論文 - 齋藤　豪

Increased cervical Chlamydia trachomatis and syphilis infections in Japanese females of reproductive age in the late 2010s: Possible cause.

Satoshi Shimano, Tasuku Mariya, Tsuyoshi Saito

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy    2021年05月  [国際誌]

　概要を見る

From 2000 to 2019, Japan's reproductive-age population gradually declined by 24%. In comparison, the Chlamydia trachomatis infection rate increased from 2016, with the syphilis infection rate increasing more sharply from 2014. Since 2013, the numbers of foreign tourists to Japan have also increased. From 2011 to 2018, the rate of increase in tourists was 5.02 times, while the rate of increase in syphilis patients was higher at 22.4 times. The lack of a one-to-one relationship between foreign tourists and syphilis cases suggests that cases of syphilis were transmitted to others. Although the prevalence of syphilis in the tourists' home countries (Korea in 2014 and China in 2013) was 20-30 times higher than that in Japan, the Japanese sex industry did not discriminate against foreign tourists, leading to increased STI infections in Japanese female sex workers. Indeed, from 2017 to 2018, a history of working in the sex industry for six months was identified as a risk factor for syphilis. The rise in Chlamydia trachomatis infections has lagged behind that of syphilis by two years, with the rate of increase lower. We suspect the difference in increasing rates of syphilis and chlamydial infections is due to the different methods of infection: syphilis can be transmitted by light physical contact, such as a kiss, whereas chlamydia requires close sexual contact, such as oral sex or sexual intercourse. Regardless, examinations and infection control are necessary to prevent the spread of STIs in Japan due to inbound tourists.

DOI PubMed

進行卵巣癌における腹水細胞診と腹水遺伝子診断

松浦 基樹, 西村 庸子, 玉手 雅人, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 269 - 269  2021年05月

医師採取HPV検査と自己採取および尿採取法によるHPV検査の比較研究

寺田 倫子, 松浦 基樹, 西村 庸子, 玉手 雅人, 長尾 沙智子, 田渕 雄大, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 228 - 228  2021年05月

体腔液セルブロックによる免疫染色の検討

玉手 雅人, 松浦 基樹, 西村 庸子, 新開 翔太, 真里谷 奨, 寺田 倫子, 岩崎 雅宏, 石岡 伸一, 杉田 真太朗, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 189 - 189  2021年05月

Does Radical trachelectomy (RT) during pregnancy have higher obstetrical and oncological risks than RT before pregnancy?

Shota Shinkai, Shinichi Ishioka, Tasuku Mariya, Yuya Fujibe, Miseon Kim, Masayuki Someya, Tsuyoshi Saito

( Research Square Platform LLC )   2021年03月

　概要を見る

Purpose Radical trachelectomy (RT) with pelvic lymphadenectomy has become a new treatment option for young patients with uterine cervical cancer stages 1A2–1B1 who desire the preservation of their fertility. However, the application of RT for pregnant patients is still controversial. We comparatively studied both obstetrical and oncological outcomes of pregnant patients who underwent vaginal RT during pregnancy and those who underwent vaginal RT before pregnancy. Methods Both obstetrical and oncological results of eight patients who underwent vaginal RT with pelvic lymphadenectomy during pregnancy in our institute between 2010 and 2020 (Group A), and ten pregnant patients who underwent vaginal RT with pelvic lymphadenectomy before pregnancy during the same period (Group B) were reviewed based on their medical charts. Results There were no significant differences in blood loss, surgical time, or surgical completeness between Group A and Group B. Nor were there significant differences in obstetrical outcomes between the two groups. However, two of the eight patients in Group A had recurrence of the cancer. None of the patients in Group B has shown any signs of recurrence thus far. Conclusion Vaginal RT during pregnancy does not affect the obstetrical prognoses of patients with early invasive uterine cervical cancer, and it might be a tolerable treatment modality for them. However, oncologically, it should be performed carefully as there is a risk of recurrence.

DOI

高次施設における帝王切開率抑制の試み

染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 367  2021年03月

妊娠時に繰り返す脱落膜ポリープを保存的に管理し第1子で死産となるも第2子で生児を得た1例

倉 ありさ, 藤部 佑哉, 石堂 茉泉, 鹿内 智史, 野藤 五沙, 新開 翔太, 嶋田 浩志, 鈴木 美紀, 石岡 伸一, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  65 ( 1 ) 32 - 37  2021年03月

PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 611  2021年03月

胃原発転移性卵巣腫瘍に対し付属器摘出術を施行した症例の検討

田中 綾一, 辻 靖, 南 妃奈, 清水 亜由美, 池田 詩子, 逸見 博文, 神 崇志, 新藤 智子, 鈴木 善法, 玉手 雅人, 松浦 基樹, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  65 ( 1 ) 43 - 48  2021年03月

　概要を見る

転移性卵巣腫瘍は胃癌または大腸癌からの転移が最も多い。胃癌からの転移性卵巣腫瘍は周囲臓器へ浸潤または癒着を認める症例は比較的少なく低侵襲に摘出可能であることが多い。胃原発転移性卵巣腫瘍に対し付属器摘出術を施行した症例について検討した。対象は2017年から2年間の間に胃癌を原発とした転移性卵巣腫瘍に対し付属器摘出術を施行した6例。周術期合併症,術後化学療法開始までの期間,無増悪期間,生存期間,術前術後のQOLの変化等について検討した。胃癌診断時の年齢の中央値は47.0歳,6例中5例に腹腔鏡下手術を選択し,周術期合併症を認めた症例は無かった。術前に下腹部痛を認めた2例は共に術後の症状の消失が確認できた。化学療法再開までの中央値は18.0日,増悪または再発をみとめた3例の無増悪期間はそれぞれ8,2,8ヵ月,付属器摘出術後12,8,12ヵ月に原病死に至った。他の3例は現在いずれも無病生存している。症状緩和目的または卵巣転移以外の病勢が充分に制御されている症例において胃原発転移性卵巣腫瘍に対する付属器摘出術は検討され得ると考えられた。(著者抄録)

Cadaver Surgery Trainingの壁と意義

玉手 雅人, 松浦 基樹, 西尾 空, 太田 未咲, 佐藤 由梨, 野呂 薫, 長尾 沙智子, 阿部 秀悦, 西村 庸子, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  65 ( 1 ) 88 - 89  2021年03月

Common iliac artery dissection as a complication of common iliac artery balloon occlusion for placenta percreta: A case report.

Kimihito Saito, Tasuku Mariya, Yuya Fujibe, Masato Saito, Naoki Hirokawa, Shinichi Ishioka, Tsuyoshi Saito

The journal of obstetrics and gynaecology research   47 ( 3 ) 1172 - 1177  2021年03月  [国際誌]

　概要を見る

A 37-year-old pregnant woman who had undergone three previous cesarean sections was diagnosed as having placenta percreta. We decided to perform cesarean hysterectomy with bilateral common iliac artery balloon occlusion (CIABO). The duration of surgery was 2 h and 2 min and total estimated blood loss was 2600 mL. Surgery was completed without any surgical complications, but the pulse oximeter waveform of the left leg became undetectable during surgery. We immediately performed angiography after closure of laparotomy and found abnormal pooling of contrast media at the left common iliac artery in the region in which the balloon was positioned. We made a diagnosis of left common iliac artery dissection caused by CIABO. We performed emergent revascularization by intravascular stenting. We conclude that CIABO can cause common iliac artery dissection by mechanical stimulation of the inflated balloon. Careful intraoperative evaluation of limb ischemia and preparation of intravascular treatment is needed for a safe procedure.

DOI PubMed

病院全体の医療安全を考える サージカルスモークについて

西尾 空, 玉手 雅人, 松浦 基樹, 寺田 倫子, 磯山 響子, 春日 芙貴子, 岡田 匡氷, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 297  2021年03月

Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.

Tasuku Mariya, Terufumi Kubo, Yoshihiko Hirohashi, Junko Yanagawa, Yuta Tabuchi, Kazuhiko Matsuo, Kiyoshi Furumura, Rena Morita, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Tadashi Hasegawa, Tsuyoshi Saito, Toshihiko Torigoe

Medical molecular morphology   54 ( 1 ) 14 - 22  2021年03月  [国内誌]

　概要を見る

Mismatch repair protein deficiency (dMMR) is a favorable prognostic factor in colorectal cancer. It is also associated with aberrant expression of HLA class I molecules, which are required for cytotoxic T lymphocyte-mediated cancer immunotherapy. Because dMMR is frequently also found in endometrial cancers (ECs), we retrospectively investigated the expression of mismatch repair proteins and HLA class I molecules in 127 EC patients. In this study, EC patients being treated in our hospital were recruited from 2005 to 2009 and observed until December 2017. Lesion specimens were evaluated via immunohistochemistry for MSH6 and PMS2 (mismatch repair proteins) and HLA class I molecules. Expression of these molecules was statistically related to clinical and pathological factors and prognosis. dMMR was detected in 33 patients and did not correlate with the expression level of HLA class I molecules (P = 0.60). On the other hand, unexpectedly, multivariate analysis revealed that intact expression of HLA class I molecules was associated with p53 overexpression (P = 0.004). Neither dMMR nor decreased expression of HLA class I molecules were prognostic factors. These results are inconsistent with previous findings for colorectal cancer. A distinctive local tissue immune microenvironment would underlie the discrepancy in the results between EC and colorectal cancer.

DOI PubMed

子宮体がんスクリーニングにおける遺伝子解析併用の有用性

松浦 基樹, 玉手 雅人, 西尾 空, 西村 庸子, 磯山 響子, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 400  2021年03月

術前化学療法が奏功し手術療法が可能となった子宮頸癌IV期病変の摘出子宮における腫瘍浸潤リンパ球(TIL)の特徴を検証した1例

常松 梨紗, 岩崎 雅宏, 郷久 晴朗, 阿部 秀悦, 小川 万梨絵, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 313  2021年03月

Study of laparoscopic monopolar devices and its thermal effects

Motoki Matsuura, Masato Tamate, Sachiko Nagao, Muna Nishio, Tadahi Okada, Yoko Nishimura, Kyoko Isoyama, Noriko Terada, Tsuyoshi Saito

European Journal of Gynaecological Oncology ( IMR Press Limited )  42 ( 1 ) 118 - 121  2021年02月

　概要を見る

Objective: Energy devices are frequently used in minimally invasive surgeries (MIS). For MIS involving gynecologic malignancies, energy devices should be used cautiously to prevent thermal injuries to nearby organs. We evaluated monopolar electrosurgery devices and measured increases in temperature in the tissue and device. Methods: Briefly, the surface of a porcine tissue was incised using short and long activation times. Subsequently, the maximum temperature at the tip of the monopolar device, the cooling time required to reach a temperature of 60 ◦C, and the maximum tissue temperature were recorded. Results: Longer activation time was correlated with a higher tip temperature. With all activation times, there was an increase in the tip temperature that exceeded 100 ◦C. The cooling time to reach 60 ◦C was faster with the short activation times than with the long activation times. Even with the same output, the temperature decreased faster in the coagulation mode, suggesting that the cooling times were shorter with lower outputs. The tissue temperature dropped to 60 ◦C or less within 1 s in the cut mode but required approximately 2 s in the coagulation mode at 40 W. The temperature of the dissected tissue increased to 60 ◦C or higher the cooling time was longer with high output and in the coagulation mode. Conclusions: We revealed that the activation of the monopolar device under routine use conditions exceeded a temperature of 100 ◦C. Additionally, the temperatures of the tip and tissue were significantly higher in proportion to the output and time. For MIS involving gynecologic malignancies, careful attention is necessary to avoid thermal injury.

DOI

Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.

Taro Murakami, Akira Takasawa, Kumi Takasawa, Taishi Akimoto, Tomoyuki Aoyama, Kazufumi Magara, Yuki Saito, Misaki Ota, Daisuke Kyuno, Soh Yamamoto, Tadashi Hasegawa, Tsuyoshi Saito, Makoto Osanai

Cancer science   112 ( 2 ) 906 - 917  2021年02月  [国際誌]

　概要を見る

Recent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential of various cancers. In the present study, we investigated the expression of junctional adhesion molecule-A (JAM-A), one of the transmembrane TJP, in uterine cervical adenocarcinoma and the significance of its expression for malignancy. Immunohistochemistry on human surgical specimens showed that JAM-A was aberrantly expressed in neoplastic regions including adenocarcinoma in situ (AIS). Knockout of JAM-A significantly suppressed cell proliferation and colony-forming and migration abilities. We also showed that an antibody specific to an extracellular region of JAM-A reduced cell proliferation ability and that loss of JAM-A increased drug sensitivity of cervical adenocarcinoma cells. Based on a comprehensive proteome analysis, we found that poliovirus receptor (PVR/CD155) was regulated by JAM-A and formed a physical interaction with JAM-A. In human surgical specimens, PVR/CD155 expression was significantly correlated with some clinicopathological features and prognosis of cervical adenocarcinoma. Interestingly, most of the PVR/CD155-positive cases expressed a high level of JAM-A, and patients with the expression pattern of PVR/CD155 positive/JAM-A high had significantly shorter periods of relapse-free survival (P = .00964) and overall survival (P = .0204) than those for the other patients. Our observations suggest that aberrant expression of JAM-A promotes malignancy of uterine cervical adenocarcinoma by regulation of PVR/CD155, and JAM-A is therefore a potential therapeutic target for this malignancy.

DOI PubMed

婦人科がんにおける腹腔細胞診の意義 進行卵巣癌における腹水細胞診の意義

松浦 基樹, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 岩崎 雅宏, 磯部 友見子, 畠山 晴良, 高根 希世子, 山口 貴世志, 池上 恒雄, 古川 洋一, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 185 - 185  2021年01月

【産婦人科感染症の最新知見】注目されている産婦人科感染症 細菌性腟症、性器クラミジア感染症

島野 敏司, 真里谷 奨, 長井 陽子, 芦川 享大, 荒井 渉, 斎藤 豪

臨床と微生物 ( (株)近代出版 )  48 ( 1 ) 041 - 045  2021年01月

　概要を見る

Nugent score 4の亜分類の提唱、帯下Gram染色標本上の検体を16S rRNAシークエンス法の遺伝子解析により、細菌の種を同定した。性器クラミジアは、2010年代後半、日本の生殖年齢女性で増加していた。(著者抄録)

ERα increases endometrial cancer cell resistance to cisplatin via upregulation of BAG3.

Shuetsu Abe, Masahiro Iwasaki, Shutaro Habata, Tasuku Mariya, Masato Tamate, Motoki Matsuura, Seiro Satohisa, Tsuyoshi Saito

Oncology letters   21 ( 1 ) 20 - 20  2021年01月  [国際誌]

　概要を見る

Endometrial cancer is a leading cause of cancer-associated mortality in women and has a poor prognosis in advanced stages. Our previous study revealed that BCL-2-associated athanogene 3 (BAG3) may contribute to enhancing cell viability through downregulation of microRNA (miR)-29b in endometrial cancer cell lines. In addition, a relationship between estrogen receptor α (ERα) and BAG3 was recently reported in several cancer cell types. The present study investigated the relationship between ERα and BAG3 in endometrial cancer cell lines. The results demonstrated that exogenous ERα overexpression enhanced BAG3 expression in the EMTOKA endometrial cancer cell line, which does not endogenously express ERα, but had no effect on BAG3 expression levels in the Ishikawa cell line, which does endogenously express ERα. In addition, ERα overexpression suppressed miR-29b expression and enhanced the expression of Mcl-1, a mediator situated downstream of BAG3, in EMTOKA cells, but not Ishikawa cells. ERα overexpression also enhanced EMTOKA, but not Ishikawa, endometrial cancer cell viability in the presence of cisplatin. These findings suggested that ERα may contribute to enhancing endometrial cancer cell resistance to anticancer agents through BAG3 overexpression.

DOI PubMed