研究者詳細 - 齋藤　豪

論文 - 齋藤　豪

分割表示 453 件中 241 - 260 件目／全件表示 >>

Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency.

Yuya Fujibe, Tasuku Mariya, Masahito Mizuuchi, Shinichi Ishioka, Masahiro Yoshida, Tsuyoshi Saito

Taiwanese journal of obstetrics & gynecology 58 ( 6 ) 849 - 851 2019年11月 [国際誌]

OBJECTIVE: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. CASE REPORT: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae. CONCLUSION: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks.

DOI PubMed

転移性女性生殖器がんにおける臨床像と捺印細胞像

玉手雅人, 松浦基樹, 長尾沙智子, 西村庸子, 真里谷奨, 寺田倫子, 郷久晴朗, 杉田真太朗, 岩崎雅宏, 齋藤豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 ) 58 ( Suppl.2 ) 601 - 601 2019年10月

当院におけるオラパリブ投与症例の検討

松浦基樹, 黒川晶子, 西村庸子, 玉手雅人, 磯山響子, 寺田倫子, 郷久晴朗, 岩崎雅宏, 齋藤豪

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 57回 P156 - 7 2019年10月

術前診断が困難であった早期卵巣癌の一例

松浦基樹, 西村庸子, 玉手雅人, 寺田倫子, 寺本瑞絵, 郷久晴朗, 岩崎雅宏, 齋藤豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 ) 58 ( Suppl.2 ) 602 - 602 2019年10月

当科において妊娠初期子宮頸部細胞診HSIL/ASC-H以上を認めた症例の検討

真里谷奨, 石岡伸一, 玉手雅人, 郷久晴朗, 松浦基樹, 岩崎雅宏, 齋藤豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 ) 58 ( Suppl.2 ) 587 - 587 2019年10月

若年女性に発症した外陰部Bowen病の一例

太田未咲, 郷久晴朗, 岩崎雅宏, 小川万梨絵, 常松梨紗, 阿部秀悦, 野呂薫, 黒川晶子, 西村庸子, 玉手雅人, 磯山響子, 寺田倫子, 松浦基樹, 齋藤豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 ) 67回 79 - 79 2019年09月

タイト結合による子宮内膜の悪性化制御機序

郷久晴朗, 嶋田浩志, 岩崎雅宏, 染谷真行, 金野匠, 菊池真, 幸野貴之, 玉手雅人, 松浦基樹, 小島隆, 齋藤豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 ) 67回 36 - 36 2019年09月

ロボット支援下手術におけるロールインからコンソールまでの定型化の必要性

西村庸子, 松浦基樹, 黒川晶子, 玉手雅人, 寺田倫子, 郷久晴朗, 岩崎雅宏, 齋藤豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 ) 67回 74 - 74 2019年09月

Pioglitazone suppresses excessive follicular development in murine preantral follicles.

Sachiko Nagao, Tsuyoshi Baba, Yuya Fujibe, Sayaka Adachi, Keiko Ikeda, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

Journal of ovarian research 12 ( 1 ) 82 - 82 2019年08月 [国際誌]

Polycystic ovary syndrome (PCOS) is an endocrine disease that is common in women in their reproductive period. Patients with this disease suffer from anovulation and hyperandrogenism. Ovulation induction with exogenous gonadotropin often causes ovarian hyperstimulation syndrome because many small antral follicles pause in their growth. Treatment with insulin sensitizers is reportedly effective for both anovulation associated with PCOS, and suppression of excessive follicular growth; however, the underlying mechanism of action remains unknown. Although pioglitazone is known as an insulin sensitizer, it also has a potent modulator of cell growth and apoptosis irrespective of insulin resistance. To clarify the effect of pioglitazone on follicular growth, we performed in vitro culture of murine preantral follicles. Secondary follicles (100-160 μm in diameter) isolated from 6-week-old ICR mice were individually cultured for 13 days. Culture conditions were as follows: 1) follicle-stimulating hormone (FSH; 33 mIU/mL; control), 2) FSH plus dihydrotestosterone (DHT; 500 ng/mL), 3) FSH plus pioglitazone (5 ng/mL), and 4) FSH plus DHT/pioglitazone. Survival rate and follicle diameter were evaluated, and concentrations of estradiol (E2) and vascular endothelial growth factor (VEGF) in culture media were measured. mRNA expression of various growth-promoting factors and Vegf within follicles were also assessed. Although no significant differences were observed with regard to survival rate, follicle diameters on day 13 were significantly different.Compared with the control group, the DHT group showed enhanced growth, while groups administered pioglitazone showed stagnation of the accelerated growth induced by DHT. Although DHT treatment enhanced the expression of bone morphogenetic protein 2 (Bmp2) mRNA, pioglitazone exposure suppressed induction of Bmp2 mRNA by DHT. Vegf mRNA and protein expression were also significantly reduced when pioglitazone was added to culture media containing DHT.Administration of pioglitazone negatively affected follicular growth and VEGF levels, which may suppress excessive follicular growth and prevent ovarian hyperstimulation syndrome.

DOI PubMed

術前に良性嚢胞腺腫と診断し、腹腔鏡手術後に卵巣癌と診断された1例

郷久晴朗, 岩崎雅宏, 鹿内智史, 常松梨紗, 阿部秀悦, 小川万梨絵, 西村庸子, 玉手雅人, 寺田倫子, 松浦基樹, 齋藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 35 ( Suppl.I ) 265 - 265 2019年08月

腹腔鏡下子宮筋腫核出術後に、ポート挿入部に腫瘍転移した1例

岩崎雅宏, 郷久晴朗, 小川万梨絵, 阿部秀悦, 松浦基樹, 玉手雅人, 西村庸子, 常松梨紗, 黒川晶子, 齋藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 35 ( Suppl.I ) 246 - 246 2019年08月

疲れにくい腹腔鏡手術男女の身体的特性から

長尾沙智子, 西村庸子, 玉手雅人, 松浦基樹, 齋藤豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 ) 35 ( Suppl.I ) 117 - 117 2019年08月

Cadaver Surgery Multi Angleな手術教育と研究

玉手雅人, 松浦基樹, 長尾沙智子, 西村庸子, 杉尾明香, 竹中慎, 明石祐史, 林茂徳, 金尾祐之, 齋藤豪