論文 - 齋藤　豪

子宮体癌と大腸癌におけるミスマッチ修復タンパク欠損と免疫逃避機構の差異に関する検討

真里谷 奨, 廣橋 良彦, 久保 輝文, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   214 - 214  2021年07月

子宮温存している若年発症子宮体部腺肉腫の2例

寺田 倫子, 松浦 基樹, 野藤 五沙, 西村 庸子, 真里谷 奨, 玉手 雅人, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   292 - 292  2021年07月

消化管ポリープ切除技術を応用した子宮頸部円錐切除術とコストの検討

玉手 雅人, 松浦 基樹, 西村 庸子, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   330 - 330  2021年07月

自己採取および尿採取HPV検査の有効性に関する検討

松浦 基樹, 寺田 倫子, 西村 庸子, 玉手 雅人, 磯山 響子, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   326 - 326  2021年07月

子宮体癌と大腸癌におけるミスマッチ修復タンパク欠損と免疫逃避機構の差異に関する検討

真里谷 奨, 廣橋 良彦, 久保 輝文, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   214 - 214  2021年07月

術前補助化学療法後の子宮頸癌再発に対しheterogeneousな免疫逃避機構が関与している可能性 症例報告(Heterogenous Immune Escape Mechanisms Might be Related to Recurrence of Cervical Cancer after the Neoadjuvant Chemotherapy: A Case Report)

常松 梨紗, 岩崎 雅宏, 廣橋 良彦, 阿部 秀悦, 小川 万梨絵, 郷久 晴朗, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   320 - 320  2021年07月

Estimation of Physiologic Ability and Surgical Stress(E-PASS)で評価した後期高齢者の婦人科手術

篠原 由梨, 玉手 雅人, 岡田 匡氷, 春日 芙貴子, 阿部 秀悦, 伊野 善彦, 寺田 倫子, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 152 - 152  2021年06月

帝王切開術後癒着症例に対する腹腔鏡下子宮全摘術での膀胱剥離の工夫

有元 千紘, 長尾 沙智子, 山崎 智子, 高田 さくら, 玉手 雅人, 恐神 博行, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 138 - 138  2021年06月

多様化する子宮全摘 腟式子宮全摘の視点 全アプローチを経験して振り返った腟式

玉手 雅人, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 13 - 19  2021年06月

手術室の医療安全を考える サージカルスモークについて

西尾 空, 玉手 雅人, 松浦 基樹, 寺田 倫子, 磯山 響子, 春日 芙貴子, 岡田 匡氷, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 153 - 153  2021年06月

多様化する手術教育の実践 がんの手術をどう学び、どう伝えるか

松浦 基樹, 玉手 雅人, 西村 庸子, 寺田 倫子, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 43 - 46  2021年06月

Increased cervical Chlamydia trachomatis and syphilis infections in Japanese females of reproductive age in the late 2010s: Possible cause.

Satoshi Shimano, Tasuku Mariya, Tsuyoshi Saito

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy    2021年05月  [国際誌]

　概要を見る

From 2000 to 2019, Japan's reproductive-age population gradually declined by 24%. In comparison, the Chlamydia trachomatis infection rate increased from 2016, with the syphilis infection rate increasing more sharply from 2014. Since 2013, the numbers of foreign tourists to Japan have also increased. From 2011 to 2018, the rate of increase in tourists was 5.02 times, while the rate of increase in syphilis patients was higher at 22.4 times. The lack of a one-to-one relationship between foreign tourists and syphilis cases suggests that cases of syphilis were transmitted to others. Although the prevalence of syphilis in the tourists' home countries (Korea in 2014 and China in 2013) was 20-30 times higher than that in Japan, the Japanese sex industry did not discriminate against foreign tourists, leading to increased STI infections in Japanese female sex workers. Indeed, from 2017 to 2018, a history of working in the sex industry for six months was identified as a risk factor for syphilis. The rise in Chlamydia trachomatis infections has lagged behind that of syphilis by two years, with the rate of increase lower. We suspect the difference in increasing rates of syphilis and chlamydial infections is due to the different methods of infection: syphilis can be transmitted by light physical contact, such as a kiss, whereas chlamydia requires close sexual contact, such as oral sex or sexual intercourse. Regardless, examinations and infection control are necessary to prevent the spread of STIs in Japan due to inbound tourists.

DOI PubMed

体腔液セルブロックによる免疫染色の検討

玉手 雅人, 松浦 基樹, 西村 庸子, 新開 翔太, 真里谷 奨, 寺田 倫子, 岩崎 雅宏, 石岡 伸一, 杉田 真太朗, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 189 - 189  2021年05月

進行卵巣癌における腹水細胞診と腹水遺伝子診断

松浦 基樹, 西村 庸子, 玉手 雅人, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 269 - 269  2021年05月

医師採取HPV検査と自己採取および尿採取法によるHPV検査の比較研究

寺田 倫子, 松浦 基樹, 西村 庸子, 玉手 雅人, 長尾 沙智子, 田渕 雄大, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 228 - 228  2021年05月

Does Radical trachelectomy (RT) during pregnancy have higher obstetrical and oncological risks than RT before pregnancy?

Shota Shinkai, Shinichi Ishioka, Tasuku Mariya, Yuya Fujibe, Miseon Kim, Masayuki Someya, Tsuyoshi Saito

( Research Square Platform LLC )   2021年03月

　概要を見る

Purpose Radical trachelectomy (RT) with pelvic lymphadenectomy has become a new treatment option for young patients with uterine cervical cancer stages 1A2–1B1 who desire the preservation of their fertility. However, the application of RT for pregnant patients is still controversial. We comparatively studied both obstetrical and oncological outcomes of pregnant patients who underwent vaginal RT during pregnancy and those who underwent vaginal RT before pregnancy. Methods Both obstetrical and oncological results of eight patients who underwent vaginal RT with pelvic lymphadenectomy during pregnancy in our institute between 2010 and 2020 (Group A), and ten pregnant patients who underwent vaginal RT with pelvic lymphadenectomy before pregnancy during the same period (Group B) were reviewed based on their medical charts. Results There were no significant differences in blood loss, surgical time, or surgical completeness between Group A and Group B. Nor were there significant differences in obstetrical outcomes between the two groups. However, two of the eight patients in Group A had recurrence of the cancer. None of the patients in Group B has shown any signs of recurrence thus far. Conclusion Vaginal RT during pregnancy does not affect the obstetrical prognoses of patients with early invasive uterine cervical cancer, and it might be a tolerable treatment modality for them. However, oncologically, it should be performed carefully as there is a risk of recurrence.

DOI

高次施設における帝王切開率抑制の試み

染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 367  2021年03月

Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.

Tasuku Mariya, Terufumi Kubo, Yoshihiko Hirohashi, Junko Yanagawa, Yuta Tabuchi, Kazuhiko Matsuo, Kiyoshi Furumura, Rena Morita, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Tadashi Hasegawa, Tsuyoshi Saito, Toshihiko Torigoe

Medical molecular morphology   54 ( 1 ) 14 - 22  2021年03月  [国内誌]

　概要を見る

Mismatch repair protein deficiency (dMMR) is a favorable prognostic factor in colorectal cancer. It is also associated with aberrant expression of HLA class I molecules, which are required for cytotoxic T lymphocyte-mediated cancer immunotherapy. Because dMMR is frequently also found in endometrial cancers (ECs), we retrospectively investigated the expression of mismatch repair proteins and HLA class I molecules in 127 EC patients. In this study, EC patients being treated in our hospital were recruited from 2005 to 2009 and observed until December 2017. Lesion specimens were evaluated via immunohistochemistry for MSH6 and PMS2 (mismatch repair proteins) and HLA class I molecules. Expression of these molecules was statistically related to clinical and pathological factors and prognosis. dMMR was detected in 33 patients and did not correlate with the expression level of HLA class I molecules (P = 0.60). On the other hand, unexpectedly, multivariate analysis revealed that intact expression of HLA class I molecules was associated with p53 overexpression (P = 0.004). Neither dMMR nor decreased expression of HLA class I molecules were prognostic factors. These results are inconsistent with previous findings for colorectal cancer. A distinctive local tissue immune microenvironment would underlie the discrepancy in the results between EC and colorectal cancer.

DOI PubMed

Common iliac artery dissection as a complication of common iliac artery balloon occlusion for placenta percreta: A case report.

Kimihito Saito, Tasuku Mariya, Yuya Fujibe, Masato Saito, Naoki Hirokawa, Shinichi Ishioka, Tsuyoshi Saito

The journal of obstetrics and gynaecology research   47 ( 3 ) 1172 - 1177  2021年03月  [国際誌]

　概要を見る

A 37-year-old pregnant woman who had undergone three previous cesarean sections was diagnosed as having placenta percreta. We decided to perform cesarean hysterectomy with bilateral common iliac artery balloon occlusion (CIABO). The duration of surgery was 2 h and 2 min and total estimated blood loss was 2600 mL. Surgery was completed without any surgical complications, but the pulse oximeter waveform of the left leg became undetectable during surgery. We immediately performed angiography after closure of laparotomy and found abnormal pooling of contrast media at the left common iliac artery in the region in which the balloon was positioned. We made a diagnosis of left common iliac artery dissection caused by CIABO. We performed emergent revascularization by intravascular stenting. We conclude that CIABO can cause common iliac artery dissection by mechanical stimulation of the inflated balloon. Careful intraoperative evaluation of limb ischemia and preparation of intravascular treatment is needed for a safe procedure.

DOI PubMed

PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 611  2021年03月