lacking effective vaccine protection. RESULTS: HPV infection exhibited a trend of affecting a younger population, and eight subtypes were more likely to occur in young people. HPV43, 51, 53, and 59 showed a higher incidence and lacked vaccine protection. We performed TSNE dimensionality reduction analysis to organize the HPV data. The results indicated that HPV16, 18, and 51 are characteristic subtypes in the younger population. The Thinprep cytologic test (TCT) also revealed that the infection with HPV43, 51, 53, and 59 also triggers significant pathological phenotypes. CONCLUSIONS: HPV51 is a subtype that occurs more frequently in young women, can induce a variety of significant pathological features, and lacks effective vaccine protection. This study inspires us to take measures to deal with HPV rejuvenation and conduct research on vaccines for specific HPV subtypes.

DOI PubMed

ASO Visual Abstract: EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery.

Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

Annals of surgical oncology   30 ( 11 ) 6705 - 6706  2023年10月  [国際誌]

DOI PubMed

卵巣癌に対するPARP阻害薬の中期成績と有害事象・内服アドヒアランスの関係性の検討

萬 和馬, 松浦 基樹, 有元 千紘, 黒川 晶子, 玉手 雅人, 齋藤 豪

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  61回   O65 - 5  2023年10月

子宮移植実現に向けた献体トレーニング

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 秋元 太志, 馬場 剛, 齋藤 豪

Organ Biology ( (一社)日本臓器保存生物医学会 )  30 ( 3 ) 111 - 111  2023年10月

小腸癌の子宮転移の一例

長尾 沙智子, 黒川 晶子, 玉手 雅人, 幅田 周太朗, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  62 ( Suppl.2 ) 525 - 525  2023年10月

EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery.

Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

Annals of surgical oncology   30 ( 11 ) 6697 - 6702  2023年10月  [国際誌]

　概要を見る

BACKGROUND: Primary lung tumors are sometimes resected when either pleural dissemination (PD) or malignant pleural effusion (MPE) exists. This study clarified the prognostic factors for non-small cell lung cancer (NSCLC) with either PD and MPE, or both, detected during or after surgery. PATIENTS AND METHODS: We examined patients with NSCLC from a multicenter database who had either PD, MPE, or both, detected during or after surgery between 2005 and 2015. Hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model adjusted for potential confounding factors. RESULTS: Among 9463 registered patients, PD, MPE, or both, were found in 114 patients with NSCLC during or after surgery. Primary tumor resection and exploratory thoracotomy were performed in 65 and 49 patients, respectively. In univariate analysis, adenocarcinoma, clinically undetected lymph node metastasis (c-N0 or unknown), EGFR mutation, and combination of chemotherapy or tyrosine kinase inhibitors after surgery were better prognostic factors for overall survival (OS), whereas in the multivariate analysis, adenocarcinoma, clinically undetected lymph node metastasis, and EGFR mutation were favorable independent prognostic factors in OS. Additionally, limited to patients with EGFR mutation, patients with primary lung tumor resection showed a significantly better 5-year OS than those with exploratory thoracotomy (86.4 vs. 44.8%; p < 0.001). CONCLUSION: Our findings show that surgical resection of primary tumors could improve the prognosis of patients with PD, MPE, or both, detected during or after surgery when the tumors harbor an EGFR mutation.

DOI PubMed

Nationwide trends in and regional factors associated with minimally invasive hysterectomy for benign indications in Japan.

Kyoko Isoyama, Motoki Matsuura, Misa Hayasaka, Sachiko Nagao, Yoko Nishimura, Toshiki Yoshioka, Yuichi Imai, Etsuko Miyagi, Yukio Suzuki, Tsuyoshi Saito

European journal of obstetrics, gynecology, and reproductive biology   289   129 - 135  2023年10月  [国際誌]

　概要を見る

OBJECTIVE: To examine the prevalence trends of minimally invasive hysterectomy for benign indications in Japan and investigate regional disparities. STUDY DESIGN: A retrospective cohort and ecological study using "The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data". SETTING: Nationwide Japan. PATIENTS: Individuals who underwent hysterectomy for benign indications from 2014 to 2020. INTERVENTIONS: Trend analysis of minimally invasive surgery (MIS) rates through laparoscopic hysterectomies (LH) and robotic-assisted laparoscopic hysterectomies (RA-LH) at the national and prefecture levels. Examination of regional factors contributing to the disparity in MIS implementation rates by second medical service area (SMSA). RESULTS: The number of LH has increased from 16,016 in 2014 to 27,755 in 2020. The nationwide MIS hysterectomy rate increased from 29% in 2014 to 55% in 2020 (p less than 0.001). More than 50% of hysterectomies have been performed as MIS since 2019. There was an increasing trend in MIS rates in all age groups. All prefectures except one showed a significant upward trend (p less than 0.05) in the MIS rates, but MIS rates varied widely (23-84%). In a multivariable model, the MIS was more likely to be performed in the SMSAs in western Japan (p = 0.011), in the SMSAs where the number of laparoscopy-qualified gynecologists is 5-10 (p = 0.013), and 11 or higher (p less than 0.001). CONCLUSIONS: This study reveals a shift towards minimally invasive surgery (MIS) in total hysterectomy procedures in Japan. However, significant disparities in the prevalence of MIS hysterectomy exist, potentially influenced by the number of laparoscopy-qualified gynecologists.

DOI PubMed

子宮原発骨肉腫の1例

南 香穂, 嶋田 浩志, 今 沙織, 鈴木 美紀, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  70回   65 - 65  2023年09月

Laparoscopic retrovesical lower uterine segment bypass for hysterectomy with previous caesarean section: Hung Up the Bladder Bypass (HUBB) technique.

Masato Tamate, Motoki Matsuura, Nagisa Wada, Takaki Adachi, Kazuma Yorozu, Chihiro Arimoto, Tsuyoshi Saito

Journal of gynecology obstetrics and human reproduction     102629 - 102629  2023年07月  [国際誌]

　概要を見る

Patients with a history of cesarean section and a highly adherent bladder may have difficulty in bladder dissection and may suffer damage. It may also be difficult to orient the patient for repair in the event of damage. In such cases, dissection from the side between the bladder and cervix is a good way to avoid complication. This video reviews the steps of the HUBB technique procedure, provides tips and tricks for performing a successful adhesiolysis, and illustrates the procedure's adaptability. The first is the identification of the uterine artery and its position. Step2, a Laparoscopic retrovesical lower uterine segment bypass is created. Step3 a Hung Up the Bladder Bypass is created, the bladder is completely dissected. Step4, an adhesiolysis and leak test is performed. In this report, we would like to introduce a technique for creating a retrovesical lower uterine segment bypass using a laparoscope and traction on the bypass to dissect the bladder.

DOI PubMed

当科における卵巣組織凍結の現状報告と北海道における小児科医の卵巣組織凍結に対する意識調査

長尾 沙智子, 玉手 雅人, 春日 芙貴子, 西村 庸子, 松浦 基樹, 久野 芳佳, 馬場 剛, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   387 - 387  2023年07月

当院における婦人科癌に対するがん遺伝子パネル検査の現状と課題

野藤 五沙, 真里谷 奨, 田中 佑弥, 室田 文子, 寺本 瑞絵, 松浦 基樹, 岩崎 雅宏, 石川 亜貴, 高田 弘一, 櫻井 晃洋, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   288 - 288  2023年07月

【AIがもたらす婦人科癌医療の新展開】深層学習を利用したHE染色からの子宮内膜癌MMR status判定の可否に関する検討

梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   153 - 153  2023年07月

【我々はこうしている～子宮頸癌手術におけるMISの工夫】我々が行う子宮頸癌に対する腹腔鏡下広汎子宮全摘術の工夫

松浦 基樹, 玉手 雅人, 長尾 沙智子, 黒川 晶子, 秋元 太志, 諸井 明仁, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   160 - 160  2023年07月

子宮頸部腺癌の生検組織における間質線維化反応の臨床的意義

秋元 太志, 松浦 基樹, 玉手 雅人, 岩崎 雅宏, 幅田 周太朗, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   316 - 316  2023年07月

献体による手術トレーニングの立ち上げと運営のコツ-本邦の手術を今後も安全かつ世界最高水準で続けるために 日本の持続的CSTに必要な横断的で多角的な思考とは?

玉手 雅人, 松浦 基樹, 齋藤 豪

医学教育 ( (一社)日本医学教育学会 )  54 ( Suppl. ) 72 - 72  2023年07月

プラチナ感受性再発卵巣がんに対するオラパリブ,ニラパリブ維持療法の比較検討

有元 千紘, 松浦 基樹, 足立 岳貴, 萬 和馬, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   350 - 350  2023年07月

Cervical conization with endoCUT mode applying gastrointestinal endoscopic polypectomy technique.

Masato Tamate, Motoki Matsuura, Tsuyoshi Saito

Obstetrics & gynecology science    2023年06月  [国際誌]

　概要を見る

OBJECTIVE: To show how endoCUT (COMPANY, CITY, STATE, COUNTRY) mode can be safely managed with cervical conization. METHODS: Demonstration of the technique and explanation of endoCUT and soft coagulation mode with narrated video footage. Cervical conization is a therapeutic and diagnostic procedure performed for the diagnosis of cervical intraepithelial lesions and cervical cancer. Specific methods include cold scalpel, ultrasonically activated device and laser, and loop electrosurgical excision procedure (LEEP), which involves transpiration and partial excision. The endoCUT mode and soft coagulation in VIO3 (COMPANY, CITY, STATE, COUNTRY) were used to perform cervical conical resection safely and at low cost (Fig. 1). The endoCUT mode was originally developed for polypectomy in gastrointestinal endoscopy, where no counter traction can be applied [1,2]. RESULTS: The endoCUT mode approach to cervical conization with several key strategies to minimize blood loss and ensure safety: 1) incisions can be made in close contact; 2) resection can be performed with minimal contact with the lesion; 3) control of bleeding from the resected transection by soft coagulation; and 4) low running cost of endoCUT mode. CONCLUSION: Conventionally, cervical conical resection has been performed by using a device capable of making a close incision (cold scalpel, ultrasonically activated device and laser, and LEEP etc.), but there have been issues with bleeding control and cost. Here, we present a new technique using the endoCUT mode and several strategies for safe and effective resection.

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